Deep gray matter iron measurement in patients with liver cirrhosis using quantitative susceptibility mapping: Relationship with pallidal T1 hyperintensity

BACKGROUND

The liver is a central organ for the metabolism of iron and manganese and the places where those metals are commonly deposited overlap in the brain.

PURPOSE/HYPOTHESIS

To elucidate the relationship between pallidal T₁ hyperintensity and iron deposition in the deep gray matter of liver cirrhosis patients using quantitative susceptibility mapping (QSM).

STUDY TYPE

Retrospective case–control study

SUBJECTS: In all, 38 consecutive liver cirrhosis patients who received brain magnetic resonance imaging (MRI) as pretransplant evaluation.

FIELD STRENGTH/SEQUENCE

QSM was reconstructed from 3D multi- or single-echo phase images at 3T. T₁-weighted images were used for the assessment of pallidal hyperintensity and pallidal index (PI).

ASSESSMENT

Patients were divided into two groups according to the presence of pallidal hyperintensity by consensus of two radiologists. Susceptibility values were acquired for five deep gray matter structures.

STATISTICAL TEST

QSM measures were compared between two groups using the t-test. We also calculated Pearson correlations between QSM measures and PI.

RESULTS

In all, 26 patients showed pallidal hyperintensity (T₁h group) and 12 did not (T₁n group). The susceptibility of the globus pallidus (GP) in the T₁h group (120.6 ± 38.1 ppb) was significantly lower than that in the T₁n group (150.0 ± 35.2, P = 0.030). The susceptibility of the dentate nucleus (DN) in the T₁h group (88.1 ± 31.0) was significantly lower than that in the T₁n group (125.6 ± 30.6, P = 0.001). Negative correlation between the susceptibility of GP (r = –0.37, P = 0.022) and the PI, and between DN (r = –0.43, P < 0.001) and the PI was found.

DATA CONCLUSION

Liver cirrhosis patients with pallidal T₁ hyperintensity had lower susceptibility values in the GP and DN than those without it. This suggests a possible interaction between iron and manganese in the brains of liver cirrhosis patients.

Level of Evidence: 3

Technical Efficacy: Stage 3

J. Magn. Reson. Imaging 2017.

from # All Medicine by Alexandros G. Sfakianakis via alkiviadis.1961 on Inoreader http://ift.tt/2i8NNvm