Random Electromyostimulation Promotes Osteogenesis and the Mechanical Properties of Rat Bones

Abstract

Exercise is often recommended as a promising non-pharmacologic countermeasure to prevent osteoporosis. However, elderly osteoporotic patients generally have physical fitness difficulties preventing them from performing effective and sustainable exercise. Electromyostimulation should be one effective modality for non-pharmacological prevention of osteoporosis without any voluntary physical movements. However, successful stimulation patterns remain controversial. As suggested by our previous in vitro studies, randomized timing of stimulation could be a candidate to maximize the osteogenic effect of electromyostimulation. In this study, the effects of random stimulation to the quadriceps on osteogenesis in the femurs were investigated using rats, in comparison with a periodic stimulation pattern. In histomorphometric assessments, both stimulation patterns demonstrated increases in bone formation rate either in cortical bone at the midshaft or in trabecular bone at the femoral neck on the stimulated side. However, maximum load and strain energy to failure were enhanced only by the random stimulation, on either the stimulated or non-stimulated side. It is concluded that randomized muscle stimulation has effective osteogenic capability at the stimulation site, similar to periodic stimulation; however, its effectiveness on mechanical properties is expandable to other non-stimulated sites.

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