Outcome Measures in Psoriasis and Atopic Eczema

Abstract

There are many new and emerging therapies for complex skin disorders such as psoriasis and atopic dermatitis. In order to measure disease severity and effect of therapy, valid outcome measures are commonly employed in clinical trials and in clinical practice. The most commonly used in psoriasis clinical trials include the Psoriasis Area and Severity Index (PASI), the extent of body surface area involvement (BSA), and various physician or investigator global assessments (PGA or IGA). Measures are also available to assess nail, palmar-plantar, scalp psoriasis, and target lesions. In eczema/atopic dermatitis studies, important measures include the Eczema Area and Severity Index (EASI), the SCORAD, and the IGA. This chapter focuses on the most commonly used and the most psychometrically valid efficacy measures in clinical trials for psoriasis and eczema.

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