IJERPH, Vol. 16, Pages 2759: Impact of Carers' Smoking Status on Childhood Obesity in the Growing up in Ireland Cohort StudyIJERPH, Vol. 16, Pages 2759: Impact of Carers' Smoking Status on Childhood Obesity in the Growing up in Ireland Cohort Study International Journal of Environmental Research and Public Health doi: 10.3390/ijerph16152759 Authors: Salome Sunday Zubair Kabir Childhood obesity is a growing concern worldwide. The association between childhood obesity and maternal smoking and/or paternal...
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Viruses, Vol. 11, Pages 708: Genome of Alaskapox Virus, A Novel Orthopoxvirus Isolated from AlaskaViruses, Vol. 11, Pages 708: Genome of Alaskapox Virus, A Novel Orthopoxvirus Isolated from Alaska Viruses doi: 10.3390/v11080708 Authors: Gigante Gao Tang McCollum Wilkins Reynolds Davidson McLaughlin Olson Li Since the eradication of smallpox, there have been increases in poxvirus infections and the emergence of several novel poxviruses that can infect humans and domestic animals. In 2015, a novel...
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Toxins, Vol. 11, Pages 451: Zearalenone Contamination in Corn, Corn Products, and Swine Feed in China in 2016–2018 as Assessed by Magnetic Bead ImmunoassayToxins, Vol. 11, Pages 451: Zearalenone Contamination in Corn, Corn Products, and Swine Feed in China in 2016–2018 as Assessed by Magnetic Bead Immunoassay Toxins doi: 10.3390/toxins11080451 Authors: Li Yang Mao Hong Du In total, 405 samples of corn, corn products, and swine feed from China in 2016–2018 were surveyed for zearalenone (ZEN) contamination...
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Pharmaceutics, Vol. 11, Pages 380: Evaluation of Tumor-Targeting Properties of an Antagonistic Bombesin Analogue RM26 Conjugated with a Non-Residualizing Radioiodine Label Comparison with a Radiometal-Labelled CounterpartPharmaceutics, Vol. 11, Pages 380: Evaluation of Tumor-Targeting Properties of an Antagonistic Bombesin Analogue RM26 Conjugated with a Non-Residualizing Radioiodine Label Comparison with a Radiometal-Labelled Counterpart Pharmaceutics doi: 10.3390/pharmaceutics11080380 Authors:...
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Electrochemical Characterization of Central Action Tricyclic Drugs by Voltammetric Techniques and Density Functional Theory CalculationsPharmaceuticals doi: 10.3390/ph12030116Authors: Edson Silvio Batista Rodrigues Isaac Yves Lopes de Macêdo Larissa Lesley da Silva Lima Douglas Vieira Thomaz Carlos Eduardo Peixoto da Cunha Mayk Teles de Oliveira Nara Ballaminut Morgana Fernandes Alecrim Murilo Ferreira de Carvalho Bruna Guimarães Isecke Karla Carneiro de Siqueira Leite Fabio Bahls Machado Freddy...
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Stereoselective Anti-Cancer Activities of Ginsenoside Rg3 on Triple Negative Breast Cancer Cell ModelsPharmaceuticals doi: 10.3390/ph12030117Authors: Nakhjavani Palethorpe Tomita Smith Price Yool Pei Townsend HardinghamGinsenoside Rg3 (Rg3) has two epimers, 20(S)-ginsenoside Rg3 (SRg3) and 20(R)-ginsenoside Rg3 (RRg3), and while Rg3 itself has been reported to have anti-cancer properties, few studies have been reported on the anti-cancer effects of the different epimers. The aim was to investigate...
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Perspectives on Interval Exercise Interventions for Non-Alcoholic Fatty Liver DiseaseMedicines doi: 10.3390/medicines6030083Authors: Hidetaka HamasakiNon-alcoholic fatty liver disease (NAFLD) is the most common chronic liver disease and is associated with an increased risk of type 2 diabetes, cardiovascular disease, cirrhosis, and liver cancer. Exercise therapy is the most effective treatment for patients with NAFLD. High-intensity interval training (HIIT) is attracting attention as a time-efficient...
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Nutritional Aspects in Diabetic CKD Patients on Tertiary CareMedicina doi: 10.3390/medicina55080427Authors: D'Alessandro Barsotti Cianchi Mannucci Morganti Tassi CupistiBackground and objectives: Diabetes is largely prevalent in the chronic kidney disease (CKD) population. Both conditions have metabolic and nutritional abnormalities that affect body composition and the presence of diabetes makes the dietary management of CKD patients more difficult. The aim of this study was to assess peculiar nutritional...
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Evaluation of Clinical and Laboratory Characteristics of Children with Pulmonary and Extrapulmonary TuberculosisMedicina doi: 10.3390/medicina55080428Authors: Aygun Akcakaya Cokugras CamcıogluBackground and objective: Tuberculosis (TB) is an important public health problem in both developing and developed countries. Childhood TB is also an important epidemiological indicator in terms of forming the future TB pool. The diagnosis of TB is difficult in children due to the lack of a standard clinical...
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Omics Meeting Onics: Towards the Next Generation of Spectroscopic-Based Technologies in Personalized MedicineJournal of Personalized Medicine doi: 10.3390/jpm9030039Authors: Weng Kung Peng Daniele PaesaniThis article aims to discuss the recent development of integrated point-of-care spectroscopic-based technologies that are paving the way for the next generation of diagnostic monitoring technologies in personalized medicine. Focusing on the nuclear magnetic resonance (NMR) technologies as the leading...
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Central Nervous System Cryptococcal Infections in Non-HIV Infected PatientsJournal of Fungi doi: 10.3390/jof5030071Authors: Justin Beardsley Tania C. Sorrell Sharon C.-A. ChenCentral nervous system (CNS) cryptococcosis in non-HIV infected patients affects solid organ transplant (SOT) recipients, patients with malignancy, rheumatic disorders, other immunosuppressive conditions and immunocompetent hosts. More recently described risks include the use of newer biologicals and recreational intravenous...
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JCM, Vol. 8, Pages 1154: Shared Care for Adults with Sickle Cell Disease: An Analysis of Care from Eight Health SystemsJCM, Vol. 8, Pages 1154: Shared Care for Adults with Sickle Cell Disease: An Analysis of Care from Eight Health Systems Journal of Clinical Medicine doi: 10.3390/jcm8081154 Authors: Arch G. Mainous Benjamin Rooks Rebecca J. Tanner Peter J. Carek Vandy Black Thomas D. Coates Adult sickle cell disease (SCD) patients frequently transition from pediatric hematology to adult primary care....
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Climate Delusion: Hurricane Sandy, Sea Level Rise, and 1840s CatastrophismHumanities doi: 10.3390/h8030131Authors: WoodThe existential global threat of inundation of the world's low-lying port cities necessitates a radical shift in the dominant climate framework of sustainability and resilience to include catastrophism. Scientists and social scientists of the industrial crisis decade of the 1840s, arguably the Anthropocene's historical origin, offer a model for theorizing twenty-first century catastrophe...
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Combined Strategies with Poly (ADP-Ribose) Polymerase (PARP) Inhibitors for the Treatment of Ovarian Cancer: A Literature ReviewDiagnostics doi: 10.3390/diagnostics9030087Authors: Stergios Boussios Peeter Karihtala Michele Moschetta Afroditi Karathanasi Agne Sadauskaite Elie Rassy Nicholas PavlidisPoly (ADP-ribose) polymerase (PARP) inhibitors are the first clinically approved drugs designed to exploit synthetic lethality, and were first introduced as a cancer-targeting strategy in 2005. They have...
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Cosmetics, Vol. 6, Pages 47: Identification of Potential Skin Sensitizers in MyrrhCosmetics, Vol. 6, Pages 47: Identification of Potential Skin Sensitizers in Myrrh Cosmetics doi: 10.3390/cosmetics6030047 Authors: Qi Zhou Yongbei Liu Yanran Tang Yalda Shokoohinia Amar G. Chittiboyina Mei Wang Cristina Avonto The exudate of Commiphora myrrha (myrrh) has been known for centuries as one of the most popular natural skin remedies. The characterization and safety assessment of myrrh ingredients are challenging...
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Dentistry Journal, Vol. 7, Pages 83: Knowledge and Attitude of Midwifery Students on Oral Health CareDentistry Journal, Vol. 7, Pages 83: Knowledge and Attitude of Midwifery Students on Oral Health Care Dentistry Journal doi: 10.3390/dj7030083 Authors: Sabounchi Sabounchi Safari Midwifery students can have an important role in transferring oral health care information to expecting mothers. The aim of this study was to assess the effect of an educational intervention on knowledge and attitudes of...
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Comparing Standardized and Parent-Reported Motor Outcomes of Extremely Preterm InfantsChildren doi: 10.3390/children6080090Authors: Maeve Morgan-Feir Andrea Abbott Anne Synnes Dianne Creighton Thevanisha Pillay Jill G. ZwickerExtremely preterm infants are at increased risk of motor impairment. The Canadian Neonatal Follow-Up Network (CNFUN) afforded an opportunity to study the outcomes of extremely preterm children. The purpose of this study was to compare 18-month corrected age (CA) motor outcomes...
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A Multimodal Approach to Stratification of Patients with Dementia: Selection of Mixed Dementia Patients Prior to AutopsyBrain Sciences doi: 10.3390/brainsci9080187Authors: Gary A. Rosenberg Jillian Prestopnik Janice Knoefel John C. Adair Jeffrey Thompson Rajikha Raja Arvind CaprihanAlzheimer's disease (AD) and vascular cognitive impairment and dementia (VCID) are major causes of dementia, and when combined lead to accelerated cognitive loss. We hypothesized that biomarkers of neurodegeneration and...
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Cancers, Vol. 11, Pages 1098: Cancer Cell Lines Are Useful Model Systems for Medical ResearchCancers, Vol. 11, Pages 1098: Cancer Cell Lines Are Useful Model Systems for Medical Research Cancers doi: 10.3390/cancers11081098 Authors: Mirabelli Coppola Salvatore Cell lines are in vitro model systems that are widely used in different fields of medical research, especially basic cancer research and drug discovery. Their usefulness is primarily linked to their ability to provide an indefinite source of...
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Beverages, Vol. 5, Pages 48: Grape Infusions: The Flavor of Grapes and Health-Promoting Compounds...
Beverages, Vol. 5, Pages 48: Grape Infusions: The Flavor of Grapes and Health-Promoting Compounds in Your Tea CupBeverages, Vol. 5, Pages 48: Grape Infusions: The Flavor of Grapes and Health-Promoting Compounds in Your Tea Cup Beverages doi: 10.3390/beverages5030048 Authors: Alice Vilela Teresa Pinto Traditionally, tea, a beverage made from the processed leaves of the tea plant, Camellia sinensis, and herbal infusions have been primarily consumed for their pleasant taste. Nowadays, they are also...
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Antioxidants, Vol. 8, Pages 266: Analysis of Methanolic Extracts and Crude Polysaccharides from the Leaves of Chuanminshen violaceum and Their Antioxidant ActivitiesAntioxidants, Vol. 8, Pages 266: Analysis of Methanolic Extracts and Crude Polysaccharides from the Leaves of Chuanminshen violaceum and Their Antioxidant Activities Antioxidants doi: 10.3390/antiox8080266 Authors: Lin Li Wang Liu Yang Cao Du Zhao Zhang Wu Qin The root of Chuanminshen violaceum is used as an important edible and medicinal...
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Research Article: Development of a calculated panel reactive antibody web service with local frequencies for platelet transfusion refractoriness risk stratificationWilliam J Gordon, Layne Ainsworth, Samuel Aronson, Jane Baronas, Richard M Kaufman, Indira Guleria, Edgar L Milford, Michael Oates, Rory Dela Paz, Melissa Y Yeung, William J LaneJ Pathol Inform 2019, 10:26 (1 August 2019)DOI:10.4103/jpi.jpi_29_19 Background: Calculated panel reactive antibody (cPRA) scoring is used to assess whether platelet...
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CytoJournal Quiz Case: A rare case of malignant metastatic tumor diagnosed on fine-needle aspiration of cervical lymph nodeArvind Ahuja, Savita KumariCytoJournal 2019, 16:15 (25 July 2019)DOI:10.4103/cytojournal.cytojournal_26_18 [HTML Full text] [PDF] [Mobile Full text] [EPub] [Sword Plugin for Repository]BetaResearch Article: The risk for malignancy using the Milan salivary gland classification categories: A 5-year retrospective reviewChristine A Liang, Jing Liu, Jaiyeola Thomas Ogunniyi,...
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Journal of Molecular Endocrinology ReviewsThe effect of adipocyte–macrophage crosstalk in obesity-related breast cancer by Ayse Basak Engin, Atilla Engin and Ipek Isik Gonul.Epigenetic arginine methylation in breast cancer: emerging therapeutic strategies by Shu-Ching M Wang, Dennis H Dowhan and George E O Muscat.Molecular mechanisms of FOXO1 in adipocyte differentiation by Junye Chen et al.Applying mass spectrometric methods to study androgen biosynthesis and metabolism in prostate cancer by Matias...
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Journal of Endocrinology Editorial30th anniversary for the developmental origins of endocrinology by Sean W Limesand, Kent L Thornburg and Jane E Harding.ReviewsCompetition for nutrients in pregnant adolescents: consequences for maternal, conceptus and offspring endocrine systems by Jacqueline M Wallace.Risk of hypertension following perinatal adversity: IUGR and prematurity by Trassanee Chatmethakul and Robert D Roghair.Periconceptional environment and the developmental origins of disease by Miguel...
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The Fox and the Crow: Predatory Open Access Journals in OtolaryngologyAlbert Mudry and Robert J. RubenGuidelines Executive SummaryClinical Practice Guideline: Sudden Hearing Loss (Update) Executive SummarySujana S. Chandrasekhar, Betty S. Tsai Do, Seth R. Schwartz, Laura J. Bontempo, Erynne A. Faucett, Sandra A. Finestone, Deena B. Hollingsworth, David M. Kelley, Steven T. Kmucha, Gul Moonis, Gayla L. Poling, J. Kirk Roberts, Robert J. Stachler, Daniel M. Zeitler, Maureen D. Corrigan, Lorraine C....
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A Cross-Sectional Study of the Prevalence and Factors Associated With Tinnitus and/or Hyperacusis in ChildrenObjectives: The aim of this study was to determine the prevalence of tinnitus and/or hyperacusis in Danish children aged 10 to 16 years, and to assess associations between tinnitus or hyperacusis and other relevant factors. Design: A cross-sectional study based on a previously established child cohort. A total of 501 children were enrolled in the project. The study was performed in eight mainstream...
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Advanced Biomedical Research ( Adv Biomed Res)Development and Primary Evaluation of a Smartphone Application for Blood Glucose Control in Hospitalized PatientsRezvan Salehidoost, Elaheh Mirtallaee, Mansour SiavashAdv Biomed Res 2019, 8:45 (25 July 2019)[ABSTRACT] [HTML FULL TEXT] [PDF] [Mobile HTML Full text ] [EPub]A Novel Algorithm in Radiation Dosimetry of Regular and Irregular Treatment FieldsFatemeh Seif, Nayyer Mostafavi, Mohammadreza Bayatiyani, Hossein TaheriAdv Biomed Res 2019, 8:46...
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State Gun Laws and Pediatric Firearm-Related MortalityMonika K. Goyal, Gia M. Badolato, Shilpa J. Patel, Sabah F. Iqbal, Kavita Parikh and Robert McCarterAdverse Childhood Experiences and Protective Factors With School EngagementAngelica Robles, Annie Gjelsvik, Priya Hirway, Patrick M. Vivier and Pamela HighNeuropsychiatric Sequelae in Adolescents With Acute Synthetic Cannabinoid ToxicitySarah Ann R. Anderson, Anna M. Oprescu, Diane Callelo, Andrew Monte, Peter S. Dayan, Yasmin L. Hurd, Alex F. Manini...
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The Impact of Racism on Child and Adolescent Health Maria Trent, Danielle G. Dooley, Jacqueline Dougé, SECTION ON ADOLESCENT HEALTH, COUNCIL ON COMMUNITY PEDIATRICS and COMMITTEE ON ADOLESCENCEManagement of Infants at Risk for Group B Streptococcal DiseaseKaren M. Puopolo, Ruth Lynfield, James J. Cummings, COMMITTEE ON FETUS AND NEWBORN and COMMITTEE ON INFECTIOUS DISEASESPrevention of Group B Streptococcal Early-Onset Disease in NewbornsSchool ReadinessP. Gail Williams, Marc Alan Lerner, COUNCIL...
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30. THE BENEFITS OF A TRULY INDIVIDUALIZED CURRICULUMPublication date: August 2019Source: Academic Pediatrics, Volume 19, Issue 6Author(s): Punit N. Jhaveri, Pooja B. Jhaveri, Brandon M. SmithBackgroundIn response to the 2013 ACMGE Program Requirements that mandated "a minimum of six educational units of an individualized curriculum determined by the learning needs and career plans of each resident and... developed through the guidance of a faculty mentor," many pediatric programs developed career-based...
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Recall of Prymat White Mustard Seeds due to Presence of Salmonella typhimurium --You are receiving this email because you have subscribed to receive email alerts from the Food Safety Authority of Ireland.
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Monatsthema im August: Leben mit LebermetastasenLebermetastasen sind ein Zeichen dafür, dass eine Krebserkrankung weiter fortschreitet. Dennoch bedeutet diese Diagnose nicht per se das nahe Ende. In einigen speziellen Fällen sind Lebermetastasen sogar direkt operativ behandelbar, sehr viel häufiger jedoch nur mithilfe geeigneter systemischer Therapien. Das Ziel einer solchen systemischen Behandlung ist jedoch, das Metastasenwachstum zumindest zu bremsen oder für eine Zeit sogar ganz aufzuhalten.>>...
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The beneficial effect of traditional Japanese herbal (Kampo) medicine, Hochu‐ekki‐to (Bu‐Zhong‐Yi‐Qi‐Tang), for patients with chronic wounds refractory to conventional therapies: A prospective, randomized trialDr. Shinsuke Akita M. D., Ph. D, Dr. Takao Namiki M. D., Ph. D., Dr. Yohei Kawasaki Ph. D, Dr. Naoaki Rikihisa M. D., Ph. D, Dr. Hideyuki Ogata M. D., Dr. Hideki Tokumoto M. D., Ph. D, Dr. Takafumi Tezuka M. D., Dr. Yoshitaka Kubota M. D., Ph. D, Dr. Motone Kuriyama M. D., Ph. D, Dr. Michimi...
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National epidemic of hepatitis A outbreaks puts restaurant customers at riskBy Dan Flynn on Aug 01, 2019 02:05 am A McDonald's in Johnson City, TN, and a Little Caesar's Pizza in Newark, NJ, put their customers at risk of exposure to hepatitis A by permitting an employee with the liver disease to report for work. They are the latest in a long list of hepatitis A developments that are examples of what the Mississippi... Continue Reading Belgian experts examine Listeria growth in butter made with...
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Zapping mosquitoes from the inside out Mosquitoes aren't just annoying at summer barbecues. In many parts of the world, they carry pathogens for Zika, dengue, yellow fever, and the most devastating of mosquito-borne diseases, malaria. According to the Centers for Disease Control and Prevention, 440,000 people died in sub-Saharan Africa in 2016 from malaria, contracted from the bite of infected female Anopheles mosquitoes.While chemical mosquito population control measures have been used with some...
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Application of thrombelastography in primary total knee and total hip replacement: a prospective 87 patients studyThrombelastography (TEG) parameters and prothrombin time (PT), activated partial thromboplastin time (APTT) are compared and analysed. According to change of TEG parameters and assessment of haemostatic state of each patient, we try to explore the feasibility of individualized anticoagulant therapies. 87 people with hip or knee diseases awaiting arthroplasty were recruited. Haemoglobin...
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Evaluation and comparison of the effect of different chemical surface treatments (monomethyl methacrylate monomer, dichloromethane, and 1:1 v/v 30% trichloromethane and monomethyl methacrylate monomer solvent) on the shear bond strength of acrylic resin teeth to the heat cure denture base resinRupali Pathak, Rajneesh Kumar, Sonali Mahajan, Priya Singh, Devesh Tiwari, Prachi DevalInternational Journal of Preventive and Clinical Dental Research 2019 6(1):1-3Background: Prefabricated acrylic resin teeth...
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Liver tumor ablation assisted by image fusionSheng-Nan LuJournal of Medical Ultrasound 2019 27(2):61-62Sonographic estimation of amniotic fluid volume using the amniotic fluid index and the single deepest pocket in a resource-limited settingGeofery Luntsi, Falmata Ali Burabe, Prince Ame Ogenyi, Joseph Dlama Zira, Nwobi Ivor Chigozie, Flavious Bobuin Nkubli, Maikudi DaudaJournal of Medical Ultrasound 2019 27(2):63-68Objective: To determine the normal value of amniotic fluid (AF) volume among pregnant...
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Development of mental health care in Sri Lanka: Lessons learnedSamudra T Kathriarachchi, V Lakmi Seneviratne, Luckshika Amarakoon, Taiwanese Journal of Psychiatry 2019 33(2):55-65Background: Sri Lanka is a multi-ethnic country with a rich cultural heritage and biodiversity. Sri Lanka has a population of 21 million with an annual population growth rate of 0.76%. Methods: The authors explored the evolution of mental health care, life-cycle approach to psychiatric disorders, addressing resource limitations...
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Histone deacetylases in strokeMei-Han Kao, Teng-Nan LinChinese Journal of Physiology 2019 62(3):95-107Stroke is the second leading cause of death and the leading cause of adult disability worldwide. Despite an impressive amount of neuroprotective agents that has been identified in experimental stroke, none of them proved efficient in clinical trials. There is a general consensus that an effective treatment requires the ability to interact with not one, but multiple pathophysiological cascades at...
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Risk of Hypoxemia by Induction Technique Among Infants and Neonates Undergoing PyloromyotomyBACKGROUND: In patients presenting for pyloromyotomy, most practitioners prioritize rapid securement of the airway due to concern for aspiration. However, there is a lack of consensus and limited evidence on the choice between rapid sequence induction (RSI) and modified RSI (mRSI). METHODS: The medical records of all patients presenting for pyloromyotomy from May 2012 to December 2018 were reviewed. The risk...
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Tick Facts: Dangers at the height of tick season From April to September, tick activity spikes throughout the United States. With high tick activity comes the importance of increasing awareness of common tick-borne illnesses and how to prevent them.A tick like this one, seen at 10x magnification, can spread a number of dangerous pathogens during the warm-weather months. (Photo by Cornel Constantin) 7/31/2019 By: Military Health System Communications Office Share this page Social Media Links Share...
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Study Suggests Reviewing Lung Cancer Screening Criteria for African Americans 07/31/2019 Clinical...
Study Suggests Reviewing Lung Cancer Screening Criteria for African Americans 07/31/2019Clinical recommendations on who should be screened for lung cancer may need to be reviewed when it comes to African Americans who smoke, findings from a new study suggest.
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MELD-Na score and postoperative complications in hernia repairImproved immediate postoperative pain following laparoscopic inguinal herniorrhaphy using self-adhering mesh: the importance of clinical practice guidelinesA study of contralateral persistent processus vaginalis in laparoscopic hernia repair in childrenAbstractPurposeThe introduction of laparoscopy for hernia repair permits intra-abdominal observation of a hernia and contralateral persistent processus vaginalis (CPPV). The current study's...
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Correction to: High incidence of invasive fungal infection during acute myeloid leukemia treatment in a resource-limited country: clinical risk factors and treatment outcomesIncorrect family name of Warissara Jutidamrongphan.Responses to Comments on Our Previous Publication ( Support Care Cancer . 2018 Feb; 26(2):657–665. doi: 10.1007/s00520-017-3881-7.)Correction to: Reliability and validity of the Pittsburgh Sleep Quality Index in breast cancer patientsThere is a typo in the Funding reference cited...
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Comment on: "Drugs That Can Kill a Toddler with One Tablet or Teaspoonful: A 2018 Updated List"Response to: "Comment on: Drugs that Can Kill a Toddler with One Tablet or Teaspoonful: A 2018 Updated List"Glucagon-Like Peptide-1 Receptor Analogues in Type 2 Diabetes: Their Use and Differential FeaturesAbstractGlucagon-like peptide-1 receptor analogues/agonists (GLP-1RAs) are well established as effective adjuncts to lifestyle modification in the treatment of type 2 diabetes (T2D) as monotherapy or...
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Adaptive Bio Receives NY State Approval for ClonoSeq in B Cell CancersPublished on Jul 31, 2019 Hologic Q3 Revenues Grow 3 Percent, Firm Raises GuidancePublished on Jul 31, 2019 Luminex Q2 Revenues Rise 4 PercentPublished on Jul 31, 2019 NanoString Q2 Revenues up 21 PercentPublished on Jul 31, 2019 Precision for Medicine Acquires Biospecimen Providers ProMedDx, GLASPublished on Aug 01, 2019Featured in Depth Single-Cell Method Could Eliminate Need for Mouse Models to Study Cancer Treatment ResistancePublished...
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Device Detects and Kills Melanoma Cells in the Blood Scientists have developed a device that uses laser beams and sound waves to detect and kill melanoma cells traveling through the bloodstream.How Cancer Is Diagnosed If you have a symptom or a test result that suggests cancer, your doctor must find out whether it is due to cancer or some other cause. This updated page describes tests that are often used to help diagnose cancer.Improving Cancer Immunotherapy by Overcoming the Problem of Exhausted...
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Could the Buddha Have Been a Naturalist?AbstractWith the naturalist worldview having become widely accepted, the trend of naturalistic Buddhism has likewise become popular in both academic and religious circles. In this article, I preliminarily reflect on this naturalized approach to Buddhism in two main sections. In section 1, I point out that the Buddha rejects theistic beliefs that claim absolute power over our destiny, opting instead to encourage us to inquire intellectually and behave morally....
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New series "Cases from a busy nuclear cardiology laboratory"What is This Image? 2019: Image 2Can 99m Tc-labeled RBC-equilibrium radionuclide angiocardiography be an adjunct imaging biomarker for marrow hyperplasia in beta-thalassemia major patients?JNC Awards: In recognition of Frans Wackers, Raymond Gibbons and William StraussEarly infected aneurysm with 18 F-FDG uptake prior to substantial anatomical changesCorrection to: Comparison of two software systems for quantification of myocardial blood...
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About a promising new HIV vaccine, hear that the United Arab Emirates will become the first Arab nation to launch a planetary-science mission and discover a plot twist in the tale of the placental microbiome.Scientists have been trying for decades to develop an effective vaccine against HIV (virus particles shown in blue). (Steve Gschmeissner/SPL)'Mosaic' HIV vaccine trial set to beginAn experimental HIV vaccine that promises the longest-lasting protection so far will start a late-stage clinical...
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Development of a novel ablation hood to prevent systemic embolization of microbubbles and particulate emboliAbstractBackgroundAtrial fibrillation ablation results in microbubbles and particulate emboli formation. We aimed to develop and test the early feasibility of a novel ablation hood to contain microbubbles and particulate emboli with the ultimate goal of preventing systemic embolization.MethodsIn seven canines, we developed, iterated, and tested a novel retractable hood that can cover the catheter-tissue...
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Wirksamkeit und Sicherheit einer Kohlenstoffionentherapie lokal rezidivierter Rektumkarzinome: Ergebnisse der J‑CROS-Studie 1404 RektumGanzbrust- oder Teilbrustbestrahlung nach 5 Jahren aus Patientensicht: Longitudinale Analyse der IMPORT-LOW-Phase III-StudieEine definitive Strahlentherapie mit einer Kurzzeit Androgendeprivationstherapie von 18 Monaten kann bei Patienten mit lokal begrenztem Prostatakarzinom mit hohen Risikofaktoren gegenüber dem Standard von 28–36 Monaten ausreichend seinAdjuvant...
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Over-expression of both VEGF-C and Twist predicts poor prognosis in human breast cancerAbstractBackgroundAngiogenesis is an indispensable step in the growth and invasiveness of breast cancers involving a series of exquisite molecular steps. Pro-angiogenic factors, including vascular endothelial growth factor (VEGF), have been recognized as pivotal therapeutic targets in the treatment of breast cancer. More recently, a highly conserved transcription factor Twist has been reported to be involved in...
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A review of the influence of mammographic density on breast cancer clinical and pathological phenotypeAbstractPurposeIt is well established that high mammographic density (MD), when adjusted for age and body mass index, is one of the strongest known risk factors for breast cancer (BC), and also associates with higher incidence of interval cancers in screening due to the masking of early mammographic abnormalities. Increasing research is being undertaken to determine the underlying histological and...
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Iohexol-measured glomerular filtration rate in children and adolescents with chronic kidney disease: a pilot study comparing venous and finger stick methods: response to comments from Dr. Luis-LimaCorrection to: Neonatal hypertension: cases, causes, and clinical approachThe original version of this article unfortunately contained a mistake. Due to a production error, the wrong "Key summary points" were included. The correct key summary points are listed below.Comments on Tașdemir et al.: A rare cause...
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Holism, Meaning Similarity and Inferential Space—a Measurement Theoretic ApproachAbstractProponents of meaning holism often invoke notions of meaning similarity and semantic spatiality in order to counter accusations that holism renders language unstable and chaotic. However, talk of such notions often falls short of being explicit and formal. In this paper I present an algebraically couched theory of inferential similarity and spatiality, motivated by measurement theory, and I apply it to the discussion...
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Progknowse, Premier Join With Three Health Systems on Predictive AnalyticsPublished on Aug 01, 2019 Multidrug-Resistant Staphylococci Profiled at Public Hospital, Community Sites in LondonPublished on Aug 01, 2019 CRISPR Patent Fight Turns Ugly as UC Accuses Broad Researchers of Lying About ClaimsPublished on Aug 01, 2019 Evolution, History of Transmissible Dog Cancer Untangled With New Exome SequencesPublished on Aug 01, 2019Featured in Depth Single-Cell Method Could Eliminate Need for Mouse Models...
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The Miracle of CPAP Mike McEvoy examines some of the physiological reasons that continuous positive airway pressure (CPAP) works for a variety of conditions.
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The Art and Science of Improving Resuscitation In this interview, physician, researcher, author and EMS medical director Mickey Eisenberg discusses the challenges of implementing resuscitation improvement programs, the importance of teamwork and collaboration and what it's like to see communities around the world committing themselves to improving resuscitation.
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Preventing Overuse Hand, Arm, and Shoulder Injuries in EMS By Robert Devich, BS, NRPEMS providers cannot change the everyday reality that they will have to lift patients; however, they can change how they lift patients.
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Fauci on Ending the HIV Epidemic: A Plan for the United StatesOpioid Injection in Rural Areas of the United States: A Potential Obstacle to Ending the HIV EpidemicAndrea M. Lerner, MD; Anthony S. Fauci, MDTRENDING NOW ON JAMAFor Mortality, Busting the Myth of 10 000 Steps per DayMounting Evidence and Netflix's Decision to Pull a Controversial Suicide SceneManagement of Patients With Acute Ischemic StrokeEffect of Intensive vs Standard Treatment of Hyperglycemia on Functional Outcome in StrokeWide...
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Optimizing Mean Arterial Pressure in Acutely Comatose Patients Using Cerebral Autoregulation Multimodal Monitoring With Near-Infrared SpectroscopyObjectives: This study investigated whether comatose patients with greater duration and magnitude of clinically observed mean arterial pressure outside optimal mean arterial blood pressure have worse outcomes than those with mean arterial blood pressure closer to optimal mean arterial blood pressure calculated by bedside multimodal cerebral autoregulation...
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Patient Satisfaction and Antibiotic Prescribing for Respiratory Infections by Telemedicine Charles B. Foster, Kathryn A. Martinez, Camille Sabella, Gregory P. Weaver and Michael B. RothbergCommentaryTelemedicine and Antibiotic Use: One Click Forward or Two Steps Back?Eli Sprecher and Jonathan A. Finkelstein
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Desquamatory Lesions of the Upper Aerodigestive Tract MucosaJérôme R. Lechien, MD, PhD, MSc1,2; Francois Mouawad, MD, PhD, MSc2Author Affiliations Article Information1Department of Anatomy, University of Mons, Mons, Belgium2Department of Otorhinolaryngology–Head and Neck Surgery, CHU de Lille, Lille, FranceJAMA Otolaryngol Head Neck Surg. Published online August 1, 2019. doi:10.1001/jamaoto.2019.1990CaseAman in his 30s was referred to the department of Otorhinolaryngology–Head & Neck Surgery...
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Intraoperative Autofluorescence Parathyroid Identification in Patients With Multiple Endocrine Neoplasia Type 1Malcolm H. Squires, MD, MS1; Lawrence A. Shirley, MD1; Chengli Shen, PhD1; et alRachel Jarvis, CNP1; John E. Phay, MD1Author Affiliations Article Information1Division of Surgical Oncology, Department of Surgery, The Ohio State University Wexner Medical Center, ColumbusJAMA Otolaryngol Head Neck Surg. Published online August 1, 2019. doi:10.1001/jamaoto.2019.1987Key PointsQuestion What are...
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Pathogenesis and complications of chronic eye rubbing in ocular allergyPurpose of review To review the updated literature regarding eye rubbing complications and its association with ocular allergy disorders. Recent findings Atopy and ocular allergy disorders, mainly vernal keratoconjunctivitis (VKC), are strongly associated with rubbing-related complications, most probably via itching and watery eye sensations that trigger the habit of chronic eye rubbing. Vigorous and prolonged rubbing may lead...
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Usefulness of the Delay Alternating with Nutation for Tailored Excitation Pulse with T1-Weighted Sampling Perfection with Application-Optimized Contrasts Using Different Flip Angle Evolution in the Detection of Cerebral Metastases: Comparison with MPRAGE ImagingD. Kim, Y.J. Heo, H.W. Jeong, J.W. Baek, J.-Y. Han, J.Y. Lee, S.-C. Jin and H.J. BaekAJNR Am J Neuroradiol first published on 1 August 2019 doi:10.3174/ajnr.A6158http://www.ajnr.org/content/early/2019/08/01/ajnr.A6158.abstractAltered Relationship...
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Diagnosing invasive pulmonary aspergillosis in ICU patients: putting the puzzle togetherPurpose of review The approach to diagnose invasive pulmonary aspergillosis in the absence of lung biopsy in ICU patients is reviewed. This approach should be based on four pillars: mycology, medical imaging, underlying conditions, and acute disease expression. Recent findings Diagnosing invasive pulmonary aspergillosis in the absence of histopathologic evidence is a matter of probability weighting. Initiating...
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Intraoperative Autofluorescence Parathyroid Identification in Patients With Multiple Endocrine Neoplasia Type 1Malcolm H. Squires, MD, MS; Lawrence A. Shirley, MD; Chengli Shen, PhD; et al.CLINICAL CHALLENGEEndoscopyDesquamatory Lesions of the Upper Aerodigestive Tract MucosaJérôme R. Lechien, MD, PhD, MSc; Francois Mouawad, MD, PhD, MScEarn CME creditRESEARCH LETTERPrevalence of Eustachian Tube Dysfunction in Adults in the United StatesAlan Shan, BS; Bryan K. Ward, MD; Adele M. Goman, PhD; et al.COMMENT...
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Significant Reduction of Murine Renal Ischemia-Reperfusion Cell Death Using the Immediate-Acting PrC-210 Reactive Oxygen Species ScavengerBackground. Ischemia-reperfusion (IR) injury remains a significant problem for all solid organ transplants; thus, an important unmet need in transplantation is the prevention of IR injury. PrC-210 has demonstrated superior prevention of reactive oxygen species damage in several preclinical studies as a free radical scavenger. Here, we describe its profound efficacy...
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Editorial introductionsNo abstract availableEditorial: Novel therapeutic options for management of electrolyte disordersNo abstract availableAdvances in management of chronic metabolic acidosis in chronic kidney diseasePurpose of review Chronic metabolic acidosis is a common complication of chronic kidney disease (CKD) and is associated with adverse consequences, such as CKD progression and muscle wasting. We review the findings from recent clinical trials that have examined the effects of sodium...
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Editorial introductionsNo abstract availableEditorial: Clinical challenges and practical information for the inflammatory bowel disease clinician todayNo abstract availableThe globalization of inflammatory bowel disease: the incidence and prevalence of inflammatory bowel disease in BrazilPurpose of review Epidemiological studies of inflammatory bowel disease (IBD) in newly industrialized countries are limited, due to a lack of medical surveillance systems and reliable and unified registries and databases....
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Intestinal lymphatic vessels and their role in chylomicron absorption and lipid homeostasisPurpose of review In this review, we describe novel findings related to intestinal lipid transport in lymphatic vessels. Recent findings Studies have shown that chylomicron entry to lacteals and lymph movement in intestinal lymphatic capillaries is an active process. Regulators of this intestinal chylomicron transport include among others the autonomous nervous system, transcription factors like PLAGL2, and...
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Highlights of the September issueNo abstract availableOptimizing observer performance of clinic blood pressure measurement: a position statement from the Lancet Commission on Hypertension GroupHigh blood pressure (BP) is a highly prevalent modifiable cause of cardiovascular disease, stroke, and death. Accurate BP measurement is critical, given that a 5-mmHg measurement error may lead to incorrect hypertension status classification in 84 million individuals worldwide. This position statement summarizes...
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May transcatheter aortic valve replacement become the preferred treatment over conventional surgery for elderly women with symptomatic severe aortic stenosis?No abstract availablePractical implementation of the Endocarditis Team in 'functional' reference centres: the Italian hospital network experience and recommendations of the Italian Society of Echocardiography and Cardiovascular ImagingThe 2015 European Society of Cardiology (ESC) guidelines for the management of infective endocarditis recommend...
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Percutaneous coronary interventions for stable ischemic heart disease in ItalyAims Although the benefits of percutaneous coronary interventions (PCIs) in patients with stable chronic ischemic heart disease (SIHD) are controversial, a large number of PCIs are currently performed in SIHD patients, frequently after coronary angiography (ad-hoc procedures), without the use of fractional flow reserve (FFR) to identify patients most likely to benefit from PCI. Methods Assessment of regional variations...
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Editorial introductionsNo abstract availableIntrathecal therapy for pain in cancer patientsPurpose of review Intrathecal drug delivery systems (IDDS) for cancer pain remain little employed despite a high level of efficiency even though the technique is widely recommended. This review aims to summarize recent advances in IDDS for cancer patients. Recent findings The respective roles of catheter positioning, volume and flow rate in diffusion of intrathecal treatments, as well as the individual roles...
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Parkin inhibits necroptosis to prevent cancer pp915 - 916 Kai Cao & Stephen W. G. Tait doi:10.1038/s41556-019-0350-1 HER2 joins AKT to inhibit STING immunity pp917 - 918 Ian D. Odell & Richard A. Flavell doi:10.1038/s41556-019-0368-4 Migrasomes take center stage pp918 - 920 Stefania Tavano & Carl-Philipp Heisenberg doi:10.1038/s41556-019-0369-3 Equal opportunities in stemness pp921 - 923 Qing Nie & Maksim V. Plikus doi:10.1038/s41556-019-0366-6 LETTERSTracing the cellular...
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Losing to Gain: The Effects of a Healthy Lifestyle Intervention on the Physical and Psychosocial Well-being of Clients in a Community-based Mental Health SettingThe original version of this article unfortunately contained an error in author group. The second author Tamatha Arms was inadvertently missed to include in the author group.Relationship Between Marital Quality, Social Support and Mental Health During PregnancyAbstractThe aim of this study was to investigate the relationship between marital...
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Arterial stiffness in chronic kidney disease: a modifiable cardiovascular risk factor?Purpose of review There is an inverse, graded relationship between worsening chronic kidney disease (CKD) and increasing cardiovascular risk independent of traditional cardiovascular risk factors. Increasing arterial stiffness is a powerful predictor of cardiovascular outcomes in CKD. Developing novel therapeutic strategies to reverse this process is an attractive concept. This review presents the results of a literature...
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A Swim-Specific Shoulder Strength and Conditioning Program for Front Crawl SwimmersALTHOUGH SWIMMING IS A WHOLE-BODY ACTIVITY, SHOULDER PROBLEMS CAN BE QUITE COMMON IN COMPETITIVE SWIMMERS. THE PROPULSION FOR SWIMMING COMES LARGELY FROM THE UPPER BODY BUT THE LOWER BODY AND TRUNK PLAY AN IMPORTANT SUPPORTING ROLE. THE SWIMMING SHOULDER KINETIC CHAIN (SSKC) DESCRIBES THE GENERATION OF SWIMMING PROPULSION USING THE WHOLE BODY. EFFECTIVE SWIMMERS WILL USE THE SSKC IN THEIR STROKE, SO EFFECTIVE STRENGTH...
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Not All Oxygrams Are Mirror Image of Capnograms: A Case ReportGenerally the oxygram and the capnogram are mirror images of each other. We report a situation where a leak in the sample line produced a typical tails-up capnogram that was not accompanied by a mirror image oxygram. Air entrainment through the breach led to dilution of the gases on their way to the analyzer. The result was an oxygram resembling a series of mountain peaks.Anesthetic Management in an Adult Patient With Costello Syndrome:...
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Myths in Emergency Medicine: New tPA Study Just a Statistical Parlor TrickNo abstract availableMedically Clear: Survival Rate High for Cardiac Arrest Patients Treated with Percutaneous Mechanical Circulatory SupportNo abstract availableBrandt's Rants: Which Tests to Run for a 94-Year-Old Feeling Oogie? All of ThemNo abstract availableSpecial Report: The Voices in My Head (and Yours Too)No abstract availableNews: Can an Incentive Formula Fix ED Wait Times?No abstract availableNews: ET3 Could Revolutionize...
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Treatment and Prognosis of High- and Low-Risk Kaeding Grade II Bone Stress InjuriesBone stress injuries (BSI) may be classified as high- or low-risk based on the anatomic location of injury and by grade based on severity. Kaeding grade II (K-GII) BSI are characterized by symptomatic marrow or periosteal edema without a fracture line. This retrospective cohort study aims to compare outcomes between high- and low-risk K-GII BSI. We hypothesize that patients with high- and low-risk K-GII BSI experience...
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Obliteration of the pulp canal caused by mandibular distraction: a case reportPublication date: Available online 30 July 2019Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): Olivia Johnson King, Sonia Afzal, Valmiki SharmaAbstractWe present a 16-year-old boy with a history of ankylosis of the temporomandibular joint (TMJ) who had been treated with a costochondral graft and mandibular distraction. The distraction seems to have caused pulp canal obliteration of the lower right second...
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24-h urine osmolality should be used in combination with other urine parameters in urolithiasis patientsOsmotic diuresis in chronic kidney disease: its significance and clinical utilityAbstractIntroductionThe kidneys contribute to maintain plasma osmolality in normal range by achieving the adequate daily osmolar urine excretion (DOUE). An equation has been described for estimating the expected daily urine volume necessary to excrete the osmolar load required to keep serum osmolality in normal range....
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Regulatory barriers to xenotransplantationPurpose of review There is a grave discordance between supply and demand for patients with failing organs largely due to an insufficient donor pool for transplantation. Xenotransplantation has been proposed as a solution to bridge this gap. Recent findings Recent success over the last decade in nonhuman primate models, due to emerging gene-editing technologies combined with novel immunosuppression regimens, has produced promising results in pancreatic islet...
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Laparoscopic Management of Post-Cesarean Section Uterocutaneous Fistula Abstract A uterocutaneous...
Laparoscopic Management of Post-Cesarean Section Uterocutaneous FistulaAbstractA uterocutaneous fistula is a rare clinical presentation that occurs following cesarean section or any other pelvic surgery. We describe a case of uterocutaneous fistula with successful surgical management. A 25-year woman was referred to our hospital with complaints of cyclical bleeding from lower segment cesarean section scar (LSCS scar). It was diagnosed as uterocutaneous fistula on ultrasonography and computed tomography....
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Molecular progression of SHH-activated medulloblastomasMedulloblastoma (MB) comprises four main molecular MB subgroups (WNT, SHH, Group 3 and Group 4) with divergent biology, outcomes and subgroup-specific differences in relapses [1, 2, 3, 4, 5, 6]. Metastatic recurrences are most common in Group 3 and 4 MB, where metastases from a single patient are genetically similar to each other, but highly divergent from the corresponding primary tumor [2, 3, 4, 5, 6]. Local recurrences in the tumor bed are...
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Adoptive CD8+ T cell therapy against cancer:Challenges and opportunitiesPublication date: 10 October 2019Source: Cancer Letters, Volume 462Author(s): Xiaotao Jiang, Jiang Xu, Mingfeng Liu, Hui Xing, Zhiming Wang, Lei Huang, Andrew L. Mellor, Wei Wang, Sha WuAbstractCancer immunotherapy is a new and promising option for cancer treatment. Unlike traditional chemo- and radiotherapy, immunotherapy actives host immune system to attack malignancies, and this potentially offers long-term protection from...
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Progressive splenomegaly and mild thrombocytosis in beta-thalassaemia trait and coexisting hereditary hemochromatosis: possible confounders for a subsequent hematological diagnosisAcute pericarditis or a systemic disease with pleuropulmonary involvement?Utility of intestinal ultrasound in the diagnosis and short-term follow-up of non-steroidal anti-inflammatory drug-induced enteropathyIs vitamin D deficiency predictor of complications development in patients with HCV-related cirrhosis?Unusual radiographic...
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Alexandros SfakianakisAnapafseos 5 . Agios NikolaosCrete.Greece.7210028410261826948891480alsfakia@gmail.com
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Determinants of immunological evasion and immunocheckpoint inhibition response in non-small cell lung cancer: the genetic frontMaria Saigi, Juan J. Alburquerque-Bejar & Montse Sanchez-Cespedes Oncogene 2019 38 :5921 - 5932; June 28, 2019; 10.1038/s41388-019-0855-xAbstract | Full TextBRIEF COMMUNICATIONSCRAF mutations in lung cancer can be oncogenic and predict sensitivity to combined type II RAF and MEK inhibitionAmir Noeparast, Philippe Giron, Alfiah Noor, Rajendra Bahadur Shahi, Sylvia De Brakeleer et...
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Le differenze cerebrali di genere che orientano le cure materne Nel cervello femminile, ma non in quello maschile, c'è un numero di gran lunga più alto di cellule sensibili all'ossitocina, l'ormone che controlla l'attaccamento e la cura... - Leggi l'articolo →
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Il Parkinson come malattia di tutto l'organismo Recenti scoperte supportano un nuovo modello per l'insorgenza di questa malattia neurodegenerativa: un ruolo cruciale è svolto dall'intestino, dove probabilmente si forma la proteina mutata... - Leggi l'articolo →
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