Editorial: Cerebrospinal fluid physiologyNo abstract availablePhysiology of cerebrospinal fluid circulationPurpose of review This article describes the physiology of cerebrospinal fluid (CSF). We review current evidence and new concepts relating to CSF physiology with respect to CSF secretion, circulation and resorption and we highlight key pathophysiological associations including the relationship between CSF and intracranial pressure. Recent findings CSF secretion occurs primarily via the choroid...
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Extreme dipping: is the cardiovascular risk increased? An unsolved issueExtreme dipping (i.e. a marked blood pressure fall during night-time period) is an alteration of circadian blood pressure (BP) rhythm frequently observed in the setting of systemic hypertension as well as in the general population. Some reports have suggested that cardiovascular prognosis in extreme dippers (ED) is similar as in dippers, whereas other studies have documented either a better or worse prognosis in ED. Available...
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Monthly Extended-Release Risperidone (RBP-7000) in the Treatment of Schizophrenia: Results From the Phase 3 ProgramPurpose/Background The Phase 3 program for RBP-7000, a once-monthly subcutaneous (SC) extended-release risperidone formulation approved for treatment of schizophrenia, consisted of a double-blind placebo-controlled trial (previously reported) and a 52-week open-label study of monthly RBP-7000 120 mg. The primary objective of the open-label study was to evaluate the long-term safety and...
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The female adolescent breast: disorders of developmentPurpose of review This article will provide an overview on female breast development and focus on common abnormalities of growth, the emerging role of breast self-awareness, and discuss trends in the evaluation and treatment of the breast masses and disorders most often encountered in the female adolescent population. Recent findings Although the embryology of breast development is unchanged, data are emerging on the role of environmental factors...
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Artificial Intelligence and Machine Learning in the Identification of Authentic and Fake Data PresentationNo abstract availableTextbooks in Plastic Surgery: Paper or Digital?No abstract availableFaces, the Frontiers of NormalityNo abstract availableGood Surgical IllustrationsNo abstract availableGutenberg's Spirit in Today's WorldNo abstract availableCraniosynostosis: A Reversible Pathology?The formation of the cranial sutures, in utero, occurs when the ossification of the skull bones reaches predestined...
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Subclinical hypothyroidism in pregnancyPurpose of review Subclinical hypothyroidism (SCH) is a common diagnosis among women of reproductive age. The importance of sufficient maternal thyroid supply during pregnancy is well known. Nevertheless, the effects of SCH during pregnancy and the efficacy of its treatment on maternofetal outcomes are not well established. This review discusses the recent evidence on SCH in pregnancy and how this evidence is reflected in current clinical care. Recent findings...
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Dysbiosis of the Duodenal Mucosal Microbiota Is Associated With Increased Small Intestinal Permeability in Chronic Liver DiseaseOBJECTIVES: Chronic liver disease (CLD) is associated with both alterations of the stool microbiota and increased small intestinal permeability. However, little is known about the role of the small intestinal mucosa-associated microbiota (MAM) in CLD. The aim of this study was to evaluate the relationship between the duodenal MAM and both small intestinal permeability and...
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Deep sequencing across germline genome-wide association study signals relating to breast cancer events in women receiving aromatase inhibitors for adjuvant therapy of early breast cancerObjective To identify additional genetic variants beyond those observed in a previous genome-wide association study (GWAS) in women treated on the MA.27 clinical trial in which women were randomized to 5 years of adjuvant therapy with anastrozole or exemestane. Patients and methods We performed a matched case–control...
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Sociedad Iberoamericana de Información Científica (SIIC),ARTÍCULOS DE FUENTES SELECCIONADASLos artículos de fuentes seleccionadas son resumidos en castellano por el Comité de Redacción Científica de SIIC.Violeth Margarett Vásquez FonsecaRELACIÓN ENTRE EL BURNOUT Y LA SATISFACCIÓN LABORAL EN PROFESIONALES DE LA SALUDEl objetivo del estudio es analizar la relación entre el grado de satisfacción laboral y el burnout en profesionales del Hospital Clínico Herminda Martín. El 91% de la muestra tiene riesgo...
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Hereditary Cancer Risk Variants Found in Significant Subset of Metastatic Breast Cancer PatientsPublished on Aug 30, 2019 Court Upholds Illumina Victory in Scripps Research Institute Patent BattlePublished on Aug 30, 2019 Medulloblastoma Single-Cell Study Yields Tumor-Initiating Cell Population Containing Outcome CluesPublished on Aug 30, 2019 In Brief This Week: Invitae, Agilent, Biovica, and MorePublished on Aug 30, 2019 People in the News: Rowan Chapman, Garret Hampton, Eric Dishman, MorePublished...
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Pakistan Journal of Biological Sciences - Current IssueIn vitro Anticancer Activity of Quinoa and Safflower Seeds and Their Preventive Effects on Non-alcoholic Fatty LiverAssociation of Perforin and Granzyme-B Levels with Hyperandrogenism in Polycystic Ovary Syndrome: A Case-Control StudyIsometric Versus Aerobic Training Effects on Vascular Adaptation in Patients with Type 2 DiabetesIn vitro Anticancer Activity of Quinoa and Safflower Seeds and Their Preventive Effects on Non-alcoholic Fatty LiverPosted:Background...
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Demographics, Psychological Distress, and Pain From Pressure InjuryBackground There is a knowledge gap regarding factors that influence the intensity of pain associated with pressure injuries. Objectives We examined the influence of age, gender, race, and comorbidity on the relationships between pressure injuries, psychological distress, and pain intensity in hospitalized adults. Methods This study was a cross-sectional, retrospective secondary analysis using data from a regional acute hospital's...
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Intraperitoneal hemorrhage during pregnancy and parturition: Case reports and literature reviewWe aim to investigate the diagnosis, treatment, and prognosis of intraperitoneal hemorrhage during pregnancy and parturition. Three cases with intraperitoneal hemorrhage during pregnancy and parturition admitted to our hospital from Jan. 2008 to Jan. 2018 were included in this study. One case showed fetal distress. Abdominal ultrasonography and abdominal CT showed pyoperitoneum in 2 cases. Abdominal puncture...
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Rohan R. Mahale, Anish Mehta, Aju Abraham John, Mahendra Javali, Mirza Masoom Abbas, andSrinivasa RangasettyAuthor information Article notes Copyright and License information DisclaimerDepartment of Neurology, Mathikere Sampangappa Ramaiah Medical College and Hospital, Bangalore, Karnataka, IndiaFor correspondence: Dr. Rohan R. Mahale, Department of Neurology, MS Ramaiah Medical College and Hospital, Bangalore - 560 054, Karnataka, India. E-mail: moc.liamg@38elahamnahorReceived 2015 Jan 13; Revised...
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Nine syndromeCorrection to: The effect of CA1 dopaminergic system on amnesia induced by harmane in miceUnfortunately, the second author name was incorrectly published in the original article. The complete correct name should read as follows.Bilateral stereotypy after unilateral cerebellar infarctionBilateral fronto-insular FLAIR hyperintensities: discussion on a case of new-onset refractory status epilepticusPosterior reversible encephalopathy syndrome caused by cerebral amyloid angiopathy-related...
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Increasing Medical Student Exposure to Interventional RadiologyCorrection To: Where is the Origin of the Last Normal Branch from Feeding Artery of Pulmonary Arteriovenous Malformations?On page 1852, the first sentence of the second paragraph "In all PAVMs, the mean diameter of the feeding artery was 7.24 ± 0.015 mm, and the mean maximum diameter of the sac was 19.10 ± 0.585 mm" should be corrected to read as follows:Transapical Coil Embolization of a Postsurgical Ascending Thoracic Aortic PseudoaneurysmAbstractAscending...
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The Impact of Hospital Costing Methods on Cost-Effectiveness Analysis: A Case Study'Tisagenlecleucel for the Treatment of Relapsed or Refractory B-cell Acute Lymphoblastic Leukaemia in People Aged up to 25 Years: An Evidence Review Group Perspective of a NICE Single Technology AppraisalAbstractAs part of the National Institute for Health and Care Excellence's (NICE's) Single Technology Appraisal (STA) process, Novartis submitted evidence on the clinical effectiveness and cost-effectiveness of tisagenlecleucel...
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Interactions between mitochondria and endoplasmic reticulum in demyelinated axonsAbstractDemyelination leads to axonal changes that involve the functions and dynamics of axonal mitochondria supporting metabolism and survival of axons. However, the changes in the physical interactions between mitochondria and endoplasmic reticulum, called mitochondria-associated membranes, are poorly understood in demyelinated axons. In this study, we investigated the three-dimensional ultrastructural changes in membrane...
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FOR YOUR PATIENTSOpioids Are Not Recommended but Often Prescribed for Migraine Across All Age Groups FOR YOUR PATIENTSObesity in Younger MS Patients Linked to Poor First-Line Therapy Response FOR YOUR PATIENTSShorter Times to Endovascular Reperfusion Therapy Lead to Better Outcomes for Acute Stroke Patients FOR YOUR PATIENTSNew Guidelines for Acute and Preventive Treatment of Pediatric Migraine: What You Should Know FOR YOUR PATIENTSPhysical Activity Moderates Amyloid-Beta Burden in Clinically Normal...
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Accounting for study participants who are ineligible for linkage: a multiple imputation approach to analyzing the linked National Health and Nutrition Examination Survey and Centers for Medicare and Medicaid Services' Medicaid dataAbstractData from the National Health and Nutrition Examination Survey have been linked to the Center for Medicare and Medicaid Services' Medicaid Enrollment and Claims Files for the survey years 1999–2004. The linked data are produced by the National Center for Health...
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Intravenous immunoglobulin for adjunctive treatment of severe infections in ICUsPurpose of review This review focuses on the emerging literature regarding the use of intravenous immunoglobulins (IVIg) in critically ill patients with severe infections. The aim is to provide an accessible summary of the most recent evidence of IVIg use in sepsis and septic shock and to help clinicians to understand why there is still equipoise regarding the potential benefit of this adjunctive therapy in this setting....
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The research odyssey of John Ross Jr: from trans-septal atrial catheterization, preload reserve, afterload mismatch to flow-function relationshipNo abstract availableThe role of physical activity in individuals with cardiovascular risk factors: an opinion paper from Italian Society of Cardiology-Emilia Romagna-Marche and SIC-SportRegular physical activity is a cornerstone in the prevention and treatment of atherosclerotic cardiovascular disease (CVD) due to its positive effects in reducing several...
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ERα-mediated alterations in circ_0023642 and miR-490-5p signaling suppress bladder cancer invasionLongxiang Wu, Mengda Zhang, Lin Qi, Xiongbing Zu, Yuan Li et al.Cell Death & Disease 2019 10: 10.1038/s41419-019-1827-3Abstract | Full TextThe Δ133p53β isoform promotes an immunosuppressive environment leading to aggressive prostate cancerMarina Kazantseva, Sunali Mehta, Ramona A. Eiholzer, Gregory Gimenez, Sara Bowie et al.Cell Death & Disease 2019 10: 10.1038/s41419-019-1861-1Abstract | Full...
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DermatologyVolume 181, Issue 3Pages: i-ix, 429-646, e57-e86September 2019Issue InformationIssue InformationPages: i-vi | First Published: 01 September 2019Editor's ChoiceEditor's ChoicePages: ix | First Published: 01 September 2019EDITORIALSEnduring support for the case reportJ.E. MellerioPages: 429-430 | First Published: 01 September 2019Pragmatic trials: lab meets bedsideG. Kirtschig, S. Lo, J. Batchelor, on behalf of the Clinical Trials Editorial Team of the British Journal of DermatologyPages:...
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Organizational Architecture, Ethical Culture, and Perceived Unethical Behavior Towards Customers: Evidence from Wholesale BankingAbstractIn this study, we propose and test a model of the effects of organizational ethical culture and organizational architecture on the perceived unethical behavior of employees towards customers. This study also examines the relationship between organizational ethical culture and moral acceptability judgment, hypothesizing that moral acceptability judgment is an important...
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Glucagon-Like Peptide-1 Receptor Agonists in Type 2 Diabetes: Their Use and Differential FeaturesThe original version of this article unfortunately contained some mistakes. The corrected details are provided below:Correction to: Safety, Tolerability, and Pharmacokinetics of GDC-0276, a Novel Na V 1.7 Inhibitor, in a First-in-Human, Single- and Multiple-Dose Study in Healthy VolunteersThe original version of this article unfortunately contained a mistake. A few entries were incorrect in Table 2.Safety,...
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Deep Neck Space Infections: A Case Series and Review of the Literature,Shivesh Maharaj, Sumaya Ahmed, Preba Pillayhttps://doi.org/10.1177/1179550619871274Article information AbstractDeep neck spaces are regions of loose connective tissue filling areas between the 3 layers of deep cervical fascia, namely, superficial, middle, and deep layers. The superficial layer is the investing layer, The pretracheal layer is the intermediate layer and the prevertebral layer is the deepest layer. Deep neck space...
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In Vitro Selection of DNA Aptamers for a Small-Molecule Porphyrin by Gold Nanoparticle-Based SELEXAbstractIn this study, a new strategy for the selection of aptamers against small-molecule target was established using gold nanoparticles (AuNPs) as the separation matrix and Zinc(II)-Protoporphyrin IX (ZnPPIX) as the target molecule without the immobilization step due to the absorption of ssDNA on AuNPs. The progress of the selection process was monitored by the recovery rate and the fluorescence enhancement...
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Delineation of the intratemporal facial nerve in a cadaveric specimen on diffusion tensor imaging using a 9.4 T magnetic resonance imaging scanner: a technical noteAbstractThe purpose of this study was to determine whether the intratemporal facial nerve could be delineated on 9.4 T magnetic resonance imaging (MRI) using T2-weighted and diffusion tensor imaging (DTI). DTI using a b value of 3000 and an isotropic resolution of 0.4 mm3 on a 9.4 T MRI scanner was performed on a whole-block celloidin-embedded...
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Onkologisches Outcome nach Notfallresektion vs. Stenting bei maligner linksseitiger KolonobstruktionErhalt vs. Resektion der Arteria colica sinistra im Rahmen der kolorektalen Karzinomchirurgie des linken HemikolonsLaparoskopische Leberresektion bei älteren PatientenFrühe oder späte Cholezystektomie bei milder biliärer akuter Pankreatitis?Intrathorakale FistelnChirurgische Versorgung tracheo-/bronchopleuraler Fisteln nach bronchoplastischer Resektion (Manschetten‑/Bifurkationsresektion)ZusammenfassungDie...
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Data science ethical considerations: a systematic literature review and proposed project frameworkAbstractData science, and the related field of big data, is an emerging discipline involving the analysis of data to solve problems and develop insights. This rapidly growing domain promises many benefits to both consumers and businesses. However, the use of big data analytics can also introduce many ethical concerns, stemming from, for example, the possible loss of privacy or the harming of a sub-category...
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Simulator-based assessment of ankle arterial systolic blood pressure measurement skillsObjective Learning basic vascular examination is a complex process. Very few studies have focused on the ability to measure the arterial systolic blood pressure at the ankle (ASBPa). The aim of this study was to objectively assess the effects of a 1-h practical educational intervention on the ability to measure ASBPa among medical students. Methods A total of 27 medical students were prospectively recruited. Two...
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Impact of energy turnover on the regulation of glucose homeostasis in healthy subjectsFranziska Büsing, Franziska Anna Hägele, Alessa Nas, Mario Hasler, Manfred James Müller et al.Nutrition & Diabetes 2019 9: 10.1038/s41387-019-0089-6Abstract | Full TextREVIEW ARTICLETopInhibitory effects of pu-erh tea on alpha glucosidase and alpha amylase: a systemic reviewChiung-Ying Yang, Yea-Yin Yen, Kuang-Chen Hung, Shang-Wei Hsu, Shou-Jen Lan et al.Nutrition & Diabetes 2019 9: 10.1038/s41387-019-0092-yAbstract | Full...
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The Human Brain Can Create Structures in Up to 11 Dimensions,"We found a world that we had never imagined." Read more »Physicists Have Published Instructions For a DIY WormholeSome entirely theoretical components required.Read more »Scientists Break Down 5 of The Latest Diet Fads, And 2 Definitely Aren't RecommendedThe mono diet sounds unpleasant.Read more »Scientists Detected 2 Black Hole Mergers Just 21 Mins Apart, But It's Not What We HopedThis could have been something big.Read more »13 Strange...
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Effect of High-Dose Vitamin D Supplementation on Volumetric Bone Density and Bone Strength: A Randomized Clinical TrialLauren A. Burt, PhD; Emma O. Billington, MD, FRCPC; Marianne S. Rose, PhD; et alJAMA PediatricsAssociation Between Maternal Fluoride Exposure During Pregnancy and IQ Scores in Offspring in CanadaRivka Green, MA; Bruce Lanphear, MD; Richard Hornung, PhD; et alJAMA Internal MedicineAssociation of Animal and Plant Protein Intake With All-Cause and Cause-Specific MortalitySanjeev Budhathoki, PhD;...
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Baseline serum levels of osteopontin predict clinical response to treatment with nivolumab in patients with non-small cell lung cancerAbstractTreatment with nivolumab improves survival and response rate in non-small cell lung cancer (NSCLC). Nevertheless, due to its high financial cost, identifying predictors of response to treatment has become an urgent need. Here, we focused on serum osteopontin (OPN), a pleiotropic protein overexpressed in lung cancer and involved in the immune response. A cohort...
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Capsule Commentary on Jetelina et al., Patient-Reported Barriers to Completing a Diagnostic Colonoscopy Following Abnormal Fecal Immunochemical Test among Uninsured PatientsCapsule Commentary on Homoya et al., Uncertainty as a Key Influence in the Decision to Admit Patients with Transient Ischemic AttackCapsule Commentary on Bond et al., Real-time Feedback in Pay-for-Performance: Does More Information Lead to Improvement?Abnormal Liver EnzymesCapsule Commentary on Zhang et al., Combined healthy lifestyle...
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Urinary Incontinence in Chronic Obstructive Pulmonary Disease: A Common Co-morbidity or a Typical Adverse Effect?AbstractUrinary incontinence (UI) is defined as a loss of bladder control and is characterized by the complaint of any involuntary leakage of urine. Evidence suggests that the prevalence of UI is higher in subjects with chronic obstructive pulmonary disease (COPD) than in age-matched controls in both sexes. UI is classified as stress, urge, and mixed, and has a considerable impact on quality...
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Differences in prevalence and associated factors between mild and severe vertebral fractures in Japanese men and women: the third survey of the ROAD studyAbstractVertebral fracture (VF) is a common osteoporotic fracture, while its epidemiology varies according to regions and ethnicities, little is known about it in Japan. Using whole-spine radiographs from a population-based cohort study, the Research on Osteoarthritis/Osteoporosis Against Disability study 3rd survey performed in 2012–2013, we estimated...
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