International Journal of Molecular SciencesIJMS, Vol. 21, Pages 497: Characterization of the Soybean GmIREG Family Genes and the Function of GmIREG3 in Conferring Tolerance to Aluminum StressIJMS, Vol. 21, Pages 497: Characterization of the Soybean GmIREG Family Genes and the Function of GmIREG3 in Conferring Tolerance to Aluminum Stress International Journal of Molecular Sciences doi: 10.3390/ijms21020497 Authors: Zhandong Cai Peiqi Xian Rongbin Lin Yanbo Cheng Tengxiang Lian Qibin Ma Hai Nian...
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AntibioticsAntibiotics, Vol. 9, Pages 26: Trends in Primary Antibiotic Resistance in H. pylori Strains Isolated in Italy between 2009 and 2019Antibiotics, Vol. 9, Pages 26: Trends in Primary Antibiotic Resistance in H. pylori Strains Isolated in Italy between 2009 and 2019 Antibiotics doi: 10.3390/antibiotics9010026 Authors: Saracino Fiorini Zullo Pavoni Saccomanno Vaira Background and aims: the increasing prevalence of strains resistant to antimicrobial agents is a critical issue for the management...
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The modeling and analysis of transesterification reaction conditions in the selection of optimal biodiesel yield and viscosityAbstract Among alternative fuels, biodiesel has been emphasized as a substantial candidate for diesel engines because of many advantages. However, the main shortcomings preventing more widespread use of biodiesel are high production cost and viscosity. In order to simultaneously overcome both of these shortcomings, the reaction conditions for the transesterification of waste...
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GSE143520 RNA-Seq of wild-type (WT) and smn2 mutants for quantitative analysis of transcriptomes and mapping SMN2-dependent degraded regionsContributors : Momoko Takagi ; Fuminori Takahashi ; Kazuya IchimuraSeries Type : Expression profiling by high throughput sequencingOrganism : Arabidopsis thalianaTo compare expression of defense-related genes between WT and smn2 mutant, we performed the RNA-seq analysis using the total RNA prepared from Arabidopsis WT and smn2 seedlings. RNA-seq profiling showed...
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Identification of Novel Pathogenic Sequence Variants of the Mismatch Repair Genes During Screening for Lynch Syndrome in a Single Centre of Eastern Hungary: AbstractIntroductionLynch syndrome is an autosomal dominant disorder, most frequent leading to colon cancer. Identification of patients with Lynch syndrome and screening of their family members are available prevention approach that can significantly decrease mortality. Unfortunately, routine screening still does not belong to standard of care...
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Functional Landscape of Common Variants Associated with Susceptibility to Epithelial Ovarian Cancer: AbstractPurpose of the ReviewTo date, genome-wide association studies (GWASs) have identified 39 genomic loci associated with risk of epithelial ovarian cancer at genome-wide significance level (p ≤ 5 × 10−8) and 13 additional loci using less strict thresholds. Follow-up functional dissection of these loci to uncover the underlining mechanisms driving cancer susceptibility has been challenging.Recent...
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Minimal Effects of Moderate Normobaric Hypoxia on the Upper Body Work–Time Relationship in Recreationally Active Women: High Altitude Medicine &Biology, Ahead of Print. AbstractBackground: Sex-based differences in metabolism and morphological characteristics may result in unique exercise responses during periods of limited oxygen availability.Purpose: To evaluate the effects of moderate normobaric hypoxia on the parameters of the work–time relationship during upper body exercise in women.Materials...
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Effects of cholesterol content on activity of P-glycoproteins and membrane physical state, and consequences for anthelmintic resistance in the nematode Haemonchus contortus: Authors: Mickaël Riou, Fabrice Guégnard, Yves Le Vern, Isabelle Grasseau, Christine Koch, Elisabeth Blesbois and Dominique Kerboeuf.<br />Parasite Vol. 27 , page 3<br />Published online: 14/01/2020<br /> Keywords: Parasite ; Eggshell ; MβCD ; Fluidity ; Cholesterol ; P-glycoproteins ; Resistance...
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Toxoplasma gondii in women of childbearing age and during pregnancy: seroprevalence study in Central and Southern Italy from 2013 to 2017: Authors: Daniela Fanigliulo, Serena Marchi, Emanuele Montomoli and Claudia Maria Trombetta.<br />Parasite Vol. 27 , page 2<br />Published online: 14/01/2020<br /> Keywords: Toxoplasma gondii ; Seroprevalence ; Women of childbearing age ; Pregnancy ; Italy.<img src="http://feeds.feedburner.com/~r/edp_parasite/~4/iajej4iCkNo"...
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Cerebrofacial venous metameric syndrome—spectrum of imaging findings: AbstractCerebrofacial venous metameric syndrome (CVMS) is a complex craniofacial vascular malformation disorder in which patients have a constellation of venous vascular malformations affecting soft tissues, bone, dura, and neural structures including the eye and brain. It is hypothesized that a somatic mutation responsible for the venous abnormalities occurred prior to migration of the neural crest cells, and because of this,...
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Evaluation of dsDNA from extracellular vesicles (EVs) in pediatric AML diagnostics: AbstractAcute myeloid leukemia (AML) is a heterogeneous malignant disease characterized by a collection of genetic and epigenetic changes. As a consequence, AML can evolve towards more aggressive subtypes during treatment, which require additional therapies to prevent future relapse. As we have previously detected double-stranded DNA (dsDNA) in tumor-derived extracellular vesicles (EVs), in this current study we attempted...
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MicroRNAs: pivotal regulators in acute myeloid leukemia: AbstractMicroRNAs are a class of small non-coding RNAs that are 19–22 nucleotides in length and regulate a variety of biological processes at the post-transcriptional level. MicroRNA dysregulation disrupts normal biological processes, resulting in tumorigenesis. Acute myeloid leukemia is an invasive hematological malignancy characterized by the abnormal proliferation and differentiation of immature myeloid cells. Due to the low 5-year survival...
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Platelet counts of adults upon acute hospital admission to internal medicine units are a predictor of mortality: AbstractThe objective of this cohort study was to examine the association between platelet counts upon acute hospitalization and mortality. The study included all adults in North and Central Denmark Regions with a first acute admission to an internal medicine unit during 2006–2012, categorized by first platelet count within +/−24 hours of admission. We assessed the association between...
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JCM, Vol. 9, Pages 212: SERS-Based Liquid Biopsy of Gastrointestinal Tumors Using a Portable Raman Device Operating in a Clinical Environment: JCM, Vol. 9, Pages 212: SERS-Based Liquid Biopsy of Gastrointestinal Tumors Using a Portable Raman Device Operating in a Clinical EnvironmentJournal of Clinical Medicine doi: 10.3390/jcm9010212Authors: Lucretia Avram Stefania D. Iancu Andrei Stefancu Vlad Moisoiu Alia Colnita Daniel Marconi Valer Donca Elena Buzdugan Rares Craciun Nicolae...
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JCM, Vol. 9, Pages 211: Continuous Fentanyl Background Infusion Regimen Optimised by Patient-Controlled Analgesia for Acute Postoperative Pain Management: A Randomised Controlled Trial: JCM, Vol. 9, Pages 211: Continuous Fentanyl Background Infusion Regimen Optimised by Patient-Controlled Analgesia for Acute Postoperative Pain Management: A Randomised Controlled TrialJournal of Clinical Medicine doi: 10.3390/jcm9010211Authors: Jihoon Hwang Sang Kee Min Yun Jeong Chae Gang Mee Lim Han Bum...
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JCM, Vol. 9, Pages 213: Beneficial Effects of Bariatric Surgery-Induced by Weight Loss on the Proteome of Abdominal Subcutaneous Adipose Tissue: JCM, Vol. 9, Pages 213: Beneficial Effects of Bariatric Surgery-Induced by Weight Loss on the Proteome of Abdominal Subcutaneous Adipose TissueJournal of Clinical Medicine doi: 10.3390/jcm9010213Authors: Bárbara María Varela-Rodríguez Paula Juiz-Valiña Luis Varela Elena Outeiriño-Blanco Susana Belén Bravo María Jesús García-Brao Enrique Mena...
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JCM, Vol. 9, Pages 214: Usefulness of the Inferior Articular Process's Cross-Sectional Area as a Morphological Parameter for Predicting Central Lumbar Spinal Stenosis: JCM, Vol. 9, Pages 214: Usefulness of the Inferior Articular Process's Cross-Sectional Area as a Morphological Parameter for Predicting Central Lumbar Spinal StenosisJournal of Clinical Medicine doi: 10.3390/jcm9010214Authors: Lee Lim Lim Kim Hypertrophy of facet joints is associated with a high risk of central lumbar spinal...
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JCM, Vol. 9, Pages 215: Virtual Reality for PEripheral Regional Anesthesia (VR-PERLA Study): JCM, Vol. 9, Pages 215: Virtual Reality for PEripheral Regional Anesthesia (VR-PERLA Study)Journal of Clinical Medicine doi: 10.3390/jcm9010215Authors: Camille Alaterre Baptiste Duceau Eileen Sung Tsai Siham Zriouel Francis Bonnet Thomas Lescot Franck Verdonk When used as an add-on to regional anesthesia, virtual reality (VR) has been reported to provide anxiety-reducing benefits and sedation-sparing...
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JCM, Vol. 9, Pages 216: Do Genomic Factors Play a Role in Diabetic Retinopathy?: JCM, Vol. 9, Pages 216: Do Genomic Factors Play a Role in Diabetic Retinopathy?Journal of Clinical Medicine doi: 10.3390/jcm9010216Authors: Andrea P. Cabrera Finny Monickaraj Sampathkumar Rangasamy Sam Hobbs Paul McGuire Arup Das Although there is strong clinical evidence that the control of blood glucose, blood pressure, and lipid level can prevent and slow down the progression of diabetic retinopathy (DR)...
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JCM, Vol. 9, Pages 218: Presbycusis: An Update on Cochlear Mechanisms and Therapies: JCM, Vol. 9, Pages 218: Presbycusis: An Update on Cochlear Mechanisms and TherapiesJournal of Clinical Medicine doi: 10.3390/jcm9010218Authors: Jing Wang Jean-Luc Puel Age-related hearing impairment (ARHI), also referred to as presbycusis, is the most common sensory impairment seen in the elderly. As our cochlea, the peripheral organ of hearing, ages, we tend to experience a decline in hearing and are at greater...
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JCM, Vol. 9, Pages 219: A Real-World Experience of Clinical, Biochemical and Genetic Assessment of Patients with Homozygous Familial Hypercholesterolemia: JCM, Vol. 9, Pages 219: A Real-World Experience of Clinical, Biochemical and Genetic Assessment of Patients with Homozygous Familial HypercholesterolemiaJournal of Clinical Medicine doi: 10.3390/jcm9010219Authors: Maria Donata Di Taranto Carola Giacobbe Alessio Buonaiuto Ilenia Calcaterra Daniela Palma Giovanna Maione Gabriella Iannuzzo...
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Sex differences in rapid non‐classical action of 17β‐estradiol on intracellular signaling and estrogen receptor alpha expression in basal forebrain cholinergic neurons in mouse: AbstractRapid non‐classical effects of 17β‐estradiol (E2) on intracellular signaling have been identified in the basal forebrain but the extent to which these actions may be different in males and females is unknown. Previous work has shown that E2 rapidly phosphorylates cAMP responsive element binding protein (CREB) via...
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A thymic stromal lymphopoietin polymorphism may provide protection from asthma by altering gene expression: AbstractBackgroundGenome‐wide association studies have identified associations of the single nucleotide polymorphism rs1837253 in the thymic stromal lymphopoietin (TSLP) gene with asthma, allergic disease and eosinophilia. The TSLP gene encodes two isoforms, long and short, and previous studies have indicated functional differences between these two isoforms. Objective: We investigated the...
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Matching‐Adjusted Comparison of Oral Corticosteroid Reduction in Asthma: Systematic Review of Biologics: AbstractBackgroundOral corticosteroid (OCS) treatment for severe asthma is associated with substantial disease burden. Thus, OCS dosage reduction is desirable. Relative efficacy of biologics in reducing OCS treatment for severe, uncontrolled asthma is not fully characterised.ObjectiveWe performed matching‐adjusted indirect comparison (MAIC) to assess the relative effects on OCS treatment reduction...
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Gingival Angiosarcoma: A Case Report and Clinicopathologic Review of 32 Cases of Primary Gingival Angiosarcoma: AbstractAngiosarcoma is a malignant neoplasm of mesenchymal origin arising from vascular endothelium and most commonly involves extremities. Gingival angiosarcoma is a rare sporadic occurring tumor. We report a case of primary angiosarcoma of gingiva along with a review of 31 cases of primary gingival angiosarcoma reported in literature till 2018. A 30-year-old lady presented with recurrent...
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Anesthesia management of a rare case of esophageal ELLA stent migration causes intestinal obstruction: Shalendra Singh, Venigalla Sri Krishna, Deepak Dwivedi, Kaminder Bir KaurInternational Journal of Health & Allied Sciences 2020 9(1):94-95Sir,Acute variceal bleeding has devastating consequences if timely management is not done. Multiple pharmacological and mechanical modalities exist to control these active bleeding sites. Recently, a specially designed removable, self-expanding mesh-metal...
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Ventilator-associated events: Incidence and mortality in intensive care unit of a superspecialty hospital of North India: Abha Sharma, Madhusmita Das, Bibhabati Mishra, Archana Thakur, Poonam Sood LoombaInternational Journal of Health & Allied Sciences 2020 9(1):62-66INTRODUCTION: The revised definition proposed in 2013 by the Centers for Disease Control and Prevention (CDC) replaced ventilator-associated pneumonia (VAP) surveillance with ventilator-associated event (VAE) surveillance for monitoring...
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Concurrent leptospirosis and tuberculosis: An expected incidence in endemic tropical country and rarity of the co-occurrence: Beuy Joob, Viroj WiwanitkitInternational Journal of Health & Allied Sciences 2020 9(1):92-92Sir,Tuberculosis is an important mycobacterial infectious disease. This infection is detectable in several developing countries. In tropical world, there are also other endemic infections. The change that tuberculosis co-occurs with other endemic infection is interesting. Regarding...
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Microalbuminuria among acutely ill febrile children: Ibrahim Aliyu, Godpower Chinedu Michae, Bukar Alhaji Grema, Bashir Mariat ZubayrInternational Journal of Health & Allied Sciences 2020 9(1):57-61INTRODUCTION: Microalbuminuria has been studied in some acute and chronic illnesses such as urinary tract infection (UTI), heart failure, and diabetes mellitus, but nothing much has been said about children with malaria and pneumonia which are most common in the tropics. Therefore, this study seeks...
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Awareness, attitude, and knowledge about pneumococcal infection and vaccination: A survey across North Delhi: Yoshita Sharma, Deepansuli Jaswal, Himanshu Shriwal, Himanshu Verma, Jyoti ShahInternational Journal of Health & Allied Sciences 2020 9(1):51-56INTRODUCTION: Pneumococcal infection is a significant public health problem and leading cause of death among young children in developing countries. In most of the cases, "Streptococcus pneumonia" is the common human pathogenic bacterium. It further...
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Adopted group therapy approach for coping with sadness among medical students: M Kishor, Preethi Prabhu, Smriti Bhargava, Rohan Jayaram, Ramaswamy SundararajanInternational Journal of Health & Allied Sciences 2020 9(1):84-85Medical students are upcoming doctors, and their wellbeing is important for society. Mental health issues particularly depression is a matter of concern among the doctors in general as it usually not talked about. Medical education is considered stressful, and depressive symptoms...
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Knowledge, awareness, and practices regarding needlestick injury among health-care workers in a tertiary care hospital of India: Annual incidence versus reporting rate: Shahna Ali, Manazir Athar, Lubna Zafar, Obaid Ahmad SiddiqiInternational Journal of Health & Allied Sciences 2020 9(1):45-50INTRODUCTION: The objective of this study was to assess the knowledge and awareness regarding needlestick injury (NSI) among health-care workers (HCWs) in a tertiary care hospital.MATERIALS AND METHODS: This...
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Mucinous carcinoma of gallbladder in a young female: A rare presentation: Nidhi Awasthi, Abhishant PandeyInternational Journal of Health & Allied Sciences 2020 9(1):78-79Mucinous carcinoma of the gallbladder is an uncommon variant encountered predominantly in the elderly population. An unusual occurrence of this relatively uncommon malignancy is described herewith in a young female.Introduction Gallbladder (GB) is the most common site for malignancy within the biliary tract, and it is the fifth...
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Physicians' knowledge and practice with regard to acute kidney injury at Omdurman Military Hospital: A cross-sectional survey: Sulafa Mohamed Ali, Safaa Badi, Bashir Alsiddig YousefInternational Journal of Health & Allied Sciences 2020 9(1):39-44INTRODUCTION: The fact that the incidence of acute kidney injury (AKI) is increasing globally, and that data from low- and middle-income countries are scarce and inadequate, necessitates that health-care professionals being knowledgeable and aware of...
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Utilization evaluation of anti-cancer agents in patients with head and neck cancer in a South Indian specialty cancer hospital: Aakanksha Sharma, Gurumurthy Parthasarathi, Himanshu PatelInternational Journal of Health & Allied Sciences 2020 9(1):67-73BACKGROUND: This study was aimed to understand prescribing patterns of anti-cancer agents in patients with head and neck cancer, and to provide practice recommendations/educational interventions to optimize medication use in patients with head and...
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Compliance to fluid and dietary restriction and treatment adherence among chronic hemodialysis patients in a tertiary care hospital, Puducherry: M Anuja, M Venkatesh AshokInternational Journal of Health & Allied Sciences 2020 9(1):34-38INTRODUCTION: Fluid and dietary restrictions play a vital role in rehabilitative care of patients on dialysis. Good adherence to the treatment regimen in hemodialysis (HD) patients can also reduce hospitalization risk. Therefore, this study was carried out to assess...
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Band of hyperpigmentation in the perioral area: Child with lip-lick cheilitis: K Jagadish Kumar, PK Ashwini, Harish ReddyInternational Journal of Health & Allied Sciences 2020 9(1):93-94Sir,Cheilitis presents as scaling on the lips often extending onto the perioral skin. Often seen during winter in childhood. It appears as dry scaly lips, often attributed to frequent licking to hydrate the dryness, named as lip-lick cheilitis.[1]A male child presented to our outpatient department with nearly...
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Radiological assessment of the calcaneal angles of Kwara populace: A retrospective study: Ade S Alabi, Bilikis E Mohammed, Susan Folashade Lewu, Richard O Neku, Bidemi S Kareem, Oyetunji A Oyewopo, Foyeke M AdigunInternational Journal of Health & Allied Sciences 2020 9(1):29-33INTRODUCTION: Estimation of sex from different dimensions has considerable forensic value, for the identification of human remains, in the estimation of sex at disaster sites and in corroborating reports from scientists....
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Ensuring patient safety through reducing medication errors: World Health Organization: Saurabh RamBihariLal Shrivastava, Prateek Saurabh ShrivastavaInternational Journal of Health & Allied Sciences 2020 9(1):86-87Patient safety refers to the prevention of harm and minimizing the chances of injuries or mistakes in the field of health care delivery. In-fact, the global estimates depict that on an annual basis in excess of 130 million adverse events are reported exclusively in health care settings...
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Safety First: Awareness and attitude regarding first aid among college students – A Cross-sectional study in Urban Bangalore: Sakthi Arasu, Savan Sara Mathew, Naveen Ramesh, Farah Naaz Fathima, Avita Rose JohnsonInternational Journal of Health & Allied Sciences 2020 9(1):25-28INTRODUCTION: First aid training is an important community survival skill necessary for all individuals as injuries and accidents have become the major epidemic of noncommunicable disease in India.OBJECTIVE: The objective...
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A study of magnitude of zinc deficiency and effectiveness of zinc supplementation among elderly with zinc deficiency: Sindhu Kilaru, Prathiba Pereira, B J Subhash Chandra, Basavanagowdappa Hattur, Sri Harsha ChalasaniInternational Journal of Health & Allied Sciences 2020 9(1):21-24INTRODUCTION: Despite the significant role played by Zinc, the body stores of Zinc are very minimal and easily depleted. Zinc deficiency is known to be associated with various pathological conditions, including impaired...
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Prevention and control of the sexually transmitted infections worldwide: Need of the hour: Saurabh RamBihariLal Shrivastava, Prateek Saurabh ShrivastavaInternational Journal of Health & Allied Sciences 2020 9(1):90-91Sexually transmitted infections have been regarded as one of the major global public health problems owing to its immense impact on the sexual and reproductive health of adults and children. The available global estimates depict that more than 360 million infections are being reported...
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Effectiveness and safety study of oral triamcinolone in patients with rheumatoid arthritis in India: Nilesh PatilInternational Journal of Health & Allied Sciences 2020 9(1):14-20INTRODUCTION: This study was conducted to assess the effectiveness and safety of low-dose oral triamcinolone (Kenacort®, Abbott Healthcare Pvt. Ltd) in combination with disease-modifying antirheumatic drugs (DMARDs) in Indian patients with rheumatoid arthritis (RA).MATERIALS AND METHODS: Patients with an established diagnosis...
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Pediatric nasopharyngeal carcinoma: Santosh Kumar Swain, Smrutipragnya Samal, Nishtha Anand, Jatindra Nath MohantyInternational Journal of Health & Allied Sciences 2020 9(1):1-6Nasopharyngeal carcinoma (NPC) is an extremely rare malignancy among pediatric age group. The relative rarity of pediatric NPC makes the diagnosis difficult and associated with late diagnosis and advanced locoregional disease. The clinical presentations of pediatric NPC are usually nonspecific. The children with NPC have...
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Peridens – Case series of nonsyndromic patients with varied clinical presentations: P Venkatalakshmi Aparna, Narmatha Namachivayam, S Leena, B SoundaryaInternational Journal of Health & Allied Sciences 2020 9(1):80-83Supernumerary tooth may be encountered by the general dental practitioner as an incidental finding on a radiographic examination or as the cause of an impacted tooth. However, in certain cases, it may be misinterpreted as a bony growth (mandibular torus) when it makes its appearance...
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Treating Hyperthyroidism in the Critically Ill Patient with Rectal Methimazole: AbstractGraves' disease is the most common cause of hyperthyroidism and is typically managed on an outpatient basis with one of anti‐thyroid drugs, radioactive iodine or thyroidectomy. We report a case of Graves' disease in a critically ill patient following duodenal repair managed with per rectum (PR) methimazole. Nabil et al demonstrated similar blood concentrations of methimazole whether given PO (per os) or PR in...
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Cancer‐derived Immunoglobulin G: A Novel Marker for Differential Diagnosis and Relapse Prediction in Parathyroid Carcinoma: AbstractObjectiveA differential diagnosis between malignant and benign parathyroid lesions is difficult due to their overlapping clinicopathological characteristics. As such, molecular markers are urgently needed. Cancer‐derived immunoglobulin G (CIgG) is a novel molecule plays important roles in carcinogenesis. The present study aimed to investigate the clinical significance...
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Long term testosterone undecanoate replacement therapy: impact of ethnicity: AbstractBackgroundTestosterone Replacement Therapy (TRT) is indicated for symptomatic male hypogonadism. However, the safety and efficacy profiles across different ethnicities for long term TRT remain unclear.ObjectiveTo measure the impact of ethnicity on various biochemical parameters following Testosterone Undecanoate (TU) replacement.MethodA retrospective analysis of 50 male patients treated with TU from 2006 to 2017...
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Rivaroxaban treatment failure: Adding a new case to the list: Fahmi Y KhanJournal of Family and Community Medicine 2020 27(1):70-71Sir,Rivaroxaban is a factor Xa inhibitor, which is commonly used for the treatment of venous thromboembolism (VTE) as one of the novel oral anticoagulants found to have a safety and efficacy profile comparable to traditional anticoagulants. However, sporadic reports from some centers have shown a failure of treatment in patients with VTE.[1],[2],[3] In this report, we...
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Quality of life of migraine patients followed in neurology clinics in Riyadh, Saudi Arabia: Fatima G AlHarbi, Mohammed A AlAteeqJournal of Family and Community Medicine 2020 27(1):37-45BACKGROUND: Migraine is a chronic disorder that negatively affects a patient's quality of life (QOL). As little is known about the QOL of migraine sufferers in Saudi Arabia, our aim was to investigate the QOL and the level of migraine-associated disability of migraine patients.MATERIALS AND METHODS: This cross-sectional...
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Evaluation of health-care providers' knowledge in the science of aerosol drug delivery: Educational sessions are necessary: Hajed M Al-OtaibiJournal of Family and Community Medicine 2020 27(1):62-66BACKGROUND: Aerosolized drugs are widely used to treat and control a variety of pulmonary diseases. However, there is increasing evidence that patients are unable to use their drug delivery device correctly. The failure of aerosolized treatment is usually the result of poorly communicated instructions....
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The status of zinc in type 2 diabetic patients and its association with glycemic control: Dhedhi M Farooq, Ali F Alamri, Basmah K Alwhahabi, Ashraf M Metwally, Khalid A KareemJournal of Family and Community Medicine 2020 27(1):29-36BACKGROUND: Zinc (Zn) is a trace element that carries antioxidant properties. Deficiency of Zn increases oxidative stress, especially in diabetes. The objective of this study was to assess the relationship between the level of Zn and glycemic control in type 2 diabetes.MATERIALS...
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Saudi mothers' perception of their children with attention-deficit hyperactivity disorder in Dammam, Al-Qatif, and Al-Khobar cities, Saudi Arabia: Zainab J Al-Mohsin, Heba A Al-Saffar, Shaher Z Al-Shehri, Marwa M ShafeyJournal of Family and Community Medicine 2020 27(1):46-52BACKGROUND: Mothers' perceptions about attention-deficit hyperactivity disorder (ADHD) are central to the management of the disorder. The aim of the study was to assess the knowledge, experiences, and attitudes of mothers with...
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The relationship between sleep quality, stress, and academic performance among medical students: Abdullah D Alotaibi, Faris M Alosaimi, Abdullah A Alajlan, Khalid A Bin AbdulrahmanJournal of Family and Community Medicine 2020 27(1):23-28BACKGROUND: Sleep is essential for the body, mind, memory, and learning. However, the relationship between sleep quality, stress, and academic performance has not been sufficiently addressed in the literature. The aim of this study was to assess the quality of sleep...
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Cardiac arrest and stroke due to unsupervised use of herbal preparation: Malak A Alshammari, Ali Hassan, Amna S Alsaihati, Faisal H Aldera, Haitham S AlaithanJournal of Family and Community Medicine 2020 27(1):67-69Despite the widespread use of herbal preparations and ongoing studies on their therapeutic potential, there are no safety standards on their usage. We report a case of a 36-year-old male patient who presented with severe muscle weakness and generalized fatigue. He had no significant medical...
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Effect of autism on parental quality of life in Arar city, Saudi Arabia: Dalal S Alenazi, Sabry M Hammad, Amal E MohamedJournal of Family and Community Medicine 2020 27(1):15-22BACKGROUND: The quality of life (QOL) of the families of children with autism is lower than that of families of normal children or children with other disabilities. The study's aim was to describe the severity of effect on the domains of the QOL of caregivers of autistic children and to identify the characteristics of caregivers...
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Healthy nutrition for a healthy child: A review on infant feeding in India: Vinoth G Chellaiyan, Fasna Liaquathali, Jasmine MarudupandiyanJournal of Family and Community Medicine 2020 27(1):1-7Appropriate infant feeding is crucial for the improvement of child survival worldwide. This review aimed to explore the recommended practices, advantages of breastfeeding, and age-appropriate complementary feeding practices. Colostrum, which serves as the first immunization for the newborn, is largely ignored...
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Association between type 2 diabetes mellitus and Helicobacter pylori infection among Saudi patients attending National Guard Primary Health Care Centers in the Western Region, 2018: Abdullah M Alzahrani, Areej A Al Zaidi, Shahad M Alzahrani, Sultana A Binmahfouz, Fayssal M FarahatJournal of Family and Community Medicine 2020 27(1):8-14BACKGROUND: Reports on Helicobacter pylori infection in diabetics are inconsistent and contradictory. This study attempted to identify the possible association between...
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Anxiety and depression and their relation to the use of electronic devices among secondary school students in Al-Khobar, Saudi Arabia, 2018–2019: Zaenb H Al Salman, Fatimah A Al Debel, Fatimah M Al Zakaria, Marwa M Shafey, Magdy A DarwishJournal of Family and Community Medicine 2020 27(1):53-61BACKGROUND: Adolescence is a critical transitional period for the development of mental illnesses such as depression or anxiety, and these days, adolescents spend less time playing outside than they do using...
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Supraglottic laryngeal sarcoidosis masquerading as supraglottitis: Sarcoidosis is a rare multisystem disorder of unknown aetiology characterised by non-caseating granulomas in involved organs; it is a diagnosis of exclusion. Laryngeal involvement affects only 0.5%–5% of those with sarcoidosis. It is an uncommon but important cause of supraglottic inflammation and oedema and should be considered in the differential diagnosis in patients with supraglottitis. This case describes a 30-year-old man who...
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Delayed diagnosis of T3 supplementation in a bodybuilder presenting with tachycardia and features of sepsis: A 25-year-old man presented generally unwell to the emergency department. Initial assessment identified systemic inflammatory response syndrome markers with an insect bite as a potential source of infection and he was treated for presumed sepsis. Tachycardia persisted and baseline thyroid function testing showed undetectable free thyroxine and thyroid-stimulating hormone (TSH), prompting further...
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Multifocal cryptococcal disease in an HIV-infected patient: from diagnostic pursuit to management peculiarities: Cryptococcosis is a life-threatening fungal infection that affects immunocompromised patients, causing predominantly meningoencephalitis and pneumonia. Lymph node involvement is rare and its identification may not be obvious. We report the case of a patient recently diagnosed with AIDS and previously treated for cryptococcal meningitis who developed multifocal cryptococcal disease despite...
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Neurological recovery after surgical intervention of a complete spinal cord injury secondary to a chronic untreated odontoid neck fracture: a lesson in patient prognostication: Odontoid fractures are injuries that can either be benign or devastatingly progress to quadriplegia and significant morbidity and mortality. Management is not clear cut for patients who already present late and with severe neurological deficits. We present a case of a type 2 odontoid fracture with associated complete spinal...
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Anaesthetic management of a parturient with hereditary haemorrhagic telangiectasia (HHT) and pulmonary haemorrhage requiring urgent caesarean section: A 25-year-old gravida 3 para 3 with a history of hereditary haemorrhagic telangiectasia (HHT) and embolised pulmonary arteriovenous malformations (PAVMs) was admitted at 36 weeks gestation with haemoptysis, epistaxis and CT evidence of recent alveolar haemorrhage. An urgent caesarean section was planned. Both previous pregnancies had been delivered...
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Congenital triangular alopecia associated with phakomatosis pigmentovascularis type ii along with Klippel Trenaunay syndrome: Aastha Gupta, Ananta Khurana, Purnima Malhotra, Kabir SardanaIndian Dermatology Online Journal 2020 11(1):91-93Phakomatosis pigmentovascularis (PPV) is characterized by the association of a vascular nevus with a pigmentary nevus and is divided into five subtypes. PPV type II or Happle's phakomatosis cesioflammea is the most common subtype comprising of nevus flammeus along...
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A rare case of extensive pemphigus vegetans: Ghanshyam K Verma, Gita R Tegta, Anuj Sharma, Mohitpreet Kaur, Sudarshan SharmaIndian Dermatology Online Journal 2020 11(1):87-90Pemphigus vegetans is a rare variant of pemphigus vulgaris characterized by pustules and/or papillomatous vegetations, preferentially affecting intertriginous and periorificial areas. It has two subtypes: Hallopeau variant and Neumann variant. Cerebriform tongue, a morphology with typical pattern of sulci and gyri over dorsum...
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An exuberant case of necrobiotic xanthogranuloma: Sofia Lopes, Nuno Gomes, Artur César, Ana Margarida Barros, Jorge Pinheiro, Filomena AzevedoIndian Dermatology Online Journal 2020 11(1):83-86Necrobiotic xanthogranuloma (NXG) is a rare form of inflammatory granulomatous disease of the skin characterized by the presence of pruritic to painful lesions, generally located in the periorbital area, although trunk and proximal extremities may also be involved. We report a case of a 69-year-old male patient...
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Giant congenital melanocytic nevi successfully treated with combined laser therapy: Jagdish Sakhiya, Dhruv Sakhiya, Mehul Patel, Feral DaruwalaIndian Dermatology Online Journal 2020 11(1):79-82Congenital melanocytic nevi are benign proliferations of cutaneous melanocytes that arise as a result of abnormal growth, development, or migration of melanoblasts. Clinically, the giant congenital nevus is greater than 20 cm in size, pigmented and often hairy. The risk of malignant melanoma for the giant nevi...
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Darier's disease - response to oral Vitamin A: report of a case and brief review: Megha Sondhi, Sanket Vashist, Vikram K MahajanIndian Dermatology Online Journal 2020 11(1):72-78Darier's disease is an uncommon chronic dermatosis of autosomal dominant inheritance with significant psychosocial morbidity and shows unsatisfactory response to several topical and systemic therapies or various resurfacing or surgical procedure. A 24-year-old woman having characteristic asymptomatic and progressive, hyperkeratotic...
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Pruritic periumbilical plaque as a presentation of a rare perforating dermatosis: Meghana Bathina, Spandana P Hegde, Akbar A Shanavaz, Prema P SaldanhaIndian Dermatology Online Journal 2020 11(1):68-71Perforating dermatoses are characterized by transepidermal elimination of altered dermal components or foreign particles. Owing to their common clinical presentation as umbilicated papules with a keratotic plug, histopathology and special staining play a very crucial role in the diagnosis. Perforating...
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Monilethrix: A report of three cases in children confirmed with dermoscopy: Remya R Rajamohanan, Biswanath Behera, Prabhakaran Nagendran, Munisamy MalathiIndian Dermatology Online Journal 2020 11(1):65-67Monilethrix is a rare hereditary disorder affecting hair resulting in hair fragility and alopecia. We report three patients of monilethrix who presented with complaints of sparse and brittle hair from early childhood. All three patients had multiple discrete hyperkeratotic papules over the scalp....
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Amniotic band syndrome with ectrodactyly-two cases: Mohabat D BariaIndian Dermatology Online Journal 2020 11(1):101-102Sir,Amniotic band syndrome (ABS) is a spectrum of asymmetrical congenital malformations owing to ring-like constrictive bands in the limbs, head, face, or occasionally the trunk.[1],[2] Originally thought to be due to a primary germ cell defect,[3] later studies of the placenta and fetus have led to the widely accepted concept of amniotic rupture.[4],[5] We report two cases of ABS...
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Co-occurrence of symmetrical drug-related intertriginous and flexural exanthema (SDRIFE) and pigmented Fixed drug eruption (FDE) in a single patient due to Doxycycline: A case report: Kananbala Sahu, Chandra S Sirka, Swetalina Pradhan, Arpita N RoutIndian Dermatology Online Journal 2020 11(1):62-64Symmetrical drug-related intertriginous and flexural exanthema (SDRIFE), and fixed drug eruption (FDE) are adverse cutaneous drug reactions. SDRIFE is most commonly associated with the use of beta-lactam...
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Sun Exposure in Children: Balancing the Benefits and Harms: Ankur K Jindal, Aman Gupta, Keshavamurthy Vinay, Anuradha BishnoiIndian Dermatology Online Journal 2020 11(1):94-98There is a common belief among the laity and even physicians that sun exposure is a useful source of vitamin D. However, despite the fact that sun exposure occurs almost throughout the year in India, vitamin D deficiency is widely prevalent. Although several authors have reported on the duration of sun exposure required to synthesize...
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Comparison of efficacy of autologous platelet-rich fibrin versus Unna's paste dressing in chronic venous leg ulcers: A comparative study: G Yuvasri, Reena RaiIndian Dermatology Online Journal 2020 11(1):58-61Background: Chronic venous leg ulcers are difficult to treat and recurrences are common. Among various modalities of treatment, platelet-rich fibrin (PRF) has shown promising results in ulcer healing by providing necessary growth factors. Unna's paste dressing has also proven to enhance wound...
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Dermoscopy of telangiectasia macularis eruptiva perstans: Smriti Kumar, Deepak Jakhar, Rachita MisriIndian Dermatology Online Journal 2020 11(1):131-132A 22-year-old male presented with multiple asymptomatic dull red to brown colored flat lesions over bilateral upper limbs. The lesions started appearing 2 years back on left forearm and were progressive in nature. Patient denied any systemic symptoms or aggravating factors. Patient was a non-alcoholic and non-smoker and denied any previous treatment....
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Real-world efficacy and safety of apremilast monotherapy in the management of moderate-to-severe Psoriasis: Bela J Shah, Deval Mistry, Navin Chaudhary, Shikha ShahIndian Dermatology Online Journal 2020 11(1):51-57Introduction: Apremilast is the new oral drug in the management of moderate-to-severe plaque psoriasis with well-established effectiveness and safety in long-term clinical trials and a few real-world studies. However, its effectiveness and safety in Indian setup have not been reported yet....
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Chronic hyperkeratotic acral plaques: Shilpi Sharma, Amita Sharma, Neirita HazarikaIndian Dermatology Online Journal 2020 11(1):123-124 Clinical and Histopathologic Findings A 37-year-old male presented with a history of gradually progressive darkening of dorsa of hands and feet with overlying hyperpigmented plaques since 5 months. It was associated with mild pruritus, and there were no systemic symptoms. On examination, there were well-defined hyperpigmented plaques distributed symmetrically over...
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Knowledge, attitudes, and practices of community pharmacists toward the management of acne vulgaris in Palestine: a cross‐sectional study: AbstractBackgroundAcne vulgaris (AV) is a common dermatological disease affecting almost 85% of teenagers. Patients with AV usually present at community pharmacies during the early stages of their disease.AimThe aim of this study was to assess community pharmacists' knowledge, attitudes, and practice toward AV management in West Bank in Palestine.MethodsThis study...
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Impact of atopic dermatitis on quality of life in adults: a systematic review and meta‐analysis: AbstractAtopic dermatitis (AD) can affect quality of life (QoL) of adult patients in whom the condition can be severe and persistent. There are currently no systematic reviews of the impact of AD on adults. This paper provides the first systematic literature review and meta‐analysis of the impact of AD on QoL in adults. A systematic search was conducted using MEDLINE, Scopus, and Web of Science for articles...
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Clinicomycological study of dermatophytosis in a tertiary care hospital in eastern India: A cross-sectional study: Bhabani S. T. P Singh, Tapaswini Tripathy, Bikash R Kar, Arunima RayIndian Dermatology Online Journal 2020 11(1):46-50Introduction: Dermatophytosis is a fungal infection of the skin, hair, and nails. In the past several years, it has emerged as a general public health problem in our country. Studies from different regions reveal varying patterns of etiological distribution of the disease....
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Rheumatoid neutrophilic dermatosis: The distinct entity with florid presentation: Indu Kumari, Atul Dongre, Swosti MohantyIndian Dermatology Online Journal 2020 11(1):114-115Sir,Rheumatoid neutrophilic dermatosis (RND) is a very rare cutaneous manifestation of severe rheumatoid arthritis (RA).[1] It usually presents as chronic, asymptomatic, symmetric erythematous and urticaria-like plaques and papules. The annular, vesicular, ulcerative or necrotic lesions are less frequently reported in a single...
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A split face comparative study of safety and efficacy of microneedling with tranexamic acid versus microneedling with Vitamin C in the treatment of melasma: Ashok Menon, Hafsa Eram, Prashanth R Kamath, Saumya Goel, Amita Murali BabuIndian Dermatology Online Journal 2020 11(1):41-45Introduction: Melasma is a common pigmentary disorder affecting the face. Although a few risk factors have been identified, the exact pathogenesis remains elusive. Many treatment modalities have been tried, but none have...
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An elderly male with asymptomatic black staining of hands: Anuradha Bishnoi, Keshavamurthy Vinay, Sendhil M KumaranIndian Dermatology Online Journal 2020 11(1):103-104Editor,An elderly male with type II diabetes mellitus, on treatment for postherpetic neuralgia, was incidentally noted to have dark brown to black colored hyperpigmentation of his hands for last 1 month. The hyperpigmentation was asymptomatic, persistent, and was most pronounced on the palmar aspect and extended till the mid-palms....
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Comparative study of clinical and dermoscopic features in nail psoriasis: Naphisabet Wanniang, Annam Navya, Varadraj Pai, Rakhi GhodgeIndian Dermatology Online Journal 2020 11(1):35-40Background, Aims, and Objectives: Nail changes have been reported in approximately 40% of psoriasis patients. Occasionally nail psoriasis may be the sole finding or the first presentation of the disease. Assessment of the nail changes associated with psoriasis can be done clinically, ultrasonographically, and most...
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Melanonychia: Etiology, Diagnosis, and Treatment: Archana Singal, Kavita BisherwalIndian Dermatology Online Journal 2020 11(1):1-11Melanonychia is a very worrisome entity for most patients. It is characterized by brownish black discoloration of nail plate and is a common cause of nail plate pigmentation. The aetiology of melanonychia ranges from more common benign causes to less common invasive and in situ melanomas. Melanonychia especially in a longitudinal band form can be due to both local and...
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Psoriatic nephropathy and its correlation with hs-CRP: A case control study: Ishmeet Kaur, Vijay Gandhi, Alpana Raizada, Sambit Nath Bhattacharya, Ashok K Tripathi, Deepak JakharIndian Dermatology Online Journal 2020 11(1):29-34Background: Psoriasis is a multisystem disorder associated with various systemic diseases such as cardiovascular diseases, diabetes mellitus and metabolic syndrome. Renal involvement in patients with psoriasis is sparsely studied and its association is still unclear. Aim:...
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Risk factors associated with head lice infestation in rural pediatric patients: Neerja Saraswat, Pooja Shankar, Ajay Chopra, Barnali Mitra, Sushil KumarIndian Dermatology Online Journal 2020 11(1):25-28Introduction: Head louse infestation is a common parasitic disease in pediatric age group. It is common in collective centers such as schools, garrisons, campuses and old age homes. It is worldwide in distribution with no strict limitation with respect to age, gender and race. Aims: Present study was...
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Chlamydia Trachomatis associated reactive arthritis: A urinary PCR based study: Megha Sharma, Susmita Sharma, Aman Sharma, Kusum SharmaIndian Dermatology Online Journal 2020 11(1):21-24Background and Objective: Chlamydia trachomatis is increasingly being associated with reactive arthritis (ReA). The present study was undertaken to assess the role of C. trachomatis in patients with ReA since such data is lacking from the Indian population. Materials and Methods: PCR using specific primers for C. trachomatis...
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Topping-Off Technology versus Posterior Lumbar Interbody Fusion in the Treatment of Lumbar Disc Herniation: A Meta-Analysis: The treatment effects of topping-off technique were still controversial. This study compared all available data on postoperative clinical and radiographic outcomes of topping-off technique and posterior lumbar interbody fusion (PLIF). PubMed, EMBASE, and Cochrane were systematically reviewed. Variations included radiographical adjacent segment disease (RASD), clinical adjacent...
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Extracellular Vesicles with Possible Roles in Gut Intestinal Tract Homeostasis and IBD: The intestinal tract consists of various types of cells, such as epithelial cells, Paneth cells, macrophages, and lymphocytes, which constitute the intestinal immune system and play a significant role in maintaining intestinal homeostasis by producing antimicrobial materials and controlling the host-commensal balance. Various studies have found that the dysfunction of intestinal homeostasis contributes to the...
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Comparing the Effect of Foot Massage with Grape Seed Oil and Sweet Almond Oil on Physiological Leg Edema in Primigravidae: A Randomized Clinical Trial: Background. Leg edema is a prevalent problem in pregnancy causing activity restrictions for pregnant women. This study was performed to compare the effect of foot massage using grape seed oil and sweet almond oil on physiological leg edema. Methods. A randomized clinical trial was conducted on 90 primigravidae referred to public health centres of...
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Acupuncture Therapy plus Hyaluronic Acid Injection for Knee Osteoarthritis: A Meta-Analysis of Randomized Controlled Trials: Objective. This meta-analysis aimed to investigate the effectiveness of acupuncture therapy plus hyaluronic acid injection versus hyaluronic acid injection alone for patients with knee osteoarthritis. Methods. Relevant randomized controlled trials that compared the combined effect of acupuncture therapy and hyaluronic acid injection with hyaluronic acid injection alone for...
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Integrated Chinese Herbal Medicine and Western Medicine on the Survival in Patients with Colorectal Cancer: A Retrospective Study of Medical Records: Recent studies suggested that Traditional Chinese Medicine could play a beneficial role in conventional cancer treatment. The aim of this retrospective cohort study was to investigate the effect of Chinese herbal medicine (CHM) combined with Western medicine on the survival of patients with colorectal cancer. A retrospective cohort study was conducted...
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20(S)-Protopanaxdiol Suppresses the Abnormal Granule-Monocyte Differentiation of Hematopoietic Stem Cells in 4T1 Breast Cancer-Bearing Mouse: Panax notoginseng (PN) has been used as a qi- and blood-activating (Huoxue) drug for thousands of years in China. It has also been widely used as an anticancer drug at present. As a Huoxue drug, the effect of PN on hematopoietic differentiation in tumor-bearing body has been paid more and more attention. Our research found that panax notoginseng saponins (PNS),...
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A Systems Pharmacology Approach for Identifying the Multiple Mechanisms of Action for the Rougui-Fuzi Herb Pair in the Treatment of Cardiocerebral Vascular Diseases: Cardiocerebral vascular diseases (CCVDs) are the main reasons for high morbidity and mortality all over the world, including atherosclerosis, hypertension, myocardial infarction, stroke, and so on. Chinese herbs pair of the Cinnamomum cassia Presl (Chinese name, rougui) and the Aconitum carmichaelii Debx (Chinese name, fuzi) can be effective...
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Neuroprotective Activity of Methanolic Extract of Lysimachia christinae against Glutamate Toxicity in HT22 Cell and Its Protective Mechanisms: Purpose. Excessive glutamate amount can give oxidative stress to neuronal cells, and the accumulation of cell death can trigger the neurodegenerative disorders. In this study, we discovered the neuroprotective effect of Lysimachia christinae Hance in the mouse hippocampal HT22 cell line. Method. Overnight incubated HT22 cells were pretreated with L. christinae...
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Deciphering the Active Ingredients and Molecular Mechanisms of Tripterygium hypoglaucum (Levl.) Hutch against Rheumatoid Arthritis Based on Network Pharmacology: Tripterygium hypoglaucum (Levl.) Hutch (THH) shows well clinical effect on rheumatoid arthritis (RA), but the active ingredients and molecular mechanisms remain unclear. This work was designed to explore these issues by network pharmacology. Compounds from THH were gathered by retrieving literatures. Compound-related and RA-related genes...
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Skin Hydration Effects of Scale-Up Fermented Cyclopia intermedia against Ultraviolet B-Induced Damage in Keratinocyte Cells and Hairless Mice: Photoaging occurs by chronic skin exposure to the sun and ultraviolet irradiation and leads to skin aging accompanied by a lack of skin hydration. We previously demonstrated the photoprotective effect of fermented Cyclopia intermedia (honeybush) extract on the skin. In this study, we evaluated the skin hydration effects of scaled-up fermented honeybush extract...
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Association of Angiopoietin Dysregulation in Placental Malaria with Adverse Birth Outcomes: Malaria in pregnancy causes adverse birth outcomes due to sequestration of Plasmodium falciparum-infected erythrocytes in the placenta. Angiopoietins are critical regulators of vascular development and formation of placental villous vasculature. Angiopoietin-1 and Angiopoietin-2 concentrations were measured in peripheral and placental plasma samples from 70 malaria-infected and 216 control women using commercially...
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Cordyceps cicadae Prevents Renal Tubular Epithelial Cell Apoptosis by Regulating the SIRT1/p53 Pathway in Hypertensive Renal Injury: Hypertensive renal injury is a primary etiology of end-stage renal disease, and satisfactory therapeutic strategies are urgently required. Cordyceps cicadae, a traditional Chinese herb, has potential renoprotective benefits and is widely used in the treatment of many kidney diseases. To investigate the mechanisms underlying the renoprotective effect of C. cicadae on...
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Efficacy and Safety of Tanshinone for Chronic Kidney Disease: A Meta-Analysis: Objective. To systematically evaluate the efficacy and safety of tanshinone for chronic kidney disease (CKD). Methods. Randomized controlled trials (RCTs) on the treatment of CKD using tanshinone were searched using 4 Chinese databases (China National Knowledge Infrastructure (CNKI), Value In Paper (VIP), Wanfang, and Chinese Biology Medicine (CBM)) and 3 English databases (PubMed, Cochrane Library, and Excerpta Medica...
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Upregulation of FEN1 Is Associated with the Tumor Progression and Prognosis of Hepatocellular Carcinoma: Background. Studies show that patients with hepatocellular carcinoma (HCC) have poor prognosis, particularly when patients are diagnosed at late stages of the disease development. The flap endonuclease 1 (FEN1) gene is overexpressed in multiple malignant tumors and may promote tumor aggressiveness. However, its expression profile and functional roles in HCC are still unclear. Here, we evaluated...
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CpG-ODN Induces a Dose-Dependent Enrichment of Immunological Niches in the Spleen and Lungs of Neonatal Chicks That Correlates with the Protective Immunity against Escherichia coli: Immunoprotective function of oligodeoxynucleotides containing CpG motifs (CpG-ODN) has been demonstrated in neonatal chickens against common bacterial pathogens such as E.coli and Salmonella sp. Our recent study reported that CpG-ODN administration enriches immune compartments in neonatal chicks. However, a causal relationship...
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Mathematical Prostate Cancer Evolution: Effect of Immunotherapy Based on Controlled Vaccination Strategy: Basic immunology research over several decades has led to an improved understanding of tumour recognition by components of the immune system and mechanism of tumour evasion from immune detection. These findings have ultimately led to creating antitumour immunotherapies in patients with different kind of cancer including prostate cancer. The increasing number of reports confirms that immune-based...
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Apolipoprotein A-V Is a Novel Diagnostic and Prognostic Predictor in Pediatric Patients with Sepsis: A Prospective Pilot Study in PICU: Background. Sepsis induces the release of lipid mediators, which control both lipid metabolism and inflammation. However, the role of serum apolipoprotein A-V (ApoA5) in sepsis is poorly understood in pediatric patients. Methods. ApoA5 was screened from serum proteomics profile in lipopolysaccharide- (LPS-) treated mice for 2 h, 24 h, and controls. Then, we conducted...
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Effects of the Proactive Interdisciplinary Self-Management (PRISMA) Program on Online Care Platform Usage in Patients with Type 2 Diabetes in Primary Care: A Randomized Controlled Trial: Online care platforms can support patients with type 2 diabetes (T2DM) in managing their health. However, in the use of eHealth, a low participation rate is common. The Proactive Interdisciplinary Self-Management (PRISMA) program, aimed at improving patients' self-management skills, was expected to encourage patients...
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Relationship between Urinary Liver-Type Fatty Acid-Binding Protein (L-FABP) and Sarcopenia in Spontaneously Diabetic Torii Fatty Rats: Background. Type 2 diabetes (T2D) is a known risk factor for diabetic kidney disease (DKD) and sarcopenia in older patients. Because there may be an interaction between DKD and sarcopenia, the aim of the present study is to investigate the relationship between urinary levels of liver-type fatty acid-binding protein (L-FABP) and sarcopenia using a novel rat model of...
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Pleiotropic Effects of a KCNQ1 Variant on Lipid Profiles and Type 2 Diabetes: A Family-Based Study in China: Objective. The genetic variant rs2237895, located in the Potassium Voltage-Gated Channel Subfamily Q Member 1 (KCNQ1) gene, has been replicated to be associated with type 2 diabetes mellitus (T2DM) susceptibility, but the relationship with lipids is conflicting. Furthermore, the common genetic predisposition to T2DM and lipids was not fully detected. Methods. In total, 5839 individuals (2220...
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Clinicopathological Features, Treatment Strategy, and Prognosis of Primary Non-Hodgkin's Lymphoma of the Duodenum: A SEER Database Analysis: Objective. Primary duodenum lymphoma (PDL) is extremely rare with limited data available in the literature. In this study, we sought to describe clinical features and identify factors affecting survival in patients with PDL using a large population cohort. Methods. The Surveillance, Epidemiology, and End Results (SEER) database was queried from 1998 to 2015....
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MSCs Contribute to the Conversion of Ly6Chigh Monocytes into Ly6Clow Subsets under AMI: Background. Ly6Chigh monocytes are inflammatory cells that accumulate in an infarcted myocardium, and Ly6Clow monocytes are believed to be reparative and curb myocardial remodeling. NR4A1 is a novel target for modulating the inflammatory phenotype of monocytes during atherogenesis. Objectives. We aimed to investigate whether MSCs can contribute to the heterogeneity of Ly6Chigh monocytes differentiated into Ly6Clow...
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Human Fat-Derived Mesenchymal Stem Cells Xenogenically Implanted in a Rat Model Show Enhanced New Bone Formation in Maxillary Alveolar Tooth Defects: Background. Due to restorative concerns, bone regenerative therapies have garnered much attention in the field of human oral/maxillofacial surgery. Current treatments using autologous and allogenic bone grafts suffer from inherent challenges, hence the ideal bone replacement therapy is yet to be found. Establishing a model by which MSCs can be placed...
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Severe Aplastic Anemia Developed after Thymectomy: A Case Report and Literature Review: Thymus neoplasms are frequently related to paraneoplastic autoimmune manifestations. Its most common associations are myasthenia gravis and pure red cell aplasia. Aplastic anemia has been increasingly documented as an initial presentation of thymoma. Nevertheless, its development after successful surgical resection of thymoma is a rare condition. We report a case of a 53-year-old man with severe aplastic anemia...
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Salvage after Retroperitoneal Kidney Allograft Torsion: Torsion of a transplanted kidney into the retroperitoneal space is a rare occurrence, with only three other reported cases. Failure after kidney transplantation is caused by surgical, immunological, and infective complications. Torsion is a complication that poses a serious risk of ischemic graft failure, and, if suspected, sonographic evaluation helps ascertain the diagnosis. Here, we present the case of a 69-year-old transplant recipient whose...
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A Survey on Recent Advances in Wearable Fall Detection Systems: With advances in medicine and healthcare systems, the average life expectancy of human beings has increased to more than 80 yrs. As a result, the demographic old-age dependency ratio (people aged 65 or above relative to those aged 15–64) is expected to increase, by 2060, from ∼28% to ∼50% in the European Union and from ∼33% to ∼45% in Asia (Ageing Report European Economy, 2015). Therefore, the percentage of people who need additional...
08:50
Topping-Off Technology versus Posterior Lumbar Interbody Fusion in the Treatment of Lumbar Disc Herniation: A Meta-Analysis: The treatment effects of topping-off technique were still controversial. This study compared all available data on postoperative clinical and radiographic outcomes of topping-off technique and posterior lumbar interbody fusion (PLIF). PubMed, EMBASE, and Cochrane were systematically reviewed. Variations included radiographical adjacent segment disease (RASD), clinical adjacent...
08:50
Altered Expression of Long Noncoding and Messenger RNAs in Diabetic Nephropathy following Treatment with Rosiglitazone: Diabetic nephropathy (DN) is characterized by metabolic disorder and inflammation. However, the regulatory effects that long noncoding RNAs (lncRNAs) have on the pathogenesis of DN and on the efficacy of rosiglitazone treatment have yet to be clearly defined. Herein, we performed unbiased RNA sequencing to characterize the transcriptomic profiles in db/db diabetic mouse model with...
08:50
Prolonged Pediatric Extracorporeal Membrane Oxygenation Support with Cardiopulmonary Failure in Juvenile Myelomonocytic Leukemia: We report a case of a child survival after extracorporeal membrane oxygenation (ECMO) support of 25 days for cardiopulmonary failure and septic shock in the context of juvenile myelomonocytic leukemia (JMML). ECMO support is still a matter of debate for the management of septic patients with malignancy. However, these patients are at increased risk for early death secondary...
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Myeloid Sarcomas Causing Unilateral Cranial Nerve Palsies in a Patient with Relapsed Acute Myeloblastic Leukemia: Myeloid sarcomas (MS) are a rare manifestation of myeloid malignancies and can often be misdiagnosed, leading to a delay in treatment. The objective of this clinical case is to highlight the challenges of the clinical presentation and to emphasize the importance of this manifestation ensuring timely diagnosis and therapy. Here, we present a 43-year-old man who was diagnosed with acute...
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Solid Pseudopapillary Neoplasm of the Pancreas with High-Grade Malignant Transformation Involving p16-RB Pathway Alterations: Solid pseudopapillary neoplasm (SPN) of the pancreas has generally been regarded as a low-grade malignant tumour that preferentially develops in young women and can have a good prognosis with surgery. Among the few patients who have died from metastatic SPN are mostly those whose tumours harbour an undifferentiated component characterized by diffuse sheets of cells with increased...
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Anti-Inflammatory Effects of Modified Buyang Huanwu Decoction: Background/Aims. Buyang Huanwu decoction (BHD) is a traditional Chinese and Korean herbal medicine prescription that has been widely used to treat various diseases including cerebral ischemia, gynecological disease, and neurological disorders. BHD is commonly used as a variable modified combination for synergistic therapeutic effects. However, the mechanism by which modified BHD (mBHD) produces anti-inflammatory effects has not been elucidated...
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Diagnostic Value of Low-Dose 256-Slice Spiral CT Angiography, MR Angiography, and 3D-DSA in Cerebral Aneurysms: Objective. To evaluate the diagnostic value of low-dose 256-slice CT angiography (CTA), MR angiography (MRA), and three dimensional-digital subtraction angiography (3D-DSA) in cerebral aneurysms. Methods. CTA, MRA, and 3D-DSA were performed in all enrolled patients to explore the diagnostic significance of the three different examinations. Results. There were 92 aneurysms confirmed during...
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Prevalence and Associated Risk Factors of Salmonella, Shigella, and Intestinal Parasites among Food Handlers in Motta Town, North West Ethiopia: Background. Intestinal parasite, Salmonella, and Shigella infections are the main public health concerns in the world, especially in developing countries due to inaccessibility of safe water and unhygienic food handling practices of food handlers. Methods. A cross-sectional study was conducted in food handlers in Motta town, from February 2019 to April 2019....
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Effects of Eplerenone on Blood Pressure and Echocardiographic and Serum Biochemical Variables in Five Healthy Dogs: A Pilot Study: Eplerenone (EP), an aldosterone antagonist, is reported to produce renal and cardiac protective effects in noncanine species. However, there are no detailed reports available on cardiovascular effects of EP in dogs. This study aimed to determine effect of EP on echocardiographic parameters, blood pressures, and biochemical variables in healthy dogs. Five healthy Beagle...
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Fusobacterium necrophorum subsp. necrophorum Liver Abscess with Pylephlebitis: An Abdominal Variant of Lemierre's Syndrome: Liver abscess associated with suppurative portal vein thrombosis (pylephlebitis) secondary to Fusobacterium necrophorum has been rarely reported. It is considered to be an abdominal variant of Lemierre's syndrome associated with significant morbidity and mortality. We report a case of 69-year-old man who developed liver abscess and pylephlebitis due to F. necrophorum with an...
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Overexpression of an Immune Checkpoint (CD155) in Breast Cancer Associated with Prognostic Significance and Exhausted Tumor-Infiltrating Lymphocytes: A Cohort Study: Purpose. The immune checkpoint inhibitor is approved for breast cancer treatment, but the low expression of PD-L1 limits the immunotherapy. CD155 is another immune checkpoint protein in cancers and interacts with ligands to regulate immune microenvironment. This study is aimed at investigating the expression of CD155 and the association...
08:47
Multimodal Retinal Image Analysis via Deep Learning for the Diagnosis of Intermediate Dry Age-Related Macular Degeneration: A Feasibility Study: Background and Objective. To determine if using a multi-input deep learning approach in the image analysis of optical coherence tomography (OCT), OCT angiography (OCT-A), and colour fundus photographs increases the accuracy of a CNN to diagnose intermediate dry age-related macular degeneration (AMD). Patients and Methods. Seventy-five participants were recruited...
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Surgical Management of a Large Chronic Prepatellar Bursitis: 2-Stage Technique: Treatment of a large chronic prepatellar bursitis can be difficult to manage surgically because of a high rate of local complications and a significant chance of recurrence. We present a 2-stage technique using negative pressure dressings which produced a good outcome with no recurrence at one year after surgery.1. IntroductionInflammation of the prepatellar bursa is a common condition, especially in males. It is typically...
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Impact of Treatment with Direct Acting Antiviral Drugs on Glycemic Control in Patients with Hepatitis C and Diabetes Mellitus: Aim. To assess the effect of treating chronic hepatitis C virus (HCV) infection with direct acting antiviral drugs (DAAs) on glycemic control in patients with concomitant diabetes mellitus (DM). Methods. We performed a retrospective case-control study in a viral hepatitis ambulatory clinic in Shreveport, Louisiana, during the period 11/01/2014 to 12/31/2017. All the clinic...
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Research Progress on Chemical Constituents and Anticancer Pharmacological Activities of Euphorbia lunulata Bunge: Euphorbia lunulata Bunge (ELB) is a traditional Chinese medicine possessing the functions of expectoration, cough relief, asthma relief, detoxification, and itching relief. Modern pharmacological studies have showed that ELB exhibits a variety of activities, such as antitumor, antibacterial, and antioxidant activities. In particular, the anticancer activities of ELB have attracted much...
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Diffusion-weighted imaging with simultaneous multi-slice echo-planar technique for the diagnosis of breast magnetic resonance imaging: AbstractPurposeTo evaluate the diagnostic potential of simultaneous multi-slice echo-planar diffusion-weighted imaging (DWI) (SMS-DWI).Materials and methodsA total of 55 consecutive patients underwent breast magnetic resonance imaging (MRI) between April and September 2018. SMS-DWI and single-shot echo-planar DWI (SS-EPI-DWI) sequences were obtained with the following...
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Techniques and challenges of the expanded endoscopic endonasal access to the ventrolateral skull base during the "far-medial" and "extreme medial" approaches: AbstractBackgroundExpanding the ventrolateral skull base corridor from the midline of lower clivus to the petroclival fissure is a challenging endonasal surgical task. Resection of lytic lesions like chondrosarcoma can cause cranial nerve morbidities and injury of ICA, necessitating accurate knowledge of correlative endoscopic anatomy with...
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Zinc Monotherapy as an Alternative Treatment Option for Decompensated Liver Disease due to Wilson Disease?: Background. Wilson disease is a rare metabolic disorder involving copper metabolism, and patients may present with a variable degree of hepatic, neurologic, and psychiatric manifestations. In the case of hepatic presentation, treatment is usually initiated with potentially toxic copper chelators (D-penicillamine or Trenton). Although zinc is of low toxicity and low cost for treatment of Wilson...
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Semicarbazide-Sensitive Amine Oxidase Increases in Calcific Aortic Valve Stenosis and Contributes to Valvular Interstitial Cell Calcification: Introduction. Calcific aortic valve stenosis (CAVS) is a common disease associated with aging. Oxidative stress participates in the valve calcification process in CAVS. Semicarbazide-sensitive amine oxidase (SSAO), also referred to as vascular adhesion protein 1 (VAP-1), transforms primary amines into aldehydes, generating hydrogen peroxide and ammonia. SSAO...
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Altered Expression of Long Noncoding and Messenger RNAs in Diabetic Nephropathy following Treatment with Rosiglitazone: Diabetic nephropathy (DN) is characterized by metabolic disorder and inflammation. However, the regulatory effects that long noncoding RNAs (lncRNAs) have on the pathogenesis of DN and on the efficacy of rosiglitazone treatment have yet to be clearly defined. Herein, we performed unbiased RNA sequencing to characterize the transcriptomic profiles in db/db diabetic mouse model with...
08:39
A repeated cross-sectional survey assessing changes in diet and nutrient quality of English primary school childrens packed lunches between 2006 and 2016: ObjectiveMandatory school meal standards were introduced in 2006 in England; however, no legislation exists for packed lunches. This study analyses provision of foods and nutrients in packed lunches in 2016 to highlight differences in diet and nutrient quality since 2006.DesignTwo cross-sectional surveys of children's packed lunches were conducted...
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Protocol for a systematic review of reporting standards of anaesthetic interventions in randomised controlled trials: IntroductionThere is significant variation in how anaesthesia is defined and reported in clinical research. This lack of standardisation complicates the interpretation of published evidence and planning of future clinical trials. This systematic review will assess the reporting of anaesthesia as an intervention in randomised controlled trials (RCT) against the Consolidated Standards...
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Cost-utility analysis of transcranial direct current stimulation (tDCS) in non-treatment-resistant depression: the DISCO randomised controlled study protocol: IntroductionDepression is among the most widespread psychiatric disorders in France. Psychiatric disorders are associated with considerable social costs, amounting to 22.6 billion for treatment and psychotropic medication in 2011. Treatment as usual (TAU), mainly consisting of pharmacotherapy and psychotherapy, is effective for only a third...
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Application of a Common Data Model (CDM) to rank the paediatric user and prescription prevalence of 15 different drug classes in South Korea, Hong Kong, Taiwan, Japan and Australia: an observational, descriptive study: ObjectiveTo measure the paediatric user and prescription prevalence in inpatient and ambulatory settings in South Korea, Hong Kong, Taiwan, Japan and Australia by age and gender. A further objective was to list the most commonly used drugs per drug class, per country.Design and settingHospital...
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Impact of loss-to-follow-up on cancer survival estimates for small populations: a simulation study using Hospital-Based Cancer Registries in Japan: ObjectivesThe accuracy of the ascertainment of vital status impacts the validity of cancer survival. This study assesses the potential impact of loss-to-follow-up on survival in Japan, both nationally and in the samples seen at individual hospitals.DesignSimulation studySetting and participantsData of patients diagnosed in 2007, provided by the Hospital-Based...
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British Medical JournalInclisiran: UK to roll out new cholesterol lowering drug from next yearThe UK government is to launch a major clinical trial of the novel cholesterol lowering drug inclisiran later this year and aims to make it available to NHS patients from 2021.Inclisiran, an...British Medical Journal8hResistant behaviour in dementia might be due to hearing lossCook and colleagues summarise many deficiencies in the care of people with dementia but do not mention hearing loss or deafness.1How...
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Cardiovascular Disease Risk in Living Kidney Donors: Knowns and UnknownsAbstract Purpose of Review This review aimed to summarize evidence regarding mid- and long-term cardiovascular risks associated with living kidney donation in adults. Recent Findings Chronic kidney disease is a major risk factor for cardiovascular disease. It is known that glomerular filtration rate declines among many donors after donation; as a result,...Current Epidemiology Reports17mThe Monoclonal Antibody NEO-201 Enhances...
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Accuracy of ventilator-associated events for the diagnosis of ventilator-associated lower respiratory tract infectionsThe aim of this study was to investigate the concordance between ventilator-associated events (VAE) and ventilator-associated lower respiratory tract infections (VA-LRTI), and their impact on outcome.Annals of Intensive Care - Latest Articles3hSurfactant protein D (SP-D) gene polymorphism rs721917 is an independent predictor of acute kidney injury development in sepsis patients: a...
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