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Plastic and Reconstructive Surgery - Published Ahead-of-PrintSystematic Surgical Approach to Alar Base Surgery in RhinoplastyIn an era with smartphone photography and social media (specifically "selfies"), basal view aesthetics is becoming increasingly important. Achieving balance between the nasal base and the remainder of the nose and face while preserving or restoring external valve function are essential to a successful rhinoplasty. Without a systematic approach to the nasal base, it is more...
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Subthalamic nucleus deep brain stimulation modulates two distinct neurocircuits.: Related ArticlesSubthalamic nucleus deep brain stimulation modulates two distinct neurocircuits.Ann Neurol. 2020 Sep 20;:Authors: Shen L, Jiang C, Hubbard CS, Ren J, He C, Wang D, Dahmani L, Guo Y, Liu Y, Xu S, Meng F, Zhang J, Liu H, Li LAbstract OBJECTIVE: Current understanding of the neuromodulatory effects of deep brain stimulation (DBS) on large-scale brain networks remains elusive, largely due to the...
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The role of melatonin and its analogues in epilepsy.: Related ArticlesThe role of melatonin and its analogues in epilepsy.Rev Neurosci. 2020 Sep 21;:Authors: Khan S, Khurana M, Vyas P, Vohora DAbstract Extensive research has gone into proposing a promising link between melatonin administration and attenuation of epileptic activity, the majority of which suggest its propensity as an antiseizure with antioxidant and neuroprotective properties. In the past few years, a number of studies highlighting...
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Physical exercise and 5-hydroxytryptophan, a precursor for serotonin synthesis, reduce penicillin-induced epileptiform activity.: Physical exercise and 5-hydroxytryptophan, a precursor for serotonin synthesis, reduce penicillin-induced epileptiform activity.Epilepsy Behav. 2020 Sep 17;112:107403Authors: Kayacan Y, Ghojebeigloo BE, Çerit G, Kocacan SE, Ayyıldız MAbstract AIM: Previous studies have shown that 5- hydroxytryptophan (5-HTP) and exercise play an important role in the synthesis...
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Preoperative Magnetic Resonance Image Quality in Motion Disorder Patients Scheduled for Deep Brain Stimulation Surgery: Background: To obtain magnetic resonance (MR) images of good quality for accurate target localization in deep brain stimulation (DBS) surgery, sedation or anesthesia may be used, although their usefulness has not been proven. Objective: To assess whether sedation or general anesthesia (GA) improve the quality of MR imaging (MRI). Methods: The records of DBS procedures for Parkinson's...
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Tolerability and toxicity of trastuzumab or trastuzumab + lapatinib in older patients: a sub-analysis of the ALTTO trial (BIG 2-06; NCCTG (Alliance) N063D).: Related ArticlesTolerability and toxicity of trastuzumab or trastuzumab + lapatinib in older patients: a sub-analysis of the ALTTO trial (BIG 2-06; NCCTG (Alliance) N063D).Breast Cancer Res Treat. 2020 Sep 19;:Authors: Pondé N, Agbor-Tarh D, Dal Lago L, Korde LA, Hilbers F, Jackisch C, Werner O, Gelber RD, Jatoi A, Dueck AC, Moreno-Aspitia...
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Transpedicular Approach for Ventral Epidural Abscess Evacuation in the Cervical Spine - A Technical Note.: Transpedicular Approach for Ventral Epidural Abscess Evacuation in the Cervical Spine - A Technical Note.World Neurosurg. 2020 Sep 17;:Authors: Lara-Reyna J, Yaeger KA, Margetis KAbstract OBJECTIVE: Spinal epidural abscess is a pathology that may require prompt surgical intervention. Ventral cervical abscesses pose a particular challenge regarding the approach for surgical evacuation....
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The Relevance of SNPs at 3'UTR Region of CASP7 and miR-371b-5p Associated Diseases: A Computational Analysis.: The Relevance of SNPs at 3'UTR Region of CASP7 and miR-371b-5p Associated Diseases: A Computational Analysis.Cell Biochem Biophys. 2020 Sep 19;:Authors: Safdar M, Zaheer S, Khailany RA, Parvez S, Naveed M, Bhuiyan P, Ozaslan M, Moatasam R, Al-Attar MS, Khan MA, Junejo YAbstract The process of genetically programmed cell death, or apoptosis, plays a crucialrolein cellular homeostasis...
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Elevated levels of nitrous dioxide are associated with lower AMH levels: a real-world analysis.: Elevated levels of nitrous dioxide are associated with lower AMH levels: a real-world analysis.Hum Reprod. 2020 Sep 20;:Authors: La Marca A, Spaggiari G, Domenici D, Grassi R, Casonati A, Baraldi E, Trenti T, Simoni M, Santi DAbstract STUDY QUESTION: Are there any associations between environmental pollutants and ovarian reserve, expressed by anti-Mullerian hormone (AMH) serum levels? ...
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KRASG12C Inhibition with Sotorasib in Advanced Solid Tumors: New England Journal of Medicine, Ahead of Print. AbstractBACKGROUNDNo therapies for targeting KRAS mutations in cancer have been approved. The KRAS p.G12C mutation occurs in 13% of non–small-cell lung cancers (NSCLCs) and in 1 to 3% of colorectal cancers and other cancers. Sotorasib is a small molecule that selectively and irreversibly targets KRASG12C.METHODSWe conducted a phase 1 trial of sotorasib in patients with advanced solid tumors...
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Tetrandrine enhances antitumor effects of the histone deacetylase inhibitor MS-275 in human cancer in a Bax- and p53-dependent manner.: Tetrandrine enhances antitumor effects of the histone deacetylase inhibitor MS-275 in human cancer in a Bax- and p53-dependent manner.Eur J Pharmacol. 2020 Sep 17;:173575Authors: Li H, Xu X, Zhang Y, Tang X, Li WAbstract MS-275 (Entinostat), is an oral histone deacetylase (HDAC) inhibitor with a high specificity for class 1 HDACs. As single agent, MS-275...
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One Step at a Time — Clinical Evidence that KRAS Is Indeed Druggable: New England Journal of Medicine, Ahead of Print. Overall survival among patients with advanced-stage KRASG12C non–small-cell lung cancer (NSCLC) or colorectal cancer is approximately 1 to 2 years; this startling statistic has fueled nearly four decades of research dedicated to the search for a KRAS-targeted drug.1,2 Because RAS has picomolar affinity for guanosine triphosphate (GTP) and intracellular GTP concentrations are exceedingly...
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Survival with Olaparib in Metastatic Castration-Resistant Prostate Cancer: New England Journal of Medicine, Ahead of Print. NEJM GroupFollow UsSign InCreate AccountSUBSCRIBEDevice Global HeaderSUBSCRIBEOR RENEWFree full text is available with an account for a limited time. Create a free account now. Already have an account? Sign in .ORIGINAL ARTICLEFREE PREVIEWSurvival with Olaparib in Metastatic Castration-Resistant Prostate CancerList of authors.Maha Hussain, M.D., Joaquin Mateo, M.D., Karim Fizazi,...
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Phase 1 dose escalation trial of volasertib in combination with decitabine in patients with acute myeloid leukemia.: Phase 1 dose escalation trial of volasertib in combination with decitabine in patients with acute myeloid leukemia.Int J Hematol. 2020 Sep 20;:Authors: Cortes J, Podoltsev N, Kantarjian H, Borthakur G, Zeidan AM, Stahl M, Taube T, Fagan N, Rajeswari S, Uy GLAbstract Polo-like kinase 1 (PLK1) regulates mitotic checkpoints and cell division. PLK1 overexpression is reported...
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Atranones from Stachybotrys chartarum and their antitumor activities in MG-63 human osteosarcoma cells.: Stachybotrys chartarum - Wikipediaen.wikipedia.org › wiki › Stachybotrys_chartarumStachybotrys chartarum also known as black mold or toxic black mold, is a variety of microfungus that produces its conidia in slime heads.Atranones from Stachybotrys chartarum and their antitumor activities in MG-63 human osteosarcoma cells.Fitoterapia. 2020 Sep 17;:104727Authors: Qin YD, Fang FM, Zhou JJ, Wang...
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Targeting DNA and mutant p53 by a naphthalimide derivative, NA20, exhibits selective inhibition in gastric tumorigenesis by blocking mutant p53-EGFR signaling pathway.: Related ArticlesTargeting DNA and mutant p53 by a naphthalimide derivative, NA20, exhibits selective inhibition in gastric tumorigenesis by blocking mutant p53-EGFR signaling pathway.Eur J Pharmacol. 2020 Sep 17;:173584Authors: Zhang G, Li L, Bi J, Wu Y, Li EAbstract Mutations of p53 in cancer cells not only subvert its...
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Deoxyelephantopin, a novel naturally occurring phytochemical impairs growth, induces G2/M arrest, ROS-mediated apoptosis and modulates lncRNA expression against uterine leiomyoma: Publication date: November 2020Source: Biomedicine & Pharmacotherapy, Volume 131Author(s): Vivek Pandey, Anima Tripathi, Anjali Rani, Pawan K. Dubey
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Elucidation of the aberrant 3′ splice site selection by cancer-associated mutations on the U2AF1:
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The shared frameshift mutation landscape of microsatellite-unstable cancers suggests immunoediting during tumor evolution:
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Management of unilateral temporomandibular joint ankylosis & orthomorphic correction in a patient with Marfan syndrome: A rare case report.: Management of unilateral temporomandibular joint ankylosis & orthomorphic correction in a patient with Marfan syndrome: A rare case report.Int J Surg Case Rep. 2020 Sep 11;75:157-161Authors: Rudagi BM, Rishabh J, Arif M, Namrata C, Shahbaaz N, Gaurav BAbstract INTRODUCTION: Marfan syndrome (MFS) is a disorder of the connective tissue that is...
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Pulmonary Comorbidities Are Associated with Increased Major Complication Rates Following Indwelling Interscalene Nerve Catheters for Shoulder Arthroplasty.: Pulmonary Comorbidities Are Associated with Increased Major Complication Rates Following Indwelling Interscalene Nerve Catheters for Shoulder Arthroplasty.Orthop Clin North Am. 2020 Oct;51(4):527-532Authors: Power I, Throckmorton TW, Smith RA, Azar FM, Brolin TJAbstract Pulmonary comorbidities and ASA physical status class III and IV...
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It's that time of year - APRIL promotes humoral immunity in humans: Publication date: Available online 21 September 2020Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Stuart G. TangyeThe protein encoded by this gene is a member of the tumor necrosis factor ligand (TNF) ligand family. This protein is a ligand for TNFRSF17/BCMA, a member of the TNF receptor family. This protein and its receptor are both found to be important for B cell development. In vivo experiments suggest an important...
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Elevated plasma sTIM-3 levels in severe Covid-19 patients: Publication date: Available online 21 September 2020Source: Journal of Allergy and Clinical ImmunologyAuthor(s): Thor Ueland, Lars Heggelund, Andreas Lind, Aleksander R. Holten, Kristian Tonby, Annika E. Michelsen, Synne Jenum, Marthe J. Jørgensen, Andreas Barratt-Due, Linda G. Skeie, Ingvild Nordøy, Mai Sasaki Aanensen Fraz, Else Quist-Paulsen E, Søren E. Pischke, Simreen K. Johal, Liv Hesstvedt, Mette Bogen, Børre Fevang, Bente Halvorsen,...
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Metastatic prostate adenocarcinoma to cervical lymph nodes: an unusual diagnosis on fine-needle aspiration biopsy.: Metastatic prostate adenocarcinoma to cervical lymph nodes: an unusual diagnosis on fine-needle aspiration biopsy.J Am Soc Cytopathol. 2020 Aug 25;:Authors: Albadri ST, Salomão DAbstract INTRODUCTION: Metastatic prostatic adenocarcinoma (PAC) has mostly involved the pelvic lymph nodes; metastases to the cervical lymph nodes are exceedingly rare. MATERIALS AND METHODS:...
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Fluoxetine attenuates prepulse inhibition deficit induced by neonatal administration of MK-801 in mice: Increasing evidence supports schizophrenia may be a neurodevelopmental and neurodegenerative disorder. Fluoxetine, a selective serotonin reuptake inhibitor, has been reported to have neuroprotective effects and be effective in treating neurodegenerative disorders including schizophrenia. The objective of the present study was to evaluate the effect and underlying neuroprotective mechanism of fluoxetine...
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Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,00306932607174,alsfakia@gmail.com,
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