Current Therapeutic Approaches to Subglottic Stenosis in Patients With GPA: A Systematic Review

xlomafota13 shared this article with you from Inoreader Current Therapeutic Approaches to Subglottic Stenosis in Patients With GPA: A Systematic Review Via ear nose throat Ear Nose Throat J. 2021 Aug 15:1455613211036246. doi: 10.1177/01455613211036246. Online ahead of print. ABSTRACT BACKGROUND: The management of subglottic stenosis (SGS) in granulomatosis patients with polyangiitis (GPA) has no clear guidelines. This systematic review aimed to identify different surgical techniques and evaluate the outcomes of applied procedures. METHODS: An electronic search was performed using 3 major databases, CINAHL, PubMed, and Clinical key, to in clude relevant studies published from the databases from inception through January 2017. All primary studies reporting treatment of SGS in cases with GPA were included. Articles were excluded if not relevant to the research topic or if they were duplicates, review articles, editorials, short comments, unpublished data, conference abstracts, case reports, animal studies, or non-English studies. RESULTS: Thirteen papers were included in our systematic review with a total of 267 cases for the qualitative review Endoscopic approaches showed favorable outcomes with the need to use multiple procedures to achieve remission. The open transcervical approach showed excellent results mainly after failure of other endoscopic techniques. Tracheostomy was necessary for severe respiratory obstruction symptoms. Medical treatment was essential for stabilizing the active disease and therefore may enhance the success rate postoperatively. CONCLUSION: Subglottic stenosis in patients with GP A requires a multidisciplinary approach to provide optimal management regarding disease activity, grade of stenosis, and severity of symptoms. PMID:34392732 | DOI:10.1177/01455613211036246 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.