Publication date: Available online 20 January 2017
Source:Archives of Oral Biology
Author(s): Luzia Hermínia Teixeira Sousa, Eveline Valeriano Moura, Ana Larissa Queiroz, Danielle Val, Hellíada Chaves, Mario Lisboa, Flávia Furlaneto, Gerly Anne Brito, Paula Goes
Objective: To evaluate the effects of osteoporosis induced by glucocorticoid (GIOP) on bone tissue of rats with experimental periodontitis (EP).Design48 male Wistar rats divided into groups: Naïve, EP, GIOP and GIOP+EP. Rats of GIOP and GIOP+EP groups received 7mg/kg of dexamethasone intramuscularly once a week for 5 weeks. Following, EP and GIOP+EP groups were subjected to ligature-induced periodontitis. Naïve group experienced no manipulation. After 11 days, the animals were euthanized and left maxillae collected for macroscopic, radiographic, micro-tomographic and microscopic analysis of alveolar bone loss (ABL). Blood samples were collected for determination of bone-specific alkaline phosphatase (BALP) levels and the right femurs were removed for radiographic and biomechanical analysis.ResultsEP caused ABL and reduced BALP levels (p<0,05), but it did not change the architecture or biomechanics of femur, compared to Naïve. GIOP did not cause ABL, but it significantly decreased alveolar bone mineral density (ABMD), bone percentage and trabecular thickness (Tb.Th) and increased alveolar bone porosity (p<0.05) and significantly reduced BALP serum levels, as well as radiographic density and Young's module of femur, compared to Naïve. There was a greater ABL in group GIOP+EP when compared to EP (p<0.05). GIOP+EP caused a greater decrease on ABMD, Tb.Th, bone percentage and increased bone porosity (p<0.05) and also presented a significant reduction in BALP levels (p<0.05), in radiographic density and in Young's module of femur compared to EP (p<0.05).ConclusionsGIOP can potentiate the destructive effects of EP on alveolar bone and alter the systemic bone loss, by promoting bone resorption and reducing osteoblast activity.
http://ift.tt/2jxwGjJ
Alexandros G .Sfakianakis,ENT,Anapafeos 5 Agios Nikolaos Crete 72100 Greece,00302841026182
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Δημοφιλείς αναρτήσεις
-
Abstract Purpose of Review Heart failure is associated with an enormous burden on both patients and health care systems in the USA. Seve...
-
Ειδοποίηση Μελετητή:[ "κλιματική αλλαγή" ] [PDF] Ρομποτική στην αυτοκινητοβιομηχανία Γ Λιάσκος - 2017 Page 1. ΣΧΟΛΗ ΤΕΧΝΟΛΟΓΙΚΩΝ ...
-
Does CBD Oil Lower Blood Pressure? This article was originally published at SundayScaries." Madeline Taylor POSTED ON January 13, 20...
-
Πέμπτη, 22 Ιουνίου 2017 Treatment of Primary and Metastatic Multifocal Mucosal Melanoma of the Oral Cavity with Imatinib Treatment of Primar...
-
Ροές που μπορεί να σας αρέσουν Να μην εμφανιστεί αυτό ξανά Cardiovascular / Cardiology News From Medical News Today Latest Health News and M...
-
Oral Candida colonization in xerostomic post‐radiotherapy head and neck cancer patients 16h ... Oral Candida colonization in xerostomic post...
-
ONKO-Internetportal-Team Mammakarzinom: Molekulare Diagnostik und Erkenntnisse zum Lebensstil In einer Langzeitbeobachtung von der Geburt ...
-
Journal of visualized experiments : JoVE,http://www.jove.com/ Surface Electromyographic Biofeedback... Journal of visualized experiments : J...
-
Πέμπτη, 17 Οκτωβρίου 2019 Behavioral Sciences, Vol. 9, Pages 110: A Qualitative Study Examining the Illness Narrative Master... Behavioral S...
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου