Complex disease: From non-coding risk variant to biological mechanism in CAD

Nature Reviews Genetics 18, 514 (2017). doi:10.1038/nrg.2017.66

Author: Linda Koch

Analyses of the genetic architecture of complex diseases such as coronary artery disease (CAD) have revealed that most genetic variants are located in non-coding regions of the genome. As regulatory variants can act over long genomic distances, the causal gene and specific mechanism through which

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