TET-mediated active DNA demethylation: mechanism, function and beyond

Nature Reviews Genetics 18, 517 (2017). doi:10.1038/nrg.2017.33

Authors: Xiaoji Wu & Yi Zhang

In mammals, DNA methylation in the form of 5-methylcytosine (5mC) can be actively reversed to unmodified cytosine (C) through TET dioxygenase-mediated oxidation of 5mC to 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC), followed by replication-dependent dilution or thymine DNA glycosylase (TDG)-dependent base excision repair. In

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