International Journal of Molecular Sciences , IJMS, Vol. 20, Pages 5244: Transcription Factor GarWRKY5 Is Involved in Salt Stress Response in Diploid Cotton Species (Gossypium aridum L.)IJMS, Vol. 20, Pages 5244: Transcription Factor GarWRKY5 Is Involved in Salt Stress Response in Diploid Cotton Species (Gossypium aridum L.) International Journal of Molecular Sciences doi: 10.3390/ijms20215244 Authors: Qi Guo Liang Zhao Xinqi Fan Peng Xu Zhenzhen Xu Xianggui Zhang Shan Meng Xinlian Shen Cotton is...
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Cancers, Vol. 11, Pages 1616: Epigenetic Reprogramming for Targeting IDH-Mutant Malignant Gliomas...
Cancers, Vol. 11, Pages 1616: Epigenetic Reprogramming for Targeting IDH-Mutant Malignant GliomasCancers, Vol. 11, Pages 1616: Epigenetic Reprogramming for Targeting IDH-Mutant Malignant Gliomas Cancers doi: 10.3390/cancers11101616 Authors: Jong-Whi Park Şevin Turcan Targeting the epigenome has been considered a compelling treatment modality for several cancers, including gliomas. Nearly 80% of the lower-grade gliomas and secondary glioblastomas harbor recurrent mutations in isocitrate dehydrogenase...
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Antibiotics, Vol. 8, Pages 190: Erratum: Kamiński, M., Łoniewski, I., Marlicz, W. Global Internet...
Antibiotics, Vol. 8, Pages 190: Erratum: Kamiński, M., Łoniewski, I., Marlicz, W. Global Internet Data on the Interest in Antibiotics and Probiotics Generated by Google Trends. Antibiotics 2019, 8(3), 147Antibiotics, Vol. 8, Pages 190: Erratum: Kamiński, M., Łoniewski, I., Marlicz, W. Global Internet Data on the Interest in Antibiotics and Probiotics Generated by Google Trends. Antibiotics 2019, 8(3), 147 Antibiotics doi: 10.3390/antibiotics8040190 Authors: Mikołaj Kamiński Igor Łoniewski Wojciech...
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The American Journal of Cultural Sociology, Volume 7 (2019)Material culture and the problem of agencyBetween legitimization and popularization: the rise and reception of U.S. cultural products in culture sections of quality European newspapers, 1960–2010AbstractA prominent feature of cultural globalization has been the rising influence of U.S. culture—and American popular culture in particular—worldwide since the mid-20th century. Relatively little is known, however, about the thoroughness, reception,...
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Synthesis, characterization and pharmacological potential of green synthesized copper nanoparticlesAbstractThe phenomenal and astonishing properties and their different application in the field of pharmaceutical made copper nanoparticles (Cu-NPs) to be in the spotlight of the researcher's focus. In the present study, copper nanoparticles were biologically synthesized with the aqueous extract of the flower Millettia pinnata, and their corresponding characteristics were studied using UV–visible spectroscopy,...
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Increasing prevalence of antibiotic resistance genes in manured agricultural soils in northern ChinaAbstractLand application of manure tends to result in the dissemination of antibiotic resistance in the environment. In this study, the influence of long-term manure application on the enrichment of antibiotic resistance genes (ARGs) and mobile genetic elements (MGEs) in agricultural soils was investigated. All the analyzed eight ARGs (tetA, tetW, tetX, sulI, sulII, ermF, aac(6′)-Ib-cr and blaTEM)...
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The Respimat ® Soft Mist Inhaler: Implications of Drug Delivery Characteristics for PatientsAbstractSuccessful treatment for respiratory diseases relies on effective delivery of medication to the lungs using an inhalation device. Different inhalers have distinct characteristics affecting drug administration and patient adherence, which can impact clinical outcomes. We report on the development of the Respimat® soft mist inhaler (SMI) and compare key attributes with metered-dose inhalers (MDIs) and...
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HypophysenadenomeZusammenfassungAufgrund der Seltenheit klinisch relevanter Hypophysenadenome erfolgt die Diagnosestellung trotz charakteristischer Symptome oft erst im fortgeschrittenen Stadium. Die typischen klinischen Erscheinungsformen werden in dieser Übersichtsarbeit dargestellt. In jüngster Vergangenheit gelang mit dem Nachweis der USP8-Mutation bei Morbus Cushing und des X‑linked-acrogigantism(X-LAG)-Syndroms ein Durchbruch bei der Erforschung molekularer Ursachen von Hypophysenadenomen....
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Tension measurements in abdominal wall hernia repair: Concept and clinical applicationsPaul L Tenzel, Jordan A Bilezikian, Frederic E Eckhauser, William W HopeInternational Journal of Abdominal Wall and Hernia Surgery 2019 2(4):119-124Tension has always been and remains an important concept in hernia repair. Revolutionary techniques in the field of hernia repair have generally aimed to reduce tension and thereby reduce recurrence rates. Despite the uniformly agreed upon idea that tension is an important...
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Biocatalytic production of D- p -hydroxyphenylglycine by optimizing protein expression and cell wall engineering in Escherichia coliAbstractD-p-hydroxyphenylglycine (D-HPG) functions as an intermediate and has important value in antibiotic industries. The high pollution and costs from chemical processes make biotechnological route for D-HPG highly desirable. Here, a whole-cell transformation process by D-hydantoinase(Hase) and D-carbamoylase(Case) was developed to produce D-HPG from DL-hydroxyphenylhydantoin(DL-HPH)...
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Prevalence of Indoor Tanning Among U.S. High School Students from 2009 to 2017AbstractIndoor tanning exposes users to high levels of ultraviolet radiation, increasing skin cancer risk. The risk is greatest for those who begin indoor tanning at a young age. The objective of this study was to assess changes in indoor tanning prevalence over time among U.S. high school students, by sex, age, and race/ethnicity. We used cross-sectional data from the 2009, 2011, 2013, 2015, and 2017 national Youth Risk...
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Biologic treatment options for the hip: A narrative reviewThe goal of surgery around the hip is to preserve both acetabular and femoral bone stock and to optimize function, specifically abductor function. Biologic options include allografts, allograft metal composites, and structural grafts that over time incorporate, are durable, and provide bone stock for future reconstruction(s). Reconstructive principles are guided by the defect(s) after tumor surgery, patient factors (age, chemotherapy, comorbid...
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First record of a fossil monkey (Primates, Cercopithecidae) from the Late Pliocene of SerbiaPublication date: December 2019Source: Journal of Human Evolution, Volume 137Author(s): Predrag Radović, Joshua Lindal, Zoran Marković, Sanja Alaburić, Mirjana RoksandicAbstractThe cercopithecid fossil record of the Balkan Peninsula extends from the Late Miocene to the Early Pleistocene, but to date no fossils of non-human primates have been identified in Serbia. Here we report the identification of two primate...
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Coordinate based meta-analysis of networks in neuroimaging studiesPublication date: 15 January 2020Source: NeuroImage, Volume 205Author(s): C.R. Tench, Radu Tanasescu, C.S. Constantinescu, W.J. Cottam, D.P. AuerAbstractMeta-analysis of summary results from published neuroimaging studies independently testing a common hypothesis is performed using coordinate based meta-analysis (CBMA), which tests for consistent activation (in the case of functional MRI studies) of the same anatomical regions. Using...
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Universal neonatal hearing screening in a tertiary care center in South IndiaRamiya Ramachandran Kaipuzha, Davis Thomas Pulimoottil, Padmanabhan KarthikeyanSaudi Journal of Otorhinolaryngology Head and Neck Surgery 2019 21(2):29-32Objective: The aim of the study is to determine the prevalence of hearing loss among newborn infants and to assess the effectiveness and utility of otoacoustic emission (OAE) as a screening tool to detect hearing impairment in newborns and the relationship between selected...
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Patients with Persistently Low MELD-Na Scores Continue to be at Risk of Liver Related DeathBackground: The vast majority of patients with cirrhosis have low Model for End Stage Liver Disease-Sodium (MELD-Na) scores, however the ability for the MELD-Na score to predict patient outcomes at low scores is unclear. Methods: Adult patients in a multicenter, Chicago-wide database of medical records with ICD-9 codes of cirrhosis and without a history of hepatocellular carcinoma were included. Records were...
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Dyslipidemia and cardiovascular diseases: Science or fairy taleBasil Nwaneri OkeahialamNigerian Journal of Cardiology 2019 16(1):1-4Echocardiographic findings in Nigerian patients with strokeJamila Ado Ya'u, Kamilu Musa Karaye, BN OkeahialamNigerian Journal of Cardiology 2019 16(1):5-10Stroke is the third leading cause of death in several industrial countries and cardio-embolism accounts for 15–30% of ischaemic strokes. Studies investigating associations between echocardiographic parameters and stroke...
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Pediatric Plasma and Platelet Transfusions on Extracorporeal Membrane Oxygenation: A Subgroup Analysis of Two Large International Point-Prevalence Studies and the Role of Local GuidelinesObjectives: To describe the indications and thresholds for plasma and platelet transfusions for pediatric extracorporeal membrane oxygenation, to compare responses to these transfusions and to describe institutional protocols directing their administration. Design: Subgroup analysis of two prospective, observational...
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Co-occurrence of Warthin's tumor with oral squamous cell carcinoma – Overlapping risk factors and implicationsAuthor links open overlay panelBhatlawandeHarshada(Postgraduate student)DesaiKarishma Madhusudan(Research Scholar)KaleAlka Dinesh(Principal and Professor)AngadiPunnya(Professor)HallikerimathSeema(Professor)ChibborahRebekah(Postgraduate student)Department of Oral Pathology and Microbiology, KLE VK Institute of Dental Sciences, KLE Academy of Higher Education and Research [KLE University],...
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Laryngoscopic techniques modulate anaesthesiologists' perception of halitosis in patients: A randomised controlled trialBACKGROUND Perception of halitosis in patients during intubation is a common and additional stressor for anaesthesiologists and may lead to potential health risks. OBJECTIVES We hypothesised that intubation with videolaryngoscopy could help reduce the anaesthesiologists' perception of patients' oral malodor during intubation. DESIGN Randomised, single-blinded, prospective, controlled...
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Specific challenges in end-of-life care for patients with hematological malignanciesPurpose of review The disease-related burden of patients with hematological malignancies is comparable with patients suffering from solid tumors. Palliative care offers relief from suffering independent of type of disease and prognosis. The prevalence of hematological malignancies is expected to increase in the next 20 years because of better therapeutic options with longer survival and because of the aging population....
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The impact of comorbidities on severe asthmaPurpose of review Severe asthma is often associated with numerous comorbidities that complicate disease management and affect patient's outcomes. They contribute to poor disease control and mimic asthma symptoms. Although some comorbidities such as obstructive sleep apnea, bronchiectasis, and chronic obstructive pulmonary disease are generally well recognized, many other may remain undiagnosed but may be detected in an expert specialist setting. The management...
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Deep anterior lamellar keratoplasty outcomes in macular and granular corneal dystrophy – A comparative cross-sectional studyShreesha Kumar Kodavoor, Bijita Deb, Dandapani RamamurthyIndian Journal of Ophthalmology 2019 67(11):1830-1833Purpose: To compare the functional and anatomical outcomes (in terms of graft uptake and rejection/failure) of deep anterior lamellar keratoplasty (DALK) in stromal corneal dystrophy (macular and granular). Methods: Sixteen eyes with macular corneal dystrophy (MCD; group...
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Virtual reality in pediatric cardiology: hype or hope for the future?Purpose of review In the field of pediatric cardiology, a sub-specialty that relies on an understanding of complex three-dimensional structures, virtual reality technology may represent a new and exciting tool for both practitioners and patients. Here, the current medical and surgical applications of virtual reality are reviewed and the potential for future applications explored. Recent findings Multiple centers have begun to develop...
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Differential expression and role of S100 proteins in chronic rhinosinusitisPurpose of review Immune system modulators have been under investigation to help elucidate the underlying pathophysiologies of chronic rhinosinusitis (CRS). Psoriasin (S100A7) and calgranulins (S100A8, S100A9, and S100A12) are S100 proteins that have been studied for their immune-mediating responses to pathogens within the context of CRS. This review highlights the expression patterns and proposed roles of S100 proteins in...
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Differential expression and role of S100 proteins in chronic rhinosinusitisPurpose of review Immune system modulators have been under investigation to help elucidate the underlying pathophysiologies of chronic rhinosinusitis (CRS). Psoriasin (S100A7) and calgranulins (S100A8, S100A9, and S100A12) are S100 proteins that have been studied for their immune-mediating responses to pathogens within the context of CRS. This review highlights the expression patterns and proposed roles of S100 proteins in...
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Systemic antibiotics in the treatment of periodontitisEsra Guzeldemir-AkcakanatDentistry and Medical Research 2019 7(2):33-33Relevance of hematological parameters in patients with recurrent aphthous stomatitisAlberto Rodriguez-Archilla, Maria BrykovaDentistry and Medical Research 2019 7(2):35-39Background: Recurrent aphthous stomatitis (RAS) continues to be a very common ulcerative disease of the oral mucosa, affecting approximately 20% of the general population. Hematinic deficiencies have been...
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Submitral left ventricular aneurysm: Characteristics, diagnosis, management, and outcomeBerhanu Nega, Dejuma Yadeta Goshu, Senbeta Guteta AbdissaJournal of Clinical Sciences 2019 16(4):105-110Left ventricular (LV) aneurysm (LVA) is an uncommon cardiac disorder. There is no documented report from Ethiopia. Our objective was to discuss a case of LVA we encountered and analyze the clinical characteristics, diagnosis, management modalities, and outcome of patients with LVA from published studies over...
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Cardiac magnetic resonance in primary prevention of sudden cardiac deathGiorgio Faganello, Aldostefano Porcari, Federico Biondi, Marco Merlo, Antonio De Luca, Giancarlo Vitrella, Manuel Belgrano, Lorenzo Pagnan, Andrea Di Lenarda, Gianfranco SinagraJournal of Cardiovascular Echography 2019 29(3):89-94Sudden death accounts for 400,000 deaths annually in the United States. Most sudden deaths are cardiac and are related to arrhythmias secondary to structural heart disease or primary electrical abnormalities...
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Epidemiology , Juvenile Idiopathic Arthritis: Incidence, clinical manifestations, and severity of juvenile idiopathic arthritis among maori and pacific island childrenConsult the pubmed abstractTo read more about "Juvenile idiopathic arthritis"Arthritis Care Res (Hoboken). 2019 Sep;71(9):1270-1275POEMS syndrome: Prevalence, clinical profiles, and prognosis in a Japanese nationwide surveyConsult the pubmed abstractTo read more about "POEMS syndrome"Neurology. 2019 Sep 3;93(10):e975-e983
Tue Oct 22, 2019 17:03
Type 2 collagen-related bone disorder: Best practice guidelines regarding diagnosis and management of patientsConsult the pubmed abstractType 2 collagen-related bone disorder
Tue Oct 22, 2019 17:03
Patient management and therapy , Alkaptonuria: A review of the potential of nitisinone for the treatment of alkaptonuriaConsult the abstractTo read more about "Alkaptonuria"Expert Opinion on Orphan Drugs, 15 Sep 2019 : 1-7Hepatic veno-occlusive disease: A review of recent developments with defibrotide for the treatment of hepatic veno-occlusive disease/sinusoidal obstruction syndromeConsult the abstractTo read more about "Hepatic veno-occlusive disease"Expert Opinion on Orphan Drugs 2019, Vol.7,...
Tue Oct 22, 2019 17:03
Diagnostic Approaches , Noninvasive prenatal screening can be used as a first-tier pregnancy screening method to improve detection rates of clinically significant fetal chromosome abnormalitiesConsult the pubmed abstractGenet Med. 2019 Sep;21(9):1998-2006A targeted next generation sequencing panel covering a high number of genes responsible for broad phenotypic spectrum can provide improved levels of diagnosis in patients with pediatric onset Mendelian diseasesConsult the pubmed abstractEur J Med...
Tue Oct 22, 2019 17:02
Therapeutic Approaches , Hereditary pulmonary alveolar proteinosis: A study showed that gene-pulmonary macrophage transplantation therapy in Csf2ra-/- mice was highly efficacious, durable, safe, and well tolerateConsult the pubmed abstractTo read more about "Hereditary pulmonary alveolar proteinosis"Mol Ther. 2019 Sep 4;27(9):1597-1611Duchenne muscular dystrophy: A study showed that anti-RANKL treatment reduced muscle inflammation and dysfunction and strengthens bone in dystrophic miceConsult the...
Tue Oct 22, 2019 17:02
Biomarkers , Locus coeruleus imaging as a biomarker for noradrenergic dysfunction in neurodegenerative diseasesConsult the pubmed abstractBrain. 2019 Sep 1;142(9):2558-2571Neuromyelitis optica spectrum disorders: Serum GFAP and neurofilament light as biomarkers of disease activity and disabilityConsult the pubmed abstractTo read more about "Neuromyelitis optica"Neurology. 2019 Sep 24;93(13):e1299-e1311
Tue Oct 22, 2019 17:02
Clinical Research , Fabry disease: A phase 3 randomized double-blind clinical trial study showed the efficacy of migalastat in patients with the classic phenotype of Fabry disease and amenable variants, regardless of disease severityConsult the pubmed abstractTo read more about "Fabry disease"Genet Med. 2019 Sep;21(9):1987-1997Uveitis: A randomized clinical trial showed that the use of mycophenolate mofetil compared with methotrexate as first-line corticosteroid-sparing treatment did not result in...
Tue Oct 22, 2019 17:01
New Genes , Neurodevelopmental disorders and opposing effects on brain size is caused by pathogenic WDFY3 variantsConsult the pubmed abstractBrain. 2019 Sep 1;142(9):2617-263046,XY and 46,XX disorders of sex development is caused by MYRF haploinsufficiencyConsult the pubmed abstractTo read more about "Genetic 46,XX disorder of sex development"To read more about "Genetic 46,XY disorder of sex development"Hum Mol Genet. 2019 Jul 15;28(14):2319-2329Neurodevelopmental disability is caused by variants...
Tue Oct 22, 2019 17:01
New syndromes , Mutations in GDF11, and the extracellular antagonist, follistatin, may cause Mendelian forms of orofacial clefting in humansA new article published in Human Mutation reported the identification, via exome sequencing, of likely pathogenic variants in two genes that encode interacting proteins previously only linked to orofacial clefting in mouse models. A variant in GDF11 (encoding growth differentiation factor 11) was identified in one family that segregated with cleft lip with or...
Tue Oct 22, 2019 17:00
Idaho National Laboratory Wantsa to Disrupt the Nuclear Industry via 3D PrintingAs 3D enhances—and in many cases completely transforms—a wide range of industries and businesses of all sizes, the potential for printing parts for nuclear plants continues to be of interest to scientists. Now, Idaho National Laboratory researchers may be on the verge of disrupting the nuclear industry, bringing forth all the benefits of 3D printing and additive manufacturing processes. The goal is to finally eliminate...
Tue Oct 22, 2019 10:35
Reduced P2X receptor levels are associated with antidepressant effect in the learned helplessness...
Reduced P2X receptor levels are associated with antidepressant effect in the learned helplessness modelPurinergic receptors, especially P2RX, are associated to the severity of symptoms in patients suffering from depressive and bipolar disorders, and genetic deletion or pharmacological blockade of P2RX7 induces antidepressant-like effect in preclinical models. However, there is scarce evidence about the alterations in P2RX7 or P2RX4 levels and in behavioral consequences induced by previous exposure...
Tue Oct 22, 2019 10:35
Influence of surface treatment on the fluorescence of composite resins subjected to in situ bleaching: AbstractObjectiveUse fluorescence analysis to evaluate the effect of polishing and surface sealant on the color of composite resin bleached with carbamide peroxide and subjected to staining.Materials and methodsForty‐eight composite resin specimens (Z250/Z350XT) were fabricated. After 24 hours stored in distilled water, all specimens were submitted to in situ bleaching with 16% home peroxide for...
Tue Oct 22, 2019 10:34
Two‐year performance of CAD/CAM fabricated resin composite inlay restorations: A randomized controlled clinical trial: AbstractObjectiveThe aim of this study was to evaluate the 2‐year clinical performance of computer‐aided design/computer‐aided manufacturing (CAD/CAM) resin composite inlay restorations in comparison with direct resin composite restorations.Materials and methodsIn 44 patients, 120 class II (mesio‐occlusal/disto‐occlusal) cavities were randomly assigned into two groups; CAD/CAM resin...
Tue Oct 22, 2019 10:34
Osteonecrosis and osteomyelitis of the jaw associated with tumour necrosis factor-alpha (TNF-α) inhibitors: a systematic review: Publication date: Available online 20 October 2019Source: British Journal of Oral and Maxillofacial SurgeryAuthor(s): R. Sacco, S. Shah, R. Leeson, V. Moraschini, C.F. de Almeida Barros Mourão, O. Akintola, A. LalliAbstractTumour necrosis factor-α (TNF-α) inhibitors are increasingly being used as immunomodulators to manage inflammatory conditions such as rheumatoid arthritis...
Tue Oct 22, 2019 10:33
Oral Vaccination with Hepatitis E Virus Capsid Protein and Immunobiotic Bacterium-Like Particles Induce Intestinal and Systemic Immunity in Mice.: Related ArticlesOral Vaccination with Hepatitis E Virus Capsid Protein and Immunobiotic Bacterium-Like Particles Induce Intestinal and Systemic Immunity in Mice.Probiotics Antimicrob Proteins. 2019 Oct 19;:Authors: Arce LP, Raya Tonetti MF, Raimondo MP, Müller MF, Salva S, Álvarez S, Baiker A, Villena J, Vizoso Pinto MGAbstract The hepatitis E...
Tue Oct 22, 2019 10:33
Impact of contralateral lymph nodal involvement and extranodal extension on survival of surgically managed HPV-positive oropharyngeal cancer staged with the AJCC eighth edition.Related ArticlesImpact of contralateral lymph nodal involvement and extranodal extension on survival of surgically managed HPV-positive oropharyngeal cancer staged with the AJCC eighth edition. Oral Oncol. 2019 Oct 17;99:104447 Authors: Miccio JA, Verma V, Kelly J, Kann BH, An Y, Park HS, Eskander A, Burtness B, Husain Z Abstract...
Tue Oct 22, 2019 10:33
Green synthesis of silver nanoparticles using apple extract and its antimicrobial properties: AbstractSilver nanoparticles (AgNPs) exhibit strong antibacterial effect against multi drug resistant bacteria. Today, silver nanoparticles have a great application, especially those obtained by green synthesis, the simple method of using the apple extract, which is eco-friendly, fast and without any harmful effects. This study focuses on the green synthesis of silver nanoparticles, which was conducted by...
Tue Oct 22, 2019 10:33
Complementary and alternative medicine use in glioma patients in France: AbstractPurposeComplementary and alternative medicine (CAM) use increases in cancer patients, including adult patients with diffuse gliomas.MethodsQuestionnaires addressing CAM use were distributed to adult patients with gliomas of WHO grades II-IV and ECOG performance score of 0–2 during hospital visits and filled in anonymously. The study was conducted in nine centers in France from May 2017 to May 2018. Descriptive cohort...
Tue Oct 22, 2019 10:32
Testing hypotheses about the underlying deficit of apraxia of speech through computational neural modelling with the DIVA model,Hayo TerbandORCID Icon,Joe Rodd &Edwin MaasPublished online: 20 Oct 2019Download citation https://doi.org/10.1080/17549507.2019.1669711 CrossMark LogoCrossMarkIn this articleCloseAbstractIntroductionMethodResultDiscussionConclusionReferences Full Article Figures & data References Citations Metrics Licensing PDFAbstractFormulae display:MathJax Logo?Purpose: A...
Tue Oct 22, 2019 10:32
[ 18 F]Florbetapir PET/MR imaging to assess demyelination in multiple sclerosisAbstract Purpose We evaluated myelin changes throughout the central nervous system in Multiple Sclerosis (MS) patients by using hybrid [18F]florbetapir PET-MR imaging. Methods We included 18 relapsing-remitting MS patients and 12 healthy controls. Each subject performed a hybrid [18F]florbetapir PET-MR and both a clinical and cognitive assessment. [18F]florbetapir...Latest Results for European Journal of Nuclear Medicine...
Tue Oct 22, 2019 10:31
Comparative study of two different perimodiolar and a straight cochlear implant electrode array: surgical and audiological outcomes: AbstractPurposeTo compare the surgical and audiological outcomes with two perimodiolar electrode arrays (Nucleus 512-Contour Advance® y Nucleus 532-Slim Perimodiolar®) and a straight electrode array (Nucleus 422/522).MethodsPatients were retrospectively selected from our cochlear implant program database. Only patients with a history of bilateral, sensorineural postlingually...
Tue Oct 22, 2019 10:31
The influence of adrenergic blockade in rats with apical periodontitis under chronic stress conditions: Publication date: Available online 20 October 2019Source: Archives of Oral BiologyAuthor(s): Rayana Duarte Khoury, Renata Falchete do Prado, Felipe de Souza Matos, Bruna Ribas de Meireles, Flávia Goulart da Rosa Cardoso, Luciane Dias de Oliveira, Cláudio Antonio Talge Carvalho, Marcia Carneiro ValeraAbstractObjectiveTo investigate the influence of chronic stress and adrenergic blockade in a rat...
Tue Oct 22, 2019 10:31
October is Cybersecurity MonthCybersecurity Month is a time to...: October is Cybersecurity MonthCybersecurity Month is a time to raise awareness of cyber threats and emphasize the importance of staying safe online.To promote cybersecurity knowledge and education among citizens and organizations, Oxford University Press has created a collection of interdisciplinary research highlighting the significance of good cyber hygiene, cybersecurity, and data protection.Image: 'Background of Codes and Computer...
Tue Oct 22, 2019 10:30
A Novel Euler's Elastica-Based Segmentation Approach for Noisy Images Using the Progressive Hedging Algorithm: AbstractEuler's elastica-based unsupervised segmentation models have strong capability of completing the missing boundaries for existing objects in a clean image, but they are not working well for noisy images. This paper aims to establish a Euler's elastica-based approach that can properly deal with the random noises to improve the segmentation performance for noisy images. The corresponding...
Tue Oct 22, 2019 10:30
CYP2C9‐mediated warfarin and milk thistle interaction: AbstractWhat is known and objectiveIn vitro studies suggest a CYP2C9‐mediated interaction between milk thistle and warfarin, but there has been no in vivo case report on this interaction.Case descriptionA White Hispanic man in his 30s was well controlled on warfarin therapy for mitral valve replacement. His INR increased from 2.64 to 4.12, and he denied changes to his medications and diet but noted starting a 'liver cleanse' supplement which...
Tue Oct 22, 2019 10:30
Meta-analysis of the associations of CYP2B6-516G>T polymorphisms with efavirenz-induced central nervous system side effects and virological outcome in HIV-infected adultsThe Pharmacogenomics Journal - Issue - nature.com science feeds18hA functional HTR1A polymorphism, rs6295, predicts short-term response to lurasidone: confirmation with meta-analysis of other antipsychotic drugsThe Pharmacogenomics Journal - Issue - nature.com science feeds18h
Tue Oct 22, 2019 10:29
Kikuchi-Fujimoto disease: a case report and the evaluation of diagnostic procedures: AbstractBackgroundKikuchi-Fujimoto disease, known as histiocytic necrotizing lymphadenitis, is a benign, self-limiting and systemic disorder involving lymph nodes with unknown aetiology. First reported in Japan, there has been an increase in its incidence globally. Because of its non-specific clinical features, the disease can be easily mistaken for other forms of lymphadenitis with a high rate of misdiagnosis and...
Tue Oct 22, 2019 10:29
Neural correlates underlying the effect of reward value on recognition memory: Publication date: Available online 21 October 2019Source: NeuroImageAuthor(s): Blake L. Elliott, Chris Blais, Samuel M. McClure, Gene A. BrewerAbstractThe prioritized encoding and retrieval of valuable information is an essential aspect of human memory. We used electroencephalography (EEG) to determine which of two hypothesized processes underlies the influence of reward value on episodic memory. One hypothesis is that...
Tue Oct 22, 2019 10:29
Dysregulated CELL signalling and reduced satellite CELL potential in ageing muscle: Publication date: Available online 21 October 2019Source: Experimental Cell ResearchAuthor(s): Ketan Patel, Biggy Simbi, Olli Ritvos, Sakthivel Vaiyapuri, Gurtej K. DhootAbstractAberrant activation of signalling pathways has been postulated to promote age related changes in skeletal muscle. Cell signalling activation requires not only the expression of ligands and receptors but also an appropriate environment that...
Tue Oct 22, 2019 10:28
The association of birthweight with age at natural menopause: a population study of women in NorwayAbstractBackgroundPrevious studies suggest that birthweight may influence age at natural menopause, but the evidence remains inconclusive. Thus, we aimed to estimate the association of birthweight with age at natural menopause.MethodsA retrospective population study of 164 608 women in Norway, aged 48–71 years. Data were obtained by two self-administered questionnaires among participants in BreastScreen...
Tue Oct 22, 2019 10:28
Intelligence artificielle et radiothérapie : quelles bases et quelles perspectives ?: Publication date: Available online 20 October 2019Source: Cancer/RadiothérapieAuthor(s): A. BurgunRésuméL'intelligence artificielle est une notion hautement polysémique. Pour réaliser un raisonnement complexe dans la vie réelle, et s'adapter à des connaissances et des situations nouvelles, deux grandes approches sont développées en informatique : les réseaux de neurones basés sur le modèle connexionniste (deep learning)...
Tue Oct 22, 2019 10:28
Optomec releases new interchangeable LENS Deposition Head for optimized DED processingOptomec, the Albuquerque-based company behind Aerosol Jet Printing technology, has introduced the Laser Engineered Net Shaping (LENS) Deposition Head (LDH 3.X), which ensures optimized directed energy deposition (DED). "As metal additive manufacturing users continue to seek higher laser powers, faster speeds, and improved deposition rates to maximize production, they don't want to sacrifice the quality of the build," said...
Tue Oct 22, 2019 10:27
Qrons and Dartmouth researchers to develop 3D printable implants for Traumatic Brain Injuries: Qrons, a New York-based biotechnology start-up, has announced an Intellectual Property (IP) License Agreement with Dartmouth College, New Hampshire, to develop 3D printable implants to treat penetrating or traumatic brain injuries (TBI). TBI is caused by sudden damage to the brain from an external force. As stated by the World Health Organization (WHO), TBI has […]Original enclosures:
Tue Oct 22, 2019 10:27
Genetic architecture of subcortical brain structures in 38,851 individualsEpidemiology : nature.com subject feeds15hMicrosatellite Instability assessment in Black South African Colorectal Cancer patients reveal an increased incidence of suspected Lynch syndromeEpidemiology : nature.com subject feeds21h
Tue Oct 22, 2019 10:27
Identification of genetic variants in <i>CFAP221</i> as a cause of primary ciliary dyskinesiaJournal of Human Genetics, Published online: 21 October 2019; doi:10.1038/s10038-019-0686-1Identification of genetic variants in CFAP221 as a cause of primary ciliary dyskinesiaJournal of Human Genetics - Issue - nature.com science feeds14hIdentification of genetic variants in <i>CFAP221</i> as a cause of primary ciliary dyskinesiaJournal of Human Genetics - Issue - nature.com science...
Tue Oct 22, 2019 10:26
Sunlight exposure, consumption of vitamin D-rich foods and vulvovaginal candidiasis in an African...
Sunlight exposure, consumption of vitamin D-rich foods and vulvovaginal candidiasis in an African population: a prevalence case–control studyEuropean Journal of Clinical Nutrition, Published online: 21 October 2019; doi:10.1038/s41430-019-0517-7Sunlight exposure, consumption of vitamin D-rich foods and vulvovaginal candidiasis in an African population: a prevalence case–control studyEuropean Journal of Clinical Nutrition - Issue - nature.com science feeds14hA lack of consideration of a dose–response...
Tue Oct 22, 2019 10:26
Insects share the same signaling pathway to form their three-dimensional bodyA signalling pathway controlling morphogenesis, the formation of the three-dimensional body shape in the fruit fly Drosophila, also has pivotal functions for early embryonic development in other insects like beetles, crickets and bugs. In these insects, the pathway is even required for the formation of the primary cell layer of the embryo. The discovery of this early function in phylogenetically distant insects suggests...
Tue Oct 22, 2019 10:25
Oxygen therapy, capillary rarefaction and blood pressure rise in premature low birth weight infants: is there a link?Journal of Human Hypertension, Published online: 21 October 2019; doi:10.1038/s41371-019-0258-zOxygen therapy, capillary rarefaction and blood pressure rise in premature low birth weight infants: is there a link?Journal of Human Hypertension - Issue - nature.com science feeds13hHypertension and type 2 diabetes: lights and shadows about causalityJournal of Human Hypertension, Published...
Tue Oct 22, 2019 10:24
Latent classes for chemical mixtures analyses in epidemiology: an example using phthalate and phenol exposure biomarkers in pregnant womenJournal of Exposure Science & Environmental Epidemiology, Published online: 21 October 2019; doi:10.1038/s41370-019-0181-yLatent classes for chemical mixtures analyses in epidemiology: an example using phthalate and phenol exposure biomarkers in pregnant womenJournal of Exposure Science and Environmental Epidemiology - AOP - nature.com science feeds13hPersonal...
Tue Oct 22, 2019 10:24
Latent classes for chemical mixtures analyses in epidemiology: an example using phthalate and phenol exposure biomarkers in pregnant womenJournal of Exposure Science & Environmental Epidemiology, Published online: 21 October 2019; doi:10.1038/s41370-019-0181-yLatent classes for chemical mixtures analyses in epidemiology: an example using phthalate and phenol exposure biomarkers in pregnant womenJournal of Exposure Science and Environmental Epidemiology - Issue - nature.com science feeds11hBlood...
Tue Oct 22, 2019 10:23
ICOSLG-mediated regulatory T cell expansion and IL-10 production promote progression of glioblastoma
ICOSLG-mediated regulatory T cell expansion and IL-10 production promote progression of glioblastoma: AbstractBackgroundTargeting immune checkpoint proteins has recently gained substantial attention due to the dramatic success of this strategy in clinical trials for some cancers. Inducible T-cell co-stimulator ligand (ICOSLG) is a member of the B7 family of immune regulatory ligands, expression of which in cancer is implicated in disease progression due to regulation of anti-tumor adaptive immunity....
Tue Oct 22, 2019 10:23
Nonselective Reinnervation as a Primary or Salvage Treatment of Unilateral Vocal Fold Palsy: Objectives/HypothesisDemonstration of voice improvement and long‐term stability following nonselective unilateral laryngeal reinnervation (ULR) in patients with unilateral vocal fold paralysis (UVFP) and severe denervation. A subgroup of patients on whom ULR was performed as a salvage technique following unsuccessful medialization was analyzed separately.Study DesignProspective cohort study.MethodsThe ansa...
Tue Oct 22, 2019 10:23
The Iberian pig fed with high-fat diet: a model of renal disease in obesity and metabolic syndromeInternational Journal of Obesity, Published online: 21 October 2019; doi:10.1038/s41366-019-0434-9The Iberian pig fed with high-fat diet: a model of renal disease in obesity and metabolic syndromeInternational Journal of Obesity - Issue - nature.com science feeds10hGenetic variation, intrauterine growth, and adverse pregnancy conditions predict leptin gene DNA methylation in blood at birth and 12 months...
Tue Oct 22, 2019 10:22
Cardiothoracic Morphology Measures in Heart Failure Patients to Inform Device Designs: AbstractPurposeApproximately 5.7 million people in the US are affected by congestive heart failure. This study aimed to quantitatively evaluate cardiothoracic morphology and variability within a cohort of heart failure patients for the purpose of optimally engineering cardiac devices for a variety of heart failure patients.MethodsCo-registered cardiac-gated and non-gated chest computed tomography (CT) scans were...
Tue Oct 22, 2019 10:22
Endobronchial Glomus Tumor in a Child ,Moshe Y. Prero, Melissa Gener, Eugenio M. Taboada, and Christopher M. OermannPublished Online:21 Oct 2019https://doi.org/10.1089/ped.2019.1065View ArticleToolsShareAbstractGlomus tumors (GTs) are rare, usually benign, mesenchymal neoplasms typically located in the cutaneous tissues of the extremities. Visceral locations have been reported in ∼5% of cases. The average age at diagnosis is 42 years. GTs originating in the respiratory tract of pediatric patients...
Tue Oct 22, 2019 10:22
Phase I study of intermittent olaparib capsule or tablet dosing in combination with carboplatin and paclitaxel (part 2)Summary Background In the first part of this extensive phase I study (NCT00516724), continuous olaparib twice daily (bid) with carboplatin and/or paclitaxel resulted in myelosuppression and dose modifications. Here, we report the safety, tolerability, and efficacy of intermittent olaparib dosing combined with carboplatin and paclitaxel. Methods Patients with advanced solid tumors...
Tue Oct 22, 2019 10:21
Proximity of Vascular Bone Channel in the Lateral Sinus Wall to Root Apices of Maxillary First Molars: A Cone-beam Computed Tomographic Analysis: Apical surgery is frequently indicated in maxillary first molars. Occasionally, a vascular anastomosis in the lateral maxillary sinus wall can be observed during surgery. The aim of this study was to examine the distance between the vascular bone channel (VBC) and the root apices of maxillary first molars using cone-beam computed tomographic imaging.
Tue Oct 22, 2019 10:21
Pharmacological treatment patterns in heart failure: a population-based cohort studyAbstract Background Although the efficacy and safety of existing therapies of heart failure (HF) have been demonstrated in clinical trials, little is known about the treatment patterns in clinical practice, especially in France. Objectives To describe the treatment initiation patterns and the subsequent treatment changes among HF patients, in the first year...Latest Results for European Journal of Clinical Pharmacology8hImpact...
Tue Oct 22, 2019 10:20
Gender Differences in Arrhythmias: Focused on Atrial Fibrillation: AbstractThere are significant differences in clinical presentation and treatment of atrial fibrillation (AF) between women and men. The primary goal of AF management is to restore sinus rhythm and to prevent various complications, including stroke and heart failure. In many areas of AF, such as prevalence, clinical manifestations, morbidity, risk factors, pathophysiology, treatment strategies, and complications, gender-specific variability...
Tue Oct 22, 2019 10:20
Acute and preventive pharmacological treatment of post-traumatic headache: a systematic review: AbstractBackgroundPost-traumatic headache (PTH) is associated with considerable disability and reduced health-related quality of life. Despite the very high prevalence of PTH, there are no evidence-based guidelines for PTH treatment. Thus, we found it timely to provide a systematic review of the current literature on acute and preventive pharmacological treatment of PTH using PubMed and Embase databases.FindingsIncluded...
Tue Oct 22, 2019 10:20
Comparison of Surgical Intervention and Mortality for Seven Surgical Emergencies in England and the United StatesObjective: To examine differences between England and the USA in the rate of surgical intervention and in-hospital mortality for 7 index surgical emergencies. Background: Considerable international variation exists in the configuration, provision, and outcomes of emergency healthcare. Methods: Patients agedAnnals of Surgery - Most Popular Articles8hDoes the Artery-first Approach Improve...
Tue Oct 22, 2019 10:20
Psychometric Properties of the Arabic Version of the Functional Assessment of Chronic Illnesses Therapy-Fatigue (FACIT-F) in Arabic Cancer Patients: The Functional Assessment of Chronic Illness Therapy (FACIT) is a measurement system that was developed to assess the health-related quality of life among patients with cancer and other chronic illnesses. The Functional Assessment of Chronic Illness Therapy- Fatigue (FACIT-F) is a 40-item questionnaire, and it is the one of most frequently used instrument...
Tue Oct 22, 2019 10:19
Clinical Infectious Diseases Advance Access , Declining Hospitalizations among Persons With HIV; Time to Leave no One BehindClinical Infectious Diseases Advance Access5hHospitalization Rates and Outcomes among Persons Living with HIV in the Southeastern United States, 1996–2016AbstractBackgroundAdvances in antiretroviral therapy, aging, and comorbidities impact hospitalization rates in HIV-infected populations. We examined temporal trends and patient characteristics associated with hospitalization...
Tue Oct 22, 2019 10:19
Resilience and long-term outcomes after trauma: An opportunity for early intervention?: BACKGROUND Resilience, or the ability to cope with difficulties, influences an individual's response to life events including unexpected injury. We sought to assess the relationship between patient self-reported resilience traits and functional and psychosocial outcomes 6 months after traumatic injury.METHODS Adult trauma patients 18 years to 64 years of age with moderate to severe injuries (Injury Severity Score,...
Tue Oct 22, 2019 10:18
Platelet-Rich Plasma Combined with Low-Dose Ultrashort Wave Therapy Accelerates Peripheral Nerve Regeneration ,Yaqiong Zhu, Zhuang Jin, Jie Fang, Jing Wang, Yu Wang, Qing Song, Xiaoqi Tian, Ying Zhang, Fang Xie, Wei Chen, Nan Peng, Jiang Peng, Yukun Luo, and Yuexiang WangPublished Online:18 Oct 2019https://doi.org/10.1089/ten.tea.2019.0187SectionsView ArticleToolsShareAbstractFinding treatments that accelerate peripheral nerve regeneration, prolongation, and functional recovery remains a challenging...
Tue Oct 22, 2019 10:18
Comparison of DNA Extraction Methods for Optimal Recovery of Metagenomic DNA from Human and Environmental Samples: AbstractMetagenomics is the study of gene pool of an entire community in a particular niche. This provides valuable information about the functionality of host-microbe interaction in a biological ecosystem. Efficient metagenomic DNA extraction is a critical pre-requisite for a successful sequencing run in a metagenomic study. Although isolation of human stool metagenomic DNA is fairly...
Tue Oct 22, 2019 10:17
3DPrint.com , 24 Massive 3D Printed Replicas of Massively Popular Manga CharactersAs I've mentioned before, 3D printing is a great way to bring part of your favorite fandom to life. There are some people who are fans of the Stars Wars universe, while others are into Star Trek. Some people like Harry Potter, and others are fans of Lord of the Rings and Game of Thrones. Maybe your thing is superheroes and comic books, which then leads us to anime and manga, in neither of which I am well-versed. Because...
Tue Oct 22, 2019 10:17
Precocious puberty and Chiari I malformation with syrinx: a case report of an unusual presentation of Costello syndrome: AbstractBackgroundCostello syndrome (CS) is a rare RASopathy causing developmental delays, short stature and classically, delayed puberty. We present a patient with CS and central precocious puberty (CPP).Case presentationA female patient with CS presented at 6 years 10 months of age with breast development. CPP was biochemically confirmed at 7 years 1 month of age, no additional...
Tue Oct 22, 2019 10:16
SAGE Publications Inc: Annals of Otology, Rhinology & Laryngology: Table of Contents , Detection of Pepsin in Oral Secretions of Infants with and without LaryngomalaciaAnnals of Otology, Rhinology &Laryngology, Ahead of Print. Objectives:Laryngomalacia is a common cause of stridor in infants and is associated with laryngopharyngeal reflux (LPR). Although pepsin in operative supraglottic lavage specimens is associated with severe laryngomalacia, detection of pepsin in oral secretions has...
Tue Oct 22, 2019 10:16
The Laryngoscope , Is Frailty Associated With Worse Outcomes After Head and Neck Surgery? A Narrative ReviewObjective Frailty has emerged as an important determinant of many health outcomes across various surgical specialties. We examined the published literature reporting on frailty as a predictor of perioperative outcomes in head and neck cancer (HNC) surgery. Study Design Narrative review with limited electronic database search and cross‐referencing of included studies. Methods PubMed was searched...
Tue Oct 22, 2019 10:13
Otolaryngologic Clinics of North America , Recurrent Laryngeal Nerve StimulatorElectrical stimulation of the recurrent laryngeal nerve is a safe and promising therapeutic approach with the potentiality to overcome the shortcomings of conventional surgical glottal enlargement. Although aberrant or synkinetic reinnervation is commonly considered an unfavorable condition, particularly for recovery of vocal fold movement, its presence is essential to ensure the effective clinical performance of laryngeal...
Tue Oct 22, 2019 10:12
Impact of human papillomavirus status on survival and recurrence in a geographic region with a low prevalence of HPV‐related cancer: A retrospective cohort study: AbstractBackgroundHuman papillomavirus (HPV)‐positive oropharyngeal squamous cell carcinoma (OPSCC) is associated with better tumor‐response rates and survival outcomes. However, in some geographic regions, the impact of HPV infection on prognosis remains unclear. The aim of this study was to describe the patterns of recurrence and survival...
Tue Oct 22, 2019 10:12
Impact of the Paris system for reporting urine cytopathology on predictive values of the equivocal diagnostic categories and interobserver agreement: Rania Bakkar, James Mirocha, Xuemo Fan, David P Frishberg, Mariza de Peralta-Venturina, Jing Zhai, Shikha BoseCytoJournal 2019 16(1):21-21Background: The Paris System (TPS) acknowledges the need for more standardized terminology for reporting urine cytopathology results and minimizing the use of equivocal terms. We apply TPS diagnostic terminologies...
Tue Oct 22, 2019 10:10
CytoJournal , Lymphoproliferative process with reactive follicular cells in thyroid fine-needle aspiration: A few simple but important diagnostic pearlsOlubunmi Shoyele, Brent Bacus, Lilliana Haddad, Yilan Li, Vinod ShidhamCytoJournal 2019 16(1):20-20Articles : CytoJournal as on December 3, 2014)24mImpact of the Paris system for reporting urine cytopathology on predictive values of the equivocal diagnostic categories and interobserver agreementRania Bakkar, James Mirocha, Xuemo Fan, David P Frishberg,...
Tue Oct 22, 2019 10:09
PeerJ Computer Science , Mercuric pollution of surface water, superficial sediments, Nile tilapia (Oreochromis nilotica Linnaeus 1758 [Cichlidae]) and yams (Dioscorea alata) in auriferous areas of Namukombe stream, Syanyonja, Busia, UgandaThe mercury content and the contamination characteristics of water, sediments, edible muscles of a non-piscivorous fish (Oreochromis nilotica Linnaeus 1758 [Cichlidae]) and yams (Dioscorea alata) from Namukombe stream in Busia gold district of Uganda were evaluated....
Tue Oct 22, 2019 10:04
ScienceDirect Publication: International Immunopharmacology , Ginsenoside Rg3 promotes Fc gamma receptor-mediated phagocytosis of bacteria by macrophages via an extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase-dependent mechanismPublication date: December 2019Source: International Immunopharmacology, Volume 77Author(s): Chun Xin, Joungmin Kim, Hui Quan, Mei Yin, Seongtae Jeong, Jeong-Il Choi, Eun-A Jang, Chang-Hun Lee, Dae-Hun Kim, Hong-Beom BaeAbstractGinsenoside...
Tue Oct 22, 2019 10:04
Behavioural Brain Research , Deferiprone ameliorates memory impairment in Scopolamine-treated rats: the impact of its iron-chelating effect on β-amyloid dispositionPublication date: Available online 20 October 2019Source: Behavioural Brain ResearchAuthor(s): Sylvia F. Fawzi, Esther T. Menze, Mariane G. TadrosAbstractAlzheimer's disease (AD) is a neurodegenerative disease characterized by cognitive and memory problems. Scopolamine (SCOP) is a natural anticholinergic drug that was proven to cause...
Tue Oct 22, 2019 10:03
Nature Communications - Molecular features of the UNC-45 chaperone critical for binding and folding muscle myosinNature Communications, Published online: 21 October 2019; doi:10.1038/s41467-019-12667-8Myosin, a motor protein essential for intracellular transport to muscle contraction, requires a chaperone UNC-45 for folding and assembly. Here authors use in vitro reconstitution and structural biology to characterize the interplay between UNC-45 and muscle myosin MHC-B.Nature Communications - current...
Tue Oct 22, 2019 10:02
bioRxiv Subject Collection: Evolutionary Biology , Lost in Translation: population genomics of porcini mushrooms (Boletus edulis) challenges use of ITS for DNA barcoding in Fungi [NEW RESULTS]The internal transcribed spacers (ITS) of the rDNA cistron are the most commonly used DNA barcoding region in Fungi. rDNA genes are repeated dozens to hundreds of times in the eukaryotic genome and it is believed that these arrays are homogenized through concerted evolution preventing the accumulation of intragenomic,...
Tue Oct 22, 2019 10:01
Annals of Neurology , The "maternal effect" on epilepsy risk: analysis of familial epilepsies and reassessment of prior evidenceABSTRACT Objective Previous studies have observed that epilepsy risk is higher among offspring of affected women than offspring of affected men. We tested whether this "maternal effect" was present in familial epilepsies, which are enriched for genetic factors that contribute to epilepsy risk. Methods We assessed evidence of a maternal effect in a cohort of families containing...
Tue Oct 22, 2019 10:00
SAGE Publications Ltd STM: Chronic Respiratory Disease: Table of Contents , High-flow nasal cannula therapy reduced the respiratory rate and respiratory distress in a standard model simulator and in patients with hypoxemic respiratory failureChronic Respiratory Disease, Volume 16, Issue , January-December 2019. High-flow nasal cannula (HFNC) therapy has been increasingly applied to treat patients with severe hypoxemic respiratory failure. We investigated whether vital signs reflect the reduction...
Tue Oct 22, 2019 09:59
American Goiter Association , Gluco-metabolic effects of pharmacotherapy-induced modulation of bile acid physiology.Related ArticlesGluco-metabolic effects of pharmacotherapy-induced modulation of bile acid physiology. J Clin Endocrinol Metab. 2019 Oct 20;: Authors: Brønden A, Knop FK Abstract CONTEXT: The discovery and characterization of the bile acid specific receptors farnesoid X receptor (FXR) and Takeda G protein-coupled receptor 5 (TGR5) have facilitated a wealth of research focusing on the...
Tue Oct 22, 2019 09:58
American Journal of Otolaryngology , Minimally invasive surgery for the treatment of hyperacusis:...
American Journal of Otolaryngology , Minimally invasive surgery for the treatment of hyperacusis: New technique and long term resultsPublication date: Available online 20 October 2019Source: American Journal of OtolaryngologyAuthor(s): Herbert Silverstein, Brian Kellermeyer, Ulyseius MartinezAbstractObjectiveA minimally invasive surgery developed by the senior author has previously been reported to significantly improve sound tolerance after surgery. This report compares the new versus original...
Tue Oct 22, 2019 09:57
Cancer Immunology, Immunotherapy , Pembrolizumab for anaplastic thyroid cancer: a case studyAbstract Blockade of the PD-1/PD-L1 pathway with targeted monoclonal antibodies has demonstrated encouraging anti-tumour activity in multiple cancer types. We present the case of a patient with BRAF-negative stage IVC anaplastic thyroid cancer (ATC) treated with the anti-PD-1 monoclonal antibody, pembrolizumab, following radiographic progression on chemoradiation. Blood samples were collected prior to and...
Tue Oct 22, 2019 09:56
Clinical & Experimental Allergy , Adverse reactions to iodinated contrast media: safety of a study protocol that includes fast full‐dose parenteral challenge‐tests searching for an alternative contrast mediaAbstract Iodinated contrast media (ICM) were introduced into clinical practice to improve both diagnostic imaging and therapeutic procedures. Current ICM formulations are based on tri‐iodobenzoic acid ring. Incidence of adverse reactions (AR) to ICM was 15% in 1975, but nowadays it has been...
Tue Oct 22, 2019 09:55
Molecules, Vol. 24, Pages 3780: Quality Formation Mechanism of Stiff Silkworm, Bombyx batryticatus Using UPLC-Q-TOF-MS-Based MetabolomicsMolecules, Vol. 24, Pages 3780: Quality Formation Mechanism of Stiff Silkworm, Bombyx batryticatus Using UPLC-Q-TOF-MS-Based Metabolomics Molecules doi: 10.3390/molecules24203780 Authors: Dongxu Xing Guanwang Shen Qingrong Li Yang Xiao Qiong Yang Qingyou Xia Bombyx batryticatus is a well-known animal in traditional Chinese medicine. The aim of the research was to...
Tue Oct 22, 2019 09:54
International Journal of Molecular SciencesIJMS, Vol. 20, Pages 5218: The Antithrombotic Function of Sphingosine-1-Phosphate on Human Adipose-Stem-Cell-Recellularized Tissue Engineered Vascular Graft In VitroIJMS, Vol. 20, Pages 5218: The Antithrombotic Function of Sphingosine-1-Phosphate on Human Adipose-Stem-Cell-Recellularized Tissue Engineered Vascular Graft In Vitro International Journal of Molecular Sciences doi: 10.3390/ijms20205218 Authors: Chih-Hsun Lin Jen-Her Lu Kai Hsia Hsinyu Lee Chao-Ling...
Tue Oct 22, 2019 09:54
Children, Vol. 6, Pages 116: Environmental and Genetic Determinants of Serum 25(OH)-Vitamin D Levels during Pregnancy and Early ChildhoodChildren, Vol. 6, Pages 116: Environmental and Genetic Determinants of Serum 25(OH)-Vitamin D Levels during Pregnancy and Early Childhood Children doi: 10.3390/children6100116 Authors: Ann-Marie Malby Schoos Cecilie Vinther Sarah Nørgaard Nicklas Brustad Jakob Stokholm Klaus Bønnelykke Hans Bisgaard Bo Lund Chawes Vitamin D insufficiency has become a common health...
Tue Oct 22, 2019 09:53
Antibodies, Vol. 8, Pages 51: Therapeutic Monoclonal Antibodies Targeting Immune Checkpoints for the Treatment of Solid TumorsAntibodies, Vol. 8, Pages 51: Therapeutic Monoclonal Antibodies Targeting Immune Checkpoints for the Treatment of Solid Tumors Antibodies doi: 10.3390/antib8040051 Authors: Gravbrot Gilbert-Gard Mehta Ghotmi Banerjee Mazis Sundararajan Recently, modulation of immune checkpoints has risen to prominence as a means to treat a number of solid malignancies, given the durable response...
Tue Oct 22, 2019 09:52
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