Correlation of tumor burden in sentinel lymph nodes with tumor burden in non-sentinel lymph nodes and survival in cutaneous melanoma.: CONCLUSIONS: In patients with CM who undergo CLND, SLN tumor burden predicts non-SLN tumor burden. SLN tumor burden parameters provide accurate prognostic stratification independent of non-SLN status and should be considered for incorporation into future staging systems and integrated risk models. PMID: 31570567 [PubMed - as supplied by publisher] (Source: Clinical...
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PET/CT-guided biopsy with respiratory motion correction: AbstractPurposeGiven the ability of positron emission tomography (PET) imaging to localize malignancies in heterogeneous tumors and tumors that lack an X-ray computed tomography (CT) correlate, combined PET/CT-guided biopsy may improve the diagnostic yield of biopsies. However, PET and CT images are naturally susceptible to problems due to respiratory motion, leading to imprecise tumor localization and shape distortion. To facilitate PET/CT-guided...
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Touchless scanner control to support MRI-guided interventions: AbstractPurposeMRI-guided interventions allow minimally invasive, radiation-free treatment but rely on real-time image data and free slice positioning. Interventional interaction with the data and the MRI scanner is cumbersome due to the diagnostic focus of current systems, confined space and sterile conditions.MethodsWe present a touchless, hand-gesture-based interaction concept to control functions of the MRI scanner typically used...
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Combined ipilimumab and nivolumab first‐line and after BRAF targeted therapy in advanced melanoma: AbstractCombination ipilimumab and nivolumab is a highly active systemic therapy for metastatic melanoma but can cause significant toxicity. We explore the safety and efficacy of this treatment in routine clinical practice, particularly in the setting of BRAF targeted therapy.Consecutive patients with unresectable stage IIIC/IV melanoma commenced on ipilimumab and nivolumab across 10 tertiary melanoma...
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Evolutionary processes of melanomas from giant congenital melanocytic nevi: AbstractMelanoma can develop in a congenital melanocytic nevus (CMN). In fact, a large CMN is associated with a high risk of developing melanoma. Although melanomas arising from CMNs are thought to have a pathogenesis distinct from conventional melanomas, no studies have been conducted on the evolution or tumor heterogeneity of CMN melanomas. We applied multi‐region whole‐exome sequencing to investigate the clonal nature...
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Landscapes, environments and societies: The development of culture in Lower Palaeolithic Europe: Publication date: December 2019Source: Journal of Anthropological Archaeology, Volume 56Author(s): Rob Davis, Nick AshtonAbstractIdentification of cultural groups is rare in the early Palaeolithic due to site formation processes including taphonomy and the effect of raw material and site function. This paper reviews a critical period in Europe at about 400 ka (MIS 11) when we may be able to identify such...
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Evaluation of breast carcinoma regression after preoperative chemotherapy by label‐free multiphoton imaging and image analysis: AbstractNeoadjuvant chemotherapy is increasingly being used in breast carcinoma as it significantly improves the prognosis and consistently leads to an increased rate of breast preservation. How to accurately assess tumor response after treatment is a crucial factor for developing reasonable therapeutic strategy. In this study, we were in an attempt to monitor tumor response...
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Distinguishing bowenoid papulosis from Bowen disease in the mouth: a case report: AbstractBowenoid papulosis (BPap) is a rare skin disorder linked to human papillomavirus (HPV) infection and characterized clinically by the presence of scattered papules or small plaques, multiple and pigmented, that involve the stratified squamous epithelium. Only 13 cases have been reported in the medical literature. Bowen disease (BD) is recognized as the main differential diagnosis of BPap. An 80‐year old white...
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Autofluorescence Excitation‐Emission Matrices (EEMs) as a quantitative tool for the assessment of meat quality: AbstractCommercially produced meat is currently graded by a complex and partly subjective multiparameter methodology; a quantitative method of grading, using small samples would be desirable. Here, we investigate the correlation between commercial grades of beef and spectral signatures of native fluorophores in such small samples. Beef samples of different commercial grades were characterized...
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Metastatic Pancreatic Adenosquamous Carcinoma to the Scalp: A Case Report and Review of the Literature: AbstractMetastatic carcinoma to the skin occurs in only a minority of patients with a visceral or internal malignancy, with breast, lung and colorectum accounting for the majority of cases. We present the case of a 66‐year‐old man with a recent violaceous nodule of the left scalp (1.2 x 1.0 x 0.2 cm) that was a metastatic pancreatic adenosquamous carcinoma, representing a seemingly rare event....
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Café noir spots: A Feature of Familial Progressive Hyper‐ and Hypopigmentation: AbstractFamilial progressive hyper‐ and hypopigmentation (FPHH) is a rare genodermatosis characterized by multiple café au lait spots and hypopigmented ash‐leaf macules intermingled with blotchy hyperpigmentation (1,2). Herein, we describe a Turkish FPHH patient with café‐noir spots.A 16‐year‐old male presented to our Pediatric Dermatology Clinic, with extensive hyperpigmentation, irregular brown patches, and hypopigmented...
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White sponge nevus: A condition not always clinically suspected: ABSTRACTWhite sponge nevus (WSN) is an uncommon benign inherited disorder characterized by white and diffuse painless lesions in oral, esophageal, or genital mucosa. The lesions may develop at birth or later in childhood or adolescence, with careful clinical examination being sufficient for diagnosis in most cases. However, microscopic analysis may be necessary particularly in adults in which other whitish oral lesions may be clinically...
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Associated primary tumors in patients with primary cutaneous lymphoma: a single center retrospective cohort study: AbstractPrimary cutaneous lymphomas (CL) are the second most common group of extranodal non‐Hodgkin lymphomas (NHL). Cutaneous T‐cell lymphomas (CTCL) account for the majority of cases.1 Many patients with CL have a rather good prognosis and for those the impact on outcome, if an associated primary neoplasm occurs, is even more critical than in the patients with aggressive CL subtypes....
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Identification of CD49a+ CD8+ resident memory T cells in vitiligo‐like lesions associated with nivolumab treatment for melanoma: AbstractImmune checkpoint inhibitor (ICI) has brought major therapeutic advances in melanoma care, but ICI can cause unique side effects, often termed immune‐related adverse events (irAEs), such as skin rash, vitiligo, colitis, and pneumonitis. Several recent studies revealed a correlation between occurrence of vitiligo‐like lesions and clinical responses in advanced melanoma...
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Use of topical calcipotriol for identification of patients with psoriasis in administrative healthcare data – a validation study: AbstractCalcipotriol has been used to treat psoriasis for more than three decades. Previous interview data of 44 Danish dermatologists and 93 general practitioners have indicated that calcipotriol (alone or combined with topical corticosteroids [TCS]) was the most commonly used treatment for newly diagnosed psoriasis patients (48‐54%) and that this was used in 71% of patients...
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Amino acid charge and epidermolysis bullosa simplex severity: Genotype‐phenotype correlations: AbstractEpidermolysis bullosa simplex (EBS) is a genetic skin disorder characterized by mechanical fragility and blistering of the skin. Localized EBS (EBS‐loc: OMIM 131800) is the mildest variant, with blistering occurring only in the hands and feet. EBS is mainly caused by autosomal dominant mutations in the KRT5 or KRT14 gene, encoding keratin 5 (K5) or keratin 14 (K14), respectively. Here, we report...
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Cross‐reactivity in beta‐lactams after a non‐immediate cutaneous adverse reaction: experience of a reference center for toxic bullous diseases and severe cutaneous adverse reactions: AbstractBackgroundCross‐reactivity among beta‐lactam antibiotics (BL) is essentially reported in immediate hypersensitivity.ObjectivesTo evaluate cross‐reactivity beyond BLs in patients with non‐immediate cutaneous adverse drug reaction (non‐immediate CADR) managed in a dermatology reference center of toxic bullous and...
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MRI safety and devices: An update and expert consensus: The use of magnetic resonance imaging (MRI) is increasing globally, and MRI safety issues regarding medical devices, which are constantly being developed or upgraded, represent an ongoing challenge for MRI personnel. To assist the MRI community, a panel of 10 radiologists with expertise in MRI safety from nine high‐volume academic centers formed, with the objective of providing clarity on some of the MRI safety issues for the 10 most frequently...
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Assessment of the Hemodynamics of Autogenous Arteriovenous Fistulas With 4D Phase Contrast‐Based Flow Quantification MRI in Dialysis Patients: BackgroundRegular monitoring of autogenous arteriovenous fistulas (AVFs) for hemodialysis patients has importance. Hence, 4D flow MRI may be an alternative for assessing the hemodynamics of AVFs.PurposeTo compare the hemodynamics of AVFs using Doppler ultrasound (DUS) and 4D‐MRI in renal dialysis patients.Study TypeCase–control study from October 2017 to April...
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Neonatal and Self‐healing Linear immunoglobulin A dermatosis: AbstractLinear immunoglobulin A dermatosis (LAD) is an autoimmune bullous dermatosis commonly reported in children over the age of 5. It is characterized by clear vesicles and blisters, arranged in a "crown of jewels" annular shape, on a normal or erythematous skin. Its common locations are the trunk, the limbs, the perineum and perioral areas. So far, 9 neonatal LAD have been reported.
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Isotretinoin and risk factors for suicide attempt: a population‐based comprehensive case series and nested case‐control study using 2010‐2014 French Health Insurance Data: AbstractBackgroundAlthough the causal role of isotretinoin in suicidal behaviour is controversial, suicide attempts (SA) do occur among patients taking isotretinoin.ObjectivesTo describe patient profiles and the management of isotretinoin among patients who committed or attempted suicide under treatment. To assess the risk factors...
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Prediction of biochemical recurrence in prostate cancer patients who underwent prostatectomy using routine clinical prostate multiparametric MRI and decipher genomic score: BackgroundBiochemical recurrence (BCR) affects a significant proportion of patients who undergo robotic‐assisted laparoscopic prostatectomy (RALP).PurposeTo evaluate the performance of a routine clinical prostate multiparametric magnetic resonance imaging (mpMRI) and Decipher genomic classifier score for prediction of biochemical...
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Maxillary central incisor gingival papilla and zenith heights with and without periodontally accelerated osteogenic orthodontics: View/Download PDF Download ---Citations---BibTeXRISOriginal Research9 (3); 172-177 doi:10.25259/APOS_74_2019 Maxillary central incisor gingival papilla and zenith heights with and without periodontally accelerated osteogenic orthodonticsMariam Alzaabi1, Donald J. Ferguson2, Laith Makki2, M. Thomas Wilcko31Private Practice in Orthodontics, Abu Dhabi, UAE,...
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Effectiveness of low binding frictional materials: Evaluation of the binding frictional resistance of improved superelastic nickel-titanium alloy wires with different bracket combinations: View/Download PDF Download ---Citations---BibTeXRISOriginal Research9 (3); 156-164 doi:10.25259/APOS_25_2019 Effectiveness of low binding frictional materials: Evaluation of the binding frictional resistance of improved superelastic nickel-titanium alloy wires with different bracket combinationsYoshio...
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Expansion in the absence of crossbite – rationale and protocol: View/Download PDF Download ---Citations---BibTeXRISExperts Corner9 (3); 126-137 doi:10.25259/APOS_115_2019 Expansion in the absence of crossbite – rationale and protocolN. R. Krishnaswamy Department of Orthodontics, Ragas Dental College and Hospital, Tamil Nadu Dr. M.G.R Medical University, Chennai, Tamil Nadu, India *Corresponding author: N. R. Krishnaswamy, Department of Orthodontics, Ragas Dental College and Hospital,...
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Skeletal and dental changes after lower posterior tooth extrusion in Class II Division 1 deep bite short-faced growing patients: View/Download PDF Download ---Citations---BibTeXRISOriginal Research9 (3); 165-171 doi:10.25259/APOS_23_2019 Skeletal and dental changes after lower posterior tooth extrusion in Class II Division 1 deep bite short-faced growing patientsPornpan Jariyavithayakul, Chairat Charoemratrote Department of Preventive Dentistry, Faculty of Dentistry, Prince of Songkla...
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Immunohistochemical study on the postnatal growth changes of the spheno-occipital synchondrosis and tibial cartilage: View/Download PDF Download ---Citations---BibTeXRISOriginal Research9 (3); 149-155 doi:10.25259/APOS_70_2019 Immunohistochemical study on the postnatal growth changes of the spheno-occipital synchondrosis and tibial cartilageTae-Min Yoon1, Sun-Hyung Park1, Mi-Jeong Kwon2, Kee-Joon Lee11Department of Orthodontics, College of Dentistry, Yonsei University, Republic of...
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Applicability of two non-radiographic tooth size prediction methods of unerupted permanent canine and premolars, for Galle district, Sri Lanka: View/Download PDF Download ---Citations---BibTeXRISOriginal Research9 (3); 178-181 doi:10.25259/APOS_19_2019 Applicability of two non-radiographic tooth size prediction methods of unerupted permanent canine and premolars, for Galle district, Sri LankaW. Kathya Perera1, Sumith Gunawardane2, Sumith Loku Pathirage11Department of Orthodontics,...
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Scoping studies: Should there be more in orthodontic literature?: View/Download PDF Download ---Citations---BibTeXRISEditorial9 (3); 124-125 doi:10.25259/APOS_118_2019 Scoping studies: Should there be more in orthodontic literature?Nikhilesh Vaid Department of Orthodontics, European University Dental College, Dubai, UAE *Corresponding author: Nikhilesh Vaid, Department of Orthodontics, European University Dental College, Dubai Healthcare City, Dubai, UAE. apospublications@gmail.com...
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Clinical guidelines to integrate temporary anchorage devices for bone-borne orthodontic appliances in the digital workflow: View/Download PDF Download ---Citations---BibTeXRISClinical Pearl9 (3); 182-189 doi:10.25259/APOS_78_2019 Clinical guidelines to integrate temporary anchorage devices for bone-borne orthodontic appliances in the digital workflowSimon Graf1, Ismaeel Hansa21Private Orthodontic Practice, Smile AG, Belp, Bern, Switzerland, 2Department of Orthodontics, European University...
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Comprehensive orthodontic treatment in an adolescent patient with Class II Division 1 malocclusion and ankylosed maxillary central incisors: View/Download PDF Download ---Citations---BibTeXRISCase Report9 (3); 190-197 doi:10.25259/APOS_52_2019 Comprehensive orthodontic treatment in an adolescent patient with Class II Division 1 malocclusion and ankylosed maxillary central incisorsMatthew Wen Jian Lau Department of Orthodontics, National Dental Centre Singapore, Singapore *Corresponding...
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Effects of functional appliance treatment on pharyngeal airway passage dimensions in Class II malocclusion subjects with retrognathic mandibles: A systematic review: View/Download PDF Download ---Citations---BibTeXRISSystematic Review9 (3); 138-148 doi:10.25259/APOS_59_2019 Effects of functional appliance treatment on pharyngeal airway passage dimensions in Class II malocclusion subjects with retrognathic mandibles: A systematic reviewAnusuya V, Ashok Kumar Jena, Jitendra Sharan Department...
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Effects of functional appliance treatment on pharyngeal airway passage dimensions in Class II malocclusion subjects with retrognathic mandibles: A systematic review: View/Download PDF Download ---Citations---BibTeXRISSystematic Review9 (3); 138-148 doi:10.25259/APOS_59_2019 Effects of functional appliance treatment on pharyngeal airway passage dimensions in Class II malocclusion subjects with retrognathic mandibles: A systematic reviewAnusuya V, Ashok Kumar Jena, Jitendra Sharan Department...
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Mycobacterium fortuitum infection associated with achalasia.: Related ArticlesMycobacterium fortuitum infection associated with achalasia.Tunis Med. 2018 May;96(5):311-313Authors: Bouchentouf RAbstract The association achalasia and non tuberculous Mycobacteria lung infection is described in the literature. Most of the time Mycobacterium Fortuitum is responsible of aspiration pneumonia that didn't respond to usual antibiotic therapy. We report a new case about a 15 year-old woman with Allgrove's...
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Recurrent Laryngeal Nerve Transection in Mice Results in Translational Upper Airway Dysfunction.: Related ArticlesRecurrent Laryngeal Nerve Transection in Mice Results in Translational Upper Airway Dysfunction.J Comp Neurol. 2019 Sep 11;:Authors: Haney MM, Hamad A, Woldu HG, Ciucci M, Nichols N, Bunyak F, Lever TEAbstract The recurrent laryngeal nerve (RLN) is responsible for normal vocal fold (VF) movement, and is at risk for iatrogenic injury during anterior neck surgical procedures in...
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Implication and Management of Incidental Oropharyngeal Papillomas-A Retrospective Case Series Review.: Related ArticlesImplication and Management of Incidental Oropharyngeal Papillomas-A Retrospective Case Series Review.Ear Nose Throat J. 2019 Oct 03;:145561319871228Authors: Kim D, Siegel J, Chouake RJ, Geliebter J, Zalvan CHAbstract INTRODUCTION: Incidental papillomas of the pharynx can be found while examining the nasopharynx, oropharynx, and hypopharynx for other disorders of the head...
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Pemphigoid gestationis in a resource-limited setting: Fadimatu Bakari, Gabriel Dogbanya, Tahir Turaki Muhammad, Hajara Umaru-Sule, Hajaratu Umar Sulayman, Solomon Avidime, Adebiyi Gbadebo AdesiyunArchives of International Surgery 2018 8(3):147-151Pemphigoid gestationis is a rare autoimmune vesicobullous dermatosis that is unique to pregnancy. It commonly occurs during the second half of pregnancy, particularly the 3rd trimester. In general, it presents with intense, itchy erythematous papules and...
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Fibrin glue reinforcement of choledochotomy closure suture line for prevention of bile leak in patients undergoing laparoscopic common bile duct exploration and primary closure: Anish Gupta, Jagdish Chander, Bhavna Gupta, Rahul JainArchives of International Surgery 2018 8(3):119-127Background: Laparoscopic common bile duct (CBD) exploration (LCBDE) allows cholecystectomy and the removal of CBD stones to be performed during the same sitting, thereby decreasing hospital stay. CBD exploration through...
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A rare case report of long-standing foreign body in the abdomen; forgotten scalpel blade in a multipara: Joel A Adze, Matthew C Taingson, Makama G Jerry, Stephen B Bature, Durosinlorun M Amina, Mohammed Caleb, Abubakar Amina, Airede Lydia, Sheyin JohnArchives of International Surgery 2018 8(3):139-142The unintended retention of foreign objects (URFOs) after invasive procedures can cause morbidity and in some cases mortality. There may be an extended period between occurrence and detection of an URFO....
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Cephalic vein cut down technique for chemoport implantantion and ease of chemoport access - A cohort study: Jency Mathews, Seethal Abraham, Rani PhilipArchives of International Surgery 2018 8(3):113-118Background: Multiple techniques have been established for the insertion of totally implantable chemotherapy ports. Cephalic vein cut down technique is considered a safe technique with reasonable success. The surgical team implanting the chemoports and the nursing team handling them have a learning...
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An overview of male breast cancer in North East India: A hospital-based study: Jagannath D Sharma, Nizara Baishya, Amal C Kataki, Chandi R KalitaArchives of International Surgery 2018 8(3):128-131Background: Breast cancer in males is a rare disease and accounts for <1% of all cancers in men. The objective of this study was to analyze the incidence and clinicopathological behavior of male breast cancer (MBC) at a tertiary cancer center of North East India.Patients and Methods: The medical records...
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Reasons for contraceptive discontinuation at Ahmadu Bello University Teaching Hospital Zaria, Northern Nigeria: Hauwa Shuaib Umar, Hajaratu UmarArchives of International Surgery 2018 8(3):108-112Background: Despite the low uptake of contraceptive methods in Nigeria and the associated obstetric and medical complications of high birth rate, some of the clients still find reason to discontinue the methods. To determine the reasons for discontinuation of contraceptive methods among clients at the Ahmadu...
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Rare presentation of patent vitellointestinal duct-Meckel's diverticulum and vitelline cyst-A case report: Vasudha R Nikam, Amit S Garud, Pratik D PatilArchives of International Surgery 2018 8(3):143-146Meckel's diverticulum is one of the most common anomalies of the gastrointestinal tract. Many of them remain unexpressed and are discovered accidentally. Vitello-intestinal duct anomalies are rare and occur in 1–2% of the population. These anomalies may present in adult life like appendicitis; hence,...
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Early experience with penetrating keratoplasty in South-South Nigeria: Initial audit of indications and outcome: Ukeme I E Umana, Ernest I Ezeh, Dennis G Nkanga, Utam A Utam, Affiong A Ibanga, Bassey A Etim, Elizabeth D Nkanga, Sylvia I AkpanArchives of International Surgery 2018 8(3):101-107Background: Corneal diseases are major causes of severe visual impairment and blindness in developing countries, unfortunately. Keratoplasty, which is a major treatment modality, is either nonexistent or at its...
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Time-related outcome in patients with traumatic brain injury admitted to neurosurgical care in a tertiary centre: David O Udoh, Oduwa O Aghahowa, Emmanuel C ObetaArchives of International Surgery 2018 8(3):95-100Background: The decreased mortality and improved outcomes associated with constantly metamorphosing trauma systems is particularly relevant in traumatic brain injuries (TBI) in which the duration from injury to neurosurgical intervention is an important determinant of outcome. With defective...
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A clinical profile and outcome of patients with acute pancreatitis: A prospective study in North India: Yamandeep Chauhan, Neha Jindal, Ram Kumar Verma, Praveen Kumar Tyagi, Madhulata Rana, Sukhwinder SinghArchives of International Surgery 2018 8(3):132-138Background: Acute Pancreatitis (AP) is an inflammatory process. The average mortality rate in severe AP approaches 2%–10%. Gall stones and alcohol abuse account for 70% of cases of acute pancreatitis. Almost all patients have acute upper abdominal...
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Loss of Xanthine Oxidoreductase Potentiates Propagation of Hepatocellular Carcinoma Stem Cells: AbstractLiver cancer stem cells (CSCs) exist in the tumor environment and are critically involved in the initiation and progression of hepatocellular carcinoma (HCC). However, the underlying molecular mechanisms of self‐renewal and maintenance of liver CSCs remain poorly understood. Herein, we identified that xanthine oxidoreductase (XOR), which was expressed at low levels in human HCC samples and liver...
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Association between Opioid Dose, Acute Post‐operative Pain and Walking Distance Following Lumbar Spine Surgery: High doses of opioids on post‐operative day 1 (POD1) did not translate into better outcomes of pain and gait distance during hospital stay following lumbar spine surgery. Rather, patients who received medium and low dose of opioids during POD1 walked greater distance on post‐operative day 2 or post‐operative day 3 after accounting for some of the main confounding factors.AbstractWhat is...
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Urokinase receptor and tissue plasminogen activator as immediate early genes in pentylenetetrazole‐induced seizures in the mouse brain: AbstractEpileptogenesis progressively leads to the rearrangement of normal neuronal networks into more excitable ones and can be viewed as a form of neuroplasticity the molecular mechanisms of which still remain obscure. Here we studied pentylenetetrazole seizure‐induced regulation of genes for plasminogen activator system in the mouse brain. We found that tissue...
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FKBP12 is a predictive biomarker for efficacy of anthracycline-based chemotherapy in breast cancer: AbstractBackgroundFK506-binding protein 12 (FKBP12) is abundant, ubiquitously expressed cytoplasmic protein with multiple functions in cell signaling transduction. Recently, we reported a novel function for FKBP12 in oncoprotein mouse double minute 2 (MDM2) self-ubiquitination and degradation, which greatly enhanced the sensitivity of cancer cells to chemotherapy. However, the clinical relevance remains...
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Species-specific optimization of PEG~SN-38 prodrug pharmacokinetics and antitumor effects in a triple-negative BRCA1-deficient xenograft: AbstractPurposeOptimal efficacy of a macromolecular prodrug requires balancing the rate of drug release with the rate of prodrug elimination. Since circulating macromolecules have different elimination rates in different species, a prodrug optimal for one species will likely not be for another. The objectives of this work were (a) to develop an approach to optimize...
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A phase Ib study of the combination regorafenib with PF-03446962 in patients with refractory metastatic colorectal cancer (REGAL-1 trial): AbstractPurposeThis study aimed to evaluate the maximum tolerated dose (MTD) and recommended phase II dose (RPTD), as well as the safety and tolerability of PF-03446962, a monoclonal antibody targeting activin receptor like kinase 1 (ALK-1), in combination with regorafenib in patients with refractory metastatic colorectal cancer.MethodsThe first stage of this...
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Population pharmacokinetics of fedratinib in patients with myelofibrosis, polycythemia vera, and essential thrombocythemia: AbstractPurposeFedratinib (SAR302503, TG101348) is an orally administered Janus kinase (JAK) 2-selective inhibitor that is being developed for the treatment of patients with myelofibrosis (MF). The objectives of this analysis were to develop a population pharmacokinetic (PK) model to characterize fedratinib concentration-time profiles in patients with MF, polycythemia vera (PV)...
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Preclinical efficacy of a novel dual PI3K/mTOR inhibitor, CMG002, alone and in combination with sorafenib in hepatocellular carcinoma: AbstractPurposeSorafenib has been the only first systemic drug that improves survival of patients with advanced hepatocellular carcinoma (HCC). However, because the response rate of sorafenib is relatively low, novel therapeutic strategies are needed to improve survival in patients with HCC. This study investigated the effect of CMG002 alone and in combination with...
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A drug–drug interaction study to assess the potential effect of acid-reducing agent, lansoprazole, on quizartinib pharmacokinetics: AbstractPurposeQuizartinib, a potent, selective FMS-like tyrosine kinase 3 (FLT3) inhibitor, is currently in phase 3 development for patients with FLT3–internal tandem duplication-mutated acute myeloid leukemia (AML). Acid-reducing agents (ARAs; e.g., proton pump inhibitors) are frequently used during AML treatment. Since quizartinib demonstrates pH-dependent solubility,...
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A population pharmacokinetic analysis of the oral CYP17 lyase and androgen receptor inhibitor seviteronel in patients with advanced/metastatic castration-resistant prostate cancer or breast cancer: AbstractPurposeSeviteronel is an orally-administered selective cytochrome P450c17a 17,20-lyase and androgen receptor inhibitor with anti-tumor activity in vitro and in vivo, and clinical activity in men with advanced castration-resistant prostate cancer (CRPC) and men and women with advanced breast cancer....
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Prospective, observational practice survey of applied skin care and management of cetuximab-related skin reactions: PROSKIN study: AbstractPurposeThe study aimed to investigate strategies to prevent and treat cetuximab-induced skin reactions and their perceived effectiveness in patients with metastatic colorectal cancer (mCRC) and recurrent/metastatic squamous cell cancer of the head and neck (SCCHN).MethodsThis open-label, prospective observational study was conducted in Switzerland.ResultsA total...
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A phase I study of the PARP inhibitor niraparib in combination with bevacizumab in platinum-sensitive epithelial ovarian cancer: NSGO AVANOVA1/ENGOT-OV24: AbstractBackgroundCombining poly(ADP-ribose) polymerase (PARP) inhibitors with antiangiogenic agents appeared to enhance activity vs PARP inhibitors alone in a randomized phase II trial.Materials and methodsIn AVANOVA (NCT02354131) part 1, patients with measurable/evaluable high-grade serous/endometrioid platinum-sensitive ovarian cancer received...
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A simple ex vivo bioassay for 5-FU transport into healthy buccal mucosal cells: AbstractPurposeFluorouracil (5-FU), a chemotherapeutic agent widely used in the treatment of numerous common malignancies, causes oral mucositis in a proportion of patients. The contribution of drug transport processes to the development of this toxicity is currently unknown. This work aimed to establish and optimise a simple phenotyping assay for 5-FU uptake into primary buccal mucosal cells (BMC).MethodsThe uptake kinetics...
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Nanoparticle albumin-bound paclitaxel: a big nano for the treatment of gastric cancer: AbstractGastric cancer (GC) is the third cause of cancer-related death worldwide. Patients with unresectable GC can be treated with chemotherapy such as paclitaxel, which is a microtubule stabilizer. The use of nanoparticle albumin-bound paclitaxel (nab-ptx) avoids hypersensitivity reactions due to the absence of solvent needed to dissolve paclitaxel and it can be administered at higher doses. The ABSOLUTE randomized...
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Sunitinib rechallenge in advanced renal cell carcinoma: outcomes of a multicenter retrospective study: AbstractPurposeThe aim of this multicenter study was to evaluate the clinical outcomes of patients with metastatic renal cell carcinoma (mRCC) who received sunitinib retreatment.MethodsClinical data from patients treated with sunitinib rechallenge in nine Spanish centers were retrospectively analyzed. All patients received first-line sunitinib until progression or intolerance, followed by one or...
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Current status of nanomedicine in the chemotherapy of breast cancer: AbstractDespite the efforts that have been made in the field of breast cancer therapy, it is a leading cause of cancer death in women and a major health problem. The current treatments combine several strategies (surgery, radiotherapy, immunotherapy, hormone therapy, and chemotherapy) depending on cancer subtype and tumour stage. The use of chemotherapy is required in certain circumstances, like before or after surgery or in advanced...
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Efficacy and safety of CT-P6 versus reference trastuzumab in HER2-positive early breast cancer: updated results of a randomised phase 3 trial: AbstractPurposeNeoadjuvant CT-P6, a trastuzumab biosimilar, demonstrated equivalent efficacy to reference trastuzumab in a phase 3 trial of HER2-positive early-stage breast cancer (EBC) (NCT02162667). We report post hoc analyses evaluating pathological complete response (pCR) and breast pCR alongside additional efficacy and safety measures.MethodsFollowing...
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A phase I delayed-start, randomized and pharmacodynamic study of metformin and chemotherapy in patients with solid tumors: AbstractPurposeMetformin activates AMP-related pathways leading to inactivation of mammalian target of rapamycin (mTOR) and suppression of its downstream effectors, crucial for cancer growth. Epidemiologic studies showed a reduced incidence and improved survival in cancer patients. We conducted a prospective phase I study to assess the safety of metformin in combination with...
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Population pharmacokinetic analysis of high-dose methotrexate in pediatric and adult oncology patients: AbstractPurposeHigh-dose methotrexate (HD-MTX) is widely used in pediatric and adult oncology treatment regimens. This study aimed to develop a population pharmacokinetic model to characterize pediatric and adult MTX exposure across various disease types and dosing regimens, and to evaluate exposure–toxicity relationships.MethodsMTX pharmacokinetic data from pediatric and adult patients were collected....
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Cisplatin ototoxicity in children: risk factors and its relationship with polymorphisms of DNA repair genes ERCC1, ERCC2, and XRCC1: AbstractPurposeWe aimed to investigate the cisplatin-related hearing toxicity and its possible relationship with polymorphic variants in DNA repair genes, ERCC1, ERCC2, and XRCC1.MethodsFifty patients treated with cisplatin in the past were included in the study. There were 29 females and 21 males; mean age 13.4 ± 6.0 years). The polymorphism in DNA repair genes was...
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Genetic increases in olfactory bulb BDNF do not enhance survival of adult-born granule cells.: Related ArticlesGenetic increases in olfactory bulb BDNF do not enhance survival of adult-born granule cells.Chem Senses. 2019 Sep 28;:Authors: McDole B, Berger R, Guthrie KAbstract Adult-born neurons produced in the dentate gyrus subgranular zone (SGZ) develop as excitatory hippocampal granule cells (GCs), while those from the subventricular zone (SVZ) migrate to the olfactory bulb (OB), where...
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Taste Sensitivity Is Associated with Food Consumption Behavior but not with Recalled Pleasantness.: Taste Sensitivity Is Associated with Food Consumption Behavior but not with Recalled Pleasantness.Foods. 2019 Sep 27;8(10):Authors: Puputti S, Hoppu U, Sandell MAbstract As taste perception varies between individuals, it might be important in explaining food consumption behavior. Previous studies have focused on sensitivity to the bitter tastant PROP (6-n-propylthiouracil) concerning eating...
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Accuracy of position determination in Ca^{2+} signaling.: Related ArticlesAccuracy of position determination in Ca^{2+} signaling.Phys Rev E. 2019 Aug;100(2-1):022401Authors: Wasnik VH, Lipp P, Kruse KAbstract A living cell senses its environment and responds to external signals. In this paper, we study theoretically the precision at which cells can determine the position of a spatially localized transient extracellular signal. To this end, we focus on the case where the stimulus is converted...
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Gingival solitary chemosensory cells are immune sentinels for periodontitis.: Related ArticlesGingival solitary chemosensory cells are immune sentinels for periodontitis.Nat Commun. 2019 Oct 03;10(1):4496Authors: Zheng X, Tizzano M, Redding K, He J, Peng X, Jiang P, Xu X, Zhou X, Margolskee RFAbstract Solitary chemosensory cells (SCCs) are epithelial sentinels that utilize bitter Tas2r receptors and coupled taste transduction elements to detect pathogenic bacterial metabolites, triggering...
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Emergency front of neck airway: What do trainers in the UK teach? A national survey.: Related ArticlesEmergency front of neck airway: What do trainers in the UK teach? A national survey.J Anaesthesiol Clin Pharmacol. 2019 Jul-Sep;35(3):318-323Authors: Qazi I, Mendonca C, Sajayan A, Boulton A, Ahmad IAbstract Background and Aims: Front of neck airway (FONA) is the final step to deliver oxygen in the difficult airway management algorithms. The Difficult Airway Society 2015 guidelines have...
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The Ventrain Device: A Future Role in Difficult Airway Algorithms?: The Ventrain Device: A Future Role in Difficult Airway Algorithms?A A Pract. 2019 Sep 16;:Authors: Morrison S, Aerts S, Saldien VAbstract The Ventrain is a small, manually operated, single-use, inspiratory flow-adjustable ventilation device that generates positive pressure during inspiration and, through a Bernoulli effect within the device, active suction during expiration. It was designed to provide emergency ventilation...
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Management of Difficult Tracheal Intubation: A Closed Claims Analysis.: Related ArticlesManagement of Difficult Tracheal Intubation: A Closed Claims Analysis.Anesthesiology. 2019 Oct;131(4):818-829Authors: Joffe AM, Aziz MF, Posner KL, Duggan LV, Mincer SL, Domino KBAbstract WHAT WE ALREADY KNOW ABOUT THIS TOPIC: Difficult or failed intubation is a major contributor to morbidity for patients and liability for anesthesiologists.Updated difficult airway management guidelines and incorporation...
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A novel anatomical consideration on the exposed segment of the facial artery: ABSTRACTSIntroductionAn understanding of the location and depth of the facial artery (FA) is essential in aesthetic surgery and various cosmetic procedures. The purpose of this study was to clarify the three‐dimensional topography of the exposed segment (ES) of the FA and to provide information to help minimize complications during clinical procedures.Materials & MethodsFrom 50 embalmed adult cadavers, the undissected...
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Eosinopenia as a marker of diagnosis and prognostic to distinguish bacterial from aseptic meningitis in pediatrics: AbstractProcalcitonin (PCT) has proven its efficacy to distinguish bacterial from aseptic meningitis in children. Nevertheless, its use in routine is limited by its cost and availability, especially in low- and middle-income countries. It is now acknowledged that eosinopenia is a marker of infection and/or severity of the systemic inflammatory response. Although no study ever demonstrated...
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Fusobacterium nucleatum tumor DNA levels are associated with survival in colorectal cancer patients: AbstractThere is increasing evidence indicating a role for Fusobacterium nucleatum (F. nucleatum) in colorectal cancer (CRC) development and prognosis. This study evaluated F. nucleatum as a prognostic biomarker, by assessing its association with post-diagnosis survival from CRC. From September 2008 to April 2012 CRC patients (n = 190) were recruited from three hospitals within the Czech Republic....
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Real-world efficacy of bezlotoxumab for prevention of recurrent Clostridium difficile infection: a retrospective study of 46 patients in five university hospitals in Finland: AbstractReports on real-world experience on efficacy of bezlotoxumab (BEZ) has been lacking thus far. We retrospectively studied the efficacy and safety of BEZ in preventing the recurrence of Clostridium difficile infection (CDI) in five university hospitals in Finland. Seventy-three percent of our 46 patients remained free...
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Prenatally androgenized female rats develop uterine hyperplasia when adult: Publication date: Available online 4 October 2019Source: Molecular and Cellular EndocrinologyAuthor(s): Silvana Rocío Ferreira, Alicia Alejandra Goyeneche, María Florencia Heber, Giselle Adriana Abruzzese, Carlos Marcelo Telleria, Alicia Beatriz MottaAbstractPrenatal hyperandrogenization (PH) is hypothesized as one of the main factors contributing to the development of polycystic ovary syndrome (PCOS). In this study, we aimed...
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Better continuity of the facial nerve demonstrated in the temporal bone on three‐dimensional T1‐weighted imaging with volume isotropic turbo spin echo acquisition than that with fast field echo at 3.0 tesla MRI: AbstractIntroductionThree‐dimensional (3D) T1‐weighted imaging (T1WI) is used for evaluation of the facial nerve. The signal intensity of normal and pathological facial nerves has been well evaluated at both 1.5T and 3.0T MRI after gadolinium (Gd)‐enhancement with various pulse sequences....
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Implementation of a Computerized Decision Support System for Computed Tomography Scan Requests for Nontraumatic Headache in the Emergency Department: Publication date: Available online 4 October 2019Source: The Journal of Emergency MedicineAuthor(s): Ana Royuela, Cristina Abad, Agustina Vicente, Alfonso Muriel, Rut Romera, Borja M. Fernandez-Felix, Jesus Corres, Patricia Fernandez Bustos, Angelica Ortega, Julio Heras-Mosteiro, Raquel Garcia Latorre, Javier ZamoraAbstractBackgroundNontraumatic headache...
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Reversible Acute Blindness in Suspected Metformin-Associated Lactic Acidosis: Publication date: Available online 4 October 2019Source: The Journal of Emergency MedicineAuthor(s): Seung Ryu, Se-Kwang Oh, Seung-Ha Son, Won-Joon Jeong, Yeon-Ho You, Young-Rok HamAbstractBackgroundMetformin is commonly used for the treatment of type 2 diabetes mellitus. Renal insufficiency is one of the contraindications for its use. Inadvertent prescription in patients with renal insufficiency may lead to metformin-associated...
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Accidental Pediatric Paliperidone Ingestion Resulting in Delayed Profound Tachycardia: Publication date: Available online 4 October 2019Source: The Journal of Emergency MedicineAuthor(s): Heather A. Borek, Nathan P. CharltonAbstractBackgroundPaliperidone is an atypical antipsychotic that is approved to treat schizophrenia in patients 12 years of age and older. There are minimal data on the clinical effects of exposure in the < 12-year-old age group.Case ReportWe report the case of a 7-year-old...
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Radiologic Imaging in Trauma Patients with Cervical Spine Immobilization at a Pediatric Trauma Center: Publication date: Available online 4 October 2019Source: The Journal of Emergency MedicineAuthor(s): Brandi C. Barnes, Pradip P. Kamat, Courtney M. McCracken, Matthew T. Santore, Michael D. Mallory, Harold K. Simon, Carmen Denease SultonAbstractBackgroundPediatric trauma patients with cervical spine (CS) immobilization using a cervical collar often require procedural sedation (PS) for radiologic...
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Xanthogranulomatous pyelonephritis with associated renal cell carcinoma: Xanthogranulomatous pyelonephritis is associated with obstruction, stones and infection. CT is the mainstay of diagnosis, but appearances can mimic other conditions, including renal cell carcinoma. Nephrectomy is commonly recommended, but conservative treatment with antibiotics has been described after tissue diagnosis. We present a case of xanthogranulomatous pyelonephritis with concomitant renal cell carcinoma, which was an...
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Melanotic neuroectodermal tumour of infancy presenting as a lytic lesion in femur: a rare tumour at a rare site with an unusual behaviour: Melanotic neuroectodermal tumour of infancy (MNTI) is an uncommon tumour, predominantly occurring in head and neck, mostly maxilla, but also in skull and mandible. Although a benign lesion, it is known to recur in 15%–27% of cases, and rarely, may undergo malignant transformation. We present a case of a 5-month-old female patient, who presented with a gradually...
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Aneurysmal bone cyst in the cervical spine:
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Induction of IgG2 and IgG4 B‐cell memory following sublingual immunotherapy for ryegrass pollen allergy: AbstractBackgroundWhilst treatment for atopic rhinitis is aimed mostly to relieve symptoms, only allergen‐specific immunotherapy (AIT) is targeted to modify the natural history of allergic diseases. This results in sustained clinical tolerance, even when treatment has stopped. The immunomodulatory effects of AIT are attributed mainly to increased regulatory T cell function and increased allergen‐specific...
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Cancers, Vol. 11, Pages 1497: Comprehensive Metab...
Allergology InternationalRecent advances in eosinophil-related diseasesPublication date: October 2019Source: Allergology International, Volume 68, Issue 4Author(s): Hiroshi NakajimaAllergology InternationalFri Oct 04, 2019 05:58Upper respiratory tract infectionAge-related pathology associated with H1N1 A/California/07/2009 influenza virus infection.Related ArticlesAge-related pathology associated with H1N1 A/California/07/2009 influenza virus infection. Am J Pathol. 2019 Oct 01;: Authors: Bissel...
pubmed: future oncologyMolecular basis and rationale for combining immune checkpoint inhibitors with chemotherapy in non-small cell lung cancer.Related ArticlesMolecular basis and rationale for combining immune checkpoint inhibitors with chemotherapy in non-small cell lung cancer. Drug Resist Updat. 2019 Sep 17;46:100644 Authors: Leonetti A, Wever B, Mazzaschi G, Assaraf YG, Rolfo C, Quaini F, Tiseo M, Giovannetti E Abstract Immunotherapy has prompted a paradigm shift in advanced non-small cell lung...
Targeted Intervention to Increase Awareness of Opioid Overprescribing Significantly Reduces Narcotic Prescribing Within an Academic Orthopaedic PracticePublication date: Available online 4 October 2019Source: Journal of Surgical EducationAuthor(s): Connor King, John Curran, Shwetha Devanagondi, Tessa Balach, Megan Conti MicaObjectiveTo evaluate the impact of a targeted intervention focused on increasing awareness of opioid overprescribing within an academic orthopaedic practice.DesignRetrospective...
BMC Research NotesA new PacBio genome sequence of an Australian Pyrenophora tritici-repentis race 1 isolateThe necrotrophic fungal pathogen Pyrenophora tritici-repentis (Ptr) is the causal agent of tan spot a major disease of wheat. We have generated a new genome resource for an Australian Ptr race 1 isolate V1 to sup...BMC Research NotesThu Oct 03, 2019 17:00Malaria outbreak investigation in Tanquae Abergelle district, Tigray region of Ethiopia: a case–control studyWe investigated this outbreak...
PeerJ Computer ScienceDifferent expression pattern of flowering pathway genes contribute to male or female organ development during floral transition in the monoecious weed Ambrosia artemisiifolia L. (Asteraceae)The highly allergenic and invasive weed Ambrosia artemisiifolia L. is a monoecius plant with separated male and female flowers. The genetic regulation of floral morphogenesis is a less understood field in the reproduction biology of this species. Therefore the objective of this work was to...
Medical Image AnalysisSegmentation and Quantification of Infarction without Contrast Agents via Spatiotemporal Generative Adversarial LearningPublication date: Available online 4 October 2019Source: Medical Image AnalysisAuthor(s): Chenchu Xu, Joanne Howey, Pavlo Ohorodnyk, Mike Roth, Heye Zhang, Shuo LiAbstractAccurate and simultaneous segmentation and full quantification (all indices are required in a clinical assessment) of the myocardial infarction (MI) area are crucial for early diagnosis and...
MedgadgetComplex Hydrogel Structures to Host Living Cells Printed Using New TechniqueHydrogels are one of the hottest materials in biomedical research these days, as anyone following this publication will attest to. They're biocompatible, have the squishy consistency of soft tissues, and they can be tinkered with to host living cells, deliver drugs, and hopefully one day serve as replacements for diseased tissues and organs. Hydrogels' unique lightness and softness, though, makes it hard to 3D print...
ScienceDirect Publication: TalantaPET probe with Aggregation Induced Emission characteristics for the specific turn-on of aromatasePublication date: 1 February 2020Source: Talanta, Volume 208Author(s): Renbo Wu, Song Liu, Yajing Liu, Yuli Sun, Hao Xiao, Yong Huang, Zequn Yang, Zehui WuAbstractAromatase is an attractive target for the diagnosis and treatment of breast cancer. To combine the anti-photobleaching properties of Aggregation Induced Emission (AIE) with the high sensitivity and whole-body...
Nutrients, Vol. 11, Pages 2377: The Effect of Coffee Consumption on the Prevalence of Diabetes Mellitus: The 2012–2016 Korea National Health and Nutrition Examination SurveyNutrients, Vol. 11, Pages 2377: The Effect of Coffee Consumption on the Prevalence of Diabetes Mellitus: The 2012–2016 Korea National Health and Nutrition Examination Survey Nutrients doi: 10.3390/nu11102377 Authors: Yejee Lim Youngmi Park Sun Kyu Choi Soyeon Ahn Jung Hun Ohn An inverse association between coffee consumption and...
Journal of Clinical MedicineJCM, Vol. 8, Pages 1633: Percutaneous Computed Tomography-Guided Coaxial Core Biopsy for the Diagnosis of Pancreatic TumorsJCM, Vol. 8, Pages 1633: Percutaneous Computed Tomography-Guided Coaxial Core Biopsy for the Diagnosis of Pancreatic Tumors Journal of Clinical Medicine doi: 10.3390/jcm8101633 Authors: Su Liu Chao Chiang Yen Tsai Endoscopic, ultrasound-guided tissue acquisition (EUS-TA) with rapid on-site evaluation is recommended as a first choice in the diagnosis...
Antibiotics, Vol. 8, Pages 176: The Preoperative Inflammatory Status Affects the Clinical Outcome...
Antibiotics, Vol. 8, Pages 176: The Preoperative Inflammatory Status Affects the Clinical Outcome in Cardiac SurgeryAntibiotics, Vol. 8, Pages 176: The Preoperative Inflammatory Status Affects the Clinical Outcome in Cardiac Surgery Antibiotics doi: 10.3390/antibiotics8040176 Authors: D'Agostino Cappabianca Rotunno Castellaneta Quagliara Carrozzo Mastro Charitos Beghi Aims: There are many reasons for the increase in post-operative mortality and morbidity in patients undergoing surgery. In fact, an...
Diiodothyronines regulate metabolic homeostasis in primary human hepatocytes by modulating mTORC1...
Diiodothyronines regulate metabolic homeostasis in primary human hepatocytes by modulating mTORC1 and mTORC2 activity.Related ArticlesDiiodothyronines regulate metabolic homeostasis in primary human hepatocytes by modulating mTORC1 and mTORC2 activity. Mol Cell Endocrinol. 2019 Sep 30;:110604 Authors: Gnocchi D, Ellis ECS, Johansson H, Eriksson M, Bruscalupi G, Steffensen KR, Parini P Abstract Until three decades, ago 3,5-diiodothyronine (3,5-T2) and 3,3'-diiodothyronine (3,3'-T2) were considered...
Gait & PostureLower Extremity Characteristics in Recurrent Clubfoot: Clinical and Gait Analysis Findings that may Influence Decisions for Additional SurgeryPublication date: Available online 4 October 2019Source: Gait & PostureAuthor(s): Kristan A. Pierz, Jessica R. Lloyd, Matthew J. Solomito, Phil Mack, Sylvia ÕunpuuGait & Posture12:59Ground reaction force adaptation during cross-slope walking on railroad ballastPublication date: Available online 4 October 2019Source: Gait & PostureAuthor(s):...
American Journal of Clinical Oncology - Published Ahead-of-PrintDefinitive Radiation Treatment Patterns and Outcomes for Low and Intermediate Risk Prostate Cancer Patients: A Cross-Continental Comparative StudyPurpose: To evaluate early-stage prostate cancer (PCa) radiotherapy treatment patterns and outcomes among Ghanaian men (GM) compared with US men (USM). Materials and Methods: This retrospective study consists of 987 National Comprehensive Cancer Network low risk, favorable intermediate risk,...
Clinical Neurology and NeurosurgeryIncreasing the diagnostic yield of stereotactic brain biopsy using intraoperative histological smearPublication date: Available online 3 October 2019Source: Clinical Neurology and NeurosurgeryAuthor(s): Bertrand Mathon, Aymeric Amelot, Karima Mokhtari, Franck BielleAbstractObjectiveThe negative biopsy rate approaches 5% in the literature. In our institution, this rate was 2.6% (42/1638) over a ten-year period (2007-2016). We aimed to assess the diagnostic yield...
Auris Nasus LarynxA summary of the Clinical Practice Guideline for the Diagnosis and Management of Voice Disorders, 2018 in JapanPublication date: Available online 4 October 2019Source: Auris Nasus LarynxAuthor(s): Hirohito Umeno, Masamitsu Hyodo, Tomoyuki Haji, Hirotaka Hara, Mitsuyoshi Imaizumi, Miyoko Ishige, Masanobu Kumada, Kiyoshi Makiyama, Noriko Nishizawa, Koichiro Saito, Osamu Shiromoto, Atsushi Suehiro, Goro Takahashi, Ichiro Tateya, Koichi Tsunoda, Koichi OmoriAbstractObjectiveTo develop...
Pediatric ganglioglioma of the brainstem and cervicomedullary junction: a retrospective cohort study.Related ArticlesPediatric ganglioglioma of the brainstem and cervicomedullary junction: a retrospective cohort study. J Neurosurg Pediatr. 2019 Oct 04;:1-7 Authors: Oushy S, Perry A, Graffeo CS, Raghunathan A, Carlstrom LP, Daniels DJ Abstract OBJECTIVE: Ganglioglioma is a low-grade central nervous system neoplasm with a pediatric predominance, accounting for 10% of all brain tumors in children. Gangliogliomas...
Anti-Cancer Drugs - Published Ahead-of-Print Efficacy of gefitinib at reduced dose in EGFR mutant...
Anti-Cancer Drugs - Published Ahead-of-PrintEfficacy of gefitinib at reduced dose in EGFR mutant non-small cell lung carcinomaAs a first-generation epidermal growth factor receptor-tyrosine kinase inhibitor, gefitinib was approved by the US Food and Drug Administration for treatment of advanced non-small cell carcinoma with sensitizing EGFR mutations. Gefitinib is known to have adverse effects, which may necessitate dose reduction or even change to alternative preparation of epidermal growth factor...
Biomarkers in the risk assessment for stroke and dementia in atrial fibrillationPurpose of review Atrial fibrillation is one of the most common clinically encountered arrhythmias exhibiting a strong association with a spectrum of cerebral injuries from the occurrence of clinical stroke, subclinical stroke, dementia, and cognitive decline. Dynamic noninvasive specific and sensitive diagnostic tests may allow a personalized approach to the atrial fibrillation patient's treatment based upon quantitative...
Precision medicine in atopic diseasesPurpose of review To analyze the status of precision medicine in atopic diseases. Recent findings Atopic diseases are increasingly recognized as heterogeneous in nature and they can be quite different in severity, response to therapy, triggers, genetic back ground, ancestral risk and type of inflammation. This significant variability in the landscape of atopic diseases is not reflected in the common treatment guidelines that follow 'one fits all' approach for...
Cell Cycle Biomarkers and Soluble Urokinase-Type Plasminogen Activator Receptor for the Prediction of Sepsis-Induced Acute Kidney Injury Requiring Renal Replacement Therapy: A Prospective, Exploratory StudyObjectives: Sepsis-induced acute kidney injury is the dominant acute kidney injury etiology in critically ill patients and is often associated with a need for renal replacement therapy. The indication and timing of renal replacement therapy are controversially discussed. We hypothesized that the...
Electrocatheter-mediated High-voltage Pulsed Radiofrequency of the Dorsal Root Ganglion in the Treatment of Chronic Lumbosacral Neuropathic Pain: A Randomized Controlled StudyObjectives: Despite the interest in scientific community, there is still poor evidence about pulsed radiofrequency efficacy in the treatment of neuropathic pain. In order to determine if high-voltage pulsed radiofrequency plus adhesiolysis (PRF-EA) showed better results than epidural adhesiolysis alone (EA), a randomized, double-blind,...
The roles of fission yeast exonuclease 5 in nuclear and mitochondrial genome stabilityPublication date: November 2019Source: DNA Repair, Volume 83Author(s): Justin L. Sparks, Kimberly J. Gerik, Carrie M. Stith, Bonita L. Yoder, Peter M. BurgersAbstractThe Exo5 family consists of bi-directional, single-stranded DNA-specific exonucleases that contain an iron-sulfur cluster as a structural motif and have multiple roles in DNA metabolism. S. cerevisiae Exo5 is essential for mitochondrial genome maintenance,...
Validation of the YuWell YE680B upper-arm blood pressure monitor in adults according to the ANSI/AAMI/ISO 81060-2: 2013 standardObjective: To evaluate the accuracy of the YuWell YE680B oscillometric upper-arm blood pressure monitor for clinic and home blood pressure measurements in adults according to the American National Standards Institute/the Association for the Advancement of Medical Instrumentation/International Organization for Standardization (ANSI/AAMI/ISO) 81060-2:2013 standard. Method:...
Clinical Tests of the Shoulder: Accuracy and Extension Using Dynamic UltrasoundShoulder pain is a common musculoskeletal disorder that has a significant impact on the patient's quality of life and functional health. Since the shoulder joint is a complex structure, the relevant symptoms of shoulder pain may not directly reflect the underlying pathology. Hence, several shoulder tests have been developed to examine shoulder problems, and their diagnostic accuracy varies. Familiarization with the performance...
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Antioxidants, Vol. 8, Pages 454: The Role of Mitochondria in the Mechanisms of Cardiac Ischemia-Reperfusion Injury: Antioxidants, Vol. 8, Pages 454: The Role of Mitochondria in the Mechanisms of Cardiac Ischemia-Reperfusion InjuryAntioxidants doi: 10.3390/antiox8100454Authors: Kuznetsov Javadov Margreiter Grimm Hagenbuchner Ausserlechner Mitochondria play a critical role in maintaining cellular function by ATP production. They are also a source of reactive oxygen species (ROS) and...
Natural Does Not Mean Safe—The Dirt on Clean Beauty Products ,Courtney Blair Rubin, MD, MBE1; Bruce Brod, MD1Author Affiliations Article Information1Department of Dermatology, University of Pennsylvania, Philadelphia.JAMA Dermatol. Published online September 25, 2019. doi:10.1001/jamadermatol.2019.2724Natural Does Not Mean SafeClean beauty, also known as natural skin care, is having a moment. From 2017 to 2018, the natural skin care market grew by 23% to 1.6 billion dollars, accounting for over 25%...
Lefamulin—A New Antibiotic for Community-Acquired Pneumonia ,Preeti N. Malani, MD, MSJ1,2Author Affiliations Article Information1Division of Infectious Diseases, Department of Internal Medicine, University of Michigan, Ann Arbor2Associate Editor, JAMAJAMA. Published online September 27, 2019. doi:10.1001/jama.2019.16215https://www.nabriva.com/pipeline-researchLefamulinThis semi-synthetic compound inhibits the synthesis of bacterial protein, which is required for bacteria to grow. It acts by binding...
Statin Use in Primary Prevention of Atherosclerotic Cardiovascular Disease According to 5 Major Guidelines for Sensitivity, Specificity, and Number Needed to TreatMartin Bødtker Mortensen, MD, PhD1,2; Børge Grønne Nordestgaard, MD, DMSc2,3Author Affiliations Article InformationJAMA Cardiol. Published online October 2, 2019. doi:10.1001/jamacardio.2019.3665Key PointsQuestion How does the number needed to treat to prevent 1 atherosclerotic cardiovascular disease event compare among 5 major statin...
Small Bowel Volvulus Caused by Small Intestinal B Cell LymphomaSpontaneous Gastric Decompression of Walled-Off Pancreatic NecrosisThe Relationship Between Postoperative Chemotherapy and Remnant Liver Regeneration and Outcomes After Hepatectomy for Colorectal Liver MetastasisAbstractBackgroundPostoperative chemotherapy for treating colorectal liver metastasis (CLM) has been introduced with the aim of improving therapeutic outcomes. However, there is no consensus on the utility of multidisciplinary...
·Pollicisation dans la prise en charge des hypoplasies et aplasies congénitales du pouce, résultats fonctionnels, à propos de 13 casPollicization in the management of congenital hypoplasias and aplasias of the thumb, functional results, about 13 casesSous presse. Épreuves corrigées par l'auteur. Disponible en ligne depuis le mardi 1 octobre 2019P. Curings, D. Adam, C. Le Lardic, P. Perrot, A. Hamel, F. DuteilleRésuméPlan Anatomie chirurgicale·Le lambeau perforant de l'artère fémorale profonde : une...
Spatial-temporal assessment of pollutions in Ekbatan lake using qualitative indices and statistical methodsAbstractThe purpose of this study was to use water quality indices and statistical methods based on physicochemical parameters for spatial-temporal assessment of Ekbatan lake pollution. Sampling stations were selected based on systematic, non-random approach, and it was performed in 7 stations, with intervals of 30 days in 2010–2011. At first, indices model of IRWQI, NSFWQI, and TLI was prepared...
Calculation of mechanical power for pressure-controlled ventilation: author's reply'The pause': honouring the passing of a patient or a collective countertransference for healthcare providers?Disseminated mucormycosisCorrection to: Paediatric intensive care admission blood pressure and risk of death in 30,334 childrenThe authors of the article entitled "Paediatric Intensive Care admission blood pressure and risk of death in 30,334 children" inform that due to an error in their database extraction,...
Towards an Appreciation of Ethics in Social Enterprise Business ModelsAbstractHow can a critical analysis of entrepreneurial intention inform an appreciation of ethics in social enterprise business models? In answering this question, we consider the ethical commitments that inform entrepreneurial action (inputs) and the hybrid organisations that emerge out of these commitments and actions (outputs). Ethical theory can be a useful way to reorient the field of social enterprise so that it is more critical...
Left atrial function and NT-proANP as markers of AF progression and impaired outcome in patients with heart failure with preserved ejection fractionUsefulness of strain imaging echocardiography in arrhythmogenic right ventricular cardiomyopathy: clinical perspectiveAbstractArrhythmogenic right ventricular cardiomyopathy (ARVC) is a rare, but severe disease that predisposes patients to ventricular arrhythmias, heart failure, and increased risk of sudden cardiac death. Because of the broad spectrum...
Endothelial dysfunction, subclinical atherosclerosis and LDL cholesterol are the independent predictors of left atrial functions in hypertensionAbstractLeft atrial function has an important role in determining optimal performance of the heart. Increase of left atrial dysfunction and volume are poor prognostic factors. In this study, we investigated independent determinants of left atrial function in non-diabetic patients with de novo hypertension. The study included 124 consecutive non-diabetic patients...
Weiter- und FortbildungAOTD-Reisestipendium 2019Reisestipendium 2020Neu aufgenommene Akademie-MitgliederNeue Stipendien ausgelobtSeit 1912 gibt es nachweisbar einen regelmäßigen Austausch zwischen japanischen und deutschen Kollegen und seit 1977 Treffen der Deutsch-Japanischen Orthopäden und Unfallchirurgen, um aktuelle Entwicklungen im gemeinsamen Fach aufzugreifen.Was macht eigentlich der NSB?PersonaliaÄrzteschulungen für den ErnstfallReisestipendium 2020Thromboseprophylaxe an das Risikoprofil...
Study on the differential gene expression of elm leaves fed on by Tetraneura akinire SasakiAbstractBackgroundTo study the essential molecular mechanism of gall formation is very important.ObjectiveTo investigate the differential gene expression in leaves fed on by Tetraneura akinire Sasaki and to provide a basis for the better understanding of the essential molecular mechanism of gall formation.MethodsThe infected leaves of the elm were divided into three periods: initial formation period (T2), growth...
Effect of Vitamin C Infusion on Organ Failure and Biomarkers of Inflammation and Vascular Injury in Patients With Sepsis and Severe Acute Respiratory Failure: The CITRIS-ALI Randomized Clinical TrialAlpha A. Fowler III, MD; Jonathon D. Truwit, MD; R. Duncan Hite, MD; et alEditorial: Is High-Dose Vitamin C Beneficial for Patients With Sepsis?; Emily B. Brant, MD; Derek C. Angus, MD, MPHJAMAEffect of Postextubation High-Flow Nasal Oxygen With Noninvasive Ventilation vs High-Flow Nasal Oxygen Alone...
Perioperative Medicine , Propofol and Sevoflurane Differentially Impact MicroRNAs in Circulating Extracellular Vesicles during Colorectal Cancer Resection: A Pilot StudyDominik Buschmann, M.Sc., Ph.D.; Florian Brandes, M.D.; Anja Lindemann, M.Sc., Ph.D.; Melanie Maerte, M.D.; Petra Ganschow, M.D.; Alexander Chouker, M.D.; Gustav Schelling, M.D.; Michael W. Pfaffl, Ph.D.; Marlene Reithmair, M.D., vet.Anesthesiology Published online October 04, 2019. doi:10.1097/ALN.0000000000002986
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