Cancer ScienceMdm2 – open questionsAbstract The Mdm2 oncoprotein and its association with p53 were discovered 30 years ago, and a cornucopia of activities and regulatory pathways have been associated with it. In this review, we will raise questions about Mdm2 and its cousin Mdm4 that we consider worth pursuing in future research, reaching from molecular structures and intracellular activities all the way to development, evolution, and cancer therapy. We anticipate that such research will not only...
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Ophthalmic Plastic & Reconstructive Surgery - Published Ahead-of-PrintEpithelial-Myoepithelial Carcinoma of the Lacrimal Gland: Case Report of Youngest PatientThe authors report a case of extremely uncommon malignancy of lacrimal gland epithelial-myoepithelial carcinoma. This carcinoma is more commonly encountered in salivary glands and comprises 1% of all salivary gland tumors. Its occurrence in the orbit is very rare with only 6 cases reported in the literature, most of which arose in a pleomorphic...
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WHO South-East Asia Journal of Public Health : 2013 - 2(2)Turning commitments into actions: perspectives on emergency preparedness in South-East AsiaRoderico H Ofrin, Anil K Bhola, Nilesh BuddhaWHO South-East Asia Journal of Public Health 2020 9(1):5-14 Emergency preparedness is a continuous process in which risk and vulnerability assessments, planning and implementation, funding, partnerships and political commitment at all levels must be sustained and acted upon. It relates to health systems strengthening,...
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Plastic and Reconstructive Surgery - Current IssueDocosahexaenoic Acid Improves Diabetic Wound Healing in a Rat Model by Restoring Impaired Plasticity of Macrophage Progenitor CellsBackground: Chronic inflammation associated with delayed diabetic wound healing is induced by disturbed polarization of macrophages derived mainly from predisposed progenitor cells in bone marrow. Docosahexaenoic acid plays a critical role in regulating the function of macrophage progenitor cells. The authors evaluated...
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Latest Results for The Journal of Primary PreventionFood Insecurity and Housing Instability Partially Mediate the Association Between Maternal Depression and Child Problem BehaviorAbstract Maternal depression is a risk factor for the development of problem behavior in children. Although food insecurity and housing instability are associated with adult depression and child behavior, how these economic factors mediate or moderate the relationship between maternal depression and child problem behavior...
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pubmed: philosophy for medic...Obesity as a barrier to kidney transplantation: Time to eliminate the body weight bias?Related ArticlesObesity as a barrier to kidney transplantation: Time to eliminate the body weight bias? Semin Dial. 2019 05;32(3):219-222 Authors: MacLaughlin HL, Campbell KL Abstract There is clear evidence that survival rates following transplantation far exceed those for remaining on dialysis, regardless of body size measured by body mass index (BMI). Studies over the past 15 years...
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pubmed: philosophy for medic...Modelling towards a more holistic medicine: The Virtual Physiological Human (VPH).Related ArticlesModelling towards a more holistic medicine: The Virtual Physiological Human (VPH). Morphologie. 2019 Dec;103(343):127-130 Authors: Van Sint Jan S, Geris L Abstract The Virtual Physiological Human (VPH) is a European initiative, rooted in the international Physiome initiative, focusing on establishing a methodological and technological framework, enabling the collaborative...
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pubmed: sleepChronotherapy for reduction of cardiovascular risk.Related ArticlesChronotherapy for reduction of cardiovascular risk. Med Clin (Barc). 2020 Apr 23;: Authors: Hermida RC, Hermida-Ayala RG, Smolensky M Abstract Numerous prospective studies establish that elevated asleep blood pressure (BP) constitutes a significant cardiovascular disease (CVD) risk factor, irrespective of daytime office BP measurements or awake and 24h BP measurements. Moreover, except for a small number of studies with...
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pubmed: sleepAssociations of sleep duration and social jetlag with cardiometabolic risk factors in the study of Latino youth.Related ArticlesAssociations of sleep duration and social jetlag with cardiometabolic risk factors in the study of Latino youth. Sleep Health. 2020 Apr 22;: Authors: Johnson DA, Reid M, Vu TT, Gallo LC, Daviglus ML, Isasi CR, Redline S, Carnethon M Abstract OBJECTIVE: We investigated associations of sleep duration and social jetlag with cardiometabolic outcomes. PARTICIPANTS:...
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AA pubmed: head and neckIntranasal Bolsters: A Novel Technique for Nasal Bone Stabilization.Related ArticlesIntranasal Bolsters: A Novel Technique for Nasal Bone Stabilization. J Craniofac Surg. 2020 Jan/Feb;31(1):e43-e45 Authors: Shokri T, Hilger PA, Lighthall JG Abstract Nasal bone stabilization, in the setting of comminuted nasal fracture or surgical osteotomy, represents a challenging surgical experience. Postoperative shifting of osseous fragments may result in compromised outcomes in an otherwise...
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pubmed: sleepThe Impact of Common Psychiatric and Behavioral Comorbidities on Functional Disability Across Time and Individuals in Post-9/11 Veterans.Related ArticlesThe Impact of Common Psychiatric and Behavioral Comorbidities on Functional Disability Across Time and Individuals in Post-9/11 Veterans. J Trauma Stress. 2020 Apr 27;: Authors: Fortenbaugh FC, Fonda JR, Fortier CB, Amick MM, Milberg WP, McGlinchey RE Abstract Returning veterans often face multiple concurrent psychiatric and behavioral...
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AA pubmed: head and neckOral Health Inequalities in 0-17-year-old Children Referred for Dental Extractions Under General Anaesthesia in Wolverhampton, 2013-2017.Related ArticlesOral Health Inequalities in 0-17-year-old Children Referred for Dental Extractions Under General Anaesthesia in Wolverhampton, 2013-2017. Community Dent Health. 2020 Apr 20;: Authors: Harper RS, Khan I, Chen R, Neville A Abstract OBJECTIVE: Describe the inequalities in oral health in children treated in a hospital located...
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pubmed: health technologyA Tunable Extruded 3D Printing Platform using Thermo-Sensitive Pastes.Related ArticlesA Tunable Extruded 3D Printing Platform using Thermo-Sensitive Pastes. Int J Pharm. 2020 Apr 23;:119360 Authors: Yang Y, Wang X, Lin X, Xie L, Ivone R, Shen J, Yang G Abstract Extruded 3D printing is emerging as an attractive fabrication technology in the field of personalized oral medicines. The objective of this study was to develop a tunable extruded 3D printing platform based on thermo-sensitive...
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Latest Results for Calcified Tissue InternationalDo Older Adults with Low Muscle Mass or Strength, in the Presence of Obesity, Have an Increased Risk of Joint Replacement Over 13 Years?Abstract This study aims to assess whether older adults with low muscle mass or strength, in the presence of obesity, have an increased risk of knee (TKR) and hip replacement (THR) over 13 years. 1082 community-dwelling older adults (51% women; mean age 62.9 ± 7.5 years) were studied at baseline and multiple time...
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pubmed: health technologyNeuroenhancement in surgeons: benefits, risks and ethical dilemmas.Related ArticlesNeuroenhancement in surgeons: benefits, risks and ethical dilemmas. Br J Surg. 2020 Apr 26;: Authors: Patel R, Ashcroft J, Darzi A, Singh H, Leff DR Abstract BACKGROUND: Surgeons traditionally aim to reduce mistakes in healthcare through repeated training and advancement of surgical technology. Recently, performance-enhancing interventions such as neurostimulation are emerging which may offset...
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JIN : Last 20 articlesCOVID-19: Possible Impact of the Genetic Background in <b><i>IFNL</i></b> Genes on Disease OutcomesJ Innate ImmunJIN : Last 20 articles15hΣήμανση της παραπάνω ενότητας ως αναγνωσμένης ScienceDirect Publication: International Journal of Biological MacromoleculesExtraction and biological activity of exopolysaccharide produced by <em>Leuconostoc mesenteroides</em> SN-8Publication date: 15 August 2020Source: International Journal of Biological...
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CancersCancers, Vol. 12, Pages 1084: Multimodal Targeted Deep Sequencing of Circulating Tumor Cells and Matched Cell-Free DNA Provides a More Comprehensive Tool to Identify Therapeutic Targets in Metastatic Breast Cancer PatientsCancers, Vol. 12, Pages 1084: Multimodal Targeted Deep Sequencing of Circulating Tumor Cells and Matched Cell-Free DNA Provides a More Comprehensive Tool to Identify Therapeutic Targets in Metastatic Breast Cancer Patients Cancers doi: 10.3390/cancers12051084 Authors: Corinna...
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Latest Results for Aesthetic Plastic SurgeryRisk and Reward: Public Perception of Gluteal Fat Grafting SafetyAbstract Background This study aims to understand how sociodemographic factors influence perceptions of "Brazilian Butt Lift" (BBL), the cosmetic procedure with the highest reported mortality rate, among adult women. We also investigate whether education about risks changes willingness to receive this procedure. Methods A Qualtrics© survey including education...Latest Results for Aesthetic...
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Proceedings of the National Academy of Sciences current issueEvolution of male pregnancy associated with remodeling of canonical vertebrate immunity in seahorses and pipefishes [Evolution]A fundamental problem for the evolution of pregnancy, the most specialized form of parental investment among vertebrates, is the rejection of the nonself-embryo. Mammals achieve immunological tolerance by down-regulating both major histocompatibility complex pathways (MHC I and II). Although pregnancy has evolved...
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Proceedings of the National Academy of Sciences current issueCorrection for Uyhazi et al., Pumilio proteins utilize distinct regulatory mechanisms to achieve complementary functions required for pluripotency and embryogenesis [Correction]DEVELOPMENTAL BIOLOGY Correction for "Pumilio proteins utilize distinct regulatory mechanisms to achieve complementary functions required for pluripotency and embryogenesis," by Katherine E. Uyhazi, Yiying Yang, Na Liu, Hongying Qi, Xiao A. Huang, Winifred Mak,...
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Αφαίρεση διαφημίσεων Free Radical Biology and MedicineDual role of oxidative stress-JNK activation in autophagy and apoptosis induced by nickel oxide nanoparticles in human cancer cellsPublication date: Available online 27 April 2020Source: Free Radical Biology and MedicineAuthor(s): Yik-Lam Cho, Hayden Weng Siong Tan, Quaiser Saquib, Yi Ren, Javed Ahmad, Rizwan Wahab, Weifeng He, Boon-Huat Bay, Han-Ming ShenFree Radical Biology and Medicine11hMicroRNA-based regulatory mechanisms underlying the synergistic...
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PLOS Genetics: New ArticlesMutations in <i>SPATA13/ASEF2</i> cause primary angle closure glaucomaby Naushin H. Waseem, Sancy Low, Amna Z. Shah, Deepa Avisetti, Pia Ostergaard, Michael Simpson, Katarzyna A. Niemiec, Belen Martin-Martin, Hebah Aldehlawi, Saima Usman, Pak Sang Lee, Anthony P. Khawaja, Jonathan B. Ruddle, Ameet Shah, Ege Sackey, Alexander Day, Yuzhen Jiang, Geoff Swinfield, Ananth Viswanathan, Giovanna Alfano, Christina Chakarova, Heather J. Cordell, David F. Garway-Heath,...
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Latest Results for Cellular and Molecular Life SciencesNoncoding RNAs in Duchenne and Becker muscular dystrophies: role in pathogenesis and future prognostic and therapeutic perspectivesAbstract Noncoding RNAs (ncRNAs), such as miRNAs and long noncoding RNAs, are key regulators of gene expression at the post-transcriptional level and represent promising therapeutic targets and biomarkers for several human diseases, including Duchenne and Becker muscular dystrophies (DMD/BMD). A role for ncRNAs in...
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edoc: No conditions. Results ordered -Date Deposited.The 2018 ISHLT/APM/AST/ICCAC/STSW recommendations for the psychosocial evaluation of adult cardiothoracic transplant candidates and candidates for long-term mechanical circulatory supportThe psychosocial evaluation is well-recognized as an important component of the multifaceted assessment process to determine candidacy for heart transplantation, lung transplantation, and long-term mechanical circulatory support (MCS). However, there is no consensus-based...
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Latest Results for EndocrineCOVID-19, hypothalamo-pituitary-adrenal axis and clinical implicationsLatest Results for Endocrine18hIdentification of gene co-expression modules and hub genes associated with the invasiveness of pituitary adenomaAbstract In pituitary adenoma (PA), invasiveness is the main cause of recurrence and poor prognosis. Thus, identifying specific biomarkers for diagnosis and effective treatment of invasive PAs is of great clinical significance. In this study, from the Gene Expression...
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International Journal of Molecular SciencesIJMS, Vol. 21, Pages 3112: Involvement of Senescence and Mitochondrial Fission in Endothelial Cell Pro-Inflammatory Phenotype Induced by Angiotensin IIIJMS, Vol. 21, Pages 3112: Involvement of Senescence and Mitochondrial Fission in Endothelial Cell Pro-Inflammatory Phenotype Induced by Angiotensin II International Journal of Molecular Sciences doi: 10.3390/ijms21093112 Authors: Miyao Cicalese Kawai Cooper Boyer Elliott Forrester Kuroda Rizzo Hashimoto...
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MicroorganismsMicroorganisms, Vol. 8, Pages 642: Temporal Dynamics of Bacterial Communities in a Pilot-Scale Vermireactor Fed with Distilled Grape MarcMicroorganisms, Vol. 8, Pages 642: Temporal Dynamics of Bacterial Communities in a Pilot-Scale Vermireactor Fed with Distilled Grape Marc Microorganisms doi: 10.3390/microorganisms8050642 Authors: María Gómez-Brandón Manuel Aira Natielo Santana Marcos Pérez-Losada Jorge Domínguez Vermicomposting has been found as a profitable approach to dispose of...
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Cancers, Vol. 12, Pages 1091: The Circular RNA Landscape of Non-Small Cell Lung Cancer CellsCancers, Vol. 12, Pages 1091: The Circular RNA Landscape of Non-Small Cell Lung Cancer Cells Cancers doi: 10.3390/cancers12051091 Authors: Nele Van Der Steen Yanhong Lyu Anne K. Hitzler Andrea C. Becker Jeanette Seiler Sven Diederichs The class of circular RNA (circRNA) is characterized by head-to-tail bonds between exons formed by backsplicing. Here, we provide a resource of circRNA expression in a comprehensive...
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International Journal of Environmental Research and Public HealthIJERPH, Vol. 17, Pages 3071: An Inventory of European Birth CohortsIJERPH, Vol. 17, Pages 3071: An Inventory of European Birth Cohorts International Journal of Environmental Research and Public Health doi: 10.3390/ijerph17093071 Authors: Pansieri Pandolfini Clavenna Choonara Bonati Many birth cohorts have been carried out. We performed a review of European birth cohorts to see the countries involved, provide a panorama of the current...
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Antibiotics, Vol. 9, Pages 215: Prevalence and Antimicrobial Susceptibility Patterns of Bacterial Pathogens in Urinary Tract Infections in University Hospital of Campania "Luigi Vanvitelli" between 2017 and 2018Antibiotics, Vol. 9, Pages 215: Prevalence and Antimicrobial Susceptibility Patterns of Bacterial Pathogens in Urinary Tract Infections in University Hospital of Campania "Luigi Vanvitelli" between 2017 and 2018 Antibiotics doi: 10.3390/antibiotics9050215 Authors: Folliero Caputo Rocca Chianese...
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Cerebral venous sinus thrombosis following transsphenoidal surgery for craniopharyngioma: A case report.: Related ArticlesCerebral venous sinus thrombosis following transsphenoidal surgery for craniopharyngioma: A case report.World J Clin Cases. 2020 Mar 26;8(6):1158-1163Authors: Chang T, Yang YL, Gao L, Li LHAbstract BACKGROUND: Cerebral venous sinus thrombosis (CVST) is a rare condition in patients with craniopharyngioma following transsphenoidal surgery. CASE SUMMARY: A 56-year-old...
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Hyoid-complex elevation and stimulation technique restores swallowing function in patients with lateral medullary syndrome: Two case reports.: Related ArticlesHyoid-complex elevation and stimulation technique restores swallowing function in patients with lateral medullary syndrome: Two case reports.World J Clin Cases. 2020 Mar 26;8(6):1142-1149Authors: Jiang YE, Lyu QQ, Lin F, You XT, Jiang ZLAbstract BACKGROUND: A swallowing disorder may occur following a brainstem stroke, especially one...
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Scaphoid metastasis as the first sign of occult gastroesophageal junction cancer: A case report.: Related ArticlesScaphoid metastasis as the first sign of occult gastroesophageal junction cancer: A case report.World J Clin Cases. 2020 Apr 06;8(7):1287-1294Authors: Zhang YJ, Wang YY, Yang Q, Li JBAbstract BACKGROUND: Metastatic tumors of the hand are very rare. They are usually late manifestations of massive advanced malignancies. However, a small portion of acrometastases are indications...
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Atypical presentation of SARS-CoV-2 infection: A case report.: Related ArticlesAtypical presentation of SARS-CoV-2 infection: A case report.World J Clin Cases. 2020 Apr 06;8(7):1265-1270Authors: Li RL, Chu SG, Luo Y, Huang ZH, Hao Y, Fan CHAbstract BACKGROUND: The first case of pneumonia subsequently attributed to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) occurred in Wuhan, Hubei Province on December 8, 2019. The symptoms included fever, coughing, and breathing difficulties....
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Systemic treatment for severe concentrated sulfuric acid burns in an adult male at high altitude: A case report.Related ArticlesSystemic treatment for severe concentrated sulfuric acid burns in an adult male at high altitude: A case report. World J Clin Cases. 2020 Apr 06;8(7):1337-1342 Authors: Zhao RM, Li Y, Chao SW, Wang HJ Abstract BACKGROUND: The aim of this study was to report a case of a patient who suffered from severe concentrated sulfuric acid burns while working at high altitude. This...
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Multiple neurofibromas plus fibrosarcoma with familial NF1 pathogenicity: A case report.: Related ArticlesMultiple neurofibromas plus fibrosarcoma with familial NF1 pathogenicity: A case report.World J Clin Cases. 2020 Apr 06;8(7):1306-1310Authors: Wang Y, Lu XF, Chen LL, Zhang YW, Zhang BAbstract BACKGROUND: Neurofibromatosis (NF) is a genetic disease consisting of seven types, of which types 1 to 4 are caused by a dominant autosomal gene mutation; such disease sometimes arises in patients...
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Head & Face Medicine - Latest ArticlesEvaluation of the relationship between malar projection and lower facial convexity in terms of perceived attractiveness in 3-dimensional reconstructed imagesThis study aimed to investigate dental student's perception of facial attractiveness with regard to different combinations of anteroposterior malar-jaw positions using 3-dimensional (3-D) reconstructed images ...Head & Face Medicine - Latest Articles5hΣήμανση της παραπάνω ενότητας ως αναγνωσμένης American...
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Cancer Research Online First ArticlesDe novo lipogenesis alters the phospholipidome of esophageal adenocarcinomaThe incidence of esophageal adenocarcinoma is rising, survival remains poor, and new tools to improve early diagnosis and precise treatment are needed. Cancer phospholipidomes quantified with mass spectrometry imaging can support objective diagnosis in minutes using a routine frozen tissue section. However, whether mass spectrometry imaging can objectively identify primary esophageal adenocarcinoma...
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Applying the New Guidelines of HER2 Testing in Breast CancerAbstract Purpose of Review The human epidermal growth factor receptor 2 (HER2) is an important prognostic and predictive biomarker in the breast cancer. The American Society of Clinical Oncology/College of American Pathology (ASCO/CAP) has published HER2 testing guidelines in breast cancer. We herein reviewed the HER2 testing guidelines in breast cancer with a focus on the application of the current guidelines. ...Latest Results2hΣήμανση...
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JBC Papers in PressThe two paralogous kiwellin proteins KWL1 and KWL1-b from maize are structurally related and have overlapping functions in plant defense [Plant Biology]Many plant-pathogenic bacteria and fungi deploy effector proteins that down-regulate plant defense responses and reprogram plant metabolism for colonization and survival in planta. Kiwellin (KWL) proteins are a widespread family of plant-defense proteins that target these microbial effectors. The KWL1 protein from maize (corn,...
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Associations of telomerase reverse transcriptase rs10069690 and rs2736100 polymorphisms with papillary thyroid carcinoma: Papillary thyroid carcinoma is one of the most common endocrine malignancies. Telomerase reverse transcriptase rs10069690 and rs2736100 polymorphisms have been studied in thyroid carcinomas with different ethnicity, but the results were inconsistent. Therefore, we evaluated the relationship between rs10069690 and rs2736100 polymorphisms and papillary thyroid carcinoma risk and...
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Duodenal neoplasms of gastric phenotype: reports of two cases and a brief review of literature: Duodenal neoplasms of gastric phenotype are uncommon epithelial neoplasms. Pyloric gland adenomas should be recognized as neoplasms with risk for transformation into invasive adenocarcinoma (Choi et al. 2018). Here we report the case histories of two male patients, who presented with duodenal polypoid lesion. Endoscopic polypectomy and endoscopic submucosal dissection were carried out, respectively. Histopathologically,...
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β-Defensin Strengthens Antimicrobial Peritoneal Mast Cell Response: Mast cells (MCs) are engaged in the processes of host defense, primarily via the presence of receptors responsible for the detection of pathogen-associated molecular patterns (PAMPs). Since BDs are exclusively host defense molecules, and MCs can elicit the antimicrobial response, this study is aimed at determining whether BDs might be involved in MC pathogen defense. We found that defensin BD-2 significantly augments the mRNA and...
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Rare Somatic MEN1 Gene Pathogenic Variant in a Patient Affected by Atypical Parathyroid Adenoma: Objective. Atypical parathyroid adenoma is a rare neoplasm, showing atypical histological features intermediate between classic benign adenoma and the rarest parathyroid carcinoma, whose the clinical behaviour and outcome is not yet understood or predictable. Up to date only two cases of atypical adenoma were found associated to a MEN1 syndrome, and only one was proved to carry a pathogenic variant of...
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Evaluation of Changes in Macular Perfusion Detected by Optical Coherence Tomography Angiography following 3 Intravitreal Monthly Bevacizumab Injections for Diabetic Macular Edema in the IMPACT Study: Objective. To evaluate macular perfusion changes following intravitreal bevacizumab injections for diabetic macular edema (DME) using spectral domain optical coherence tomography angiography (SD-OCTA). Methods. This study was a prospective noncomparative interventional case series. Treatment naïve patients...
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Distinguishing Kawasaki Disease from Febrile Infectious Disease Using Gene Pair Signatures: Kawasaki disease (KD) is an acute systemic vasculitis of childhood with prolonged fever, and the diagnosis of KD is mainly based on clinical criteria, which is prone to misdiagnosis with other febrile infectious (FI) diseases. Currently, there remain no effective molecular markers for KD diagnosis. In this study, we aimed to use a relative-expression-based method k-TSP and resampling framework to identify...
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Effect of Quercetin on PC12 Alzheimer's Disease Cell Model Induced by Aβ25-35 and Its Mechanism Based on Sirtuin1/Nrf2/HO-1 Pathway: Objective. This study is aimed at studying the effect of quercetin on the Alzheimer disease cell model induced by Aβ25-35 in PC12 cells and its mechanism of action. Methods. The AD cell model was established by Aβ25-35. Quercetin was used at different concentrations (0, 10, 20, 40, and 80 μmol/L). The morphology of cells was observed, and the effect on cell survival...
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Efficacy and Safety of Lamivudine or Telbivudine in Preventing Mother-to-Child Transmission of Hepatitis B Virus: A Real-World Study: Background. There are few large sample studies evaluating the safety and efficacy of lamivudine (LAM) or telbivudine (LdT) in preventing hepatitis B mother-to-child transmission (MTCT) in highly viremic mothers in the third trimester of pregnancy in real-world settings. The purpose of this study was to analyze a large sample size of HBV-infected mothers to better understand...
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Comparative Lipid-Lowering/Increasing Efficacy of 7 Statins in Patients with Dyslipidemia, Cardiovascular Diseases, or Diabetes Mellitus: Systematic Review and Network Meta-Analyses of 50 Randomized Controlled Trials: Objective. The drug efficacy may differ among different statins, and evidence from head-to-head comparisons is sparse and inconsistent. The study is aimed at comparing the lipid-lowering/increasing effects of 7 different statins in patients with dyslipidemia, cardiovascular diseases,...
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Left Ventricular Ejection Fraction Is Associated with the Risk of Thrombus in the Left Atrial Appendage in Patients with Atrial Fibrillation: Introduction. Atrial fibrillation (AF) is associated with high risk of ischemic stroke. The most frequent thrombus location in AF is the left atrial appendage (LAA). Transthoracic echocardiography (TTE) is a basic diagnostic examination in patients (pts) with AF. Objectives. To analyse the relations between basic echocardiographic features, well-established...
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Thumb Interphalangeal Joint Replacement as an Alternative to Joint Fusion: Arthrodesis is the generally accepted treatment for symptomatic osteoarthritis of the interphalangeal (IP) joint of the thumb. For 7 thumbs in 5 patients, an IP joint replacement was offered as a pain alleviating and motion conserving treatment option for osteoarthritis. In these cases, an offlabel use of the SR-PIP prosthesis was performed. All patients did well postoperatively with reasonable pain-free range of motion of...
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The Diagnostic Yields and Safety of Double-Balloon Enteroscopy in Obscure Gastrointestinal Bleeding and Incomplete Small Bowel Obstruction: Comparison between the Adults and Elderly: Background. Double-balloon enteroscopy (DBE) is widely used worldwide. However, comparisons between the diagnostic yields in adults and the elderly remain scarce. Aim. The aim of this study is to compare the diagnostic yields and safety of DBE between adults and elderly with obscure gastrointestinal bleeding and incomplete...
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High Expression of Both Resistin and Fascin-1 Predicts a Poor Prognosis in Patients with Colorectal Cancer: Emerging evidence indicates that resistin and fascin-1 may possess a causal role in the development of several types of cancers. However, the clinical significance of resistin expression in colorectal cancer (CRC) tissues is unclear, and there are no reports of any correlation between resistin and fascin-1. Our analyses explored the expression of resistin in CRC tissue and analyzed the clinical...
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99mTc-CXCR4-L for Imaging of the Chemokine-4 Receptor Associated with Brain Tumor Invasiveness: Biokinetics, Radiation Dosimetry, and Proof of Concept in Humans: Overexpression of the chemokine-4 receptor (CXCR4) in brain tumors is associated with high cancer cell invasiveness. Recently, we reported the preclinical evaluation of 99mTc-CXCR4-L (cyclo-D-Tyr-D-[NMe]Orn[EDDA-99mTc-6-hydrazinylnicotinyl]-Arg-NaI-Gly) as a SPECT radioligand capable of specifically detecting the CXCR4 protein. This research...
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The Efficacy of Pegylated Liposomal Doxorubicin-Based Neoadjuvant Chemotherapy in Breast Cancer: A Retrospective Case-Control Study in Taiwan: Breast cancer is a global issue regarding women's health, and high incident rates remain in the Taiwanese female population. Chemotherapy, using anthracycline-based chemotherapeutic agents in neoadjuvant settings, has been introduced as a promising new therapeutic option for treatment of invasive breast cancer. Set apart from conventional anthracycline regimens...
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Host ESCRT factors are recruited during Chikungunya virus infection and are required the intracellular viral replication cycle [Cell Biology]: Chikungunya fever (CHIKF) is a re-emerging zoonotic disease caused by Chikungunya virus (CHIKV), a member of the alphavirus genus in the Togaviridae family. Only a few studies have reported on the host factors required for intracellular CHIKV trafficking. Here, we conducted an imaging-based small interfering RNA (siRNA) screen to identify human host factors...
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The Efficacy and Safety of Elobixibat for the Elderly with Chronic Constipation: A Multicenter Retrospective Cohort Study: Backgrounds and Aims. Elobixibat is a bile acid transporter inhibitor indicated for constipation. Previous studies were performed mainly for the nonelderly and were biased to female. We analyzed the efficacy of elobixibat also for the elderly and male. Materials and Methods. This was a multicenter retrospective cohort study. The subjects were patients aged ≥20 years treated for...
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Impacts of Outdoor Air Pollution on Human Semen Quality: A Meta-Analysis and Systematic Review: Introduction. Several studies have explored the association between outdoor air pollution and semen quality. However, the results were inconsistent. We performed the current meta-analysis to evaluate the role of outdoor air pollution in semen quality. Material and Methods. Databases including PubMed, Web of Science, and Embase were searched to identify relevant studies. Relative data in participants under...
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ARDS and Massive Pulmonary Embolism: The Combined Use of Extracorporeal Membrane Oxygenation (ECMO) with Thrombolytics: Pancreatitis causes a systemic inflammatory response that can lead to acute respiratory distress syndrome (ARDS). We present a case of severe ARDS complicated by a pulmonary embolism (PE) in a 39-year-old female that developed rapidly progressive pancreatitis secondary to hypertriglyceridemia.
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Fatal Methanol Poisoning Caused by Drinking Adulterated Locally Distilled Alcohol: Wakiso District, Uganda, June 2017: Background. Methanol, an industrial solvent, can cause illness and death if ingested. In June 2017, the Uganda Ministry of Health was notified of a cluster of deaths which occurred after drinking alcohol. We investigated to determine the cause of outbreak, identify risk factors, and recommend evidence-based control measures. Methods. We defined a probable case as acute loss of eyesight...
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Methotrexate-Associated Lymphoproliferative Disorder Developed Ectopically in the Maxillary Gingiva and Bilateral Lungs: A 58-year-old Japanese woman complained of a painful right maxillary premolar gingiva and ulcer. The patient had RA and had been treated with several immunosuppressive drugs such as methotrexate. Head and neck CT indicated no obvious bone destruction with maxillary. However, chest CT indicated the presence of nodular mass of the bilateral lungs. FDG-PET/CT indicated the presence...
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Lipoprotein Particle Predictors of Arterial Stiffness after 17 Years of Follow Up: The Malmö Diet and Cancer Study: Background. Central arterial stiffness is a surrogate of cardiovascular risk and predicts cardiovascular mortality. Apolipoprotein B lipoproteins are also established cardiovascular risk factors. It is not known whether specific lipoprotein subclasses measured in the Malmö Diet and Cancer Study and previously shown to be associated with coronary heart disease also predict arterial stiffening...
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Fibrinogen as a Prognostic Predictor in Pediatric Patients with Sepsis: A Database Study: Background. Systemic inflammatory response and vascular endothelial cell injury during sepsis lead to coagulopathy. Fibrinogen has been reported as a biomarker of coagulopathy; however, the prognostic value of fibrinogen remains undefined in pediatric patients with sepsis. The aim of this study was to assess fibrinogen level on pediatric intensive care unit (PICU) admission and to elucidate the relationship...
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IL-33 Inhibits Hepatitis B Virus through Its Receptor ST2 in Hydrodynamic HBV Mouse Model: Interleukin-33 has been demonstrated to be associated with liver damage. However, its potential value in hepatitis B virus (HBV) infection remains unknown. This study was designed to investigate the role of IL-33 in hydrodynamic HBV mouse model. Different doses of IL-33 were used to treat HBV wild-type, ST2 knockout, CD8+ T depletion, NK depletion C57BL/6 mice and C.B-17 SCID and nod SCID mouse, respectively....
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Propofol Attenuates Hypoxia-Induced Inflammation in BV2 Microglia by Inhibiting Oxidative Stress and NF-κB/Hif-1α Signaling: Hypoxia-induced neuroinflammation typically causes neurological damage and can occur during stroke, neonatal hypoxic-ischemic encephalopathy, and other diseases. Propofol is widely used as an intravenous anesthetic. Studies have shown that propofol has antineuroinflammatory effect. However, the underlying mechanism remains to be fully elucidated. Thus, we aimed to investigate...
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Resveratrol Attenuates High Glucose-Induced Vascular Endothelial Cell Injury by Activating the E2F3 Pathway: Type 2 diabetes mellitus (T2DM) is the most common metabolic disease. High glucose-induced macrovascular disease and microangiopathy are major complications of diabetes. E2F3, a member of the E2F transcription factor family, is closely related to cardiovascular diseases. Resveratrol, a nonflavonoid polyphenolic compound widely found in plants, has been shown to have cardiovascular protection....
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Robotic Partial Nephrectomy with Indocyanine Green Fluorescence Navigation: Partial nephrectomy (PN) is a recommended type of treatment of localised renal tumors. Real-time intraoperative imaging technique, such as fluorescence imaging with indocyanine green (ICG) administration helps to improve intraoperative and postoperative outcomes in patients who underwent PN. Our work presents results of patients who underwent robotic PN with ICG navigation. A total of 37 patients underwent robotic PN with...
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Exosomes as Mediators of Cell-to-Cell Communication in Thyroid Disease: Exosomes are a type of extracellular vehicle, formed by budding cell membranes, containing proteins, DNA, and RNA. Concentrated cargoes from parent cells are enveloped in exosomes, which are cell specific and may have functions in the recipient cell, reflecting a novel physiological and pathological mechanism in disease development. As a transmitter, exosomes shuttle to different cells or tissues and mediate communications among...
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Adenocarcinoma with Neuroendocrine Differentiation of the Colon Accompanying Osteoclast-Like Giant Cells: Introduction. Neuroendocrine differentiation in colorectal cancer is reportedly associated with poorer grade of tumor differentiation, nodal and distant metastasis, and other unfavorable features, contributing to a worse clinical outcome. Colorectal cancer with osteoclast-like giant cells (OGCs) is extremely rare. Case Presentation. An 86-year-old woman was diagnosed as double cancer of the transverse...
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Association of Brain-Gut Peptides with Inflammatory Cytokines in Moyamoya Disease: Systemic inflammation has been shown to play a pivotal role in the pathogenesis of moyamoya disease (MMD). Brain-gut peptides exhibit regulatory effects in the secretion of proinflammatory cytokines. To investigate the association between brain-gut peptides and inflammation in the occurrence of MMD, 41 patients with MMD, as well as 74 age- and sex-matched healthy individuals were enrolled. The levels of four brain-gut...
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A Small-Sized Population of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Shows High Stemness Properties and Therapeutic Benefit: Mesenchymal stem cells (MSCs) represent a promising means to promote tissue regeneration. However, the heterogeneity of MSCs impedes their use for regenerative medicine. Further investigation of this phenotype is required to develop cell therapies with improved clinical efficacy. Here, a small-sized population of human umbilical cord blood-derived MSCs (UCB-MSCs)...
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Crosstalk of MicroRNAs and Oxidative Stress in the Pathogenesis of Cancer: Oxidative stress refers to an imbalance between reactive oxygen species (ROS) generation and body's capability to detoxify the reactive mediators or to fix the relating damage. MicroRNAs are considered to be important mediators that play essential roles in the regulation of diverse aspects of carcinogenesis. Growing studies have demonstrated that the ROS can regulate microRNA biogenesis and expression mainly through modulating...
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Pulmonary Alveolar Microlithiasis: An Isolated Case in a Hispanic Male: Pulmonary alveolar microlithiasis (PAM) is an uncommon hereditary lung disease characterized by widespread deposition of calcium phosphate microliths within the alveolar spaces. It is considered an autosomal recessive disease with a mutation in a gene encoding a sodium phosphate cotransporter. The imaging findings in the early phase of disease can be mistaken for miliary tuberculosis or sarcoidosis. However, the classic radiologic...
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Associations between the Neutrophil-to-Lymphocyte Ratio and Diabetic Complications in Adults with Diabetes: A Cross-Sectional Study: Objective. The neutrophil-to-lymphocyte ratio (NLR) is an inexpensive and easily measurable laboratory index indicating systemic inflammation, while the application of many other inflammatory markers has been limited in daily clinical practice. However, large population studies about investigating the associations of the NLR level with diabetic complications including...
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OtolaryngologyDeveloping world perspectives in otolaryngology: infectious complications in otolaryngologyNo abstract availableOtolaryngologyWed Apr 22, 2020 03:00Head and neck surgical antibiotic prophylaxis in resource-constrained settingsPurpose of review Antimicrobial resistance represents a global threat and causes almost 700 000 deaths per year. The rapid dissemination of resistant bacteria is occurring globally, turning this into the primary threat to public health in the 21st century and...
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Remove ads Plastic and Reconstructive Surgery - Current IssueA Structured Facial Feminization Fresh Tissue Surgical Simulation Laboratory Improves Trainee Confidence and KnowledgeNo abstract availablePlastic and Reconstructive Surgery - Current IssueTue Apr 28, 2020 09:49Discussion: Docosahexaenoic Acid Improves Diabetic Wound Healing in a Rat Model by Restoring Impaired Plasticity of Macrophage Progenitor CellsNo abstract availablePlastic and Reconstructive Surgery - Current IssueTue Apr 28, 2020...
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Respiratory Care current issueThe Timed Inspiratory Effort Index as a Weaning Predictor: Analysis of Intra- and Interobserver ReproducibilityBACKGROUND:Prolonged ventilatory weaning may expose patients to unnecessary discomfort, increase the risk of complications, and raise the costs of hospital treatment. In this scenario, indexes that reliably predict successful liberation can be helpful.OBJECTIVE:To evaluate the intra- and interobserver reproducibility of the timed inspiratory effort index as...
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Cellular and Molecular BiologyA potential ex vivo infection model of human induced pluripotent stem cell-3D organoids beyond coronavirus disease 2019.Related ArticlesA potential ex vivo infection model of human induced pluripotent stem cell-3D organoids beyond coronavirus disease 2019. Histol Histopathol. 2020 Apr 27;:18223 Authors: Zhou H, Liu LP, Fang M, Li YM, Zheng YW Abstract The novel coronavirus disease 2019 (COVID-19) outbreak began in the city of Wuhan, whereupon it rapidly spread throughout...
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Rare CancersAcute promyelocytic leukemia during pregnancy: A case report and 10-year institutional review of hematologic malignancies during pregnancy.Related ArticlesAcute promyelocytic leukemia during pregnancy: A case report and 10-year institutional review of hematologic malignancies during pregnancy. Pathol Res Pract. 2019 Dec;215(12):152672 Authors: Fei F, Faye-Petersen OM, Vachhani P, Jamy O, Reddy VV Abstract Acute promyelocytic leukemia (APL) manifesting during pregnancy is a very rare...
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Head and NeckThe functional head impulse test: Comparing gain and percentage of correct answers.Related ArticlesThe functional head impulse test: Comparing gain and percentage of correct answers. Prog Brain Res. 2019;248:241-248 Authors: Versino M, Colnaghi S, Corallo G, Mandalà M, Ramat S Abstract OBJECTIVES: The video head impulse test (vHIT) provides as output a gain value that summarizes the behavior of the vestibulo-ocular reflex as the ratio of a measure of eye movement to the corresponding...
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Head and NeckMajor head and neck reconstruction during the COVID-19 pandemic: The University of Pittsburgh approach.Related ArticlesMajor head and neck reconstruction during the COVID-19 pandemic: The University of Pittsburgh approach. Head Neck. 2020 Apr 27;: Authors: Ranasinghe V, Mady LJ, Kim S, Ferris RL, Duvvuri U, Johnson JT, Solari MG, Sridharan S, Kubik M Abstract The 2019 novel coronavirus (COVID-19) pandemic has created significant challenges to the delivery of care for patients with advanced...
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Alcohol and HomeostasisThe Timing of Water and Beverage Consumption During the Day Among Children and Adults in the United States: Analyses of NHANES 2011-2016 Data.Related ArticlesThe Timing of Water and Beverage Consumption During the Day Among Children and Adults in the United States: Analyses of NHANES 2011-2016 Data. Nutrients. 2019 Nov 08;11(11): Authors: Vieux F, Maillot M, Rehm CD, Barrios P, Drewnowski A Abstract Dietary Guidelines for Americans 2015-20 recommend replacing sugar sweetened...
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Latest Results for Applied Microbiology and BiotechnologyAnalysis of microbial contamination of household water purifiersAbstract Household water purifiers are increasingly used to treat drinking water at the household level, but their influence on the microbiological safety of drinking water has rarely been assessed. In this study, representative purifiers, based on different filtering processes, were analyzed for their impact on effluent water quality. The results showed that purifiers reduced...
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J Clin NeurosciApplication of the Willis Covered Stent in the treatment of intracranial unruptured aneurysms in internal carotid artery: A retrospective single-center experience.Related ArticlesApplication of the Willis Covered Stent in the treatment of intracranial unruptured aneurysms in internal carotid artery: A retrospective single-center experience. J Clin Neurosci. 2020 Apr 23;: Authors: Yan P, Zhang Y, Ma C, Liang F, Zhu H, Jiang C Abstract The purpose of this study was to retrospectively...
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Nature Communications - current - nature.com science feedsCytosine base editors with minimized unguided DNA and RNA off-target events and high on-target activityNature Communications, Published online: 28 April 2020; doi:10.1038/s41467-020-15887-5Cytosine base editors have been reported to induce off-target mutations in DNA and RNA. Here the authors identify next-generation CBEs with reduced guide-independent off-target editing profiles and retain high on-target editing activity.Nature Communications...
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pubmed: "world neurosurg"[jo...Management of Aneurysmal Subarachnoid Hemorrhage - Variation in Clinical Practice and Unmet Need for Follow-up among Survivors - A Single Center Perspective.Related ArticlesManagement of Aneurysmal Subarachnoid Hemorrhage - Variation in Clinical Practice and Unmet Need for Follow-up among Survivors - A Single Center Perspective. World Neurosurg. 2020 Apr 24;: Authors: Delpirou-Nouh C, Samkutty DG, Chandrashekhar S, Santucci JA, Ford L, Xu C, Hollabaugh KM, Bohnstedt...
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International journal of pediatric otorhinolaryngology,http://goo.gl/4YdRhzPediatric laryngoscopy and bronchoscopy during the COVID-19 pandemic: A four-center collaborative protocol to improve safety with perioperative management strategies and creation of a surgical tent with disposable drapes.Related ArticlesPediatric laryngoscopy and bronchoscopy during the COVID-19 pandemic: A four-center collaborative protocol to improve safety with perioperative management strategies and creation of a surgical...
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1.Phytomedicine. 2020 Apr 16;70:153227. doi: 10.1016/j.phymed.2020.153227. [Epub ahead of print]Breast Tumor Microenvironment: Emerging target of therapeutic phytochemicals.Malla RR1, Deepak K2, Merchant N3, Dasari VR4.Author informationAbstractTriple negative breast cancer (TNBC) is the most aggressive and challenging form of breast cancers. Tumor microenvironment (TME) of TNBC is associated with induction of metastasis, immune system suppression, escaping immune detection and drug resistance. TME...
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pubmed: "j korean neurosurg ...Preface : Invited Issue Editor Professor Dachling Pang and the Changing Concepts in Spinal Dysraphism during the Last Two Decades.Related ArticlesPreface : Invited Issue Editor Professor Dachling Pang and the Changing Concepts in Spinal Dysraphism during the Last Two Decades. J Korean Neurosurg Soc. 2020 Apr 27;: Authors: Kim CY, Kim SK PMID: 32336062 [PubMed - as supplied by publisher]pubmed: "j korean neurosurg ...Tue Apr 28, 2020 15:33Enlargement of Extraspinal...
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Radiotherapy and OncologyImplications for cancer care in iran during COVID-19 pandemicPublication date: Available online 25 April 2020Source: Radiotherapy and OncologyAuthor(s): Mohammad Amin Akbarzadeh, Mohammad-Salar HosseiniRadiotherapy and OncologyTue Apr 28, 2020 17:25Radiotherapy imaging: an unexpected ally in fighting COVID 19 pandemicPublication date: Available online 25 April 2020Source: Radiotherapy and OncologyAuthor(s): Luca Boldrini, Nicola Dinapoli, Vincenzo ValentiniRadiotherapy and...
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Clinical and translational oncologyDynamic monitoring of HER2 amplification in circulating DNA of patients with metastatic colorectal cancer treated with cetuximabAbstract Purpose Cetuximab (CTX) has been used to treat metastatic colorectal cancer (mCRC) with wild-type (wt) RAS and BRAF genes. Meanwhile HER2 amplification reportedly denoted CTX-resistant mCRC tumors. We investigated whether monitoring of HER2 amplification in circulating DNA allowed early detection of mCRC progression and CTX resistance....
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ScienceDirect Publication: Annals of Allergy, Asthma & ImmunologyNot Just a Rash Diagnosis! The Allergist's Role in Improving Recognition of Omenn SyndromePublication date: Available online 28 April 2020Source: Annals of Allergy, Asthma & ImmunologyAuthor(s): Aparna Daley, Doerthe A. Andreae, Alexandra HorwitzScienceDirect Publication: Annals of Allergy, Asthma & ImmunologyTue Apr 28, 2020 20:35Rapid Desensitization to antineoplastic drugs in an outpatient Immunoallergology Clinic: outcomes...
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BioMed Research InternationalIdentification and Analysis of Estrogen Receptor α Promoting Tamoxifen Resistance-Related lncRNAs70-75% breast cancer patients are estrogen receptor alpha positive (ERα+), and the antiestrogen drug tamoxifen has been used for the past three decades. However, in 20-30% of these patients, tamoxifen therapy fails due to intrinsic or acquired resistance. A previous study has showed ERα signaling still exerts significant roles in the development of tamoxifen resistance and...
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bioRxiv Subject Collection: Evolutionary BiologyOceans apart: Heterogeneous patterns of parallel evolution in sticklebacks [NEW RESULTS]An important model system for the study of genomic mechanisms underlying parallel ecological adaptation in the wild is the three-spined stickleback (Gasterosteus aculeatus), which has repeatedly colonized and adapted to freshwater from the sea throughout the northern hemisphere. Previous studies have identified numerous genomic regions showing consistent genetic...
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Journal of the American Chemical Society: Latest Articles (ACS Publications)[ASAP] An Analysis of the Binding Function and Structural Organization of the Protein CoronaJournal of the American Chemical SocietyDOI: 10.1021/jacs.0c01853Journal of the American Chemical Society: Latest Articles (ACS Publications)Tue Apr 28, 2020 07:00[ASAP] Programming Cell–Cell Communications with Engineered Cell Origami ClustersJournal of the American Chemical SocietyDOI: 10.1021/jacs.0c01580Journal of the American...
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Journal of Bone and Mineral MetabolismEffects of mild hyperbaric oxygen on osteoporosis induced by hindlimb unloading in ratsAbstract Introduction Disuse-induced bone loss is caused by a suppression of osteoblastic bone formation and an increase in osteoclastic bone resorption. There are few data available for the effects of environmental conditions, i.e., atmospheric pressure and/or oxygen concentration, on osteoporosis. This study examined the effects of mild hyperbaric oxygen at 1317 hPa with...
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VaccinesVaccines, Vol. 8, Pages 204: Systemic Sclerosis and Vaccinations: A Register-Based Cohort Study about Seasonal Influenza and Streptococcus pneumoniae Vaccination Rate and Uptake from Liguria Regional Center, Northwest ItalyVaccines, Vol. 8, Pages 204: Systemic Sclerosis and Vaccinations: A Register-Based Cohort Study about Seasonal Influenza and Streptococcus pneumoniae Vaccination Rate and Uptake from Liguria Regional Center, Northwest Italy Vaccines doi: 10.3390/vaccines8020204 Authors:...
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NanomaterialsNanomaterials, Vol. 10, Pages 842: Enhancement of Birefringence in Reduced Graphene Oxide Doped Liquid CrystalNanomaterials, Vol. 10, Pages 842: Enhancement of Birefringence in Reduced Graphene Oxide Doped Liquid Crystal Nanomaterials doi: 10.3390/nano10050842 Authors: Mareddi Bharath Kumar Mohammad Awwal Adeshina Daekyung Kang Youngho Jee Taewan Kim Muhan Choi Jonghoo Park We investigated the effect of reduced graphene oxide (rGO) doping on the birefringence of 5CB liquid crystal (LC)....
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Disseminated histoplasmosis in primary Sjögren syndrome: A case report.: Related ArticlesDisseminated histoplasmosis in primary Sjögren syndrome: A case report.World J Clin Cases. 2020 Apr 06;8(7):1319-1325Authors: Li JA, Cheng YY, Cui ZT, Jiang W, Zhang WQ, Du ZH, Gao B, Xie YY, Meng HMAbstract BACKGROUND: Sjögren syndrome (SS) is a chronic and systemic autoimmune disease characterized by lymphocytic infiltration of the exocrine glands. And histoplasmosis is an invasive mycosis caused by...
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Clinical effects of apatinib mesylate for treatment of multiple brain micrometastases: Two case reports.: Related ArticlesClinical effects of apatinib mesylate for treatment of multiple brain micrometastases: Two case reports.World J Clin Cases. 2020 Apr 06;8(7):1326-1336Authors: Guo JH, Wang YY, Zhang JW, Liu PM, Hao YJ, Duan HRAbstract BACKGROUND: Apatinib is a small-molecule multitargeted tyrosine kinase inhibitor. Apatinib has demonstrated encouraging antitumor activities. This study...
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