Initiative Suggests Angiosarcoma Therapies [News ...Identification of Therapeutic Vulnerabilities in ...The effect of systemic rifampicin treatment on inf...Conventional magnetic resonance imaging–based rad...Resource-Stratified Guideline-Based Cancer Care Sh...Trigeminal Neuralgia with Radiographic Absence of ...Inflammation-induced hypoparathyroidism triggered... Journal of Medical Imaging and Radiation Oncolog...High-risk human papillomavirus-mediated adenocarci...Proton therapy for head and neck...
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Initiative Suggests Angiosarcoma Therapies [News in Brief]Angiosarcoma Project researchers have uncovered some details about the molecular underpinnings of angiosarcoma, pointing to potential therapeutic options. Their work also suggests that a research model based on direct patient participation can overcome common barriers to studying rare diseases.Cancer Discovery current issueWed Apr 01, 2020 10:05Not So FASt: Tumor Cells Resisting Death Drive CAR T-cell Dysfunction [In the Spotlight]Summary:In...
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Identification of Therapeutic Vulnerabilities in Small-cell Neuroendocrine Prostate CancerPurpose:Small-cell neuroendocrine prostate cancer (SCNPC) exhibits an aggressive clinical course and incidence rates seem to be increasing following resistance to potent androgen receptor (AR) antagonists. Currently, treatment options are limited and few model systems are available to identify new approaches for treatment. We sought to evaluate commonalities between SCNPC and other aggressive neuroendocrine...
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The effect of systemic rifampicin treatment on inferior alveolar nerve regeneration in rats following crush injury: Axonal regeneration of the inferior alveolar nerve (IAN) is a therapeutic target for functional recovery after peripheral nerve injury. Rifampicin exerts anti‐apoptotic, anti‐inflammatory, and anti‐oxidant effects on nerve tissues that may enhance functional recovery after peripheral nerve injury. The aim of the present study was to evaluate the therapeutic effects of systemic rifampicin...
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Conventional magnetic resonance imaging–based radiomic signature predicts telomerase reverse transcriptase promoter mutation status in grade II and III gliomasAbstract Purpose Telomerase reverse transcriptase (TERT) promoter mutation status is an important biomarker for the precision diagnosis and prognosis prediction of lower grade glioma (LGG). This study aimed to construct a radiomic signature to noninvasively predict the TERT promoter status in LGGs. Methods Eighty-three local patients with pathology-confirmed...NeuroradiologyWed...
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Resource-Stratified Guideline-Based Cancer Care Should Be a Priority: Historical Context and Examples of Success.Related ArticlesResource-Stratified Guideline-Based Cancer Care Should Be a Priority: Historical Context and Examples of Success. Am Soc Clin Oncol Educ Book. 2020 Mar;40:1-10 Authors: Hunter N, Dempsey N, Tbaishat F, Jahanzeb M, Al-Sukhun S, Gralow JR Abstract Low- and middle-income countries (LMICs) are shouldering most of the burden of the rapidly increasing cancer incidence and mortality...
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Three Cases of Trigeminal Neuralgia with Radiographic Absence of Meckel's Cave.: Related ArticlesThree Cases of Trigeminal Neuralgia with Radiographic Absence of Meckel's Cave.Stereotact Funct Neurosurg. 2019;97(4):249-254Authors: Cleary DR, Handwerker J, Ansari H, Ben-Haim SAbstract Trigeminal neuralgia (TN) is a debilitating but treatable disease. Classic TN has referable vascular compression of the trigeminal nerve, but rarely secondary sources of anatomic compression will present, including...
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Inflammation-induced hypoparathyroidism triggered by combination immune checkpoint blockade for melanoma.Related ArticlesInflammation-induced hypoparathyroidism triggered by combination immune checkpoint blockade for melanoma. J Immunother Cancer. 2019 02 21;7(1):52 Authors: Trinh B, Sanchez GO, Herzig P, Läubli H Abstract BACKGROUND: Treatment with a combination of PD-1 and CTLA-4 targeted checkpoint inhibition has improved outcome of melanoma patients and led to durable remissions but is also associated...
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Journal of Medical Imaging and Radiation OncologyEvaluation of the anterior inferior tibiofibular and anterior talofibular ligaments using 2D oblique coronal imaging and 3D isotropic resolution T2‐weighted fast spin‐echo sequences at 3.0 T: Is there additional diagnostic value?Abstract Introduction To compare diagnostic performance of additional two‐dimensional (2D) oblique coronal view and three‐dimensional (3D) T2‐weighted fast spin‐echo(FSE) images for diagnosing injury of the anterior inferior...
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High-risk human papillomavirus-mediated adenocarcinoma of palatine tonsil.: Related ArticlesHigh-risk human papillomavirus-mediated adenocarcinoma of palatine tonsil.Pathol Res Pract. 2020 Mar 19;:152924Authors: Alexiev BA, Behdad A, Lu X, Cheng E, Samant SAbstract We describe the case of a human papillomavirus-mediated adenocarcinoma of palatine tonsil in a 51-year-old male. Histologically, the tumor exhibited a predominantly cribriform and tubular (glandular) growth of cuboidal and columnar...
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Proton therapy for head and neck squamous cell carcinomas: A review of the physical and clinical challenges.: Related ArticlesProton therapy for head and neck squamous cell carcinomas: A review of the physical and clinical challenges.Radiother Oncol. 2020 Mar 27;147:30-39Authors: Beddok A, Vela A, Calugaru V, Tessonnier T, Kubes J, Dutheil P, Gerard A, Vidal M, Goudjil F, Florescu C, Kammerer E, Benezery K, Herault J, Poortmans P, Bourhis J, Thariat J, GORTEC, the 3 French proton centersAbstract...
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Discoid drug‐induced lupus erythematosus induced by anti‐TNF agents is a very rare subtype of cutaneous lupus: 3 cases and literature reviewWiley: Dermatologic Therapy: Table of ContentsWed Apr 01, 2020 21:00Coronavirus disease 2019 (COVID‐19): facts and controversiesWiley: Dermatologic Therapy: Table of ContentsWed Apr 01, 2020 21:00Severe de‐novo palmoplantar and nail psoriasis complicating Nivolumab treatment for metastatic melanoma.Abstract Nivolumab, a fully human IgG4 immune checkpoint modulator,...
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Orbital Hydatid Cyst: A 31-year-old woman presented to the emergency department with a history of blurred vision in the left eye over a 4-week period and progressive bulging of the left eye over a 2-week period. Physical examination revealed nontender proptosis of the left eye, paresis of the left abducens nerve, and…
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Advanced Mycosis Fungoides: A 53-year-old man with a history of treated stage 1A mycosis fungoides that had been diagnosed 7 years earlier presented with a 2-month history of new and rapidly progressing lesions on his face and body. Examination of the head and neck showed multiple coalescing subcutaneous nodular lesions and…
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Benign and Malignant Granular Cell Tumor of the Hypopharynx: Two Faces of a Rare Entity: AbstractGranular cell tumors (GCT) are rare soft tissue tumors that involve the head and neck in 50% of patients. Two distinct variants of GCT, one benign (bGCT) and the other malignant (mGCT), involving the hypopharynx, a subsite of the larynx, are presented here. The clinical presentations, radiographic features, pathologic diagnosis in these two variants of GCT are discussed. The mGCT was diagnosed only after...
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The Efficacy of Surgical Excision Plus Adjuvant Multimodal Therapies in the Treatment of Keloids: A Systematic Review and Meta-Analysis.: Related ArticlesThe Efficacy of Surgical Excision Plus Adjuvant Multimodal Therapies in the Treatment of Keloids: A Systematic Review and Meta-Analysis.Dermatol Surg. 2020 Mar 27;:Authors: Ellis MM, Jones LR, Siddiqui F, Sunkara PR, Ozog DMAbstract BACKGROUND: Research evaluating the efficacy of multimodal therapy for the treatment of keloids has reported...
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Delayed Traumatic Pseudoaneurysm of the Dorsal Nasal Artery.: Related ArticlesDelayed Traumatic Pseudoaneurysm of the Dorsal Nasal Artery.J Craniofac Surg. 2020 Mar 27;:Authors: Kim TH, Lim EJ, Kim S, Park JHAbstract A pseudoaneurysm is an uncommon pathology arising from any artery in the human body. It typically presents as a pulsatile swelling in contact with a blood vessel. Of pseudoaneurysms of the head and neck region, the most common site is the superficial temporal artery while that...
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Analysis of HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinomas and Paired Normal Mucosae Reveals Cyclin D1 Deregulation and Compensatory Effect of Cyclin D2.: Related ArticlesAnalysis of HPV-Positive and HPV-Negative Head and Neck Squamous Cell Carcinomas and Paired Normal Mucosae Reveals Cyclin D1 Deregulation and Compensatory Effect of Cyclin D2.Cancers (Basel). 2020 Mar 26;12(4):Authors: Novotný J, Bandúrová V, Strnad H, Chovanec M, Hradilová M, Šáchová J, Šteffl M, Grušanović...
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Luteolin-7-O-Glucoside Inhibits Oral Cancer Cell Migration and Invasion by Regulating Matrix Metalloproteinase-2 Expression and Extracellular Signal-Regulated Kinase Pathway.: Related ArticlesLuteolin-7-O-Glucoside Inhibits Oral Cancer Cell Migration and Invasion by Regulating Matrix Metalloproteinase-2 Expression and Extracellular Signal-Regulated Kinase Pathway.Biomolecules. 2020 Mar 26;10(4):Authors: Velmurugan BK, Lin JT, Mahalakshmi B, Chuang YC, Lin CC, Lo YS, Hsieh MJ, Chen MKAbstract ...
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Initiative Suggests Angiosarcoma Therapies [News ...Identification of Therapeutic Vulnerabilities in ...The effect of systemic rifampicin treatment on inf...Conventional magnetic resonance imaging–based rad...Resource-Stratified Guideline-Based Cancer Care Sh...Trigeminal Neuralgia with Radiographic Absence of ...Inflammation-induced hypoparathyroidism triggered... Journal of Medical Imaging and Radiation Oncolog...High-risk human papillomavirus-mediated adenocarci...Proton therapy for head and neck...
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Fluorescence-guided imaging for resection margin evaluation in head and neck cancer patients using cetuximab-800CW: A quantitative dose-escalation study.: Related ArticlesFluorescence-guided imaging for resection margin evaluation in head and neck cancer patients using cetuximab-800CW: A quantitative dose-escalation study.Theranostics. 2020;10(9):3994-4005Authors: Voskuil FJ, de Jongh SJ, Hooghiemstra WTR, Linssen MD, Steinkamp PJ, de Visscher SAHJ, Schepman KP, Elias SG, Meersma GJ, Jonker PKC,...
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Analysis of dose using CBCT and synthetic CT during head and neck radiotherapy: A single centre feasibility study.: Related ArticlesAnalysis of dose using CBCT and synthetic CT during head and neck radiotherapy: A single centre feasibility study.Tech Innov Patient Support Radiat Oncol. 2020 Jun;14:21-29Authors: Hay LK, Paterson C, McLoone P, Miguel-Chumacero E, Valentine R, Currie S, Grose D, Schipani S, Wilson C, Nixon I, James A, Duffton AAbstract Objectives: The study aimed to assess the...
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LHPP inhibits cell growth and migration and triggers autophagy in papillary thyroid cancer by regulating the AKT/AMPK/mTOR signaling pathway.: Related ArticlesLHPP inhibits cell growth and migration and triggers autophagy in papillary thyroid cancer by regulating the AKT/AMPK/mTOR signaling pathway.Acta Biochim Biophys Sin (Shanghai). 2020 Mar 30;:Authors: Sun W, Qian K, Guo K, Chen L, Xiang J, Li D, Wu Y, Ji Q, Sun T, Wang ZAbstract In recent decades, the incidence rate of papillary thyroid...
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RSRC1 loss-of-function variants cause mild to moderate autosomal recessive intellectual disability.: Related ArticlesRSRC1 loss-of-function variants cause mild to moderate autosomal recessive intellectual disability.Brain. 2020 Mar 30;:Authors: Scala M, Mojarrad M, Riazuddin S, Brigatti KW, Ammous Z, Cohen JS, Hosny H, Usmani MA, Shahzad M, Riazuddin S, Stanley V, Eslahi A, Person RE, Elbendary HM, Comi AM, Poskitt L, Salpietro V, Genomics QS, Rosenfeld JA, Williams KB, Marafi D, Xia F, Biderman...
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Outcomes of sinonasal mucosal melanomas with endoscopic and open resection: a retrospective cohort study.: Related ArticlesOutcomes of sinonasal mucosal melanomas with endoscopic and open resection: a retrospective cohort study.J Neurooncol. 2020 Mar 29;:Authors: Almutuawa DM, Strohl MP, Gruss C, van Zante A, Yom SS, McDermott MW, El-Sayed IHAbstract PURPOSE: To compare the outcomes of Sinonasal Mucosal Melanomas (SNMM) treated with endoscopic and open resection. METHODS: A retrospective...
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EGF-induced COX-2 regulates metastasis of head and neck squamous cell carcinoma through upregulation of ANGPTL4.: Related ArticlesEGF-induced COX-2 regulates metastasis of head and neck squamous cell carcinoma through upregulation of ANGPTL4.Cancer Sci. 2020 Mar 29;:Authors: Chiang KH, Shieh JM, Shen CJ, Chang TW, Wu PT, Hsu JY, Tsai JP, Chang WC, Chen BKAbstract Epidermal growth factor receptor (EGFR) expression and activation are the major causes of metastasis in cancers such as head and...
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Severe radiation thyroiditis after radioactive iodine for treatment of Graves' disease.: Related ArticlesSevere radiation thyroiditis after radioactive iodine for treatment of Graves' disease.Singapore Med J. 2020 Mar 31;:Authors: Tay WL, Lee LMY, Tong AKT, Chng CLAbstract Radiation thyroiditis resulting from radioactive iodine-131 treatment for Graves' disease is an uncommon complication. Although a majority of patients are asymptomatic or manifest mild symptoms that can be managed conservatively,...
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Iron deficiency and sleep - A scoping review.: Related ArticlesIron deficiency and sleep - A scoping review.Sleep Med Rev. 2020 Feb 08;51:101274Authors: Leung W, Singh I, McWilliams S, Stockler S, Ipsiroglu OSAbstract Iron deficiency (ID) is associated with sleep disorders, but standardized assessment of iron status in the diagnostic work-up and iron supplementation as treatment have not been considered in clinical practice. We investigated associations of ID with type and severity of sleep...
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Mechanical Thrombectomy Using a Stent Retriever with an Intermediate Catheter for Partially Occluded Middle Cerebral-artery Fenestration.: Related ArticlesMechanical Thrombectomy Using a Stent Retriever with an Intermediate Catheter for Partially Occluded Middle Cerebral-artery Fenestration.World Neurosurg. 2020 Mar 26;:Authors: Liao G, Zhang Z, Che X, Liang HAbstract BACKGROUND: Middle cerebral artery fenestration (MCAF) is a rare vascular variant of the middle cerebral artery (MCA). When...
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Subarachnoid contrast accumulation and Alberta Stroke Program Early CT Score applied to contrast accumulation after thrombectomy as predictors of symptomatic hemorrhage.: Related ArticlesSubarachnoid contrast accumulation and Alberta Stroke Program Early CT Score applied to contrast accumulation after thrombectomy as predictors of symptomatic hemorrhage.World Neurosurg. 2020 Mar 26;:Authors: Kim H, Lee SJ, Lee TK, Jung KOAbstract BACKGROUND: Areas of contrast accumulation (CA) are commonly...
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Systematic Review and Meta-Analysis of Management Strategies and Outcomes in Adult Spinal Neurocysticercosis.: Related ArticlesSystematic Review and Meta-Analysis of Management Strategies and Outcomes in Adult Spinal Neurocysticercosis.World Neurosurg. 2020 Mar 26;:Authors: Barrie U, Badejo O, Aoun SG, Adeyemo E, Moler N, Christian ZK, Caruso JP, El Ahmadieh TY, Ban VS, MacAllister MC, Reyes VP, Hall K, Whitworth L, Bagley CAAbstract OBJECTIVE: Spinal involvement in neurocysticercosis is...
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Genetics and Extracellular Vesicles of Pediatrics Sleep Disordered Breathing and Epilepsy.: Related ArticlesGenetics and Extracellular Vesicles of Pediatrics Sleep Disordered Breathing and Epilepsy.Int J Mol Sci. 2019 Nov 04;20(21):Authors: Khalyfa A, Sanz-Rubio DAbstract Sleep remains one of the least understood phenomena in biology, and sleep disturbances are one of the most common behavioral problems in childhood. The etiology of sleep disorders is complex and involves both genetic and...
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Intracranial Epidural Abscess in a 9-Year-Old Boy With Precocious Puberty and Use of Continuous Positive Airway Pressure.: Related ArticlesIntracranial Epidural Abscess in a 9-Year-Old Boy With Precocious Puberty and Use of Continuous Positive Airway Pressure.J Child Neurol. 2020 Mar 30;:883073820912047Authors: Edlund W, Patel N, DeLone D, Kotagal SAbstract Intracranial extension of rhinosinusitis is rare in children. We report a 9-year-old immunocompetent boy with central precocious puberty...
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Subclinical impairment of dynamic left ventricular systolic and diastolic function in patients with obstructive sleep apnea and preserved left ventricular ejection fraction.: Related ArticlesSubclinical impairment of dynamic left ventricular systolic and diastolic function in patients with obstructive sleep apnea and preserved left ventricular ejection fraction.BMC Pulm Med. 2020 Mar 29;20(1):76Authors: D'Andrea A, Canora A, Sperlongano S, Galati D, Zanotta S, Polistina GE, Nicoletta C, Ghinassi...
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Obstructive sleep apnoea and cardiovascular consequences: Pathophysiological mechanisms.: Related ArticlesObstructive sleep apnoea and cardiovascular consequences: Pathophysiological mechanisms.Arch Cardiovasc Dis. 2020 Mar 26;:Authors: Arnaud C, Bochaton T, Pépin JL, Belaidi EAbstract Obstructive sleep apnoea syndrome is a growing health concern, affecting nearly one billion people worldwide; it is an independent cardiovascular risk factor, associated with incident obesity, insulin resistance,...
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Obstructive sleep apnoea and cardiovascular consequences: Pathophysiological mechanisms.: Related ArticlesObstructive sleep apnoea and cardiovascular consequences: Pathophysiological mechanisms.Arch Cardiovasc Dis. 2020 Mar 26;:Authors: Arnaud C, Bochaton T, Pépin JL, Belaidi EAbstract Obstructive sleep apnoea syndrome is a growing health concern, affecting nearly one billion people worldwide; it is an independent cardiovascular risk factor, associated with incident obesity, insulin resistance,...
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Cleidocranial Dysplasia: Management of the Multiple Craniofacial and Skeletal Anomalies.: Related ArticlesCleidocranial Dysplasia: Management of the Multiple Craniofacial and Skeletal Anomalies.J Craniofac Surg. 2020 Mar 27;:Authors: Jirapinyo C, Deraje V, Huang G, Gue S, Anderson PJ, Moore MHAbstract Cleidocranial dysplasia (CCD) is a rare autosomal dominant disorder caused by mutations in the Runx2 gene. The CCD is characterized by frontal bossing, a patent anterior fontanelle, presence...
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Differential Activating Effects of Thyrotropin-Releasing Hormone and its Analog Taltirelin on Motor Output to the Tongue Musculature In-Vivo.: Related ArticlesDifferential Activating Effects of Thyrotropin-Releasing Hormone and its Analog Taltirelin on Motor Output to the Tongue Musculature In-Vivo.Sleep. 2020 Mar 28;:Authors: Liu WY, Liu H, Aggarwal J, Huang ZL, Horner RLAbstract Thyrotropin-releasing hormone (TRH) is produced by the hypothalamus but most brain TRH is located elsewhere where...
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