Risk of colorectal cancer in patients with periodontal disease severity: a nationwide, population-based cohort study

Abstract

Background

Periodontal disease (PD) and colorectal cancer (CRC) were associated with chronic inflammation. This retrospective cohort study examined the association between PD severity and CRC in a large-scale, population-based Chinese cohort.

Methods

A total of approximately 106,487 individuals with newly diagnosed PD and 106,487 age-matched and sex-matched patients without PD from 2000 to 2002 were identified from Taiwan's National Health Insurance Research Database (NHIRD).

Results

The Kaplan–Meier analysis revealed that the cumulative incidence of CRC was significantly higher in patients with PD than in those without PD (log-rank test, P < 0.001). After adjustment for age, sex, and comorbidities, patients with PD were associated with a significantly higher risk of CRC compared with those without PD (adjusted HR = 1.64, 95% CI = 1.50–1.80). Further, the risk of CRC appeared to increase with increasing frequency of PD medical visits [adjusted HR (95% CI) was 1.78 (1.58–2.02) and 1.53 (1.35–1.74) for annual visits > 10 and < 4, respectively].

Conclusion

Based on our study, PD severity was associated with an increase in the risk of CRC. Further mechanistic research is needed.

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