Reward and avoidance learning in the context of aversive environments and possible implications for depressive symptomsAbstractBackgroundAversive stimuli in the environment influence human actions. This includes valence-dependent influences on action selection, e.g., increased avoidance but decreased approach behavior. However, it is yet unclear how aversive stimuli interact with complex learning and decision-making in the reward and avoidance domain. Moreover, the underlying computational mechanisms...
Correction to: Real-World Data of Prasugrel vs. Ticagrelor in Acute Myocardial Infarction: Results from the RENAMI RegistryThe first author's name which previously read.Prasugrel and Ticagrelor: the Romulus and Remus of Antiplatelet Therapy?The Efficacy and Safety of Aerosolized Iloprost in Pulmonary Arterial Hypertension: A Systematic Review and Meta-AnalysisAbstractBackgroundThis systematic review and meta-analysis was conducted to investigate the efficacy and safety of the chronic administration...
Six new monacolin analogs from red yeast ricePublication date: 20 May 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 5Author(s): Bing-Yu LIU, Fei XU, Jian BAI, Dao-Jiang YAN, Le ZHANG, Dan ZHANG, You-Cai HUAbstractSix novel monacolin analogs, monacolins V1–V6 (1–6), together with seven known ones (7–13), were isolated from the ethyl acetate extract of red yeast rice. Their structures and absolute configurations were determined by spectroscopic methods, especially 2D NMR (1H-1HCOSY,...
Safety and Tolerability of Adjunctive Brivaracetam in Pediatric Patients < 16 Years with Epilepsy: An Open-Label TrialAbstractObjectiveThis trial evaluated the short-term safety and tolerability, steady-state pharmacokinetics, and preliminary efficacy of brivaracetam oral solution in children aged 1 month to < 16 years with epilepsy.MethodsThis was a phase IIa, open-label, single-arm, fixed three-step dose escalation trial of 3-weeks duration (N01263; NCT00422422). Patients were taking one...
A Prospective Randomized Trial Comparing Topical Intranasal Lidocaine and Levobupivacaine in Patients Undergoing Endoscopic Binostril Transnasal Transsphenoidal Resection of Pituitary TumorsIntroduction: Local anesthetic intranasal packing is used in transnasal surgery to reduce hemodynamic fluctuations. We hypothesized that the long acting local anesthetic levobupivacaine would provide superior hemodynamic stability and postoperative analgesia compared with lidocaine in endoscopic transnasal transsphenoidal...
Renal allograft dysfunction: An update on immunological graft injuryPraveen Kumar Etta, MV RaoIndian Journal of Transplantation 2019 13(2):69-77Renal transplantation is the treatment of choice in most patients with end-stage renal disease, especially with improvement in surgical techniques and immunosuppressive regimens; however, the long-term graft survival remains to be improved. Immunological graft injury leading to rejection plays a major role in long-term graft loss. With pretransplant immunological...
Correction to: Real-World Data of Prasugrel vs. Ticagrelor in Acute Myocardial Infarction: Results from the RENAMI RegistryThe first author's name which previously read.Prasugrel and Ticagrelor: the Romulus and Remus of Antiplatelet Therapy?The Efficacy and Safety of Aerosolized Iloprost in Pulmonary Arterial Hypertension: A Systematic Review and Meta-AnalysisAbstractBackgroundThis systematic review and meta-analysis was conducted to investigate the efficacy and safety of the chronic administration...
Reward and avoidance learning in the context of aversive environments and possible implications for depressive symptomsAbstractBackgroundAversive stimuli in the environment influence human actions. This includes valence-dependent influences on action selection, e.g., increased avoidance but decreased approach behavior. However, it is yet unclear how aversive stimuli interact with complex learning and decision-making in the reward and avoidance domain. Moreover, the underlying computational mechanisms...
Intradiaphragmatic Bronchogenic CystsThe Vein of Henle RevisitedEffective and Safe Living Donor Hepatectomy Under Intermittent Inflow Occlusion and Outflow Pressure ControlGastric Synovial SarcomaGiant Primary Retroperitoneal Dedifferentiated LiposarcomaPrimary Sarcomatoid Malignant Mesothelioma of the PancreasIleal Endometriosis: a Rare Cause of Enterocutaneous FistulaRobotic Single-Site Plus One Port: Pancreas EnucleationAbstractPurposeLaparoscopic approaches to enucleation of the pancreas have...
select article The utility of narrow band imaging in endoscopic diagnosis of laryngopharyngeal refluxResearch articleAbstract onlyThe utility of narrow band imaging in endoscopic diagnosis of laryngopharyngeal refluxChangding He, Jinchao Yu, Fang Huang, Jun ShaoIn Press, Accepted Manuscript, Available online 28 June 2019Purchase PDFArticle previewAbstractAbstractObjectiveThis study assessed the utility of narrow band imaging (NBI) in patients with symptoms of laryngopharyngeal reflux (LPR) and tried...
Vitamin D und Omega-3-Fettsäuren senken das Risiko für Krebs und kardiovaskuläre Ereignisse nichtDurvalumab nach einer Radiochemotherapie ist beim NSCLC im Stadium III derzeit die vielversprechendste TherapieRadiochirurgie und operative neurovaskuläre Dekompression annähernd gleichwertig bei der Behandlung von TrigeminusneuralgienTomotherapy in malignant mesothelioma: a planning study to establish dose constraintsAbstractPurposeA planning study was performed for helical tomotherapy treatment. We...
Intellectual directions for History and Philosophy of the Life Sciences , 2019–2023From parts to mechanisms: research heuristics for addressing heterogeneity in cancer geneticsAbstractA major approach to cancer research in the late twentieth century was to search for genes that, when altered, initiated the development of a cell into a cancerous state (oncogenes) or failed to stop this development (tumor suppressor genes). But as researchers acquired the capacity to sequence tumors and incorporated...
Arguing Against the Expressive Function of Punishment: Is the Standard Account that Insufficient?AbstractThis paper critically appraises the arguments that have been offered for what can be called 'the expressive function of punishment'. According to this view, what distinguishes punishment from other kinds of non-punitive hard treatment is that punishment conveys a censorial/reprobative message about what the punished has done, and that this expressive function should therefore be accepted as part...
Correction to: Brentuximab vedotin use in a jaundiced case with resistant Hodgkin lymphomaThe original version of this article contained a mistake in one of the author names. Cem Irili should have been Cem Mirili.Isolated extramedullary leukemic involvement of the heart presenting as fulminant heart failureMultidimensional radar dot-plots, do we need it for the screening of acute promyelocytic leukemia?Geriatric nutritional risk index (GNRI) just before allogeneic hematopoietic stem cell transplantation...
Impact of coccidiostat and phytase supplementation on gut microbiota composition and phytate degradation in broiler chickensAbstractBackgroundThere is good evidence for a substantial endogenous phytase activity originating from the epithelial tissue or the microbiota resident in the digestive tract of broiler chickens. However, ionophore coccidiostats, which are frequently used as feed additives in broiler diets to prevent coccidiosis, might affect the bacterial composition and the abundance of phytase...
AI in Interventional Radiology: There is Momentum for High-Quality Data RegistriesIntraabdominal Hemorrhage from Ruptured Ectopic Varices Treated by Antegrade Embolization via a Recanalized Paraumbilical VeinAbstractA 49-year-old man with alcoholic liver cirrhosis was admitted to our hospital with abdominal pain. Contrast-enhanced CT demonstrated massive hemorrhagic ascites and ectopic varices fed by right colic and ileocolic veins. The varices were treated with selective embolization via a recanalized...
Climatic variations within the dry valleys in southwestern China and the influences of artificial reservoirsAbstractClimatic variation within a typical dry-valley area located in the southern Hengduan Mountains of China is studied, and the potential regional climate influences of large reservoirs in the area are discussed. Six meteorological stations near a reservoir are identified and classified into two categories (dry and non-dry valleys) to compare their level of climate change. Temperatures...
Ajay Kumar Mishra (Ed): Smart Ceramics: Preparation, Properties, and ApplicationsRaymond Hill, Terry Kenakin and Tom Blackburn (Eds): Pharmacology for Chemists—Drug Discovery in ContextCongress, Conferences, and WorkshopsIdentification and Quantification of Related Impurities of a Novel Ketolide Antibiotic NafithromycinAbstractNafithromycin (NFT, WCK 4873) is a novel antimicrobial drug being developed to treat infections caused by Gram-positive bacteria. It is a second-generation drug of the lactone...
Danshensu Ameliorates Cardiac Ischaemia Reperfusion Injury through Activating Sirt1/FoxO1/Rab7 Signal PathwayAbstractObjective: To explore the specific molecular mechanisms of Danshensu (DSS) in the treatment of ischemia reperfusion injury (IRI). Methods: IRI model was established with isolated rat hearts by performing global ischaemia for 30 min, and then followed by 60 min reperfusion. Also, H9C2 cells were subjected to 4-h hypoxia followed by 3-h reoxygenation. Then 10 μmol/L DSS were added in...
AUMENTO DA PREVALÊNCIA DE ANGIODISPLASIAS NA ENTEROSCOPIA POR VIDEOCAPSULA EM DOENTES EM HEMODIALISEAtualmente, a enteroscopia por video-cápsula (EVC) assume-se definitivamente como o exame de primeira linha para estudo do intestino delgado (ID) na hemorragia digestiva obscura (HDO). Este estudo corrobora a elevada prevalência de angiectasias no ID em doentes com HDO em hemodiálise, sendo que a hemodiálise demonstrou ser um factor de risco independente para a sua ocorrência.*Rita Herculanodescribe...
PAQUIMENINGITIS HIPERTRÓFICA POSINFECCIOSA: PRESENTACIÓN DE CASO CLÍNICOLa paquimeningitis hipertrófica es una entidad infrecuente que puede ser idiopática o secundaria, y dado que incluso un diagnóstico acertado y un correcto tratamiento pueden dejar secuelas neurológicas graves o incluso producir la muerte, presentamos este caso en el que consideramos que la causa fue una meningitis que no recibió tratamiento adecuado al inicio de los síntomas y que tuvo una respuesta satisfactoria al tratamiento...
EL AMPARO ECONOMICO PARA MEJORAR EL TRATAMIENTO DE LA TUBERCULOSIS(especial para SIIC © Derechos reservados)El objetivo de nuestro estudio es analizar las diferencias de los datos clínicos y epidemiológicos entre pacientes con y sin inclusión en el régimen de amparo, y si el subsidio fue un factor de éxito en el tratamiento.Autor:Cristina ChiricoColumnista Experta de SIICInstitución:Programa Control de la TuberculosisArtículos publicados por Cristina ChiricoCoautoresAlejandra Iannizzotto* Hugo Telles**...
Prioritizing PlatonismAbstractSome see concrete foundationalism as providing the central task for sparse ontology, that of identifying which concreta ground other concreta but aren't themselves grounded by concreta. There is, however, potentially much more to sparse ontology. The thesis of abstract foundationalism, if true, provides an additional task: identifying which abstracta ground other abstracta but aren't themselves grounded by abstracta. We focus on two abstract foundationalist theses—abstract...
Correction to: Phase I-II trial of imatinib mesylate (Gleevec; STI571) in treatment of recurrent oligodendroglioma and mixed oligoastrocytoma. North central cancer treatment group study N0272 (ALLIANCE/NCCTG)The last author's first name was truncated in the initial online publication. The original article has been corrected.Nomograms for predicting the overall and cause-specific survival in patients with malignant peripheral nerve sheath tumor: a population-based studyAbstractBackgroundMalignant...
Danshensu Ameliorates Cardiac Ischaemia Reperfusion Injury through Activating Sirt1/FoxO1/Rab7 Signal PathwayAbstractObjective: To explore the specific molecular mechanisms of Danshensu (DSS) in the treatment of ischemia reperfusion injury (IRI). Methods: IRI model was established with isolated rat hearts by performing global ischaemia for 30 min, and then followed by 60 min reperfusion. Also, H9C2 cells were subjected to 4-h hypoxia followed by 3-h reoxygenation. Then 10 μmol/L DSS were added in...
Irma Elizabeth Gonzalez CurielLOS PÉPTIDOS ANTIMICROBIANOS Y SUS BENEFICIOS EN EL TRATAMIENTO DE LAS ÚLCERAS DE PIE DIÁBETICOEn la presente revisión se analiza, sobre la base de los estudios realizados tanto in vivocomo in vitro el posible uso de péptidos antimicrobianos y sus inductores en el tratamiento de úlceras de pie diabético.Seguir leyendoVivian MolinaTRATAMIENTO DE LA ISQUEMIA CEREBRAL GLOBAL EN JERBOS DE MONGOLIAEl tratamiento con dosis orales únicas de las combinaciones policosanol (100...
doi: http://dx.doi.org/10.21840/siic/157370LOS PEPTIDOS ANTIMICROBIANOS Y SUS BENEFICIOS EN EL TRATAMIENTO DE LAS ULCERAS DE PIE DIABETICO Resumen La úlcera de pie diabético es una de las complicaciones más importantes de la diabetes mellitus tipo 2; de hecho, hasta un 30% de los pacientes diabéticos presentan esta complicación. En los últimos años se han implementado nuevas terapias para tratar de promover la rápida cicatrización de este tipo de úlceras, enfocándose en la terapia antibiótica, el...
¿Disminuyen las complicaciones cutáneas tras la cirugía de fracturas de tobillo con el uso de Aquacel Extra Ag®?Publication date: Available online 22 June 2019Source: Revista Española de Cirugía Ortopédica y TraumatologíaAuthor(s): M. Luque-Valenzuela, A.J. Sánchez-Aguilera, A. Martín-Vivaldi-Jiménez, R. Jódar-Graus, N. Prados-OlletaResumenIntroducciónLas fracturas de tobillo representan un 10% del total de fracturas. La mayor parte requieren tratamiento quirúrgico, que conlleva un importante riesgo...
Effect of electroacupuncture on NF-κB and NLRP3 inflammasome in uterine tissues of rats with primary dysmenorrheaAbstractObjectiveTo observe the effect of electroacupuncture (EA) on nuclear factor kappa B (NF-κB) and nucleotide-binding oligomerization domain-like receptor protein 3 (NLRP3) inflammasome in uterine tissues of rats with primary dysmenorrhea (PD), thus to explore the possible mechanism of EA for PD.MethodsFifty female Sprague-Dawley (SD) rats were randomly divided into a normal group,...
Preparation and biological evaluation of quinoline amines as anticancer agents and its molecular dockingAbstractA series of 2-chloro N-substituted amino quinolines (2a–2j) were prepared and characterized by analytical and spectroscopic methods. As quinoline is an important pharmacophoric moiety, the prepared compounds were screened against a non-small cell lung cancer cell line, A549. One of the compounds, 2-chloro-8-methyl-N-(quinolin-5-yl)quinolin-4-amine (2b) is found to be active with inhibition...
A case of type A acute aortic dissection with a common carotid trunkAbstractWe present a rare case of common carotid artery with acute type A aortic dissection. A 72-year-old woman underwent emergent aortic arch repair using Antegrade selective cerebral protection. Bottom-tapped cannulae were inserted into three orifices of arch vessels, however, regional cerebral oxygen saturation decreased after rewarming. We found that arch branches were in order from front to back, right subclavian artery, common...
The effect of exercise on memory and BDNF signaling is dependent on intensityAbstractThe aims of the present study were to investigate in brain of adult rats (1) whether exercise-induced activation of brain-derived neurotrophic factor (BDNF)/tropomyosin-related kinase B (TrkB) pathway is dependent on exercise intensity modality and (2) whether exercise-induced improvement of memory is proportional to this pathway activation. Wistar rats were subjected to low (12 m/min) or high (18 m/min) exercise...
Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00306932607174,00302841026182,alsfakia@gmail.com
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