Pathology-confirmed versus non pathology-confirmed cancer diagnoses: incidence, participant characteristics, and survival: AbstractCancer diagnoses which are not confirmed by pathology are often under-registered in cancer registries compared to pathology-confirmed diagnoses. It is unknown how many patients have a non pathology-confirmed cancer diagnosis, and whether their characteristics and survival differ from patients with a pathology-confirmed diagnosis. Participants from the prospective population-based...
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Evaluation of CCR5‐Δ32 Mutation among Individuals with High Risk Behaviours, Neonates Born to HIV‐1 Infected Mothers, HIV‐1 Infected Individuals, and Healthy People in an Iranian Population: AbstractOne of the important genetic factors related to resistance to HIV‐1 infection is the presence of the C‐C chemokine receptor type 5 delta 32 (CCR5‐Δ32) homozygous genotype (Δ32/Δ32). The aim of this study was to evaluate the CCR5‐Δ32 mutation among individuals with high‐risk behaviours, neonates born to...
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Placental Infection of Hepatitis B Virus among Thai Pregnant Women: Clinical Risk Factors and Its Association with Fetal infection: AbstractObjectivesTo identify the risk factors of placental and fetal infections among HBsAg‐positive women.MethodsA prospective cohort study involving HBsAg‐positive pregnant women was conducted. Maternal risk factors, including serum HBeAg status, anti‐HBcIgM, and HBV‐DNA levels were determined. Placental infection was identified by PCR and confirmed by DNA sequencing....
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Towards simple tools to assess functional effects of contaminants on natural microbial and invertebrate sediment communities: AbstractSurface sediments can accumulate contaminants that affect microorganisms and invertebrates and disturb benthic ecological functions. However, effects of contaminants on ecological functions supported by sediment communities are understudied. Here, we tested the relevance of two simple tools to assess the ecotoxicological effects of metal contamination on natural sediment...
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Comparative evaluation of four suspended particulate matter (SPM) sampling devices and their use for monitoring SPM quality: AbstractRepresentative sampling of suspended particulate matter is fundamental for assessing river sediment quality, including the distribution and physicochemical characterisation of particles at different hydrological events. This study compares time-integrated samplers and discrete sampling methods, focusing on (a) the representativeness of the different methods and (b)...
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Impaired intrinsic functional connectivity between the thalamus and visual cortex in migraine without aura: Resting-state functional magnetic resonance imaging (fMRI) has confirmed disrupted visual network connectivity in migraine without aura (MwoA). The thalamus plays a pivotal role in a number of pain conditions,... Research articleOpen AccessPublished: 19 December 2019Impaired intrinsic functional connectivity between the thalamus and visual cortex in migraine without auraHeng-Le Wei, Xin Zhou,...
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Soluble levels of sCD40L and s4‐1BB are associated with a poor prognosis in elderly patients with colorectal cancer: AbstractBackground and ObjectivesThe prognosis of colorectal cancer (CRC) has improved in the last decades, however, a lower overall survival persists in the elderly. The understanding of immunity changes in the elderly with CRC will allow the emergence of new treatments with higher response rates. 4‐1BB and CD40L, an immune checkpoint stimulator, play an important role in T‐cell responses...
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Clinical presentation and surgical outcomes in primary aldosteronism differ by race: AbstractBackgroundPrimary aldosteronism (PA) is the most common cause of secondary hypertension; early diagnosis and intervention correlate with outcomes. We hypothesized that race may influence clinical presentation and outcomes.MethodsWe conducted a retrospective analysis of patients with PA (1997‐2017) who underwent adrenal vein sampling (AVS). Patients were classified by self‐reported race as black or non‐black....
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Towards a standard pathological and molecular characterization of recurrent glioma in adults: a RANO effort: AbstractRegardless of subtype, diffuse gliomas of adulthood are characterized by inexorable progression through treatment. Cancer recurrence in the context of therapy is by no means unique to gliomas. For many tumors residing outside the central nervous system (CNS), tissue-based analyses are routinely employed to document the molecular and cellular features of disease recurrence. Such interventions...
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Evaluation of Store Environment Changes of an In-Store Intervention to Promote Fruits and Vegetables
IJERPH, Vol. 17, Pages 65: Evaluation of Store Environment Changes of an In-Store Intervention to Promote Fruits and Vegetables in Latino/Hispanic-Focused Food Stores: IJERPH, Vol. 17, Pages 65: Evaluation of Store Environment Changes of an In-Store Intervention to Promote Fruits and Vegetables in Latino/Hispanic-Focused Food StoresInternational Journal of Environmental Research and Public Health doi: 10.3390/ijerph17010065Authors: Jennifer Sanchez-Flack Barbara Baquero Shih-Fan Lin George...
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IJERPH, Vol. 17, Pages 66: Emergencies in Long-Term Care Services for the Elderly in Korea: A Mixed-Methods Study: IJERPH, Vol. 17, Pages 66: Emergencies in Long-Term Care Services for the Elderly in Korea: A Mixed-Methods StudyInternational Journal of Environmental Research and Public Health doi: 10.3390/ijerph17010066Authors: Soon Ok Kim Sun Hee Bae This mixed-methods study explored ways to enhance the emergency response abilities of workers in long-term care services for the elderly. Based...
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Changes in heparan sulfate sulfotransferases and cell-surface heparan sulfate during SKM-1 cells granulocytic differentiation and A549 cells epithelial-mesenchymal transition: AbstractHeparan sulfate (HS) with various sulfation patterns is one of important modulators of cancer cell fate through interacting with numerous growth factors. Here we found HS 2-O sulfotransferase 1 (HS2ST1) was downregulated at both mRNA and protein levels during granulocytic differentiation of SKM-1 leukemia cells and...
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Perception of quality of intraoperative fluoroscopy and the influence on postoperative management: an international survey: AbstractPurposeIntraoperative precise visualization of fractures and assessment of the quality of reduction is essential in orthopedic trauma surgery. Fluoroscopic skills will lead to an increased detection rate of minimal abnormalities needing revision intraoperatively. The definition of fluoroscopic skills and the interpretation of acceptable "minimal abnormalities" remains...
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Pharmaceutics, Vol. 12, Pages 8: Curcumin-In-Deformable Liposomes-In-Chitosan-Hydrogel as a Novel Wound Dressing: Pharmaceutics, Vol. 12, Pages 8: Curcumin-In-Deformable Liposomes-In-Chitosan-Hydrogel as a Novel Wound DressingPharmaceutics doi: 10.3390/pharmaceutics12010008Authors: Selenia Ternullo Laura Victoria Schulte Werning Ann Mari Holsæter Nataša Škalko-Basnet A liposomes-in-hydrogel system as an advanced wound dressing for dermal delivery of curcumin was proposed for improved chronic...
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The Potential Role of Cycloastragenol in Promoting Diabetic Wound Repair In Vitro: Background. Refractory wound healing is a severe complication of diabetes with a significant socioeconomic burden. Whereas current therapies are insufficient to accelerate repair, stem cell-based therapy is increasingly recognized as an alternative that improves healing outcomes. The aim of the present study is to explore the role of cycloastragenol (CAG), a naturally occurring compound in Astragali Radix, in ameliorating...
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Inhibition of HMGB1 Promotes Osseointegration under Hyperglycemic Condition through Improvement of BMSC Dysfunction: High mobility group box 1 (HMGB1) participates actively in oxidative stress damage and the latter relates closely to diabetic complications, including poor implant osseointegration. This article is aimed at investigating the effects of HMGB1 on dysfunction of bone marrow stromal cells (BMSCs) and impaired osseointegration under diabetic environment. In vitro, BMSCs were treated with...
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GSE138205 ChIP-seq experiments for "THAP11F80L cobalamin disorder-associated mutation reveals normal and pathogenic THAP11 functions in gene expression and cell proliferation": Contributors : Maykel Lopes ; Philippe L'Hôte ; Hamonie Dehaene ; Viviane Praz ; Winship HerrSeries Type : Genome binding/occupancy profiling by high throughput sequencingOrganism : Homo sapiensTwelve human THAP proteins share the THAP domain, an evolutionary conserved zinc-finger DNA-binding domain. Studies of different...
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Pathogens, Vol. 9, Pages 8: Cancer-Associated Fibroblasts in Undifferentiated Nasopharyngeal Carcinoma: A Putative Role for the EBV-Encoded Oncoprotein, LMP1: Pathogens, Vol. 9, Pages 8: Cancer-Associated Fibroblasts in Undifferentiated Nasopharyngeal Carcinoma: A Putative Role for the EBV-Encoded Oncoprotein, LMP1Pathogens doi: 10.3390/pathogens9010008Authors: Mhairi A. Morris Undifferentiated nasopharyngeal carcinoma (NPC) is 100% associated with Epstein–Barr virus (EBV) infection, and biopsies...
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Prenatal Diagnosis of Umbilical Cord Ulcer: A Report of Two Cases: Umbilical cord ulcer is related to fetal intestinal atresia or meconium; perforation of the ulcer causes fetal deterioration leading to fetal and neonatal death owing to fetal hemorrhage. However, to the best of our knowledge, a method to diagnose umbilical cord ulcer prenatally is not available. No reports exist about the prenatal findings before perforation of umbilical cord ulcer using ultrasonography. We encountered two cases...
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Anaerobic Bacteremias in Left Ventricular Assist Devices and Advanced Heart Failure: Left ventricular assisted devices (LVADs) have revolutionized the treatment of advanced heart failure, providing meaningful increases in survival, functional capacity, and quality of life. There are two categories of LVADs patients: (1) bridge-to-transplant and (2) destination therapy. Advanced heart failure and destination LVADs often carry a poor prognosis. The overall 1-year mortality rate remains as high as 30%....
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Continuous intravenous low-dose diclofenac sodium to control a central fever after ischemic stroke in the intensive care unit: a case report and review of the literature: Elevation in body temperature within the first 24 hours of ischemic stroke is fairly common and known to be associated with worse outcomes. Only after thoroughly ruling out infection and the noninfectious etio... Case reportOpen AccessOpen Peer ReviewPublished: 18 December 2019Continuous intravenous low-dose diclofenac sodium to...
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Neck paraganglioma and follicular lymphoma: a case report: AbstractBackgroundParagangliomas and pheochromocytomas are sympathetic or parasympathetic tumors derived from the paraganglia and the adrenal medulla, respectively. Paragangliomas and pheochromocytomas can be sporadic or familial, the latter frequently being multifocal and possibly due to succinate dehydrogenase complex genes mutations. In addition, 12% of sporadic paragangliomas are related to covered succinate dehydrogenase complex mutations....
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Chemotherapy-associated neutropenic enterocolitis of the transverse colon post right hemicolectomy: AbstractNeutropenic enterocolitis (NE) is a life-threatening infection of the immunocompromised. NE ubiquitously affects the cecum, often with involvement of the ascending colon and ileum. Classically, NE is associated with high mortality leading to the frequent use of aggressive treatment strategies including surgery. Although conservative approaches are often successful, there are currently no standardized...
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Development of multiple adrenal myelolipomas after trauma-induced adrenal haemorrhage: Adrenal myelolipomas represent a benign neoplasm with known associations with many chronic diseases, 21-hydroxylase deficiency and cancer. However, the aetiology of adrenal myelolipomas remains unknown. Here, we present a case of a patient with image-proven bilateral adrenal haemorrhages caused by trauma with the subsequent development of bilateral adrenal myelolipomas several years later. Resection and pathological...
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Lupus cystitis: unusual cause of renal failure in systemic lupus erythematosus: A 42-year-old woman presented with chronic fever, abdominal pain, intermittent loose stools and dysuria for 3 months. She had recently developed acute dyspnoea with acute kidney injury. She was found to have a contracted, thick-walled bladder with bilateral hydroureteronephrosis. She underwent bilateral percutaneous nephrostomies, following which her renal function recovered. She satisfied the clinical and immunological...
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Organising pneumonia in Rhupus syndrome: Interstitial lung disease (ILD) is seen in 17% of patients with Rhupus syndrome. Organising pneumonia (OP), a subtype of connective tissue disease-associated ILD, is rare but associated with good outcomes. Here, we present a patient with Rhupus who developed OP.
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Native valve endocarditis caused by ErysipelothrixRhusiopathiae: presenting with refractory heart failure and requiring surgical valve replacement--report on a rare zoonosis: Erysipelothrix Rhusiopathiae is a Gram-positive bacillus that is ubiquitous in nature. The bacterium is a zoonotic pathogen known to infect wild and domestic animals. Human infections, however, are uncommon and typically present with localised or generalised cutaneous lesions. Systemic infection in the form of bacteraemia with...
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Is dapsone still relevant in immune thrombocytopenia in resource limited settings?: Immune thrombocytopenia is an autoimmune disorder characterised by autoantibody production against platelets, increased platelet destruction and impaired thrombopoiesis. Steroids are the first-line agents whenever treatment is indicated; however, some patients may not respond and the responders may as well relapse while the dose is being tapered. Side effects of steroids prohibits their long-term use and patients...
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Sertraline-induced hypersensitivity pneumonitis: Hypersensitivity pneumonitis (HP), also known as extrinsic allergic alveolitis, is a granulomatous, non-IgE-mediated hypersensitivity reaction of the alveoli and distal bronchioles presenting as an acute, subacute or chronic condition. It is most commonly associated with exposure to extrinsic allergens (eg, avian dust, mould and tobacco) and medications including antiarrhythmics (eg, amiodarone), cytotoxics (eg, methotrexate) and antiepileptics (eg,...
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Five-Year Recall after Treatment of External Cervical Resorption: The management of external cervical resorption can be challenging. This study described a two-step procedure for the treatment of external cervical resorption. It involved nonsurgical root canal treatment and a dental amalgam core buildup, followed by a surgical approach to restore the root structure using resin-modified glass ionomer (Geristore®). The patient was recalled for a period of five years, and the overall outcome was successful.
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A new deep learning method for image deblurring in optical microscopic systems: Deconvolution is the most commonly used image processing method in optical imaging systems to remove the blur caused by the point‐spread‐function (PSF). While this method has been successful in deblurring, it suffers from several disadvantages, such as slow processing time due to multiple iterations required to deblur and suboptimal in cases where the experimental operator chosen to represent PSF is not optimal. In this...
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Risk of spread in adult-onset isolated focal dystonia: a prospective international cohort study.: Related ArticlesRisk of spread in adult-onset isolated focal dystonia: a prospective international cohort study.J Neurol Neurosurg Psychiatry. 2019 Dec 17;:Authors: Berman BD, Groth CL, Sillau SH, Pirio Richardson S, Norris SA, Junker J, Brüggemann N, Agarwal P, Barbano RL, Espay AJ, Vizcarra JA, Klein C, Bäumer T, Loens S, Reich SG, Vidailhet M, Bonnet C, Rose E, Jinnah HA, Perlmutter JSAbstract ...
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Mutation signature analysis identifies increased mutation caused by tobacco smoke associated DNA adducts in larynx squamous cell carcinoma compared with oral cavity and oropharynx.: Related ArticlesMutation signature analysis identifies increased mutation caused by tobacco smoke associated DNA adducts in larynx squamous cell carcinoma compared with oral cavity and oropharynx.Sci Rep. 2019 Dec 17;9(1):19256Authors: South AP, den Breems NY, Richa T, Nwagu U, Zhan T, Poojan S, Martinez-Outschoorn U,...
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Many-isocenter optimization for robotic radiotherapy.: Related ArticlesMany-isocenter optimization for robotic radiotherapy.Phys Med Biol. 2019 Dec 18;:Authors: Lyu Q, Neph R, Yu VY, Ruan D, Boucher S, Sheng KAbstract Despite significant dosimetric gains, clinical implementation of the 4π non-coplanar radiotherapy on the widely available C-arm gantry system is hindered by limited clearance, and the need to perform complex coordinated gantry and couch motion. A robotic radiotherapy platform...
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Narrow Band Imaging for lingual tonsil hypertrophy and inflammation, in laryngo-pharyngeal reflux disease: AbstractPurposeThe objective of this study is to analyse the relationship between the endoscopic signs of laryngo-pharyngeal reflux, the lingual tonsil hypertrophy (LTH) and its inflammation, adopting Narrow Band Imaging (NBI) technology.MethodsWe enrolled, as cases, patients with clinical diagnosis of laryngopharyngeal reflux disease (LPRD), a Reflux Symptom Index (RSI) ≥ 13, and a Reflux Finding...
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The effect of canal diameter on audiologic results in patients with cochlear implantation with large vestibular aqueduct syndrome.: Related ArticlesThe effect of canal diameter on audiologic results in patients with cochlear implantation with large vestibular aqueduct syndrome.Eur Arch Otorhinolaryngol. 2019 Dec 17;:Authors: Demir B, Cesur S, Incaz S, Alberalar ND, Ciprut A, Batman CAbstract PURPOSE: To compare audiologic results according to vestibular aqueduct (VA) diameter in patients...
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The effect of anatomic variations and maxillary sinus volume in antrochoanal polyp formation.: Related ArticlesThe effect of anatomic variations and maxillary sinus volume in antrochoanal polyp formation.Eur Arch Otorhinolaryngol. 2019 Dec 17;:Authors: Başer E, Sarıoğlu O, Arslan İB, Çukurova İAbstract PURPOSE: The antrochoanal polyp (ACP), otherwise known as the Killain polyp, is a benign lesion that originates from maxillary sinus mucosa, extending from the accessory ostium towards the...
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Panel 2- Recent Advance in Otitis Media Bioinformatics: Publication date: Available online 18 December 2019Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Ann Hermansson, Diego Preciado, Jian-Dong Li, Kensei Komatsu, Arwa Kurabi, Gustavo Nino, Stephanie Val, Shyan Vijayasekaran, Oren ZivAbstractObjectivesTo update the medical literature on recent large-scale studies employing bioinformatics data analysis tools in otitis media (OM) disease models with a principal focus on...
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Recent advances in understanding the natural history of the otitis media microbiome and its response to environmental pressures: Publication date: Available online 18 December 2019Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Robyn L. Marsh, Celestine Aho, Jemima Beissbarth, Seweryn Bialasiewicz, Michael Binks, Anders Cervin, Lea-Ann S. Kirkham, Katherine P. Lemon, Mary PE. Slack, Heidi C. Smith-VaughanAbstractObjectiveTo perform a comprehensive review of otitis media microbiome...
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Panel 8: Vaccines and Immunology: Publication date: Available online 18 December 2019Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Mark R. Alderson, Tim Murphy, Stephen I. Pelton, Laura A. Novotny, Laura L. Hammitt, Arwa Kurabi, Jian-Dong Li, Ruth B. Thornton, Lea-Ann S. KirkhamAbstractObjectiveTo review and highlight significant advances made towards vaccine development and understanding of the immunology of otitis media (OM) since the 19th International Symposium on Recent...
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Trajectory of change in the swallowing status in spinal muscular atrophy type I: Publication date: Available online 18 December 2019Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Young-Ah Choi, Dong-In Suh, Jong-Hee Chae, Hyung-Ik ShinAbstractObjectivesThis study aimed to elucidate the change in progressive swallowing dysfunction from birth up to 2 years of age to provide clinical insights into the management of swallowing difficulty in patients with spinal muscular atrophy...
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Intracranial complications of pediatric rhinosinusitis: identifying risk factors and interventions affecting length of hospitalization: Publication date: Available online 19 December 2019Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Corina Din-Lovinescu, Ghayoour Mir, Conor Blanco, Kevin Zhao, Thomas Mazzoni, Arno Fried, Mostafa El Khashab, Giant LinAbstractObjectiveTo identify risk factors and interventions affecting length of hospitalization (LOH) and clinical outcome...
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Experience with cholesteatoma behind an intact tympanic membrane in children: Publication date: Available online 19 December 2019Source: American Journal of OtolaryngologyAuthor(s): Urík Milan, Kaliariková Andrea, Machač Josef, Jurajda MichalAbstractIntroductionTo systematically investigate all surgeries for cholesteatoma behind an intact tympanic membrane at our department. To identify predictive factors that can help the surgeon to plan surgery, surgical techniques, and follow-up treatment.Material...
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Deep cervical fascia as an anatomical landmark of lingual lymph nodes: An anatomic and histologic study: Publication date: Available online 18 December 2019Source: Auris Nasus LarynxAuthor(s): Kohtaro Eguchi, Satoru Muro, Koh Miwa, Kumiko Yamaguchi, Keiichi AkitaAbstractObjectivesWe aimed to discuss the definition of lingual lymph nodes based on the deep cervical fascia anatomy.MethodsA total of 11 cadavers were histopathologically evaluated. Specimens were dissected into serial stepwise cross-sections....
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Auditory, video head impulse test and vestibular evoked myogenic potentials findings in adults with human immunodeficiency virus: Even though there is an association between hearing loss and human immunodeficiency virus (HIV), particularly in low- and middle-income countries, further research is needed to investigate the nature of such hearing loss. Likewise, despite documented vestibular alterations in people with HIV, the true occurrence, presentation, and nature of these manifestations are yet...
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Management of extracranial arteriovenous malformations of the head and neck: The purpose of this study was to review the outcomes of the different therapies for extracranial head and neck arteriovenous malformations (AVMs).AVMs are high-flow congenital vascular anomalies. They are composed of a complex system of vessels directly connecting feeding arteries to draining veins forming a nidus.They may be potentially life-threatening due to progressive symptoms and infiltrative disease. Extracranial...
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Machine Learning Model to Help Predict Survival Among Patients With OSCC: This cohort study describes a model using machine learning to help predict 5-year overall survival among patients with oral squamous cell carcinoma (OSCC) and compares this model with a prediction model created from the TNM (Tumor, Node, Metastasis) clinical and pathologic stage.Omar A. Karadaghy, MD1; Matthew Shew, MD1; Jacob New, PhD2; et alAndrés M. Bur, MD1Author Affiliations1Department of Otolaryngology–Head and Neck Surgery,...
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Determining Operative Candidacy and Avoiding Regret: Every surgical oncologist bristles when considering whether to offer an operation of questionable benefit. Patient, oncologic, and clinician factors all influence whether a surgery is indicated and how to effectively navigate the necessary preoperative counseling and preparation. The inherent risks and rewards of cancer surgery are magnified when the underlying physical fitness of the patient is in question. Even when dealing with technically feasible...
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Association of Preoperative Functional Performance With Outcomes After HNC Surgical Treatment: This cohort study evaluates the association of the addition of adult patients' functional performance to other important preoperative clinical characteristics with 30-day and 90-day hospital readmissions and overall survival after surgical treatment of head and neck cancer.A Clinical Severity Staging SystemSampat Sindhar, BS1; Dorina Kallogjeri, MD, MPH1,2; Troy S. Wildes, MD3; et alMichael S. Avidan, MBBCh3;...
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Treatment of Head and Neck Cancer—Sometimes, Less Is More: In this issue of JAMA Otolaryngology-Head & Neck Surgery, Saraswathula and colleagues used the Surveillance, Epidemiology, and End Results Program (SEER)–Medicare outcomes and claims database to compare the value of 3 different radiotherapy (RT) regimens (ie, RT alone, RT plus cisplatin, or RT plus cetuximab) administered to patients older than 65 years with locally advanced head and neck cancer (HNC) of the oral cavity, oropharynx, larynx,...
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Development of a Novel Composite Pathologic Risk Stratification for Surgically Resected HPV-Associated Oropharyngeal Cancer: This retrospective cohort study assesses the performance of the traditional pathologic risk stratification system for surgically resected human papillomavirus–associated oropharyngeal squamous cell carcinoma and proposes an alternate composite risk stratification system.John D. Cramer, MD1; Yusuf Dundar, MD1; Jeffrey Hotaling, MD1; et alS. Naweed Raza, MD1; Ho-Sheng Lin, MD1Author...
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Care Value for Older Patients Receiving Radiotherapy With or Without Cisplatin or Cetuximab for Head/Neck Cancer: This cohort study uses the SEER-Medicare outcomes and claims database to evaluate the quality, outcomes, and costs associated with radiation therapy with or without cisplatin or cetuximab for older adults with stage III to IVB head and neck cancer.Anirudh Saraswathula, BS1; Michelle M. Chen, MD, MHS2; A. Dimitrios Colevas, MD3; et alVasu Divi, MD2Author Affiliations1Stanford University...
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Outcomes in Patients 80 Years or Older Undergoing Major Head and Neck Ablation and Reconstruction: This cohort study examines factors associated with 30-day postoperative complications, 90-day mortality, and 90-day functional decline and creates a preoperative risk stratification system for elderly patients undergoing head and neck ablation and reconstruction.Tanya Fancy, MD1; Andrew T. Huang, MD2; Jason I. Kass, MD, PhD3; et alEric D. Lamarre, MD4; Patrick Tassone, MD4; Avinash V. Mantravadi, MD5;...
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Association of Older Age and Frailty With Depression and Postoperative Regret About Major Head and Neck Surgery: This cohort study assesses whether age and frailty are associated with preoperative and/or worsening postoperative depression and postoperative decision regret in patients undergoing major head and neck surgery and identifies additional factors associated with depression and decision regret.Carissa M. Thomas, MD, PhD1,2; Michael C. Sklar, MD3; Jie Su, MSc4; et alWei Xu, PhD4,5; John R....
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Intraoperative Nerve Monitoring Parameters and Facial Nerve Outcome in Parotidectomy for Benign Disease: This case series study analyzes intraoperative facial nerve monitoring data from adult patients who had a parotidectomy operation and identifies the monitoring parameters associated with postoperative nerve weakness.Catherine T. Haring, MD1; Susan E. Ellsperman, MD1; Bruce M. Edwards, AuD1; et alPaul Kileny, PhD1; Deborah Kovatch, MA, MBA, CCC-A1; Gregory R. Mannarelli, AuD1; Melanie A. Meloch,...
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Risk of Head and Neck Cancer in Patients With Prior Hematologic Malignant Tumors: This study uses Veterans Affairs Corporate Data Warehouse data to examine whether there is an association between prior hematologic malignant tumor and risk of head and neck cancer and assesses the overall survival among these patients.Alia Mowery, BS1; Michael Conlin, MD2; Daniel Clayburgh, MD, PhD2,3Author Affiliations1School of Medicine, Oregon Health and Science University, Portland2Operative Care Division, Portland...
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An Enlarging Right Neck Mass in a 25-Year-Old Woman: Kevin J. Doré, BS1; Prashanthi Divakar, MD2; Konstantinos Linos, MD3Author Affiliations1Geisel School of Medicine at Dartmouth, Hanover, New Hampshire2Section of Otolaryngology, Department of Surgery, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire3Department of Pathology, Dartmouth-Hitchcock Medical Center, Lebanon, New HampshireJAMA Otolaryngol Head Neck Surg. Published online December 19, 2019. doi:https://doi.org/10.1001/jamaoto.2019.3842A...
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Unilateral Vocal Fold Immobility After Prolonged Endotracheal Intubation: This subgroup analysis of a cohort study examines the incidence of and risk factors for unilateral vocal fold immobility after more than 12 hours of mechanical ventilation in a medical intensive care unit.
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Permanent Facial Paralysis and Hearing Loss After Aural Irrigation: Removal of cerumen can be achieved through different methods, which each have advantages and disadvantages. One method is aural irrigation, which carries a risk of tympanic perforation or otitis externa. More serious complications are rare but important to recognize. We report the first case of permanent facial palsy and hearing loss following aural irrigation, to our knowledge. This is a unique report of a rare but important complication...
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Correlation of mucus inflammatory proteins and olfaction in chronic rhinosinusitis: BackgroundChronic rhinosinusitis (CRS) is one of the most common causes of olfactory loss, but the pathophysiology underlying olfactory dysfunction in CRS has not been fully elucidated. Previous studies found correlations between olfactory cleft (OC) inflammatory cytokines/chemokines and olfaction in CRS. The purpose of this study was to evaluate the relationship between OC mucus inflammatory proteins and olfaction...
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Effect of oxidized cellulose on human respiratory mucosa and submucosa and its implications for endoscopic skull‐base approaches: BackgroundRegenerated oxidized cellulose (ROC) sheets have gained popularity as an adjunct to a vascularized nasoseptal flap for closure of dural defects after endoscopic endonasal skull‐base approaches (EESBS). However, evidence supporting its impact on the healing process is uncertain. This study was performed to evaluate the impact of ROC on the nasal mucosa and assess...
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Risk factors for neo‐osteogenesis in cystic fibrosis and non‒cystic fibrosis chronic rhinosinusitis: BackgroundThe purpose of this retrospective review was to determine how patient‐related factors and culture data affect neo‐osteogenesis in patients with chronic rhinosinusitis (CRS) and patients with cystic fibrosis (CF) with CRS.MethodsInformation from a database associated with a large tertiary medical center was used to assess adult patients with CF CRS and non‐CF CRS (total, n = 102; CF CRS,...
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Narrow Band Imaging for lingual tonsil hypertrophy and inflammation, in laryngo-pharyngeal reflux disease: ConclusionsNBI allowed us to identify endoscopically the presence of enlarged lingual tonsil, crypt inflammation and superficial mucosal changes, in patients affected by LPRD.Level of evidence2 (prospective, case –control study). (Source: European Archives of Oto-Rhino-Laryngology)
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Laryngeal adductor reflex hyperexcitability may predict permanent vocal fold paralysis: Laryngeal adductor reflex–continuous intraoperative neuromonitoring (LAR‐CIONM) is a novel method of continuous intraoperative neuromonitoring. In contrast to other vagal nerve monitoring techniques, which elicit a laryngeal compound muscle action potential, LAR‐CIONM elicits a laryngeal reflex response (LAR). In 300 nerves at risk monitored with LAR‐CIONM, two patients have had postoperative permanent vocal fold...
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Endoscopic Fluorescence‐Guided Surgery for Sinonasal Cancer Using an Antibody‐Dye Conjugate: ObjectiveEndoscopic resection of sinonasal squamous cell carcinoma has become the standard of care, but challenges remain in obtaining clear resection margins. The current study evaluated the feasibility of endoscopic fluorescence‐guided surgery (FGS) to improve surgical resection in a human sinus surgical model.MethodsA fluorescence endoscope optimized for near‐infrared (NIR) fluorescence detection was evaluated...
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Effects of Chronic Ephedrine Toxicity on Functional Connections, Cell Apoptosis, and CREB-Related Proteins in the Prefrontal Cortex of Rhesus Monkeys: AbstractEphedrine abuse has spread in many parts of the world, severely threatening human health. The mechanism of ephedrine toxicity is still unclear. To explore the possible neural mechanisms of ephedrine toxicity, this study established a non-human primate model of ephedrine exposure, analyzed the functional connectivity changes in its prefrontal...
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HMGB1 Mediates Paraquat-Induced Neuroinflammatory Responses via Activating RAGE Signaling Pathway: AbstractParaquat (PQ), a widely characterized neurotoxicant, has been generally accepted as one of the environmental factors in the etiology of Parkinson's disease (PD). Despite the direct evidence that PQ could induce inflammatory responses in central nervous system, the putative adverse effects of PQ on the neuroimmune interactions have rarely been investigated. High-mobility group box 1 (HMGB1) has...
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Inflammatory pseudotumour of the alveolar process of the maxilla as clinical manifestation of IgG4-related disease: a case report and literature review: Publication date: Available online 19 December 2019Source: International Journal of Oral and Maxillofacial SurgeryAuthor(s): W.L. Kouwenberg, F.J. Dieleman, S.M. Willems, A.J.W.P. RosenbergAbstractIgG4-related disease (IgG4-RD) is an uncommon immune-mediated condition considered to be a systemic disease, described in multiple organ systems. IgG4-RD...
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Speech changes in patients with a full rehabilitation for severe tooth wear, a first evaluation study: AbstractObjectiveThe aim of this study was to evaluate changes in speech characteristics and self-perceived quality of speech in tooth wear patients, after occlusal rehabilitation.Materials and methodsPatients with tooth wear were included in this study after informed consent. The amount of tooth wear was scored with Tooth Wear Evaluation System (TWES). To assess the perspective of the patient,...
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Key focus areas: In line with the Global Strategy for Women's, Children's and Adolescents' Health, PMNCH focuses on the most vulnerable and marginalized, placing equity at the centre of its work. The Partnership recognizes the substantial impact of health-enhancing sectors on women's, children's and adolescents' health, and engages across sectors to identify links and opportunities to promote greater partner participation in multisectoral knowledge sharing, advocacy, action and accountability to...
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Article in PressPrevalence of QTc prolongation in patients with advanced cancer receiving palliative care – a cause for concern?Janet R. Hardy, BSc, FRACP, MD (Prof)1,∗,'Correspondence information about the author BSc, FRACP, MD Janet R. HardyEmail the author BSc, FRACP, MD Janet R. Hardy, Dr Daniel Bundock2, Dr Jessica Cross2, Kristen Gibbons, Senior Epidemiologist (A/Prof)3, Ross Pinkerton (Prof)4, Dr Korana Kindl5, Phillip Good (A/Prof)5, Jennifer Philip (Prof)6PlumX MetricsDOI: https://doi.org/10.1016/j.jpainsymman.2019.12.356AbstractContextMedications...
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Steroid use in cervicofacial infection. A Maxillofacial Trainee Research Collaborative (MTReC) project: Introduction: Defining current inpatient management of cervicofacial infections is key to identifying strategies to optimise management. Steroid use is beneficial in peritonsillar abscess and orbital abscess, but there are no studies of steroid use in odontogenic cervicofacial infections. Our previous research identified widespread variation in practice, necessitating a national project to define...
Thu Dec 19, 2019 09:41
High-throughput methylation profiling of cell-free plasma DNA in head and neck cancer: a pilot study
High-throughput methylation profiling of cell-free plasma DNA in head and neck cancer: a pilot study: Background: A promising platform to provide genetic biomarker led stratification in head and neck cancer (HNSCC) is a liquid biopsy - utilising tumour derived cell-free plasma DNA (cfDNA). One liquid biopsy biomarker that has generated interest is the methylation status of key promotor genes. Tumour DNA methylation patterns in HNSCC have been shown to be biomarkers of treatment response and survival....
Thu Dec 19, 2019 09:41
Adaptation of an osteotome to produce a predictable sagittal split ramus osteotomy: When using an osteotome (as opposed to a technique using a spreader) for bilateral sagittal split osteotomy, it is important to separate the buccal cortex from the intramedullary bone (involving the inferior alveolar neurovascular bundle) before the split by twisting the osteotome).1 A thin sharp osteotome is usually malleted into the groove created on the buccal shelf, and the junction is separated in advance. During...
Thu Dec 19, 2019 09:40
Comparison of Hogan pharyngeal flap and sphincter pharyngoplasty in postoperative velopharyngeal function: The purpose of this study was to compare speech and breathing after sphincter pharyngoplasty and the Hogan pharyngeal flap in the management of cleft-related velopharyngeal insufficiency (VPI). We reviewed 78 patients with VPI who had either the Hogan flap (n=30) or sphincter pharyngoplasty (n=48) between 2009 and 2011. Velopharyngeal function, nasal patency, and speech were compared. In the...
Thu Dec 19, 2019 09:40
Clinicopathological study of involvement of the submandibular gland in oral squamous cell carcinoma: Our purpose was to provide a pathological basis for preservation of the submandibular glands during neck dissection for oral squamous cell carcinoma (SCC) by investigating whether intraglandular lymph nodes exist in submandibular glands, and the modes of involvement of submandibular glands in oral SCC. We studied the records of 95 patients with oral SCC (other than that in the floor of the mouth)...
Thu Dec 19, 2019 09:40
Diphtheritic angina in the tongue and floor of the mouth: unusual presentation: We present the case of a young man with pseudomembranous plaques on the tongue and floor of the mouth, who received systemic and locoregional medical treatment, with a satisfactory outcome after 14 days. (Source: The British Journal of Oral and Maxillofacial Surgery)
Thu Dec 19, 2019 09:40
Factors Influencing Buprenorphine Prescribing among Physicians in New York State: Background. Increasing access to buprenorphine is an important strategy for curtailing the opioid epidemic. Research is needed to understand what facilitates prescribing among waivered physicians and how to increase the willingness and capacity to prescribe. This study describes prescribing patterns in a sample of buprenorphine-waivered physicians in New York (NY) in 2016 and examines factors influencing prescribing...
Thu Dec 19, 2019 09:39
Antioxidant Effect of the Castanea sativa Mill. Leaf Extract on Oxidative Stress Induced upon Human Spermatozoa: This study was aimed at evaluating in vitro the effects of a 75% ethanolic extract of leaves of Castanea sativa Mill. (var. Bastarda Rossa, Mount Amiata, Tuscany, Italy) on ejaculated human sperm. Total polyphenols and total flavonoids contained in the extract were determined by a colorimetric assay and HPLC-DAD. The DPPH test and electrochemistry were utilized to study the antioxidant...
Thu Dec 19, 2019 09:39
Conditioned Medium from Adipose-Derived Stem Cell Inhibits Jurkat Cell Proliferation through TGF-β1 and p38/MAPK Pathway: Background. Since the first report on the immunomodulatory and immunosuppressive properties of Adipose-Derived Stem Cells (ADSCs), many studies have elucidated the underlying molecular mechanism of their suppressive activity on mixed lymphocyte reaction (MLR). However, a gap exists in our understanding of the molecular mechanism of ADSC-conditioned medium (ADSC-CM) on MLR. Methods....
Thu Dec 19, 2019 09:38
Syringic acid promotes proliferation and migration of Schwann cells via down-regulating miR-451-5p: AbstractSchwann cells are the main force in spontaneous regeneration after peripheral nerve injury. The neurotrophic factors could promote the regeneration, but clinical applications of these factors are limited by some constraints. Hence, searching for new substances to elevate the function of Schwann cells and facilitate the regeneration of nerve is urgently needed. Syringic acid (SA) is a natural...
Thu Dec 19, 2019 09:38
Disruption of crosstalk between LX-2 and liver cancer stem-like cells from MHCC97H cells by DFOG via inhibiting FOXM1: AbstractHepatic stellate cell (HSC) line LX-2 is activated by liver cancer stem-like cells (LCSLCs) and produces various cytokines that make up most of the hepatocellular carcinoma (HCC) microenvironment. The new genistein derivative, 7-difluoromethoxyl-5,4′-di-n-octylgenistein (DFOG), shows anticancer effects in multiple malignancies by controlling forkhead box M1 (FOXM1). In this...
Thu Dec 19, 2019 09:38
Exosome-encapsulated miR-505 from ox-LDL-treated vascular endothelial cells aggravates atherosclerosis by inducing NET formation: AbstractNeutrophil extracellular traps (NETs) play an important role in the pathological process of atherosclerosis (AS). This study aims to evaluate whether exosomes from oxidized low-density lipoprotein (ox-LDL)-treated vascular endothelial cells (VECs) aggravate AS by inducing NET formation. Exosomes from the peripheral blood of healthy donors and AS patients (namely...
Thu Dec 19, 2019 09:37
SRC3 expressed in bone marrow mesenchymal stem cells promotes the development of multiple myeloma: AbstractSRC3 plays critical roles in various biological processes of diseases, including proliferation, apoptosis, migration, and cell cycle arrest. However, the effect of SRC3 expression in mesenchymal stem cells (MSCs) on multiple myeloma (MM) is not clear yet. In our study, MSCs (MSC-SRC3, MSC-SRC3−/−) and MM cells were co-cultured in a direct or indirect way. The proliferation of MM cells was studied...
Thu Dec 19, 2019 09:37
Expression of Nup93 is associated with the proliferation, migration and invasion capacity of cervical cancer cells: AbstractCervical cancer is a prevalent and devastating malignancy in females worldwide. Nucleoporin 93 (Nup93), a member of the nuclear pore complex, plays an important role in transport across the nuclear pore. Several nucleoporins have been linked to cancer. However, the oncogenic role and underlying mechanism of Nup93 in cervical cancer development have not been reported. In this...
Thu Dec 19, 2019 09:37
A novel protein L-cofilin2 identified in Lampetra morii with roles of immune response and cell proliferation promotion: Cofilin2, an actin-binding protein, is expressed in many eukaryotic cells. It binds to and depolymerizes the actin filaments, and its activity is regulated by phosphorylation, dephosphorylation, and pH [1]. Cofilins have been reported to have multiple functions, including cytokinesis, cell locomotion [2], cellular stress responses [3], and pathological situations [4]. Under normal...
Thu Dec 19, 2019 09:37
Decreased expression of piR-35413 in human papillary thyroid cancer: The piRNAs (PIWI-interacting RNAs) are ~26–31 nt in length and are very similar to but little longer than the microRNAs (miRNAs) in size [1]. Since the discovery of the first piRNA in 2006, the number of piRNA sequences has now reached 173 million from 264 datasets in 21 organisms [2]. And, there are 8,438,265 piRNAs identified in the human genome, which far exceeds the total number of miRNAs (~2000) [2], suggesting that piRNAs...
Thu Dec 19, 2019 09:36
The expression changes of circular RNAs between LH + 2 and LH + 7 human endometrium: Compatible endometrial receptivity is essential for successful implantation. The underlying molecular mechanisms are continuously explored in assisted reproduction field, focusing on the protein-encoding genes and microRNAs (miRNAs) [1,2]. However, the effects of circular RNAs (circRNAs) on endometrial receptivity, as well as the regulatory mechanisms, are poorly understood. circRNAs are a special class of non-coding...
Thu Dec 19, 2019 09:36
Quercetin improves endothelial insulin sensitivity in obese mice by inhibiting Drp1 phosphorylation at serine 616 and mitochondrial fragmentation: AbstractStudies have shown that endothelial insulin resistance induced by oxidative stress contributes to vascular dysfunction in metabolic disorders. Quercetin, a natural antioxidant, has been recently shown to exert protective effects on endothelial function. However, the effects of quercetin on endothelial insulin resistance and its underlying mechanism...
Thu Dec 19, 2019 09:36
Accuracy of Ultrasound in Diagnosis of Pneumothorax: A Comparison between Neonates and Adults—A Systematic Review and Meta-Analysis: Objective. The present systematic review and meta-analysis were conducted to investigate the accuracy of ultrasound in the diagnosis of pneumothorax in neonates and adults. Method. The searches were conducted by two independent researchers (MS and HD) to find the relevant studies published from 01/01/2009 until the end of 01/01/2019. We searched for published literature...
Thu Dec 19, 2019 09:35
Steps to Develop a Mobile App for Pain Assessment of Cancer Patients: A Usability Study: Health-related mobile apps have the potential to allow patients and providers to proactively and responsibly manage pain together. However, there is a gap between the science of pain and current mobile apps. To develop a prototype science-based pain assessment mobile app (PainSmart) for Android smartphones, pain assessment tasks were extracted from a clinical guideline. These tasks were then converted to activity...
Thu Dec 19, 2019 09:35
Visualizations Integrated Into Consumer Health Technologies Support Self-management of Chronic Diseases: A Systematic Review: While chronic diseases remain a global problem, visualizations of data and information are a potential solution to assist patients with chronic disease in communication, self-management, and decision making. The purpose of this systematic review is to synthesize evidence regarding data and information visualizations integrated into consumer health informatics solutions for...
Thu Dec 19, 2019 09:35
Using an Evidence-Based Approach for Electronic Health Record Downtime Education in Nurse Onboarding
Using an Evidence-Based Approach for Electronic Health Record Downtime Education in Nurse Onboarding: Electronic health record systems have been widely implemented throughout healthcare settings over the last few years, and nurses rely on these systems to obtain information about patients, make clinical decisions, and deliver safe and appropriate care. Health information technology systems have electronic health record downtime episodes both due to scheduled maintenance and unforeseen circumstances....
Thu Dec 19, 2019 09:34
The relationship of trauma exposure to heart rate variability during wake and sleep in midlife women
The relationship of trauma exposure to heart rate variability during wake and sleep in midlife women: AbstractTraumatic experiences are common and linked to cardiovascular disease (CVD) risk, yet the mechanisms underlying these relationships is less well understood. Few studies have examined trauma exposure and its relation to autonomic influence over cardiac function, a potential pathway linking trauma exposure to CVD risk. Investigating autonomic influence over cardiac function during both wake...
Thu Dec 19, 2019 09:34
PrP is a central player in toxicity mediated by soluble aggregates of neurodegeneration-causing proteins: AbstractNeurodegenerative diseases are an enormous public health problem, affecting tens of millions of people worldwide. Nearly all of these diseases are characterized by oligomerization and fibrillization of neuronal proteins, and there is great interest in therapeutic targeting of these aggregates. Here, we show that soluble aggregates of α-synuclein and tau bind to plate-immobilized PrP in...
Thu Dec 19, 2019 09:34
Evaluation of thrombotic events in patients with immune thrombocytopenia: AbstractImmune thrombocytopenia (ITP) has been reported to be associated with thrombotic events. The incidence of thrombosis in 303 newly diagnosed ITP patients in our institute between 2000 and 2016 was retrospectively reviewed. During a median follow-up of 3.6 years, 16 thrombotic events (12 arterial and four venous) occurred. The median platelet count at thrombotic events was 102 × 109/l. At 10 years, the cumulative thrombosis...
Thu Dec 19, 2019 09:34
A comparative effectiveness study of lipegfilgrastim in multiple myeloma patients after high dose melphalan and autologous stem cell transplant: AbstractG-CSF administration after high-dose chemotherapy and autologous stem cell transplantation (ASCT) has been shown to expedite neutrophil recovery. Several studies comparing filgrastim and pegfilgrastim in the post-ASCT setting concluded that the two are at least equally effective. Lipegfilgrastim (LIP) is a new long-acting, once-per-cycle G-CSF. This...
Thu Dec 19, 2019 09:33
Effects of vitamin D in an animal model of Alzheimer's disease: behavioral assessment with biochemical investigation of Hippocampus and serum: AbstractRegulatory role of vitamin D (VitD) in cognitive memory and learning has been proposed. Here, we examine the behavioral and biochemical effects of VitD in Alzheimer's disease (AD), as the most common form of dementia, in male Wistar rats. Animals (n = 48) were randomly divided into six groups: control, sham solvent, sham surgery, VitD (by intraperitoneal...
Thu Dec 19, 2019 09:33
Protective effects of Chrysin against memory impairment, cerebral hyperemia and oxidative stress after cerebral hypoperfusion and reperfusion in rats: AbstractStroke is devastating and a leading cause of morbidity and mortality worldwide. Cerebral ischemia-reperfusion and its subsequent reactive hyperemia lead to neuronal damage in the hippocampus and cognitive decline. Chrysin (5, 7-dihydroxyflavone) is a well-known member of the flavonoid family with antioxidant and neuroprotective effects. Therefore,...
Thu Dec 19, 2019 09:33
Cytokine/chemokine dysregulation in progressive MS patient is apparent and can be modulated by calpain inhibition: AbstractThis study examines the cytokine/chemokine profile of a 62-year-old African American male with progressive multiple sclerosis (MS). MRI images of the MS patient demonstrated generalized white matter involvement with multiple lesions in the periventricular area. A 42-plex Discovery Assay® (Eve Technologies) of the patient's plasma and peripheral blood mononuclear cells (PBMCs)...
Thu Dec 19, 2019 09:33
Detection and quantification of synthetic cathinones and selected piperazines in hair by LC-MS/MS: AbstractNew psychoactive substances (NPS)—such as synthetic cathinones and piperazines—are defined as substances designed to replicate the effects of traditional illegal drugs, including cocaine, ecstasy and amphetamines. These substances are known to potentially be much more potent than their analogs. In the past, there were many poisonings and deaths associated with NPS. Because of this, NPS identification...
Thu Dec 19, 2019 09:33
An Unusual Case of Simultaneous Cricoid and Thyroid Cartilage Metastases from Prostatic Adenocarcinoma on 68 Ga-PSMA PET/CT: AbstractAlthough prostate cancer can metastasize to any part of the body, laryngeal cartilage metastasis is extremely rare and few cases have been published so far. Here we present the case of a 65-year-old male patient, recently diagnosed with prostate adenocarcinoma, referred for staging with 68Ga-PSMA PET/CT. He was found to have extensive skeletal metastasis along with...
Thu Dec 19, 2019 09:32
Neoadjuvant Chemotherapy Benefits Survival in High-Grade Upper Tract Urothelial Carcinoma: A Propensity Score-Based Analysis: AbstractBackgroundTo evaluate the benefit of neoadjuvant chemotherapy (NAC) for survival in high-grade upper tract urothelial carcinoma (UTUC), a propensity score-based analysis was performed with high-grade UTUC patients from multiple urologic centers.MethodsFrom three urologic centers, 48 high-grade UTUC patients who received chemotherapy followed by surgery (NAC group)...
Thu Dec 19, 2019 09:32
Intra fractional 6D head movement increases with time of mask fixation during stereotactic intracranial RT-sessions: AbstractBackgroundThe present study investigates the intrafractional accuracy of a frameless thermoplastic mask used for head immobilization during stereotactic radiotherapy. Non-invasive masks cannot completely prohibit head movements. Previous studies attempted to estimate the magnitude of intrafractional inaccuracy by means of pre- and postfractional measurements only. However,...
Thu Dec 19, 2019 09:31
Clinical features and treatment outcomes of limited-stage mantle cell lymphoma: Consortium for Improving Survival of Lymphoma report: AbstractLimited-stage (Ann Arbor stage I or II) mantle cell lymphoma (MCL) is an extremely rare disease. Thus, there is little data on the clinical features and treatment outcomes of patients with early-stage MCL. We examined consecutive stage I or II MCL 41 cases diagnosed between 2000 and 2016 in 16 institutions of the Consortium for Improving Survival of Lymphoma...
Thu Dec 19, 2019 09:31
CD73 expression and pathologic response to neoadjuvant chemotherapy in triple negative breast cancer
CD73 expression and pathologic response to neoadjuvant chemotherapy in triple negative breast cancer: AbstractThe immune system plays a key role in tumor surveillance and escape. Recently, CD73 has been proposed as a prognostic biomarker associated with disease-free survival and overall survival in triple negative breast cancer (TNBC). In this study, we investigated the role of both CD73 expression and stromal tumor–infiltrating lymphocytes (TILs) in predicting the pathologic response of TNBC to...
Thu Dec 19, 2019 09:31
Intensity-modulated radiotherapy is superior to three-dimensional conformal radiotherapy in the trimodality management of muscle-invasive bladder cancer with daily cone beam computed tomography optimization: AbstractObjectiveIntensity-modulated radiation therapy (IMRT) using a volumetric-modulated arc therapy technique may offer dosimetric and clinical benefits compared to the historical standard of care 3D conformal radiotherapy (3D-CRT) in definitive treatment of bladder cancer. We hypothesized...
Thu Dec 19, 2019 09:31
Role of VEGFs in metabolic disorders: AbstractObesity and metabolic disorders are important public health problems. In this review, the role of vasculature network and VEGF in the adipose tissue maintenance and supplementation is discussed. Angiogenesis is a key process implicated in regulation of tissues homeostasis. Dysregulation of new blood vessels formation may be crucial and contribute to the onset of several pathological conditions, including metabolic syndrome-associated disorders. Adipose...
Thu Dec 19, 2019 09:30
Robot motion design using bunraku emotional expressions – focusing on Jo-Ha-Kyū in sounds and movements: AbstractOne of the UNESCO intangible cultural heritages Bunraku puppets can play one of the most beautiful puppet motions in the world. The Bunraku puppet motions can express emotions without the so-called 'Uncanny Valley.' We try to convert these emotional motions into robot affective motions so that robots can interact with human beings more comfortable. In so doing, in the present paper, we...
Thu Dec 19, 2019 09:30
Middle East respiratory syndrome coronavirus (MERS-CoV) – The Kingdom of Saudi Arabia: From 1 through 30 November 2019, the National IHR Focal Point of Saudi Arabia reported 10 additional cases of Middle East respiratory syndrome (MERS-CoV) infection and one associated deaths. The cases were reported from Riyadh (4), Madinah (2), Al-Qassim (1), Assir (1), Taif (1), and Makkah (1) regions.The link below provides details of the 10 reported cases:
Thu Dec 19, 2019 09:29
Pre- and intraoperative acoustic and functional assessment of the novel APrevent® VOIS implant during routine medialization thyroplasty.: Related ArticlesPre- and intraoperative acoustic and functional assessment of the novel APrevent® VOIS implant during routine medialization thyroplasty.Eur Arch Otorhinolaryngol. 2019 Dec 16;:Authors: Ho GY, Leonhard M, Denk-Linnert DM, Schneider-Stickler BAbstract PURPOSE: Persistent unilateral vocal fold paralysis (UFVP) with glottal insufficiency often...
Thu Dec 19, 2019 09:28
Psychiatric Distress as a Common Risk Factor for Tinnitus and Joint Pain: A National Population-Based Survey.: Related ArticlesPsychiatric Distress as a Common Risk Factor for Tinnitus and Joint Pain: A National Population-Based Survey.Clin Exp Otorhinolaryngol. 2019 Dec 18;:Authors: Park E, Kim H, Choi IH, Han HM, Han K, Jung HH, Im GJAbstract Objectives: This study aimed to investigate the relationship between tinnitus and joint pain from representative samples of Koreans. Methods:...
Thu Dec 19, 2019 09:28
Hemostasis of idiopathic recurrent epistaxis in children with microwave ablation: a prospective pilot case series: AbstractObjectiveWe evaluated microwave ablation (MWA) for treatment of idiopathic recurrent anterior epistaxis (RAE) in children, in terms of technical feasibility, efficacy, and safety.Study designA prospective pilot case series.SettingTertiary university hospital.MethodsChildren with idiopathic RAE were treated with endoscopic MWA and reevaluated at 1 and 4 weeks and at 6 months thereafter....
Thu Dec 19, 2019 09:28
Headache after septoplasty: Publication date: Available online 18 December 2019Figures (2)Source: European Annals of Otorhinolaryngology, Head and Neck DiseasesAuthor(s): S. Chastanet, D. Goga, A. Paré
Thu Dec 19, 2019 09:26
Nasopharyngeal Cultures in Children; When, What and Why?: Publication date: Available online 17 December 2019Source: International Journal of Pediatric OtorhinolaryngologyAuthor(s): Samuel Flyman, Ann Hermansson, Marie Gisselsson SolénAbstractIntroductionNasopharyngeal cultures are commonly used to determine the causative bacteria in upper airway infections. However, several bacteria can occupy the nasopharynx simultaneously and most healthy children are asymptomatic carriers of presumptive pathogens....
Thu Dec 19, 2019 09:23
Hearing Improvement after Sudden Sensorineural Hearing Loss as a Predictor of Vestibular Schwannoma: Introduction: Sudden sensorineural hearing loss (SSNHL) can be the presenting symptom of vestibular schwannoma (VS). Usually, steroidal treatment is given before magnetic resonance imaging (MRI) is performed. Objectives: The aim of this study was to investigate whether there is a different pattern of steroidal treatment response after SSNHL in patients with and without a VS, in order to determine...
Thu Dec 19, 2019 09:22
Pharyngeal motility in patients submitted to type I thyroplasty: Publication date: Available online 18 December 2019Source: Brazilian Journal of OtorhinolaryngologyAuthor(s): Bruno Rezende Pinna, Fernando A.M. Herbella, Noemi de BiaseAbstractIntroductionType 1 thyroplasty is performed to improve glottis closure as well as dysphagic symptoms in patients with unilateral vocal fold immobility.ObjectivesThis study aims to compare the motility of the pharynx and upper esophageal sphincter in patients...
Thu Dec 19, 2019 09:22
Pediatric nasal tip abscesses: We report on 7 children/teenagers who presented with an advanced nasal tip abscess that required intravenous antibiotics and surgical drainage, despite adequate pre-admission antibiotic therapy with amoxicillin/clavulanic acid or cephalosporins. Cultures were positive forStaphylococcus aureus, that was clindamycin-resistant but TMP/SMX sensitive. (Source: European Archives of Oto-Rhino-Laryngology)
Thu Dec 19, 2019 09:21
Deep cervical fascia as an anatomical landmark of lingual lymph nodes: An anatomic and histologic study: AbstractObjectivesWe aimed to discuss the definition of lingual lymph nodes based on the deep cervical fascia anatomy.MethodsA total of 11 cadavers were histopathologically evaluated. Specimens were dissected into serial stepwise cross-sections. The deep cervical fascia and lymph nodes were evaluated by staining the cross-sections with Elastica van Gieson and hematoxylin and eosin stains, respectively....
Thu Dec 19, 2019 09:20
Hemostasis of idiopathic recurrent epistaxis in children with microwave ablation: a prospective pilot case series: We evaluated microwave ablation (MWA) for treatment of idiopathic recurrent anterior epistaxis (RAE) in children, in terms of technical feasibility, efficacy, and safety. Hemostasis of idiopathic recurrent epistaxis in children with microwave ablation: a prospective pilot case seriesZheng-cai Lou Journal of Otolaryngology - Head & Neck Surgery volume 48, Article number: 72 (2019)...
Thu Dec 19, 2019 09:18
Balloon dilatation for paediatric airway stenosis: evidence from the UK Airway Intervention Registry
Balloon dilatation for paediatric airway stenosis: evidence from the UK Airway Intervention Registry: AbstractObjectivesTo assess the safety and efficacy in routine clinical practice of balloon dilatation procedures in the treatment of paediatric airway stenosis.DesignObservational data collection in prospective online research databaseSettingAcute NHS Trusts with ENT department undertaking complex paediatric airway workParticipants: Children (<18) undergoing balloon dilatation treatment for airway...
Thu Dec 19, 2019 09:16
The effect of three‐dimensional visualization on performance in endoscopic endonasal surgery: a clinical training study using surgical navigation for movement analysis in a randomized cross over design: AbstractObjectivesEndoscopic imaging techniques and endoscopic endonasal surgery (EES) expertise have evolved rapidly. Only few studies have assessed the effect of three‐dimensional (3D) endoscopy on endoscopic sinus surgery (ESS). The present study aimed to objectively and subjectively assess the...
Thu Dec 19, 2019 09:16
Technical note: Atraumatic compression of the pinna – an alternative application of the external nasal splint: AbstractKeloid scars represent a pathological dermal response to injury characterised by aberrant fibroblast proliferation and resultant overproduction of collagen1. Distinct from hypertrophic scars, keloids infiltrate surrounding normal tissue and rarely regress.2 Keloid lesions extend beyond the margins of the original injury and may cause significant functional, cosmetic and psychological...
Thu Dec 19, 2019 09:16
Flexible laser Sphenopalatine artery ligation: an alternative to the classic approach: AbstractEpistaxis is one of the most common ENT emergencies and also a well‐known reason for hospital admission. About 5‐15% of hospital admissions will finally require surgical treatment, with the most preferable method being ligation of the sphenopalatine artery (SPA)1. We are aiming to present an alternative to the classic approach which may help the surgeon overcome any obstacles leading to difficult access...
Thu Dec 19, 2019 09:15
Prognostic values of preoperative platelet‐to‐lymphocyte ratio (PLR) and platelet‐related indices in advanced hypopharyngeal squamous cell carcinoma: AbstractObjectivesTo investigate the prognostic values of preoperative platelet‐to‐lymphocyte ratio (PLR) and platelet‐related indices in advanced hypopharyngeal squamous cell carcinoma (HPSCC).MethodsThe data of 247 eligible advanced HPSCC patients were reviewed retrospectively. Pretreatment hematological parameters were categorized into 2 groups based...
Thu Dec 19, 2019 09:15
A novel water occlusion test for disorders causing pulsatile tinnitus: Our experience in 32 patients
A novel water occlusion test for disorders causing pulsatile tinnitus: Our experience in 32 patients: AbstractPulsatile tinnitus (PT) originates mainly from the vascular structures near the cochlea and the vascular sound is believed to be transmitted to the cochlea by bony or vascular structures.Digital pressure test over the internal jugular vein ipsilateral to PT side is a simple test for differentiating venous from arterial PT by lessening venous flow.Pulsation of dehiscent venous sinus wall itself...
Thu Dec 19, 2019 09:15
Cochlear Implantation in Congenital Long-QT Syndrome: A Comprehensive Study.: Related ArticlesCochlear Implantation in Congenital Long-QT Syndrome: A Comprehensive Study.J Int Adv Otol. 2019 Dec;15(3):352-357Authors: Anto R, Maheswari S, Vadivu S, Kameswaran MAbstract OBJECTIVES: Jervell and Lange-Nielsen syndrome is a rare autosomal recessive disease characterized by congenital sensorineural deafness and significant QT interval prolongation. Aims were to study the prevalence of long QT in...
Thu Dec 19, 2019 09:14
The Analysis of GJB2, GJB3, and GJB6 Gene Mutations in Patients with Hereditary Non-Syndromic Hearing Loss Living in Sivas.: Related ArticlesThe Analysis of GJB2, GJB3, and GJB6 Gene Mutations in Patients with Hereditary Non-Syndromic Hearing Loss Living in Sivas.J Int Adv Otol. 2019 Dec;15(3):373-378Authors: Küçük Kurtulgan H, Altuntaş EE, Yıldırım ME, Özdemir Ö, Bağcı B, Sezgin İAbstract OBJECTIVES: The aim of the present study was to investigate the presence of GJB2, GJB3, and GJB6 gene...
Thu Dec 19, 2019 09:13
Analysis of the Microbiome in the Adenoids of Korean Children with Otitis Media with Effusion.: Related ArticlesAnalysis of the Microbiome in the Adenoids of Korean Children with Otitis Media with Effusion.J Int Adv Otol. 2019 Dec;15(3):379-385Authors: Kim SK, Hong SJ, Pak KH, Hong SMAbstract OBJECTIVES: The adenoid pad, which is located between the orifice of the Eustachian tube (ET) and posterior nasal cavity, can affect the development of otitis media with effusion (OME) because of its...
Thu Dec 19, 2019 09:12
Clinical Characteristics and Treatment Outcomes of Congenital Cholesteatoma.: Related ArticlesClinical Characteristics and Treatment Outcomes of Congenital Cholesteatoma.J Int Adv Otol. 2019 Dec;15(3):386-390Authors: Song IS, Han WG, Lim KH, Nam KJ, Yoo MH, Rah YC, Choi JAbstract OBJECTIVES: Since its introduction in 2002, the staging system for congenital cholesteatoma, as defined by Potsic, has been used widely owing to its simplicity and predictability. The aim of the present study was...
Thu Dec 19, 2019 09:12
Endoscope-Assisted Surgery for Petrous Bone Cholesteatoma with Hearing Preservation.: Related ArticlesEndoscope-Assisted Surgery for Petrous Bone Cholesteatoma with Hearing Preservation.J Int Adv Otol. 2019 Dec;15(3):391-395Authors: Orhan KS, Çelik M, Polat B, Aydemir L, Aydoseli A, Sencer A, Güldiken YAbstract OBJECTIVES: Petrous bone cholesteatoma is a rare pathologic entity and may be a difficult surgical challenge because of potential involvement of the facial nerve, carotid artery, dura...
Thu Dec 19, 2019 09:12
Health Related Quality of Life after the Bony Obliteration Tympanoplasty for COM with Cholesteatoma using the COMQ12 - A Disease Specific PROM.: Related ArticlesHealth Related Quality of Life after the Bony Obliteration Tympanoplasty for COM with Cholesteatoma using the COMQ12 - A Disease Specific PROM.J Int Adv Otol. 2019 Dec;15(3):396-399Authors: Baetens W, Dinther JV, Vanspauwen R, Maryn Y, Zarowski A, Offeciers EAbstract OBJECTIVES: This study aimed to investigate the effect of canal...
Thu Dec 19, 2019 09:12
Mastoid Obliteration with Synthetic Materials: A Review of the Literature.: Related ArticlesMastoid Obliteration with Synthetic Materials: A Review of the Literature.J Int Adv Otol. 2019 Dec;15(3):400-404Authors: Skoulakis C, Koltsidopoulos P, Iyer A, Kontorinis GAbstract Canal wall down mastoidectomy is a surgical technique used for the eradication of middle ear disease. The remaining large mastoid bowl is associated with a number of issues; one of the main techniques that have been developed...
Thu Dec 19, 2019 09:12
Prevention of Craniofacial Pain Secondary to Harvesting of Temporalis Fascia - A Novel Technique.: Related ArticlesPrevention of Craniofacial Pain Secondary to Harvesting of Temporalis Fascia - A Novel Technique.J Int Adv Otol. 2019 Dec;15(3):405-408Authors: Bhat VK, Ajur S, Bongale KR, Sachidananda RAbstract OBJECTIVES: A lesser known after effect of harvesting temporalis fascia is the post-surgical craniofacial pain. The aim of the study was to evaluate this pain after tympanomastoid surgeries...
Thu Dec 19, 2019 09:11
The Comparison of the Right and Left Sigmoid Sinus Cross-Sectional Areas in Fetal Period and the Factors Affecting the Venous Dominance.: Related ArticlesThe Comparison of the Right and Left Sigmoid Sinus Cross-Sectional Areas in Fetal Period and the Factors Affecting the Venous Dominance.J Int Adv Otol. 2019 Dec;15(3):409-414Authors: Özalp H, Aktekin M, Hamzaoğlu V, Vayisoğlu Y, Karataş MA, Karşıyaka D, Uzmansel D, Bozdoğan Arpacı R, Cayan F, Eti CM, Kanık A, Baskan FC, Aladağ ZC, Ertaş E, Dağtekin...
Thu Dec 19, 2019 09:11
Surgical Outcomes of Intratemporal Facial Nerve Schwannomas According to Facial Nerve Manipulation.: Related ArticlesSurgical Outcomes of Intratemporal Facial Nerve Schwannomas According to Facial Nerve Manipulation.J Int Adv Otol. 2019 Dec;15(3):415-419Authors: Kang WS, Han JJ, Rhee J, Lee JH, Koo JW, Chung JWAbstract OBJECTIVES: The aim of this study was to evaluate the preoperative and postoperative facial nerve (FN) function in patients with FN schwannoma (FNS) and analyze the duration...
Thu Dec 19, 2019 09:11
Efficacy of Epley Maneuver on Quality of Life of Elderly Patients with Subjective BPPV.: Related ArticlesEfficacy of Epley Maneuver on Quality of Life of Elderly Patients with Subjective BPPV.J Int Adv Otol. 2019 Dec;15(3):420-424Authors: Uz U, Uz D, Akdal G, Çelik OAbstract OBJECTIVES: This study aimed to evaluate the efficacy of the repositioning maneuver on quality of life in elderly patients with dizziness and/or vertigo. MATERIALS AND METHODS: This controlled, prospective randomized...
Thu Dec 19, 2019 09:11
Head-Shaking Nystagmus in the Early Stage of Unilateral Meniere's Disease.: Related ArticlesHead-Shaking Nystagmus in the Early Stage of Unilateral Meniere's Disease.J Int Adv Otol. 2019 Dec;15(3):425-430Authors: Stadio AD, Ricci G, Ralli M, Paolo T, Agostini G, Faralli MAbstract OBJECTIVES: The aim of the present study was to evaluate the ability of head-shaking nystagmus (HSNy), evoked after the resolution of a vertigo spell, to predict an imminent crisis in the early stage of Meniere's...
Thu Dec 19, 2019 09:10
A New Application of CBCT Image Fusion in Temporal Bone Studies.: Related ArticlesA New Application of CBCT Image Fusion in Temporal Bone Studies.J Int Adv Otol. 2019 Dec;15(3):431-435Authors: Iso-Mustajärvi M, Sipari S, Lehtimäki A, Tervaniemi J, Löppönen H, Dietz AAbstract OBJECTIVES: Temporal bone (TB) studies are essential during the development of new arrays. Postoperative cochlear histology is still regarded as golden standard for the assessment of electrode localization and trauma...
Thu Dec 19, 2019 09:07
Menière's Disease and Caloric Stimulation: Some News from an Old Test.: Related ArticlesMenière's Disease and Caloric Stimulation: Some News from an Old Test.J Int Adv Otol. 2019 Dec;15(3):442-446Authors: Cerchiai N, Navari E, Miccoli M, Casani APAbstract OBJECTIVES: The aim of the present study was to improve the instrumental diagnosis of assessing Menière's disease (MD) if the frequency and slow-phase velocity (SPV) of the thermally induced nystagmus analyzed through the caloric vestibular...
Thu Dec 19, 2019 09:07
Validation and Factor Analysis of the Lithuanian Version of the Dizziness Handicap Inventory.: Related ArticlesValidation and Factor Analysis of the Lithuanian Version of the Dizziness Handicap Inventory.J Int Adv Otol. 2019 Dec;15(3):447-453Authors: Valančius D, Ulytė A, Masiliūnas R, Paškonienė A, Ulozienė I, Kaski D, Vaicekauskienė L, Lesinskas E, Jatužis D, Ryliškienė KAbstract OBJECTIVES: This study aimed to validate the Lithuanian version of the Dizziness Handicap Inventory (DHI-L),...
Thu Dec 19, 2019 09:07
The Long-Term Efficacy of Cochlear Implantation for Hearing Loss in Muckel-Wells Syndrome.: Related ArticlesThe Long-Term Efficacy of Cochlear Implantation for Hearing Loss in Muckel-Wells Syndrome.J Int Adv Otol. 2019 Dec;15(3):454-458Authors: Ogawa B, Aoki M, Ohnishi H, Ohashi T, Hayashi H, Kuze B, Ito YAbstract Muckle-Wells syndrome (MWS), a subclass of cryopyrin-associated periodic syndrome (CAPS), sometimes includes complications of bilateral progressive sensorineural hearing loss. A...
Thu Dec 19, 2019 09:06
Cochlear Implantation after Bromate Intoxication-Induced Bilateral Deafness: A Case Report.: Related ArticlesCochlear Implantation after Bromate Intoxication-Induced Bilateral Deafness: A Case Report.J Int Adv Otol. 2019 Dec;15(3):459-462Authors: Sung-Won C, Youngmo CAbstract Hearing loss is a common consequence of the strong acidosis induced by bromate poisoning. Partial hearing recovery has been achieved through medical or rehabilitative therapy but reports of surgical otology treatment...
Thu Dec 19, 2019 09:06
Cryptic Early Gastric Carcinoma in Gastric Stump: Challenges in Diagnostic Evaluation: Partial gastrectomy, performed for any indication, is a well-recognized risk factor for carcinoma developing in the gastric remnant (so-called "gastric stump carcinoma"). In symptomatic patients with gastro-enteric anastomosis, it is a common practice to endoscopically evaluate the patency and the status of the anastomosis and procure biopsy samples when endoscopic abnormalities are noted. We describe a case with...
Thu Dec 19, 2019 09:05
Fatal chronic meningitis caused by <em>Candida dubliniensis</em> after liver transplantation: Publication date: Available online 17 December 2019Source: Medical Mycology Case ReportsAuthor(s): Mariam Gheshlaghi, Jannik Helweg-LarsenAbstractWe report a case of fatal chronic Candida dubliniensis meningitis complicated by severe hydrocephalus secondary to liver transplantation, in which diagnosis was considerably delayed.Candida dubliniensis is a fungal opportunistic pathogen originally...
Thu Dec 19, 2019 09:05
Persistent candida arthritis successfully treated with micafungin instillation and surgery. A case report: Publication date: Available online 17 December 2019Source: Medical Mycology Case ReportsAuthor(s): Jeroen C. van Egmond, Nicole G.M. Hunfeld, Bart J.A. Rijnders, Jan A.N. VerhaarAbstractWe report a rare case of C. krusei knee arthritis treated with instillation of micafungin and arthroscopy. A 49-year-old man hospitalized for treatment of Acute Myeloid Leukemia developed knee arthritis with...
Thu Dec 19, 2019 09:04
Emergent laparoscopic dome resection and omental suturing to the splenic parenchymal edge for a spontaneously ruptured non-parasitic large splenic cyst in a pediatric patient: a case report: AbstractBackgroundSpontaneously ruptured large splenic cyst is a rare in children, and traditionally total or partial splenectomy has been performed for treating an emergent case. We herein present a first case with spontaneously ruptured pediatric splenic cyst treated with emergent laparoscopic dome resection...
Thu Dec 19, 2019 09:04
A patient with metformin-associated lactic acidosis successfully treated with continuous renal replacement therapy: a case report: Metformin has been widely used as a first-line agent to treat type 2 diabetes mellitus. Lactic acidosis is a rare but serious adverse effect in patients treated with metformin. Recent studies noted a correlati...
Thu Dec 19, 2019 09:04
Dermatofibrosarcoma protuberans – the use of neoadjuvant imatinib for treatment of an uncommon breast malignancy: a case report: AbstractBackgroundDermatofibrosarcoma protuberans is a rare soft tissue malignancy that, if left untreated, can be locally destructive and life-threatening. Dermatofibrosarcoma protuberans is uncommon in the breast, and the similarity of its morphologic features with other spindle cell malignancies can make correct identification difficult. Immunohistochemistry and molecular...
Thu Dec 19, 2019 09:04
Streptococcus constellatus: a rare causative agent of pyogenic liver abscess: A 26-year-old man who was previously well presented to the emergency in septic shock. He had a preceding history of fever, right upper abdominal pain and jaundice. On examination, there was tenderness over the right hypochondrium and epigastrium, without features of generalised peritonitis. His blood tests were suggestive of sepsis with deranged liver function tests. CT scan of the abdomen showed multiples abscesses in...
Thu Dec 19, 2019 09:03
Mycobacterium bovis prosthetic joint infection following intravesical instillation of BCG for bladder cancer: A 91-year-old man with a history of intravesicular BCG therapy for recurrent bladder cancer and bilateral total hip arthroplasty (THA) presented with left hip pain. He was noted to have a fluid collection over the left lateral hip and hip X-ray showed loosening of the prosthetic hip stem indicative of a prosthetic joint infection (PJI). He subsequently underwent removal of the THA and insertion...
Thu Dec 19, 2019 09:03
Type 2 diabetes mellitus complicated with idiopathic hypoparathyroidism where poor glycaemic control was associated with low adherence to exercise and medication due to hypocalcaemia: We report a rare case of type 2 diabetes mellitus (T2DM) complicated with idiopathic hypoparathyroidism. A 36-year-old Japanese man was admitted to our hospital owing to poor glycaemic control and hypocalcaemia. The patient had myalgia resulting from hypocalcaemia, which prevented adequate exercise. He considered the...
Thu Dec 19, 2019 09:03
Elevated GALNT10 expression identifies immunosuppressive microenvironment and dismal prognosis of patients with high grade serous ovarian cancer: AbstractHigh grade ovarian serous cancer (HGSC) is a malignant disease with high mortality. Glycosylation plays important roles in tumor invasion and immune evasion, but its effect on the immune microenvironment of HGSC remains unclear. This study examined the association of glycosyltransferase expression with HGSC prognosis and explored the underlying...
Thu Dec 19, 2019 09:03
EBV‐directed viral‐specific T‐lymphocyte therapy for the treatment of EBV‐driven lymphoma in two patients with primary immunodeficiency and DNA repair defects: AbstractChildren with ataxia telangiectasia (AT), a primary immunodeficiency caused by mutations in ATM, which is critical for repairing DNA defects, are at risk for the development of hematologic malignancy, frequently driven by infection with Epstein‐Barr virus (EBV). Conventional chemotherapy is poorly tolerated by patients with AT, with...
Thu Dec 19, 2019 09:03
Salvage treatment for children with relapsed/refractory germ cell tumors: The Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP) experience: AbstractBackgroundMalignant germ cell tumors (GCTs) are a heterogeneous group of rare neoplasms in children. Optimal outcome is achieved with multimodal therapies for patients with both localized and advanced disease, especially after the introduction of platinum‐based chemotherapy regimens. In this respect, data on salvage treatment for children...
Thu Dec 19, 2019 09:02
Donor selection in a pediatric stem cell transplantation cohort using PIRCHE and HLA‐DPB1 typing: AbstractBackgroundNew strategies to optimize donor selection for hematopoietic stem cell transplantation (HSCT) have mainly been evaluated in adults, but the disease spectrum requiring HSCT differs significantly in children and has consequences for the risk of complications, such as graft‐versus‐host disease (GvHD).ProceduresHere we evaluated whether HLA‐DPB1 and Predicted Indirectly ReCognizable HLA‐Epitope...
Thu Dec 19, 2019 09:02
Prognostic value of H3K27me3 in children with ependymoma: AbstractObjectiveTo investigate the expression of H3K27me3 in different anatomical sites and analyze its prognostic value in children with ependymoma.MethodsA total of 188 children diagnosed with ependymoma were admitted to the Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, between 2012 and 2017, and regular follow‐up was conducted. Expression of H3K27me3 was analyzed by immunohistochemistry and scored semiquantitatively....
Thu Dec 19, 2019 09:02
Surge of serum interleukin‐2 level in a Japanese patient with cytarabine syndrome: Cytarabine syndrome is a rare clinical condition characterized by fever, malaise, myalgia, arthralgia, and/or rash that occurs after receipt of cytarabine. Our patient developed fever, malaise, and diffuse body pain shortly following cytarabine initiation despite receiving prophylactic dexamethasone.Feb 19, 2016(PDF) Cytarabine syndrome despite corticosteroid ...https://www.researchgate.net › publication › 282468863_Cytarabine_syndro...
Thu Dec 19, 2019 09:02
Treatment of pediatric high‐grade central nervous system tumors with high‐dose methotrexate in combination with multiagent chemotherapy: A single‐institution experience: AbstractBackgroundEffective treatment for pediatric embryonal brain tumors includes dose‐intensive multiagent chemotherapy (DIMAC) followed by high‐dose chemotherapy with stem cell rescue (HDCSCR). Use of repeated cycles of DIMAC including high‐dose methotrexate (HDMTX) without HDCSCR has not been described.ProcedureWe retrospectively...
Thu Dec 19, 2019 09:01
Simultaneous osteosarcoma and renal cell carcinoma with BRCA1 mutation in a young male adult with prior oligodendroglioma:
Thu Dec 19, 2019 09:01
PD-L1 and MRN synergy in platinum-based chemoresistance of head and neck squamous cell carcinoma: British Journal of Cancer, Published online: 19 December 2019; doi:10.1038/s41416-019-0697-xPD-L1 and MRN synergy in platinum-based chemoresistance of head and neck squamous cell carcinomaAbstractBackgroundWe have been investigating the molecular mechanisms of cisplatin-induced chemoresistance in head and neck squamous cell carcinoma (HNSCC). Based on our previous findings, the present study investigates...
Thu Dec 19, 2019 09:00
The Cytosolic DNA-Sensing cGAS-STING Pathway in Cancer [Review]: The recognition of DNA as an immune-stimulatory molecule is an evolutionarily conserved mechanism to initiate rapid innate immune responses against microbial pathogens. The cGAS–STING pathway was discovered as an important DNA-sensing machinery in innate immunity and viral defense. Recent advances have now expanded the roles of cGAS–STING to cancer. Highly aggressive, unstable tumors have evolved to co-opt this program to drive tumorigenic...
Thu Dec 19, 2019 08:59
MRI Tumor Regression Grade and Circulating Tumor DNA as Complementary Tools to Assess Response and Guide Therapy Adaptation in Rectal Cancer: Purpose:Response to preoperative chemo-radiotherapy (CRT) varies. We assessed whether circulating tumor DNA (ctDNA) might be an early indicator of tumor response or progression to guide therapy adaptation in rectal cancer.Experimental Design:A total of 243 serial plasma samples were analyzed from 47 patients with localized rectal cancer undergoing CRT. Up to...
Thu Dec 19, 2019 08:59
EGFR amplification induces increased DNA damage response and renders selective sensitivity to Talazoparib (PARP inhibitor) in glioblastoma: Purpose: Exploration of novel strategies to extend the benefit of PARP inhibitors beyond BRCA-mutant cancers is of great interest in personalized medicine. Here we identified EGFR-amplification as a potential biomarker to predict sensitivity to PARP inhibition, providing selection for GBM patient population who will benefit from PARP inhibition therapy. Experimental...
Thu Dec 19, 2019 08:58
Cell-Free Circulating Tumor DNA Variant Allele Frequency Associates with Survival in Metastatic Cancer: Purpose: Physicians are expected to assess prognosis both for patient counseling and for determining suitability for clinical trials. Increasingly, cell-free circulating tumor DNA (cfDNA) sequencing is being performed for clinical decision-making. We sought to determine whether variant allele frequency (VAF) in cfDNA is associated with prognosis. Experimental Design: We performed a retrospective...
Thu Dec 19, 2019 08:58
5-hydroxymethylcytosine profiles in circulating cell-free DNA associate with disease burden in children with neuroblastoma: Purpose: 5-hydroxymethylcytosine (5-hmC) is an epigenetic marker of open chromatin and active gene expression. We profiled 5-hmC with Nano-hmC-Seal technology using 10ng of plasma derived cell-free DNA (cfDNA) in blood samples from patients with neuroblastoma to determine its utility as a biomarker. Experimental Design: For the Discovery cohort, one hundred 5-hmC profiles were...
Thu Dec 19, 2019 08:58
Agrin in the Muscularis Mucosa Serves as a Biomarker Distinguishing Hyperplastic Polyps from Sessile Serrated Lesions: Purpose: Sessile serrated lesions (SSL) are precursors to colon carcinoma (CRC), and their distinction from other polyps, in particular hyperplastic polyps (HPs), presents significant diagnostic challenges. We evaluated expression patterns in colonic polyps of previously identified CRC-associated extracellular matrix (ECM) proteins to identify markers distinguishing SSLs from other...
Thu Dec 19, 2019 08:58
Intra-articular venous malformation of the knee in children: magnetic resonance imaging findings and significance of synovial involvement: AbstractBackgroundIntra-articular venous malformations of the knee are an uncommon cause of unilateral knee pain in children. Timely diagnosis is important because lesions with intrasynovial involvement can lead to joint space hemorrhage and secondary cartilage damage.ObjectiveTo describe our tertiary center's experience of diagnostics and typical magnetic resonance...
Thu Dec 19, 2019 08:58
Comparison of image quality between synthetic and patients' electrocardiogram-gated 320-row pediatric cardiac computed tomography: AbstractBackgroundPediatric cardiac computed tomography (CT) can be acquired without electrode placement by using synthetic electrocardiogram (ECG).ObjectiveTo determine whether the depiction of gross cardiac structures and coronary arteries in 320-row pediatric CT is not inferior when CT is gated with synthetic ECG at 150 beats per minute (bpm), compared to the patients'...
Thu Dec 19, 2019 08:58
EFFICHRONIC study protocol: a non-controlled, multicentre European prospective study to measure the efficiency of a chronic disease self-management programme in socioeconomically vulnerable populations: IntroductionMore than 70% of world mortality is due to chronic conditions. Furthermore, it has been proven that social determinants have an enormous impact on both health-related behaviour and on the received attention from healthcare services. These determinants cause health inequalities. The objective...
Thu Dec 19, 2019 08:50
Association between severity of depressive symptoms and chronic knee pain in Korean adults aged over 50 years: a cross-sectional study using nationally representative data: ObjectivesTo identify the association between the presence and severity of depressive symptoms and those of chronic knee pain.DesignA retrospective cross-sectional study.ParticipantsWe used data from the sixth Korea National Health and Nutrition Examination Survey (KNHANES VI-2) performed in 2014. Overall, 7550 patients were included...
Thu Dec 19, 2019 08:49
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Thu Dec 19, 2019 08:41
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